{
    "info": {
        "nct_id": "NCT02816164",
        "official_title": "A Multi Centre Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Chemotherapy-Induced Febrile Neutropenia in Early Stage Breast Cancer (REaCT-G2)",
        "inclusion_criteria": "* Histologically confirmed primary breast cancer\n* Planned to start docetaxel component of FEC-D or AC-D, or first cycle of; dose-dense AC-T, TC, FEC-D or TAC chemotherapy\n* ≥19 years of age\n* Able to provide verbal consent\nHealthy volunteers allowed\nMust have minimum age of 19 Years",
        "exclusion_criteria": "* Contraindication to Filgrastim",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Histologically confirmed primary breast cancer",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Histologically confirmed"
                        ],
                        "criterion": "breast cancer",
                        "requirement_type": "confirmation method",
                        "expected_value": "histological"
                    },
                    {
                        "exact_snippets": [
                            "primary breast cancer"
                        ],
                        "criterion": "breast cancer",
                        "requirement_type": "type",
                        "expected_value": "primary"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Histologically confirmed"
                        ],
                        "criterion": "breast cancer",
                        "requirement_type": "confirmation method",
                        "expected_value": "histological"
                    },
                    {
                        "exact_snippets": [
                            "primary breast cancer"
                        ],
                        "criterion": "breast cancer",
                        "requirement_type": "type",
                        "expected_value": "primary"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Planned to start docetaxel component of FEC-D or AC-D, or first cycle of; dose-dense AC-T, TC, FEC-D or TAC chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Planned to start docetaxel component of FEC-D or AC-D"
                        ],
                        "criterion": "docetaxel component of FEC-D or AC-D",
                        "requirement_type": "planned start",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "first cycle of; dose-dense AC-T, TC, FEC-D or TAC chemotherapy"
                        ],
                        "criterion": "dose-dense AC-T, TC, FEC-D or TAC chemotherapy",
                        "requirement_type": "first cycle",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Planned to start docetaxel component of FEC-D or AC-D"
                                ],
                                "criterion": "docetaxel component of FEC-D or AC-D",
                                "requirement_type": "planned start",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "first cycle of; dose-dense AC-T, TC, FEC-D or TAC chemotherapy"
                                ],
                                "criterion": "dose-dense AC-T, TC, FEC-D or TAC chemotherapy",
                                "requirement_type": "first cycle",
                                "expected_value": true
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to provide verbal consent",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Able to provide verbal consent"
                        ],
                        "criterion": "verbal consent",
                        "requirement_type": "ability",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Able to provide verbal consent"
                        ],
                        "criterion": "verbal consent",
                        "requirement_type": "ability",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 19 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 19 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 19
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 19 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 19
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ≥19 years of age",
                "criterions": [
                    {
                        "exact_snippets": [
                            ">=19 years of age"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 19
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            ">=19 years of age"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 19
                                }
                            ]
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Contraindication to Filgrastim",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Contraindication to Filgrastim"
                        ],
                        "criterion": "Filgrastim",
                        "requirement_type": "contraindication",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Contraindication to Filgrastim"
                    ],
                    "criterion": "Filgrastim",
                    "requirement_type": "contraindication",
                    "expected_value": true
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}