{
    "info": {
        "nct_id": "NCT02558504",
        "official_title": "Clinical and Medico-economic Evaluation of Radiofrequency Ablation Versus Oesophagectomy in the Treatment of High Grade Dysplasia in Barrett's Oesophagus",
        "inclusion_criteria": "* Age over 18 years,\n* General Condition WHO 0, 1 or 2,\n* ASA Class I and II, eligible for endoscopic or surgical treatment with curative intent,\n* Histological diagnosis of high grade glandular epithelial neoplasia (Vienna 4-1 to 4-46), possibly multifocal or stage 0 (Tis, N0, M0),\n* Endoscopic and histological confirmed diagnosis of intestinal metaplasia,\n* Histological diagnosis confirmed by two endoscopies with biopsies and two pathological readings; biopsies should be carried out according to the protocol of the SFED (four-quadrant biopsies every cm) with at least once acetic acid for staining. Operators describe Barrett's esophagus using he SFED planimetric model. The final exam will be no more than two months before the date of treatment and should have been achieved in investigator establishment,\n* Extension height of Barrett's esophagus upstream of the upper part of the gastric folds or palisade vessels:\n\n  * Minimum 1 cm,\n  * Maximum 12 cm.\n* In case of previous treatment by mucosal resection or submucosal dissection (DSM) for severe dysplasia or microinvasive carcinoma:\n\n  * the resected lesion must have been well differentiated and confined to the muscular mucosa (m3 maximum) on histological analysis,\n  * resection should be more than two months,\n  * resection must have been macroscopically complete laterally,\n  * resection must have been histologically complete in depth,\n  * resection must have been histologically complete laterally with regard to the microinvasive cancer, that is to say with a clear margin of safety (margin may be high-grade dysplasia provided that the latter has not macroscopic translation),\n  * At least one endoscopic and histologic follow-up should be conducted with dye in a period of less than two months before the date of treatment, and at the investigator establishment.\n* Patient may take an inhibitor of proton pump equivalent to 2 times 40 mg of esomeprazole,\n* No mediastinal or celiac, or suspected metastatic lymph nodes by EUS,\n* Affiliation to a social security system or similar,\n* Lack of participation in another clinical study,\n* Informed consent signed.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* - Aged under 18,\n* Lack of informed consent signed,\n* Radiofrequency treatment history,\n* on going neoplastic history with a short prognosis,\n* Concomitant participation in another clinical study\n* Contraindication to general anesthesia,\n* Patient with an esophageal location of scleroderma\n* Presence of a cardiac pacemaker or stimulator\n* Pregnant women or likely to be in the absence of effective contraception,\n* Esophageal stenosis preventing the passage of an endoscope,\n* Histology other than glandular neoplasia,\n* History of or current history of esophageal cancer invading the submucosal layer of the esophagus or more,\n* Surgical treatment history (except anti-reflux treatment) or esophageal radiotherapy,\n* previous esophageal treatment by another method ablation: photodynamic therapy, argon plasma coagulation, laser, ....\n* Esophageal varices observed in endoscopy,\n* Coagulopathy or taking anticoagulants responsible an INR> 1.3 or a platelet count <75,000 per microL,\n* Life expectancy of less than 3 years, due to intercurrent disease, especially neoplastic,\n* Severe Medical pathology:\n\n  * Liver cirrhosis (Child-Pugh all stages)\n  * Respiratory failure:\n\nVEMS (Maximum Expiratory Volume Second) <1L / min\n\nPaO2 <60 mmHg\n\nPaCO2> 45 mmHg\n\n* Renal failure (Cl Cr < 60 mL /min /1,73m²),\n* Heart attack within the last six months or progressive coronary artery disease,\n* Severe distal arteriopathie > stage II of Leriche and Fontaine",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age over 18 years,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Age over 18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 18
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Age over 18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 18
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* General Condition WHO 0, 1 or 2,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "General Condition WHO 0, 1 or 2"
                        ],
                        "criterion": "WHO performance status",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 2
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "General Condition WHO 0, 1 or 2"
                        ],
                        "criterion": "WHO performance status",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 2
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ASA Class I and II, eligible for endoscopic or surgical treatment with curative intent,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "ASA Class I and II"
                        ],
                        "criterion": "ASA class",
                        "requirement_type": "classification",
                        "expected_value": [
                            "I",
                            "II"
                        ]
                    },
                    {
                        "exact_snippets": [
                            "eligible for endoscopic or surgical treatment"
                        ],
                        "criterion": "treatment eligibility",
                        "requirement_type": "eligibility",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "curative intent"
                        ],
                        "criterion": "treatment intent",
                        "requirement_type": "intent",
                        "expected_value": "curative"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "ASA Class I and II"
                                ],
                                "criterion": "ASA class",
                                "requirement_type": "classification",
                                "expected_value": [
                                    "I",
                                    "II"
                                ]
                            },
                            {
                                "exact_snippets": [
                                    "eligible for endoscopic or surgical treatment"
                                ],
                                "criterion": "treatment eligibility",
                                "requirement_type": "eligibility",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "curative intent"
                        ],
                        "criterion": "treatment intent",
                        "requirement_type": "intent",
                        "expected_value": "curative"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histological diagnosis of high grade glandular epithelial neoplasia (Vienna 4-1 to 4-46), possibly multifocal or stage 0 (Tis, N0, M0),",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Histological diagnosis of high grade glandular epithelial neoplasia"
                        ],
                        "criterion": "high grade glandular epithelial neoplasia",
                        "requirement_type": "diagnosis",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Vienna 4-1 to 4-46"
                        ],
                        "criterion": "Vienna classification",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 4.1
                                },
                                {
                                    "operator": "<=",
                                    "value": 4.46
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "possibly multifocal"
                        ],
                        "criterion": "multifocal",
                        "requirement_type": "possibility",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "stage 0 (Tis, N0, M0)"
                        ],
                        "criterion": "cancer stage",
                        "requirement_type": "stage",
                        "expected_value": "0 (Tis, N0, M0)"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Histological diagnosis of high grade glandular epithelial neoplasia"
                                ],
                                "criterion": "high grade glandular epithelial neoplasia",
                                "requirement_type": "diagnosis",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "Vienna 4-1 to 4-46"
                                ],
                                "criterion": "Vienna classification",
                                "requirement_type": "range",
                                "expected_value": {
                                    "comparisons": [
                                        {
                                            "operator": ">=",
                                            "value": 4.1
                                        },
                                        {
                                            "operator": "<=",
                                            "value": 4.46
                                        }
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": [
                                    "possibly multifocal"
                                ],
                                "criterion": "multifocal",
                                "requirement_type": "possibility",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "stage 0 (Tis, N0, M0)"
                                ],
                                "criterion": "cancer stage",
                                "requirement_type": "stage",
                                "expected_value": "0 (Tis, N0, M0)"
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Endoscopic and histological confirmed diagnosis of intestinal metaplasia,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Endoscopic and histological confirmed diagnosis of intestinal metaplasia"
                        ],
                        "criterion": "intestinal metaplasia",
                        "requirement_type": "diagnosis confirmation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Endoscopic and histological confirmed diagnosis of intestinal metaplasia"
                        ],
                        "criterion": "intestinal metaplasia",
                        "requirement_type": "diagnosis confirmation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Extension height of Barrett's esophagus upstream of the upper part of the gastric folds or palisade vessels:",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Extension height of Barrett's esophagus"
                        ],
                        "criterion": "Barrett's esophagus",
                        "requirement_type": "extension height",
                        "expected_value": "upstream of the upper part of the gastric folds or palisade vessels"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Extension height of Barrett's esophagus"
                        ],
                        "criterion": "Barrett's esophagus",
                        "requirement_type": "extension height",
                        "expected_value": "upstream of the upper part of the gastric folds or palisade vessels"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Minimum 1 cm,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Minimum 1 cm"
                        ],
                        "criterion": "size",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 1
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Minimum 1 cm"
                        ],
                        "criterion": "size",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 1
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Maximum 12 cm.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Maximum 12 cm"
                        ],
                        "criterion": "size",
                        "requirement_type": "maximum",
                        "expected_value": {
                            "operator": "<=",
                            "value": 12
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Maximum 12 cm"
                        ],
                        "criterion": "size",
                        "requirement_type": "maximum",
                        "expected_value": {
                            "operator": "<=",
                            "value": 12
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* In case of previous treatment by mucosal resection or submucosal dissection (DSM) for severe dysplasia or microinvasive carcinoma:",
                "criterions": [
                    {
                        "exact_snippets": [
                            "previous treatment by mucosal resection"
                        ],
                        "criterion": "mucosal resection",
                        "requirement_type": "previous treatment",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "previous treatment by",
                            "submucosal dissection (DSM)"
                        ],
                        "criterion": "submucosal dissection",
                        "requirement_type": "previous treatment",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "severe dysplasia"
                        ],
                        "criterion": "dysplasia",
                        "requirement_type": "severity",
                        "expected_value": "severe"
                    },
                    {
                        "exact_snippets": [
                            "microinvasive carcinoma"
                        ],
                        "criterion": "carcinoma",
                        "requirement_type": "invasiveness",
                        "expected_value": "microinvasive"
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "or_criteria": [
                        {
                            "exact_snippets": [
                                "previous treatment by mucosal resection"
                            ],
                            "criterion": "mucosal resection",
                            "requirement_type": "previous treatment",
                            "expected_value": true
                        },
                        {
                            "exact_snippets": [
                                "previous treatment by",
                                "submucosal dissection (DSM)"
                            ],
                            "criterion": "submucosal dissection",
                            "requirement_type": "previous treatment",
                            "expected_value": true
                        }
                    ]
                },
                "then_criteria": {
                    "or_criteria": [
                        {
                            "exact_snippets": [
                                "severe dysplasia"
                            ],
                            "criterion": "dysplasia",
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        },
                        {
                            "exact_snippets": [
                                "microinvasive carcinoma"
                            ],
                            "criterion": "carcinoma",
                            "requirement_type": "invasiveness",
                            "expected_value": "microinvasive"
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* the resected lesion must have been well differentiated and confined to the muscular mucosa (m3 maximum) on histological analysis,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "resected lesion must have been well differentiated"
                        ],
                        "criterion": "resected lesion",
                        "requirement_type": "differentiation",
                        "expected_value": "well differentiated"
                    },
                    {
                        "exact_snippets": [
                            "resected lesion must have been",
                            "confined to the muscular mucosa (m3 maximum)"
                        ],
                        "criterion": "resected lesion",
                        "requirement_type": "location",
                        "expected_value": "muscular mucosa (m3 maximum)"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "resected lesion must have been well differentiated"
                        ],
                        "criterion": "resected lesion",
                        "requirement_type": "differentiation",
                        "expected_value": "well differentiated"
                    },
                    {
                        "exact_snippets": [
                            "resected lesion must have been",
                            "confined to the muscular mucosa (m3 maximum)"
                        ],
                        "criterion": "resected lesion",
                        "requirement_type": "location",
                        "expected_value": "muscular mucosa (m3 maximum)"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* resection should be more than two months,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "resection should be more than two months"
                        ],
                        "criterion": "resection",
                        "requirement_type": "time since",
                        "expected_value": {
                            "operator": ">",
                            "value": 2
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "resection should be more than two months"
                        ],
                        "criterion": "resection",
                        "requirement_type": "time since",
                        "expected_value": {
                            "operator": ">",
                            "value": 2
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* resection must have been macroscopically complete laterally,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "resection must have been macroscopically complete laterally"
                        ],
                        "criterion": "resection",
                        "requirement_type": "completeness",
                        "expected_value": "macroscopically complete laterally"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "resection must have been macroscopically complete laterally"
                        ],
                        "criterion": "resection",
                        "requirement_type": "completeness",
                        "expected_value": "macroscopically complete laterally"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* resection must have been histologically complete in depth,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "resection must have been histologically complete in depth"
                        ],
                        "criterion": "resection",
                        "requirement_type": "completeness",
                        "expected_value": "histologically complete in depth"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "resection must have been histologically complete in depth"
                        ],
                        "criterion": "resection",
                        "requirement_type": "completeness",
                        "expected_value": "histologically complete in depth"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* resection must have been histologically complete laterally with regard to the microinvasive cancer, that is to say with a clear margin of safety (margin may be high-grade dysplasia provided that the latter has not macroscopic translation),",
                "criterions": [
                    {
                        "exact_snippets": [
                            "resection must have been histologically complete laterally"
                        ],
                        "criterion": "resection",
                        "requirement_type": "completeness",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "clear margin of safety"
                        ],
                        "criterion": "margin of safety",
                        "requirement_type": "clarity",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "margin may be high-grade dysplasia"
                        ],
                        "criterion": "margin",
                        "requirement_type": "grade",
                        "expected_value": "high-grade dysplasia"
                    },
                    {
                        "exact_snippets": [
                            "provided that the latter has not macroscopic translation"
                        ],
                        "criterion": "macroscopic translation",
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": [
                                "margin may be high-grade dysplasia"
                            ],
                            "criterion": "margin",
                            "requirement_type": "grade",
                            "expected_value": "high-grade dysplasia"
                        },
                        {
                            "exact_snippets": [
                                "provided that the latter has not macroscopic translation"
                            ],
                            "criterion": "macroscopic translation",
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": [
                                "resection must have been histologically complete laterally"
                            ],
                            "criterion": "resection",
                            "requirement_type": "completeness",
                            "expected_value": true
                        },
                        {
                            "exact_snippets": [
                                "clear margin of safety"
                            ],
                            "criterion": "margin of safety",
                            "requirement_type": "clarity",
                            "expected_value": true
                        }
                    ]
                },
                "else_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": [
                                "resection must have been histologically complete laterally"
                            ],
                            "criterion": "resection",
                            "requirement_type": "completeness",
                            "expected_value": true
                        },
                        {
                            "exact_snippets": [
                                "clear margin of safety"
                            ],
                            "criterion": "margin of safety",
                            "requirement_type": "clarity",
                            "expected_value": true
                        }
                    ]
                }
            }
        },
        {
            "identified_line": {
                "line": "* At least one endoscopic and histologic follow-up should be conducted with dye in a period of less than two months before the date of treatment, and at the investigator establishment.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "At least one endoscopic and histologic follow-up should be conducted"
                        ],
                        "criterion": "endoscopic and histologic follow-up",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": ">=",
                            "value": 1
                        }
                    },
                    {
                        "exact_snippets": [
                            "dye"
                        ],
                        "criterion": "dye",
                        "requirement_type": "use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "in a period of less than two months before the date of treatment"
                        ],
                        "criterion": "time period before treatment",
                        "requirement_type": "duration",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 2
                                },
                                {
                                    "operator": ">=",
                                    "value": 0
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "at the investigator establishment"
                        ],
                        "criterion": "location of follow-up",
                        "requirement_type": "location",
                        "expected_value": "investigator establishment"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "At least one endoscopic and histologic follow-up should be conducted"
                                ],
                                "criterion": "endoscopic and histologic follow-up",
                                "requirement_type": "quantity",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 1
                                }
                            },
                            {
                                "exact_snippets": [
                                    "dye"
                                ],
                                "criterion": "dye",
                                "requirement_type": "use",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "in a period of less than two months before the date of treatment"
                        ],
                        "criterion": "time period before treatment",
                        "requirement_type": "duration",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 2
                                },
                                {
                                    "operator": ">=",
                                    "value": 0
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "at the investigator establishment"
                        ],
                        "criterion": "location of follow-up",
                        "requirement_type": "location",
                        "expected_value": "investigator establishment"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient may take an inhibitor of proton pump equivalent to 2 times 40 mg of esomeprazole,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "inhibitor of proton pump"
                        ],
                        "criterion": "proton pump inhibitor",
                        "requirement_type": "allowance",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "equivalent to 2 times 40 mg of esomeprazole"
                        ],
                        "criterion": "esomeprazole dosage",
                        "requirement_type": "equivalence",
                        "expected_value": "2 times 40 mg"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "inhibitor of proton pump"
                        ],
                        "criterion": "proton pump inhibitor",
                        "requirement_type": "allowance",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "equivalent to 2 times 40 mg of esomeprazole"
                        ],
                        "criterion": "esomeprazole dosage",
                        "requirement_type": "equivalence",
                        "expected_value": "2 times 40 mg"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Affiliation to a social security system or similar,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Affiliation to a social security system or similar"
                        ],
                        "criterion": "social security system affiliation",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Affiliation to a social security system or similar"
                        ],
                        "criterion": "social security system affiliation",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Lack of participation in another clinical study,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Lack of participation in another clinical study"
                        ],
                        "criterion": "participation in another clinical study",
                        "requirement_type": "absence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Lack of participation in another clinical study"
                        ],
                        "criterion": "participation in another clinical study",
                        "requirement_type": "absence",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Informed consent signed.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Informed consent signed"
                        ],
                        "criterion": "informed consent",
                        "requirement_type": "signed",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Informed consent signed"
                        ],
                        "criterion": "informed consent",
                        "requirement_type": "signed",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histological diagnosis confirmed by two endoscopies with biopsies and two pathological readings; biopsies should be carried out according to the protocol of the SFED (four-quadrant biopsies every cm) with at least once acetic acid for staining. Operators describe Barrett's esophagus using he SFED planimetric model. The final exam will be no more than two months before the date of treatment and should have been achieved in investigator establishment,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Histological diagnosis confirmed by two endoscopies with biopsies"
                        ],
                        "criterion": "histological diagnosis",
                        "requirement_type": "confirmation",
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                    },
                    {
                        "exact_snippets": [
                            "two pathological readings"
                        ],
                        "criterion": "pathological readings",
                        "requirement_type": "quantity",
                        "expected_value": ">= 2"
                    },
                    {
                        "exact_snippets": [
                            "biopsies should be carried out according to the protocol of the SFED (four-quadrant biopsies every cm)"
                        ],
                        "criterion": "biopsies protocol",
                        "requirement_type": "adherence",
                        "expected_value": "SFED protocol"
                    },
                    {
                        "exact_snippets": [
                            "at least once acetic acid for staining"
                        ],
                        "criterion": "acetic acid staining",
                        "requirement_type": "frequency",
                        "expected_value": ">= 1"
                    },
                    {
                        "exact_snippets": [
                            "Operators describe Barrett's esophagus using the SFED planimetric model"
                        ],
                        "criterion": "Barrett's esophagus description",
                        "requirement_type": "method",
                        "expected_value": "SFED planimetric model"
                    },
                    {
                        "exact_snippets": [
                            "The final exam will be no more than two months before the date of treatment"
                        ],
                        "criterion": "final exam timing",
                        "requirement_type": "timing",
                        "expected_value": "<= 2 months before treatment"
                    },
                    {
                        "exact_snippets": [
                            "should have been achieved in investigator establishment"
                        ],
                        "criterion": "exam location",
                        "requirement_type": "location",
                        "expected_value": "investigator establishment"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Histological diagnosis confirmed by two endoscopies with biopsies"
                                ],
                                "criterion": "histological diagnosis",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "two pathological readings"
                                ],
                                "criterion": "pathological readings",
                                "requirement_type": "quantity",
                                "expected_value": ">= 2"
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "biopsies should be carried out according to the protocol of the SFED (four-quadrant biopsies every cm)"
                        ],
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                    },
                    {
                        "exact_snippets": [
                            "at least once acetic acid for staining"
                        ],
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                        "requirement_type": "frequency",
                        "expected_value": ">= 1"
                    },
                    {
                        "exact_snippets": [
                            "Operators describe Barrett's esophagus using the SFED planimetric model"
                        ],
                        "criterion": "Barrett's esophagus description",
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                        "expected_value": "SFED planimetric model"
                    },
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                        "exact_snippets": [
                            "The final exam will be no more than two months before the date of treatment"
                        ],
                        "criterion": "final exam timing",
                        "requirement_type": "timing",
                        "expected_value": "<= 2 months before treatment"
                    },
                    {
                        "exact_snippets": [
                            "should have been achieved in investigator establishment"
                        ],
                        "criterion": "exam location",
                        "requirement_type": "location",
                        "expected_value": "investigator establishment"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No mediastinal or celiac, or suspected metastatic lymph nodes by EUS,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "No mediastinal",
                            "lymph nodes"
                        ],
                        "criterion": "mediastinal lymph nodes",
                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "No celiac",
                            "lymph nodes"
                        ],
                        "criterion": "celiac lymph nodes",
                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "No",
                            "suspected metastatic lymph nodes"
                        ],
                        "criterion": "suspected metastatic lymph nodes",
                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "by EUS"
                        ],
                        "criterion": "EUS",
                        "requirement_type": "method of detection",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "No mediastinal",
                                            "lymph nodes"
                                        ],
                                        "criterion": "mediastinal lymph nodes",
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    },
                                    {
                                        "exact_snippets": [
                                            "by EUS"
                                        ],
                                        "criterion": "EUS",
                                        "requirement_type": "method of detection",
                                        "expected_value": true
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "No celiac",
                                            "lymph nodes"
                                        ],
                                        "criterion": "celiac lymph nodes",
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    },
                                    {
                                        "exact_snippets": [
                                            "by EUS"
                                        ],
                                        "criterion": "EUS",
                                        "requirement_type": "method of detection",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "No",
                                    "suspected metastatic lymph nodes"
                                ],
                                "criterion": "suspected metastatic lymph nodes",
                                "requirement_type": "presence",
                                "expected_value": false
                            },
                            {
                                "exact_snippets": [
                                    "by EUS"
                                ],
                                "criterion": "EUS",
                                "requirement_type": "method of detection",
                                "expected_value": true
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* - Aged under 18,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Aged under 18"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 18
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Aged under 18"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 18
                            }
                        ]
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Lack of informed consent signed,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Lack of informed consent signed"
                        ],
                        "criterion": "informed consent",
                        "requirement_type": "signed",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Lack of informed consent signed"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "signed",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Radiofrequency treatment history,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Radiofrequency treatment history"
                        ],
                        "criterion": "radiofrequency treatment",
                        "requirement_type": "history",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Radiofrequency treatment history"
                    ],
                    "criterion": "radiofrequency treatment",
                    "requirement_type": "history",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* on going neoplastic history with a short prognosis,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "on going neoplastic history"
                        ],
                        "criterion": "neoplastic history",
                        "requirement_type": "status",
                        "expected_value": "ongoing"
                    },
                    {
                        "exact_snippets": [
                            "short prognosis"
                        ],
                        "criterion": "prognosis",
                        "requirement_type": "duration",
                        "expected_value": "short"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "on going neoplastic history"
                        ],
                        "criterion": "neoplastic history",
                        "requirement_type": "status",
                        "expected_value": "ongoing"
                    },
                    {
                        "exact_snippets": [
                            "short prognosis"
                        ],
                        "criterion": "prognosis",
                        "requirement_type": "duration",
                        "expected_value": "short"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concomitant participation in another clinical study",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Concomitant participation in another clinical study"
                        ],
                        "criterion": "participation in another clinical study",
                        "requirement_type": "concomitant",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Concomitant participation in another clinical study"
                    ],
                    "criterion": "participation in another clinical study",
                    "requirement_type": "concomitant",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Contraindication to general anesthesia,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Contraindication to general anesthesia"
                        ],
                        "criterion": "general anesthesia",
                        "requirement_type": "contraindication",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Contraindication to general anesthesia"
                    ],
                    "criterion": "general anesthesia",
                    "requirement_type": "contraindication",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient with an esophageal location of scleroderma",
                "criterions": [
                    {
                        "exact_snippets": [
                            "esophageal location of scleroderma"
                        ],
                        "criterion": "scleroderma",
                        "requirement_type": "location",
                        "expected_value": "esophageal"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "esophageal location of scleroderma"
                        ],
                        "criterion": "scleroderma",
                        "requirement_type": "location",
                        "expected_value": "esophageal"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Presence of a cardiac pacemaker or stimulator",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Presence of a cardiac pacemaker or stimulator"
                        ],
                        "criterion": "cardiac pacemaker or stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Presence of a cardiac pacemaker or stimulator"
                    ],
                    "criterion": "cardiac pacemaker or stimulator",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant women or likely to be in the absence of effective contraception,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Pregnant women"
                        ],
                        "criterion": "pregnancy",
                        "requirement_type": "status",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "absence of effective contraception"
                        ],
                        "criterion": "contraception",
                        "requirement_type": "effectiveness",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": [
                                "Pregnant women"
                            ],
                            "criterion": "pregnancy",
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": [
                                "absence of effective contraception"
                            ],
                            "criterion": "contraception",
                            "requirement_type": "effectiveness",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Esophageal stenosis preventing the passage of an endoscope,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Esophageal stenosis"
                        ],
                        "criterion": "esophageal stenosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "preventing the passage of an endoscope"
                        ],
                        "criterion": "endoscope passage",
                        "requirement_type": "ability",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Esophageal stenosis"
                        ],
                        "criterion": "esophageal stenosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "preventing the passage of an endoscope"
                        ],
                        "criterion": "endoscope passage",
                        "requirement_type": "ability",
                        "expected_value": false
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histology other than glandular neoplasia,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Histology other than glandular neoplasia"
                        ],
                        "criterion": "histology",
                        "requirement_type": "type",
                        "expected_value": "other than glandular neoplasia"
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Histology other than glandular neoplasia"
                    ],
                    "criterion": "histology",
                    "requirement_type": "type",
                    "expected_value": "other than glandular neoplasia"
                }
            }
        },
        {
            "identified_line": {
                "line": "* History of or current history of esophageal cancer invading the submucosal layer of the esophagus or more,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "History of or current history of esophageal cancer"
                        ],
                        "criterion": "esophageal cancer",
                        "requirement_type": "history",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "invading the submucosal layer of the esophagus or more"
                        ],
                        "criterion": "esophageal cancer invasion",
                        "requirement_type": "severity",
                        "expected_value": "submucosal layer or more"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "History of or current history of esophageal cancer"
                                ],
                                "criterion": "esophageal cancer",
                                "requirement_type": "history",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "invading the submucosal layer of the esophagus or more"
                                ],
                                "criterion": "esophageal cancer invasion",
                                "requirement_type": "severity",
                                "expected_value": "submucosal layer or more"
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Surgical treatment history (except anti-reflux treatment) or esophageal radiotherapy,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Surgical treatment history"
                        ],
                        "criterion": "surgical treatment",
                        "requirement_type": "history",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "esophageal radiotherapy"
                        ],
                        "criterion": "esophageal radiotherapy",
                        "requirement_type": "history",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Surgical treatment history"
                                ],
                                "criterion": "surgical treatment",
                                "requirement_type": "history",
                                "expected_value": true
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": [
                                        "Surgical treatment history"
                                    ],
                                    "criterion": "surgical treatment",
                                    "requirement_type": "type",
                                    "expected_value": "anti-reflux"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "esophageal radiotherapy"
                        ],
                        "criterion": "esophageal radiotherapy",
                        "requirement_type": "history",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* previous esophageal treatment by another method ablation: photodynamic therapy, argon plasma coagulation, laser, ....",
                "criterions": [
                    {
                        "exact_snippets": [
                            "previous esophageal treatment by another method ablation"
                        ],
                        "criterion": "esophageal treatment",
                        "requirement_type": "previous method",
                        "expected_value": [
                            "photodynamic therapy",
                            "argon plasma coagulation",
                            "laser"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": [
                                        "previous esophageal treatment by another method ablation"
                                    ],
                                    "criterion": "esophageal treatment",
                                    "requirement_type": "previous method",
                                    "expected_value": "photodynamic therapy"
                                }
                            ]
                        }
                    },
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": [
                                        "previous esophageal treatment by another method ablation"
                                    ],
                                    "criterion": "esophageal treatment",
                                    "requirement_type": "previous method",
                                    "expected_value": "argon plasma coagulation"
                                }
                            ]
                        }
                    },
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": [
                                        "previous esophageal treatment by another method ablation"
                                    ],
                                    "criterion": "esophageal treatment",
                                    "requirement_type": "previous method",
                                    "expected_value": "laser"
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Esophageal varices observed in endoscopy,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Esophageal varices observed in endoscopy"
                        ],
                        "criterion": "esophageal varices",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Esophageal varices observed in endoscopy"
                    ],
                    "criterion": "esophageal varices",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Coagulopathy or taking anticoagulants responsible an INR> 1.3 or a platelet count <75,000 per microL,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Coagulopathy"
                        ],
                        "criterion": "coagulopathy",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "taking anticoagulants"
                        ],
                        "criterion": "anticoagulants",
                        "requirement_type": "usage",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "INR> 1.3"
                        ],
                        "criterion": "INR",
                        "requirement_type": "value",
                        "expected_value": {
                            "operator": ">",
                            "value": 1.3
                        }
                    },
                    {
                        "exact_snippets": [
                            "platelet count <75,000 per microL"
                        ],
                        "criterion": "platelet count",
                        "requirement_type": "value",
                        "expected_value": {
                            "operator": "<",
                            "value": 75000
                        }
                    }
                ]
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                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Coagulopathy"
                                ],
                                "criterion": "coagulopathy",
                                "requirement_type": "presence",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "INR> 1.3"
                                ],
                                "criterion": "INR",
                                "requirement_type": "value",
                                "expected_value": {
                                    "operator": ">",
                                    "value": 1.3
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                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "taking anticoagulants"
                                ],
                                "criterion": "anticoagulants",
                                "requirement_type": "usage",
                                "expected_value": true
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": [
                                            "INR> 1.3"
                                        ],
                                        "criterion": "INR",
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                                            "value": 1.3
                                        }
                                    },
                                    {
                                        "exact_snippets": [
                                            "platelet count <75,000 per microL"
                                        ],
                                        "criterion": "platelet count",
                                        "requirement_type": "value",
                                        "expected_value": {
                                            "operator": "<",
                                            "value": 75000
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
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        },
        {
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                    {
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                            "Life expectancy of less than 3 years"
                        ],
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                        "requirement_type": "duration",
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                            "value": 3
                        }
                    },
                    {
                        "exact_snippets": [
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                    {
                        "exact_snippets": [
                            "especially neoplastic"
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                        "requirement_type": "presence",
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                    }
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                                "intercurrent disease"
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                        "Life expectancy of less than 3 years"
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                        "value": 3
                    }
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        },
        {
            "identified_line": {
                "line": "* Severe Medical pathology:",
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                    {
                        "exact_snippets": [
                            "Severe Medical pathology"
                        ],
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                ]
            },
            "logical_structure": {
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                    "exact_snippets": [
                        "Severe Medical pathology"
                    ],
                    "criterion": "medical pathology",
                    "requirement_type": "severity",
                    "expected_value": "severe"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Liver cirrhosis (Child-Pugh all stages)",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Liver cirrhosis"
                        ],
                        "criterion": "liver cirrhosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Child-Pugh all stages"
                        ],
                        "criterion": "Child-Pugh stage",
                        "requirement_type": "range",
                        "expected_value": [
                            "A",
                            "B",
                            "C"
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                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": [
                            "Liver cirrhosis"
                        ],
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                        "requirement_type": "presence",
                        "expected_value": true
                    },
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                        "exact_snippets": [
                            "Child-Pugh all stages"
                        ],
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        },
        {
            "identified_line": {
                "line": "* Respiratory failure:",
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                    {
                        "exact_snippets": [
                            "Respiratory failure"
                        ],
                        "criterion": "respiratory failure",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Respiratory failure"
                    ],
                    "criterion": "respiratory failure",
                    "requirement_type": "presence",
                    "expected_value": true
                }
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        },
        {
            "identified_line": {
                "line": "VEMS (Maximum Expiratory Volume Second) <1L / min",
                "criterions": [
                    {
                        "exact_snippets": [
                            "VEMS (Maximum Expiratory Volume Second) <1L / min"
                        ],
                        "criterion": "VEMS (Maximum Expiratory Volume Second)",
                        "requirement_type": "quantity",
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                                {
                                    "operator": "<",
                                    "value": 1
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                ]
            },
            "logical_structure": {
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                        "VEMS (Maximum Expiratory Volume Second) <1L / min"
                    ],
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                    "requirement_type": "quantity",
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                            {
                                "operator": "<",
                                "value": 1
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        {
            "identified_line": {
                "line": "PaO2 <60 mmHg",
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                    {
                        "exact_snippets": [
                            "PaO2 <60 mmHg"
                        ],
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                        "requirement_type": "level",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 60
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "exact_snippets": [
                        "PaO2 <60 mmHg"
                    ],
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                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 60
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                        ]
                    }
                }
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        },
        {
            "identified_line": {
                "line": "PaCO2> 45 mmHg",
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                    {
                        "exact_snippets": [
                            "PaCO2> 45 mmHg"
                        ],
                        "criterion": "PaCO2",
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": ">",
                            "value": 45
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "exact_snippets": [
                        "PaCO2> 45 mmHg"
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                    "requirement_type": "level",
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                        "operator": ">",
                        "value": 45
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                }
            }
        },
        {
            "identified_line": {
                "line": "* Renal failure (Cl Cr < 60 mL /min /1,73m²),",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Renal failure"
                        ],
                        "criterion": "renal failure",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Cl Cr < 60 mL /min /1,73m²"
                        ],
                        "criterion": "creatinine clearance",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": "<",
                            "value": 60
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Renal failure"
                        ],
                        "criterion": "renal failure",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Cl Cr < 60 mL /min /1,73m²"
                        ],
                        "criterion": "creatinine clearance",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": "<",
                            "value": 60
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Heart attack within the last six months or progressive coronary artery disease,",
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                    {
                        "exact_snippets": [
                            "Heart attack within the last six months"
                        ],
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                        "requirement_type": "time since occurrence",
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                                    "operator": "<=",
                                    "value": 6
                                }
                            ]
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                    },
                    {
                        "exact_snippets": [
                            "progressive coronary artery disease"
                        ],
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                        "requirement_type": "progression",
                        "expected_value": true
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                ]
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            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Heart attack within the last six months"
                                ],
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                                "requirement_type": "time since occurrence",
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                                    "comparisons": [
                                        {
                                            "operator": "<=",
                                            "value": 6
                                        }
                                    ]
                                }
                            },
                            {
                                "exact_snippets": [
                                    "progressive coronary artery disease"
                                ],
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                                "requirement_type": "progression",
                                "expected_value": true
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Severe distal arteriopathie > stage II of Leriche and Fontaine",
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                    {
                        "exact_snippets": [
                            "Severe distal arteriopathie"
                        ],
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                        "requirement_type": "severity",
                        "expected_value": "severe"
                    },
                    {
                        "exact_snippets": [
                            "> stage II of Leriche and Fontaine"
                        ],
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                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 2
                                }
                            ]
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Severe distal arteriopathie"
                        ],
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                        "requirement_type": "severity",
                        "expected_value": "severe"
                    },
                    {
                        "exact_snippets": [
                            "> stage II of Leriche and Fontaine"
                        ],
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                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 2
                                }
                            ]
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}