{
    "info": {
        "nct_id": "NCT02550769",
        "official_title": "Multicenter Prospective Randomized Controlled Study of the Transanal Total Mesorectal Excision Versus Laparoscopic Low Anterior Resection in Rectal Cancer",
        "inclusion_criteria": "* Age over 18 years\n* Patients with rectal cancer stage: cT1-2-3, cN0-1, cM0.\n* Tumor equal or below 10 cm from the anal verge, candidates to (ETM) low anterior resection and anastomosis, with or without preoperative chemo-radiotherapy.\n* Adenocarcinoma of low or moderate differentiation\n* ASA I, II, III.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Do not sign informed consent\n* Pregnant patients\n* Liver cirrhosis\n* Undifferentiated adenocarcinoma.\n* cT4\n* Metastatic disease (M1)\n* chronic renal failure on dialysis\n* ASA IV\n* BMI <18 and> 35 kg / m2",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age over 18 years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Age over 18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Age over 18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">",
                            "value": 18
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with rectal cancer stage: cT1-2-3, cN0-1, cM0.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "rectal cancer"
                        ],
                        "criterion": "rectal cancer",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "stage: cT1-2-3"
                        ],
                        "criterion": "cT stage",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 1
                                },
                                {
                                    "operator": "<=",
                                    "value": 3
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "cN0-1"
                        ],
                        "criterion": "cN stage",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 1
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "cM0"
                        ],
                        "criterion": "cM stage",
                        "requirement_type": "value",
                        "expected_value": "0"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "rectal cancer"
                        ],
                        "criterion": "rectal cancer",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "stage: cT1-2-3"
                        ],
                        "criterion": "cT stage",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 1
                                },
                                {
                                    "operator": "<=",
                                    "value": 3
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "cN0-1"
                        ],
                        "criterion": "cN stage",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 1
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "cM0"
                        ],
                        "criterion": "cM stage",
                        "requirement_type": "value",
                        "expected_value": "0"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumor equal or below 10 cm from the anal verge, candidates to (ETM) low anterior resection and anastomosis, with or without preoperative chemo-radiotherapy.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Tumor equal or below 10 cm from the anal verge"
                        ],
                        "criterion": "tumor distance from anal verge",
                        "requirement_type": "distance",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 10
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "candidates to (ETM) low anterior resection and anastomosis"
                        ],
                        "criterion": "surgical candidacy",
                        "requirement_type": "procedure",
                        "expected_value": "(ETM) low anterior resection and anastomosis"
                    },
                    {
                        "exact_snippets": [
                            "with or without preoperative chemo-radiotherapy"
                        ],
                        "criterion": "preoperative chemo-radiotherapy",
                        "requirement_type": "necessity",
                        "expected_value": [
                            "with",
                            "without"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Tumor equal or below 10 cm from the anal verge"
                                ],
                                "criterion": "tumor distance from anal verge",
                                "requirement_type": "distance",
                                "expected_value": {
                                    "comparisons": [
                                        {
                                            "operator": "<=",
                                            "value": 10
                                        }
                                    ]
                                }
                            },
                            {
                                "exact_snippets": [
                                    "candidates to (ETM) low anterior resection and anastomosis"
                                ],
                                "criterion": "surgical candidacy",
                                "requirement_type": "procedure",
                                "expected_value": "(ETM) low anterior resection and anastomosis"
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": [
                                    "with or without preoperative chemo-radiotherapy"
                                ],
                                "criterion": "preoperative chemo-radiotherapy",
                                "requirement_type": "necessity",
                                "expected_value": "with"
                            },
                            {
                                "exact_snippets": [
                                    "with or without preoperative chemo-radiotherapy"
                                ],
                                "criterion": "preoperative chemo-radiotherapy",
                                "requirement_type": "necessity",
                                "expected_value": "without"
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adenocarcinoma of low or moderate differentiation",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Adenocarcinoma"
                        ],
                        "criterion": "adenocarcinoma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "low or moderate differentiation"
                        ],
                        "criterion": "differentiation",
                        "requirement_type": "severity",
                        "expected_value": [
                            "low",
                            "moderate"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Adenocarcinoma"
                        ],
                        "criterion": "adenocarcinoma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "low or moderate differentiation"
                        ],
                        "criterion": "differentiation",
                        "requirement_type": "severity",
                        "expected_value": [
                            "low",
                            "moderate"
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ASA I, II, III.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "ASA I, II, III"
                        ],
                        "criterion": "ASA classification",
                        "requirement_type": "category",
                        "expected_value": [
                            "I",
                            "II",
                            "III"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "ASA I, II, III"
                        ],
                        "criterion": "ASA classification",
                        "requirement_type": "category",
                        "expected_value": [
                            "I",
                            "II",
                            "III"
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Do not sign informed consent",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Do not sign informed consent"
                        ],
                        "criterion": "informed consent",
                        "requirement_type": "signed",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Do not sign informed consent"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "signed",
                    "expected_value": false
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant patients",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Pregnant patients"
                        ],
                        "criterion": "pregnancy",
                        "requirement_type": "status",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Pregnant patients"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "status",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Liver cirrhosis",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Liver cirrhosis"
                        ],
                        "criterion": "liver cirrhosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Liver cirrhosis"
                    ],
                    "criterion": "liver cirrhosis",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Undifferentiated adenocarcinoma.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Undifferentiated adenocarcinoma"
                        ],
                        "criterion": "adenocarcinoma",
                        "requirement_type": "differentiation",
                        "expected_value": "undifferentiated"
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Undifferentiated adenocarcinoma"
                    ],
                    "criterion": "adenocarcinoma",
                    "requirement_type": "differentiation",
                    "expected_value": "undifferentiated"
                }
            }
        },
        {
            "identified_line": {
                "line": "* cT4",
                "criterions": [
                    {
                        "exact_snippets": [
                            "cT4"
                        ],
                        "criterion": "cT4",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "cT4"
                    ],
                    "criterion": "cT4",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic disease (M1)",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Metastatic disease"
                        ],
                        "criterion": "metastatic disease",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "M1"
                        ],
                        "criterion": "metastatic disease",
                        "requirement_type": "stage",
                        "expected_value": "M1"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Metastatic disease"
                        ],
                        "criterion": "metastatic disease",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "M1"
                        ],
                        "criterion": "metastatic disease",
                        "requirement_type": "stage",
                        "expected_value": "M1"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* chronic renal failure on dialysis",
                "criterions": [
                    {
                        "exact_snippets": [
                            "chronic renal failure"
                        ],
                        "criterion": "renal failure",
                        "requirement_type": "chronicity",
                        "expected_value": "chronic"
                    },
                    {
                        "exact_snippets": [
                            "on dialysis"
                        ],
                        "criterion": "dialysis",
                        "requirement_type": "treatment",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "chronic renal failure"
                        ],
                        "criterion": "renal failure",
                        "requirement_type": "chronicity",
                        "expected_value": "chronic"
                    },
                    {
                        "exact_snippets": [
                            "on dialysis"
                        ],
                        "criterion": "dialysis",
                        "requirement_type": "treatment",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ASA IV",
                "criterions": [
                    {
                        "exact_snippets": [
                            "ASA IV"
                        ],
                        "criterion": "ASA classification",
                        "requirement_type": "classification",
                        "expected_value": "IV"
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "ASA IV"
                    ],
                    "criterion": "ASA classification",
                    "requirement_type": "classification",
                    "expected_value": "IV"
                }
            }
        },
        {
            "identified_line": {
                "line": "* BMI <18 and> 35 kg / m2",
                "criterions": [
                    {
                        "exact_snippets": [
                            "BMI <18"
                        ],
                        "criterion": "BMI",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 18
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "> 35 kg / m2"
                        ],
                        "criterion": "BMI",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 35
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "BMI <18"
                        ],
                        "criterion": "BMI",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 18
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "> 35 kg / m2"
                        ],
                        "criterion": "BMI",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 35
                                }
                            ]
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}