{
    "info": {
        "nct_id": "NCT02415257",
        "official_title": "Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function",
        "inclusion_criteria": "* Vestibular schwannoma advised to surgical treatment\n* No measurable remaining vestibular function\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* impaired decision making\n* neurofibromatosis\n* signs for central dysfunction\n* remaining vestibular function\n* Patients are advised not to participate in the gentamicin arm if\n* hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz) and speech discrimination better than 70%\n* the neurosurgeon aim at hearing preservation surgery and do not want to risk gentamicin associated hearing loss",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Vestibular schwannoma advised to surgical treatment",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Vestibular schwannoma"
                        ],
                        "criterion": "vestibular schwannoma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "advised to surgical treatment"
                        ],
                        "criterion": "surgical treatment",
                        "requirement_type": "recommendation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Vestibular schwannoma"
                        ],
                        "criterion": "vestibular schwannoma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "advised to surgical treatment"
                        ],
                        "criterion": "surgical treatment",
                        "requirement_type": "recommendation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No measurable remaining vestibular function",
                "criterions": [
                    {
                        "exact_snippets": [
                            "No measurable remaining vestibular function"
                        ],
                        "criterion": "vestibular function",
                        "requirement_type": "quantity",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "No measurable remaining vestibular function"
                    ],
                    "criterion": "vestibular function",
                    "requirement_type": "quantity",
                    "expected_value": false
                }
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* impaired decision making",
                "criterions": [
                    {
                        "exact_snippets": [
                            "impaired decision making"
                        ],
                        "criterion": "decision making",
                        "requirement_type": "impairment",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "impaired decision making"
                    ],
                    "criterion": "decision making",
                    "requirement_type": "impairment",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* neurofibromatosis",
                "criterions": [
                    {
                        "exact_snippets": [
                            "neurofibromatosis"
                        ],
                        "criterion": "neurofibromatosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "neurofibromatosis"
                    ],
                    "criterion": "neurofibromatosis",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* signs for central dysfunction",
                "criterions": [
                    {
                        "exact_snippets": [
                            "signs for central dysfunction"
                        ],
                        "criterion": "central dysfunction",
                        "requirement_type": "signs",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "signs for central dysfunction"
                    ],
                    "criterion": "central dysfunction",
                    "requirement_type": "signs",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* remaining vestibular function",
                "criterions": [
                    {
                        "exact_snippets": [
                            "remaining vestibular function"
                        ],
                        "criterion": "vestibular function",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "remaining vestibular function"
                    ],
                    "criterion": "vestibular function",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients are advised not to participate in the gentamicin arm if",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Patients are advised not to participate in the gentamicin arm"
                        ],
                        "criterion": "gentamicin arm participation",
                        "requirement_type": "advisability",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Patients are advised not to participate in the gentamicin arm"
                    ],
                    "criterion": "gentamicin arm participation",
                    "requirement_type": "advisability",
                    "expected_value": false
                }
            }
        },
        {
            "identified_line": {
                "line": "* hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz) and speech discrimination better than 70%",
                "criterions": [
                    {
                        "exact_snippets": [
                            "hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz)"
                        ],
                        "criterion": "hearing",
                        "requirement_type": "pure tone average",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 30
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "speech discrimination better than 70%"
                        ],
                        "criterion": "speech discrimination",
                        "requirement_type": "percentage",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 70
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz)"
                        ],
                        "criterion": "hearing",
                        "requirement_type": "pure tone average",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 30
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "speech discrimination better than 70%"
                        ],
                        "criterion": "speech discrimination",
                        "requirement_type": "percentage",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 70
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* the neurosurgeon aim at hearing preservation surgery and do not want to risk gentamicin associated hearing loss",
                "criterions": [
                    {
                        "exact_snippets": [
                            "hearing preservation surgery"
                        ],
                        "criterion": "hearing preservation surgery",
                        "requirement_type": "aim",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "gentamicin associated hearing loss"
                        ],
                        "criterion": "gentamicin associated hearing loss",
                        "requirement_type": "risk",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": [
                                "hearing preservation surgery"
                            ],
                            "criterion": "hearing preservation surgery",
                            "requirement_type": "aim",
                            "expected_value": true
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": [
                                "gentamicin associated hearing loss"
                            ],
                            "criterion": "gentamicin associated hearing loss",
                            "requirement_type": "risk",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}