{
    "info": {
        "nct_id": "NCT02200978",
        "official_title": "A Multicenter and Randomized Prospective Study for Improving the Outcome of Childhood Acute Promyeloid Leukemia",
        "inclusion_criteria": "* Patients less than 16 years old with newly diagnosed PML-RARa positive acute promyelocytic leukemia.\nHealthy volunteers allowed\nMust have maximum age of 16 Years",
        "exclusion_criteria": "* Patients who have coma, convulsion or paralysis due to intracranial hemorrhage or central nervous system leukemia at diagnosis.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients less than 16 years old with newly diagnosed PML-RARa positive acute promyelocytic leukemia.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "less than 16 years old"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 16
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "newly diagnosed"
                        ],
                        "criterion": "acute promyelocytic leukemia",
                        "requirement_type": "diagnosis status",
                        "expected_value": "newly diagnosed"
                    },
                    {
                        "exact_snippets": [
                            "PML-RARa positive"
                        ],
                        "criterion": "PML-RARa",
                        "requirement_type": "status",
                        "expected_value": "positive"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "less than 16 years old"
                        ],
                        "criterion": "age",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 16
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "newly diagnosed"
                        ],
                        "criterion": "acute promyelocytic leukemia",
                        "requirement_type": "diagnosis status",
                        "expected_value": "newly diagnosed"
                    },
                    {
                        "exact_snippets": [
                            "PML-RARa positive"
                        ],
                        "criterion": "PML-RARa",
                        "requirement_type": "status",
                        "expected_value": "positive"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 16 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "maximum age of 16 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "maximum",
                        "expected_value": {
                            "operator": "<=",
                            "value": 16
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "maximum age of 16 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "maximum",
                        "expected_value": {
                            "operator": "<=",
                            "value": 16
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients who have coma, convulsion or paralysis due to intracranial hemorrhage or central nervous system leukemia at diagnosis.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "coma"
                        ],
                        "criterion": "coma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "convulsion"
                        ],
                        "criterion": "convulsion",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "paralysis"
                        ],
                        "criterion": "paralysis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "intracranial hemorrhage"
                        ],
                        "criterion": "intracranial hemorrhage",
                        "requirement_type": "cause",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "central nervous system leukemia"
                        ],
                        "criterion": "central nervous system leukemia",
                        "requirement_type": "cause",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "coma"
                                        ],
                                        "criterion": "coma",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "intracranial hemorrhage"
                                        ],
                                        "criterion": "intracranial hemorrhage",
                                        "requirement_type": "cause",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "convulsion"
                                        ],
                                        "criterion": "convulsion",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "intracranial hemorrhage"
                                        ],
                                        "criterion": "intracranial hemorrhage",
                                        "requirement_type": "cause",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "paralysis"
                                        ],
                                        "criterion": "paralysis",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "intracranial hemorrhage"
                                        ],
                                        "criterion": "intracranial hemorrhage",
                                        "requirement_type": "cause",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "coma"
                                        ],
                                        "criterion": "coma",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "central nervous system leukemia"
                                        ],
                                        "criterion": "central nervous system leukemia",
                                        "requirement_type": "cause",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "convulsion"
                                        ],
                                        "criterion": "convulsion",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "central nervous system leukemia"
                                        ],
                                        "criterion": "central nervous system leukemia",
                                        "requirement_type": "cause",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "paralysis"
                                        ],
                                        "criterion": "paralysis",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "central nervous system leukemia"
                                        ],
                                        "criterion": "central nervous system leukemia",
                                        "requirement_type": "cause",
                                        "expected_value": true
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}