{
    "info": {
        "nct_id": "NCT01994382",
        "official_title": "A Phase 1/2a Open-Label, Multi-Dose, Multi-Center Escalation and Exploratory Study of Cerdulatinib (PRT062070) in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) or B-Cell or T-Cell Non-Hodgkin Lymphoma (NHL)",
        "inclusion_criteria": "Phase 1 Inclusion\n\n• Participant at least 18 years of age with histologically confirmed CLL/SLL or B-cell non-Hodgkin lymphoma (diffuse large B-cell lymphoma [DLBCL], FL, mantle cell lymphoma [MCL], marginal zone lymphoma [MZL], lymphoplasmacytic lymphoma).\n\nPhase 2a Inclusion\n\n* Histological evidence: FL Grade 1-3A, with relapsed or refractory disease; aggressive NHL (aNHL), defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, peripheral T-cell lymphoma (PTCL), or cutaneous T-cell lymphoma (CTCL) (with mycosis fungoides [MF]/Sézary Syndrome [SS]) with relapsed or refractory disease\n* Received B-cell receptor (BCR) and/or BCL2 inhibitors and were intolerant or had relapsed/refractory disease afterwards\n* Prior treatment for lymphoid malignancy for progressive /refractory disease\n* ≥1 prior regimen (minimum 2 cycles) with antibody conjugate/cytotoxic chemotherapy.\n* Measurable disease defined as: ≥1 lesion that measures ≥1.5 centimeter (cm) single dimension via computed tomography (CT), CT/positive-emission tomography (PET) with nodal or mass lesions; quantifiable circulating tumor cells; and for CTCL: Modified Severity Weighted Assessment Tool (mSWAT) >0\n* Ability to provide diagnostic reports\n\nGeneral Inclusion\n\n* Eastern Cooperative Oncology Group (ECOG) Score of 0 or 1\n* Hematologic absolute neutrophil count (ANC) >1000/microliter (uL) and platelet >75,000/uL\n* Creatinine levels as specified by Investigator\n* Bilirubin <2.0 mg/deciliter [dL] (if Gilberts then <2.5 mg/dL) and aspartate aminotransferase (AST)/alanine aminotransferase (ALT) <2.5*ULN\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Richter's syndrome, Burkitt's lymphoma, or Burkitt-like Lymphoma (transformed DLBCL from follicular NHL are eligible)\n* Prior transplant with stem cell infusion within 90 days of Day 1 or active graft-versus-host treatment within 8 weeks of Day 1\n* Prior therapy with Spleen Tyrosine Kinase (SYK) inhibitors\n* Chronic treatment with strong CYP3A4 inhibitor/inducer\n* Known lymphomatous involvement of the central nervous system (CNS)\n* Persistent, unresolved National Cancer Institute (NCI) Common Toxicity Criteria for Adverse Events (CTCAE) version 5.0 ≥Grade 2, previous drug-related toxicity (except alopecia, erectile impotence, hot flashes, libido, neuropathy).\n* Prior monoclonal antibody (including alemtuzumab), radioimmunoconjugate, antibody drug conjugate, phototherapy, radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy, or any test agent within 3 weeks of Day 1\n* For CTCL: (total skin electron beam therapy [TSEBT]) within 12 weeks, or initiation of topical steroid, nitrogen mustard, or topical retinoid within 2 weeks. Stable topical regimen for ≥4 weeks prior to Day 1 allowed.\n* Known carrier or infection for human immunodeficiency virus (HIV)/hepatitis B or C. If hepatitis C virus (HCV) antibody (ab)+, must be polymerase chain reaction (PCR)- to be eligible. If hepatitis B virus (HBV) ab+, must be hepatitis B surface antigen (HBsAg)- or undetectable HBV deoxyribonucleic acid (DNA) to be eligible.\n* Active infection requiring systemic treatment,\n* Significant gastrointestinal (GI) disease, previous major gastric/bowel surgery, difficulty swallowing, or malabsorption syndrome\n* Major surgery within 4 weeks\n* Previous malignancies within 2 years unless relapse risk is small (<5%).\n* Current use of systemic steroids >20 mg QD prednisone (or equivalent)\n* Breastfeeding or pregnant (intention to become) females or participation in other clinical trials",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "• Participant at least 18 years of age with histologically confirmed CLL/SLL or B-cell non-Hodgkin lymphoma (diffuse large B-cell lymphoma [DLBCL], FL, mantle cell lymphoma [MCL], marginal zone lymphoma [MZL], lymphoplasmacytic lymphoma).",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Participant at least 18 years of age"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    },
                    {
                        "exact_snippets": [
                            "histologically confirmed CLL/SLL"
                        ],
                        "criterion": "CLL/SLL",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "histologically confirmed",
                            "B-cell non-Hodgkin lymphoma"
                        ],
                        "criterion": "B-cell non-Hodgkin lymphoma",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "diffuse large B-cell lymphoma [DLBCL]"
                        ],
                        "criterion": "diffuse large B-cell lymphoma",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "FL"
                        ],
                        "criterion": "FL",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "mantle cell lymphoma [MCL]"
                        ],
                        "criterion": "mantle cell lymphoma",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "marginal zone lymphoma [MZL]"
                        ],
                        "criterion": "marginal zone lymphoma",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "lymphoplasmacytic lymphoma"
                        ],
                        "criterion": "lymphoplasmacytic lymphoma",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Participant at least 18 years of age"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": [
                                    "histologically confirmed CLL/SLL"
                                ],
                                "criterion": "CLL/SLL",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "histologically confirmed",
                                    "B-cell non-Hodgkin lymphoma"
                                ],
                                "criterion": "B-cell non-Hodgkin lymphoma",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "diffuse large B-cell lymphoma [DLBCL]"
                                ],
                                "criterion": "diffuse large B-cell lymphoma",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "FL"
                                ],
                                "criterion": "FL",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "mantle cell lymphoma [MCL]"
                                ],
                                "criterion": "mantle cell lymphoma",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "marginal zone lymphoma [MZL]"
                                ],
                                "criterion": "marginal zone lymphoma",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "lymphoplasmacytic lymphoma"
                                ],
                                "criterion": "lymphoplasmacytic lymphoma",
                                "requirement_type": "confirmation",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "histologically confirmed",
                            "B-cell non-Hodgkin lymphoma"
                        ],
                        "criterion": "B-cell non-Hodgkin lymphoma",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histological evidence: FL Grade 1-3A, with relapsed or refractory disease; aggressive NHL (aNHL), defined as DLBCL, FL Grade 3B, MCL, and transformed NHL with relapsed disease; CLL/SLL, peripheral T-cell lymphoma (PTCL), or cutaneous T-cell lymphoma (CTCL) (with mycosis fungoides [MF]/Sézary Syndrome [SS]) with relapsed or refractory disease",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Histological evidence: FL Grade 1-3A"
                        ],
                        "criterion": "FL Grade",
                        "requirement_type": "histological evidence",
                        "expected_value": [
                            "1",
                            "2",
                            "3A"
                        ]
                    },
                    {
                        "exact_snippets": [
                            "relapsed or refractory disease"
                        ],
                        "criterion": "disease",
                        "requirement_type": "status",
                        "expected_value": [
                            "relapsed",
                            "refractory"
                        ]
                    },
                    {
                        "exact_snippets": [
                            "aggressive NHL (aNHL), defined as DLBCL, FL Grade 3B, MCL, and transformed NHL"
                        ],
                        "criterion": "aggressive NHL",
                        "requirement_type": "definition",
                        "expected_value": [
                            "DLBCL",
                            "FL Grade 3B",
                            "MCL",
                            "transformed NHL"
                        ]
                    },
                    {
                        "exact_snippets": [
                            "relapsed disease"
                        ],
                        "criterion": "disease",
                        "requirement_type": "status",
                        "expected_value": "relapsed"
                    },
                    {
                        "exact_snippets": [
                            "CLL/SLL"
                        ],
                        "criterion": "CLL/SLL",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "peripheral T-cell lymphoma (PTCL)"
                        ],
                        "criterion": "peripheral T-cell lymphoma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "cutaneous T-cell lymphoma (CTCL) (with mycosis fungoides [MF]/Sézary Syndrome [SS])"
                        ],
                        "criterion": "cutaneous T-cell lymphoma",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "relapsed or refractory disease"
                        ],
                        "criterion": "disease",
                        "requirement_type": "status",
                        "expected_value": [
                            "relapsed",
                            "refractory"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "Histological evidence: FL Grade 1-3A"
                                        ],
                                        "criterion": "FL Grade",
                                        "requirement_type": "histological evidence",
                                        "expected_value": [
                                            "1",
                                            "2",
                                            "3A"
                                        ]
                                    },
                                    {
                                        "exact_snippets": [
                                            "relapsed or refractory disease"
                                        ],
                                        "criterion": "disease",
                                        "requirement_type": "status",
                                        "expected_value": [
                                            "relapsed",
                                            "refractory"
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "aggressive NHL (aNHL), defined as DLBCL, FL Grade 3B, MCL, and transformed NHL"
                                        ],
                                        "criterion": "aggressive NHL",
                                        "requirement_type": "definition",
                                        "expected_value": [
                                            "DLBCL",
                                            "FL Grade 3B",
                                            "MCL",
                                            "transformed NHL"
                                        ]
                                    },
                                    {
                                        "exact_snippets": [
                                            "relapsed disease"
                                        ],
                                        "criterion": "disease",
                                        "requirement_type": "status",
                                        "expected_value": "relapsed"
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "CLL/SLL"
                                ],
                                "criterion": "CLL/SLL",
                                "requirement_type": "presence",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "relapsed or refractory disease"
                                ],
                                "criterion": "disease",
                                "requirement_type": "status",
                                "expected_value": [
                                    "relapsed",
                                    "refractory"
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "peripheral T-cell lymphoma (PTCL)"
                                ],
                                "criterion": "peripheral T-cell lymphoma",
                                "requirement_type": "presence",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "relapsed or refractory disease"
                                ],
                                "criterion": "disease",
                                "requirement_type": "status",
                                "expected_value": [
                                    "relapsed",
                                    "refractory"
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "cutaneous T-cell lymphoma (CTCL) (with mycosis fungoides [MF]/Sézary Syndrome [SS])"
                                ],
                                "criterion": "cutaneous T-cell lymphoma",
                                "requirement_type": "presence",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "relapsed or refractory disease"
                                ],
                                "criterion": "disease",
                                "requirement_type": "status",
                                "expected_value": [
                                    "relapsed",
                                    "refractory"
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Received B-cell receptor (BCR) and/or BCL2 inhibitors and were intolerant or had relapsed/refractory disease afterwards",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Received B-cell receptor (BCR) and/or BCL2 inhibitors"
                        ],
                        "criterion": "B-cell receptor (BCR) and/or BCL2 inhibitors",
                        "requirement_type": "receipt",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "intolerant"
                        ],
                        "criterion": "intolerance to B-cell receptor (BCR) and/or BCL2 inhibitors",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "relapsed/refractory disease"
                        ],
                        "criterion": "relapsed/refractory disease",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "or_criteria": [
                        {
                            "exact_snippets": [
                                "intolerant"
                            ],
                            "criterion": "intolerance to B-cell receptor (BCR) and/or BCL2 inhibitors",
                            "requirement_type": "presence",
                            "expected_value": true
                        },
                        {
                            "exact_snippets": [
                                "relapsed/refractory disease"
                            ],
                            "criterion": "relapsed/refractory disease",
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": [
                        "Received B-cell receptor (BCR) and/or BCL2 inhibitors"
                    ],
                    "criterion": "B-cell receptor (BCR) and/or BCL2 inhibitors",
                    "requirement_type": "receipt",
                    "expected_value": true
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Prior treatment for lymphoid malignancy for progressive /refractory disease",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Prior treatment for lymphoid malignancy"
                        ],
                        "criterion": "prior treatment",
                        "requirement_type": "indication",
                        "expected_value": "lymphoid malignancy"
                    },
                    {
                        "exact_snippets": [
                            "progressive /refractory disease"
                        ],
                        "criterion": "disease status",
                        "requirement_type": "type",
                        "expected_value": [
                            "progressive",
                            "refractory"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Prior treatment for lymphoid malignancy"
                        ],
                        "criterion": "prior treatment",
                        "requirement_type": "indication",
                        "expected_value": "lymphoid malignancy"
                    },
                    {
                        "exact_snippets": [
                            "progressive /refractory disease"
                        ],
                        "criterion": "disease status",
                        "requirement_type": "type",
                        "expected_value": [
                            "progressive",
                            "refractory"
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ≥1 prior regimen (minimum 2 cycles) with antibody conjugate/cytotoxic chemotherapy.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "≥1 prior regimen"
                        ],
                        "criterion": "prior regimen",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 1
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "minimum 2 cycles"
                        ],
                        "criterion": "cycles",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 2
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "antibody conjugate/cytotoxic chemotherapy"
                        ],
                        "criterion": "treatment type",
                        "requirement_type": "type",
                        "expected_value": [
                            "antibody conjugate",
                            "cytotoxic chemotherapy"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "≥1 prior regimen"
                        ],
                        "criterion": "prior regimen",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 1
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "minimum 2 cycles"
                        ],
                        "criterion": "cycles",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 2
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "antibody conjugate/cytotoxic chemotherapy"
                        ],
                        "criterion": "treatment type",
                        "requirement_type": "type",
                        "expected_value": [
                            "antibody conjugate",
                            "cytotoxic chemotherapy"
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Ability to provide diagnostic reports",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Ability to provide diagnostic reports"
                        ],
                        "criterion": "diagnostic reports",
                        "requirement_type": "availability",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Ability to provide diagnostic reports"
                        ],
                        "criterion": "diagnostic reports",
                        "requirement_type": "availability",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Eastern Cooperative Oncology Group (ECOG) Score of 0 or 1",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Eastern Cooperative Oncology Group (ECOG) Score"
                        ],
                        "criterion": "ECOG Score",
                        "requirement_type": "value",
                        "expected_value": [
                            "0",
                            "1"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "Eastern Cooperative Oncology Group (ECOG) Score"
                        ],
                        "criterion": "ECOG Score",
                        "requirement_type": "value",
                        "expected_value": "0"
                    },
                    {
                        "exact_snippets": [
                            "Eastern Cooperative Oncology Group (ECOG) Score"
                        ],
                        "criterion": "ECOG Score",
                        "requirement_type": "value",
                        "expected_value": "1"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hematologic absolute neutrophil count (ANC) >1000/microliter (uL) and platelet >75,000/uL",
                "criterions": [
                    {
                        "exact_snippets": [
                            "absolute neutrophil count (ANC) >1000/microliter (uL)"
                        ],
                        "criterion": "absolute neutrophil count",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": ">",
                            "value": 1000
                        }
                    },
                    {
                        "exact_snippets": [
                            "platelet >75,000/uL"
                        ],
                        "criterion": "platelet",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": ">",
                            "value": 75000
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "absolute neutrophil count (ANC) >1000/microliter (uL)"
                        ],
                        "criterion": "absolute neutrophil count",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": ">",
                            "value": 1000
                        }
                    },
                    {
                        "exact_snippets": [
                            "platelet >75,000/uL"
                        ],
                        "criterion": "platelet",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "operator": ">",
                            "value": 75000
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine levels as specified by Investigator",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Creatinine levels"
                        ],
                        "criterion": "creatinine",
                        "requirement_type": "levels",
                        "expected_value": "as specified by Investigator"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Creatinine levels"
                        ],
                        "criterion": "creatinine",
                        "requirement_type": "levels",
                        "expected_value": "as specified by Investigator"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin <2.0 mg/deciliter [dL] (if Gilberts then <2.5 mg/dL) and aspartate aminotransferase (AST)/alanine aminotransferase (ALT) <2.5*ULN",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Bilirubin <2.0 mg/deciliter [dL]"
                        ],
                        "criterion": "bilirubin",
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<",
                            "value": 2.0
                        }
                    },
                    {
                        "exact_snippets": [
                            "if Gilberts then <2.5 mg/dL"
                        ],
                        "criterion": "bilirubin",
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<",
                            "value": 2.5
                        }
                    },
                    {
                        "exact_snippets": [
                            "aspartate aminotransferase (AST)",
                            "<2.5*ULN"
                        ],
                        "criterion": "aspartate aminotransferase",
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<",
                            "value": 2.5
                        }
                    },
                    {
                        "exact_snippets": [
                            "alanine aminotransferase (ALT)",
                            "<2.5*ULN"
                        ],
                        "criterion": "alanine aminotransferase",
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<",
                            "value": 2.5
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "condition": {
                            "exact_snippets": [
                                "if Gilberts then <2.5 mg/dL"
                            ],
                            "criterion": "Gilberts syndrome",
                            "requirement_type": "presence",
                            "expected_value": true
                        },
                        "then_criteria": {
                            "exact_snippets": [
                                "if Gilberts then <2.5 mg/dL"
                            ],
                            "criterion": "bilirubin",
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.5
                            }
                        },
                        "else_criteria": {
                            "exact_snippets": [
                                "Bilirubin <2.0 mg/deciliter [dL]"
                            ],
                            "criterion": "bilirubin",
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.0
                            }
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "aspartate aminotransferase (AST)",
                                    "<2.5*ULN"
                                ],
                                "criterion": "aspartate aminotransferase",
                                "requirement_type": "level",
                                "expected_value": {
                                    "operator": "<",
                                    "value": 2.5
                                }
                            },
                            {
                                "exact_snippets": [
                                    "alanine aminotransferase (ALT)",
                                    "<2.5*ULN"
                                ],
                                "criterion": "alanine aminotransferase",
                                "requirement_type": "level",
                                "expected_value": {
                                    "operator": "<",
                                    "value": 2.5
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Phase 1 Inclusion",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Phase 2a Inclusion",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "General Inclusion",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Prior transplant with stem cell infusion within 90 days of Day 1 or active graft-versus-host treatment within 8 weeks of Day 1",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Prior transplant with stem cell infusion within 90 days of Day 1"
                        ],
                        "criterion": "stem cell infusion",
                        "requirement_type": "time since",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 90
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "active graft-versus-host treatment within 8 weeks of Day 1"
                        ],
                        "criterion": "graft-versus-host treatment",
                        "requirement_type": "time since",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 8
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Prior transplant with stem cell infusion within 90 days of Day 1"
                                ],
                                "criterion": "stem cell infusion",
                                "requirement_type": "time since",
                                "expected_value": {
                                    "comparisons": [
                                        {
                                            "operator": "<=",
                                            "value": 90
                                        }
                                    ]
                                }
                            },
                            {
                                "exact_snippets": [
                                    "active graft-versus-host treatment within 8 weeks of Day 1"
                                ],
                                "criterion": "graft-versus-host treatment",
                                "requirement_type": "time since",
                                "expected_value": {
                                    "comparisons": [
                                        {
                                            "operator": "<=",
                                            "value": 8
                                        }
                                    ]
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior therapy with Spleen Tyrosine Kinase (SYK) inhibitors",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Prior therapy with Spleen Tyrosine Kinase (SYK) inhibitors"
                        ],
                        "criterion": "Spleen Tyrosine Kinase (SYK) inhibitors",
                        "requirement_type": "prior therapy",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Prior therapy with Spleen Tyrosine Kinase (SYK) inhibitors"
                    ],
                    "criterion": "Spleen Tyrosine Kinase (SYK) inhibitors",
                    "requirement_type": "prior therapy",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Chronic treatment with strong CYP3A4 inhibitor/inducer",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Chronic treatment with strong CYP3A4 inhibitor/inducer"
                        ],
                        "criterion": "chronic treatment",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "strong CYP3A4 inhibitor/inducer"
                        ],
                        "criterion": "CYP3A4 inhibitor/inducer",
                        "requirement_type": "strength",
                        "expected_value": "strong"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Chronic treatment with strong CYP3A4 inhibitor/inducer"
                        ],
                        "criterion": "chronic treatment",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "strong CYP3A4 inhibitor/inducer"
                        ],
                        "criterion": "CYP3A4 inhibitor/inducer",
                        "requirement_type": "strength",
                        "expected_value": "strong"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Known lymphomatous involvement of the central nervous system (CNS)",
                "criterions": [
                    {
                        "exact_snippets": [
                            "lymphomatous involvement of the central nervous system (CNS)"
                        ],
                        "criterion": "lymphomatous involvement of the central nervous system",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "lymphomatous involvement of the central nervous system (CNS)"
                    ],
                    "criterion": "lymphomatous involvement of the central nervous system",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "* Persistent, unresolved National Cancer Institute (NCI) Common Toxicity Criteria for Adverse Events (CTCAE) version 5.0 ≥Grade 2, previous drug-related toxicity (except alopecia, erectile impotence, hot flashes, libido, neuropathy).",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Persistent, unresolved National Cancer Institute (NCI) Common Toxicity Criteria for Adverse Events (CTCAE) version 5.0 ≥Grade 2"
                        ],
                        "criterion": "NCI CTCAE version 5.0 toxicity",
                        "requirement_type": "severity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 2
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "previous drug-related toxicity"
                        ],
                        "criterion": "drug-related toxicity",
                        "requirement_type": "persistence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "alopecia"
                        ],
                        "criterion": "alopecia",
                        "requirement_type": "exclusion",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "erectile impotence"
                        ],
                        "criterion": "erectile impotence",
                        "requirement_type": "exclusion",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "hot flashes"
                        ],
                        "criterion": "hot flashes",
                        "requirement_type": "exclusion",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "libido"
                        ],
                        "criterion": "libido",
                        "requirement_type": "exclusion",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "neuropathy"
                        ],
                        "criterion": "neuropathy",
                        "requirement_type": "exclusion",
                        "expected_value": true
                    }
                ]
            },
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                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "and_criteria": [
                                                            {
                                                                "and_criteria": [
                                                                    {
                                                                        "and_criteria": [
                                                                            {
                                                                                "not_criteria": {
                                                                                    "exact_snippets": [
                                                                                        "alopecia"
                                                                                    ],
                                                                                    "criterion": "alopecia",
                                                                                    "requirement_type": "exclusion",
                                                                                    "expected_value": true
                                                                                }
                                                                            },
                                                                            {
                                                                                "not_criteria": {
                                                                                    "exact_snippets": [
                                                                                        "erectile impotence"
                                                                                    ],
                                                                                    "criterion": "erectile impotence",
                                                                                    "requirement_type": "exclusion",
                                                                                    "expected_value": true
                                                                                }
                                                                            }
                                                                        ]
                                                                    },
                                                                    {
                                                                        "not_criteria": {
                                                                            "exact_snippets": [
                                                                                "hot flashes"
                                                                            ],
                                                                            "criterion": "hot flashes",
                                                                            "requirement_type": "exclusion",
                                                                            "expected_value": true
                                                                        }
                                                                    }
                                                                ]
                                                            },
                                                            {
                                                                "not_criteria": {
                                                                    "exact_snippets": [
                                                                        "libido"
                                                                    ],
                                                                    "criterion": "libido",
                                                                    "requirement_type": "exclusion",
                                                                    "expected_value": true
                                                                }
                                                            }
                                                        ]
                                                    },
                                                    {
                                                        "not_criteria": {
                                                            "exact_snippets": [
                                                                "neuropathy"
                                                            ],
                                                            "criterion": "neuropathy",
                                                            "requirement_type": "exclusion",
                                                            "expected_value": true
                                                        }
                                                    }
                                                ]
                                            },
                                            {
                                                "exact_snippets": [
                                                    "Persistent, unresolved National Cancer Institute (NCI) Common Toxicity Criteria for Adverse Events (CTCAE) version 5.0 ≥Grade 2"
                                                ],
                                                "criterion": "NCI CTCAE version 5.0 toxicity",
                                                "requirement_type": "severity",
                                                "expected_value": {
                                                    "comparisons": [
                                                        {
                                                            "operator": ">=",
                                                            "value": 2
                                                        }
                                                    ]
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": [
                                            "previous drug-related toxicity"
                                        ],
                                        "criterion": "drug-related toxicity",
                                        "requirement_type": "persistence",
                                        "expected_value": true
                                    }
                                ]
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": [
                                        "alopecia"
                                    ],
                                    "criterion": "alopecia",
                                    "requirement_type": "exclusion",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": [
                                "erectile impotence"
                            ],
                            "criterion": "erectile impotence",
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior monoclonal antibody (including alemtuzumab), radioimmunoconjugate, antibody drug conjugate, phototherapy, radiotherapy, chemotherapy, immunotherapy, immunosuppressive therapy, or any test agent within 3 weeks of Day 1",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Prior monoclonal antibody"
                        ],
                        "criterion": "monoclonal antibody",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "including alemtuzumab"
                        ],
                        "criterion": "alemtuzumab",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "radioimmunoconjugate"
                        ],
                        "criterion": "radioimmunoconjugate",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "antibody drug conjugate"
                        ],
                        "criterion": "antibody drug conjugate",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "phototherapy"
                        ],
                        "criterion": "phototherapy",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "radiotherapy"
                        ],
                        "criterion": "radiotherapy",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "chemotherapy"
                        ],
                        "criterion": "chemotherapy",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "immunotherapy"
                        ],
                        "criterion": "immunotherapy",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "immunosuppressive therapy"
                        ],
                        "criterion": "immunosuppressive therapy",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "any test agent"
                        ],
                        "criterion": "test agent",
                        "requirement_type": "prior use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "within 3 weeks of Day 1"
                        ],
                        "criterion": "time since last treatment",
                        "requirement_type": "duration",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 3
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
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                        {
                            "or_criteria": [
                                {
                                    "exact_snippets": [
                                        "Prior monoclonal antibody"
                                    ],
                                    "criterion": "monoclonal antibody",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "including alemtuzumab"
                                    ],
                                    "criterion": "alemtuzumab",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "radioimmunoconjugate"
                                    ],
                                    "criterion": "radioimmunoconjugate",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "antibody drug conjugate"
                                    ],
                                    "criterion": "antibody drug conjugate",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "phototherapy"
                                    ],
                                    "criterion": "phototherapy",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "radiotherapy"
                                    ],
                                    "criterion": "radiotherapy",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "chemotherapy"
                                    ],
                                    "criterion": "chemotherapy",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "immunotherapy"
                                    ],
                                    "criterion": "immunotherapy",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "immunosuppressive therapy"
                                    ],
                                    "criterion": "immunosuppressive therapy",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                },
                                {
                                    "exact_snippets": [
                                        "any test agent"
                                    ],
                                    "criterion": "test agent",
                                    "requirement_type": "prior use",
                                    "expected_value": true
                                }
                            ]
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": [
                        "within 3 weeks of Day 1"
                    ],
                    "criterion": "time since last treatment",
                    "requirement_type": "duration",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 3
                            }
                        ]
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Known carrier or infection for human immunodeficiency virus (HIV)/hepatitis B or C. If hepatitis C virus (HCV) antibody (ab)+, must be polymerase chain reaction (PCR)- to be eligible. If hepatitis B virus (HBV) ab+, must be hepatitis B surface antigen (HBsAg)- or undetectable HBV deoxyribonucleic acid (DNA) to be eligible.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Known carrier or infection for human immunodeficiency virus (HIV)"
                        ],
                        "criterion": "HIV infection",
                        "requirement_type": "carrier or infection",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Known carrier or infection for",
                            "hepatitis B"
                        ],
                        "criterion": "hepatitis B infection",
                        "requirement_type": "carrier or infection",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Known carrier or infection for",
                            "hepatitis C"
                        ],
                        "criterion": "hepatitis C infection",
                        "requirement_type": "carrier or infection",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "If hepatitis C virus (HCV) antibody (ab)+, must be polymerase chain reaction (PCR)-"
                        ],
                        "criterion": "HCV antibody",
                        "requirement_type": "presence",
                        "expected_value": "positive"
                    },
                    {
                        "exact_snippets": [
                            "If hepatitis C virus (HCV) antibody (ab)+, must be polymerase chain reaction (PCR)-"
                        ],
                        "criterion": "HCV PCR",
                        "requirement_type": "presence",
                        "expected_value": "negative"
                    },
                    {
                        "exact_snippets": [
                            "If hepatitis B virus (HBV) ab+, must be hepatitis B surface antigen (HBsAg)-"
                        ],
                        "criterion": "HBV antibody",
                        "requirement_type": "presence",
                        "expected_value": "positive"
                    },
                    {
                        "exact_snippets": [
                            "If hepatitis B virus (HBV) ab+, must be hepatitis B surface antigen (HBsAg)-"
                        ],
                        "criterion": "HBsAg",
                        "requirement_type": "presence",
                        "expected_value": "negative"
                    },
                    {
                        "exact_snippets": [
                            "undetectable HBV deoxyribonucleic acid (DNA)"
                        ],
                        "criterion": "HBV DNA",
                        "requirement_type": "detectability",
                        "expected_value": "undetectable"
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Known carrier or infection for human immunodeficiency virus (HIV)"
                                ],
                                "criterion": "HIV infection",
                                "requirement_type": "carrier or infection",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Known carrier or infection for",
                                    "hepatitis B"
                                ],
                                "criterion": "hepatitis B infection",
                                "requirement_type": "carrier or infection",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Known carrier or infection for",
                                    "hepatitis C"
                                ],
                                "criterion": "hepatitis C infection",
                                "requirement_type": "carrier or infection",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "If hepatitis C virus (HCV) antibody (ab)+, must be polymerase chain reaction (PCR)-"
                                ],
                                "criterion": "HCV antibody",
                                "requirement_type": "presence",
                                "expected_value": "positive"
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": [
                                        "If hepatitis C virus (HCV) antibody (ab)+, must be polymerase chain reaction (PCR)-"
                                    ],
                                    "criterion": "HCV PCR",
                                    "requirement_type": "presence",
                                    "expected_value": "negative"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "If hepatitis B virus (HBV) ab+, must be hepatitis B surface antigen (HBsAg)-"
                                ],
                                "criterion": "HBV antibody",
                                "requirement_type": "presence",
                                "expected_value": "positive"
                            },
                            {
                                "not_criteria": {
                                    "or_criteria": [
                                        {
                                            "exact_snippets": [
                                                "If hepatitis B virus (HBV) ab+, must be hepatitis B surface antigen (HBsAg)-"
                                            ],
                                            "criterion": "HBsAg",
                                            "requirement_type": "presence",
                                            "expected_value": "negative"
                                        },
                                        {
                                            "exact_snippets": [
                                                "undetectable HBV deoxyribonucleic acid (DNA)"
                                            ],
                                            "criterion": "HBV DNA",
                                            "requirement_type": "detectability",
                                            "expected_value": "undetectable"
                                        }
                                    ]
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active infection requiring systemic treatment,",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Active infection"
                        ],
                        "criterion": "infection",
                        "requirement_type": "activity",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "requiring systemic treatment"
                        ],
                        "criterion": "infection",
                        "requirement_type": "treatment requirement",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Active infection"
                        ],
                        "criterion": "infection",
                        "requirement_type": "activity",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "requiring systemic treatment"
                        ],
                        "criterion": "infection",
                        "requirement_type": "treatment requirement",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Significant gastrointestinal (GI) disease, previous major gastric/bowel surgery, difficulty swallowing, or malabsorption syndrome",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Significant gastrointestinal (GI) disease"
                        ],
                        "criterion": "gastrointestinal disease",
                        "requirement_type": "severity",
                        "expected_value": "significant"
                    },
                    {
                        "exact_snippets": [
                            "previous major gastric/bowel surgery"
                        ],
                        "criterion": "gastric/bowel surgery",
                        "requirement_type": "history",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "difficulty swallowing"
                        ],
                        "criterion": "swallowing",
                        "requirement_type": "difficulty",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "malabsorption syndrome"
                        ],
                        "criterion": "malabsorption syndrome",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "Significant gastrointestinal (GI) disease"
                        ],
                        "criterion": "gastrointestinal disease",
                        "requirement_type": "severity",
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                    },
                    {
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                            "previous major gastric/bowel surgery"
                        ],
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                        "requirement_type": "history",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "difficulty swallowing"
                        ],
                        "criterion": "swallowing",
                        "requirement_type": "difficulty",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "malabsorption syndrome"
                        ],
                        "criterion": "malabsorption syndrome",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Major surgery within 4 weeks",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Major surgery within 4 weeks"
                        ],
                        "criterion": "major surgery",
                        "requirement_type": "time since",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 4
                                }
                            ]
                        }
                    }
                ]
            },
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                    "exact_snippets": [
                        "Major surgery within 4 weeks"
                    ],
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                    "requirement_type": "time since",
                    "expected_value": {
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                            {
                                "operator": "<=",
                                "value": 4
                            }
                        ]
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous malignancies within 2 years unless relapse risk is small (<5%).",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Previous malignancies within 2 years"
                        ],
                        "criterion": "previous malignancies",
                        "requirement_type": "time since diagnosis",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 2
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "relapse risk is small (<5%)"
                        ],
                        "criterion": "relapse risk",
                        "requirement_type": "severity",
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                                {
                                    "operator": "<",
                                    "value": 5
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
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                        {
                            "exact_snippets": [
                                "Previous malignancies within 2 years"
                            ],
                            "criterion": "previous malignancies",
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
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                                    {
                                        "operator": "<=",
                                        "value": 2
                                    }
                                ]
                            }
                        },
                        {
                            "exact_snippets": [
                                "relapse risk is small (<5%)"
                            ],
                            "criterion": "relapse risk",
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 5
                                    }
                                ]
                            }
                        }
                    ]
                },
                "then_criteria": null,
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                    "exact_snippets": [
                        "Previous malignancies within 2 years"
                    ],
                    "criterion": "previous malignancies",
                    "requirement_type": "time since diagnosis",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 2
                            }
                        ]
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Current use of systemic steroids >20 mg QD prednisone (or equivalent)",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Current use of systemic steroids"
                        ],
                        "criterion": "systemic steroid use",
                        "requirement_type": "current use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            ">20 mg QD prednisone (or equivalent)"
                        ],
                        "criterion": "systemic steroid dosage",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 20
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Current use of systemic steroids"
                        ],
                        "criterion": "systemic steroid use",
                        "requirement_type": "current use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            ">20 mg QD prednisone (or equivalent)"
                        ],
                        "criterion": "systemic steroid dosage",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 20
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Breastfeeding or pregnant (intention to become) females or participation in other clinical trials",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Breastfeeding"
                        ],
                        "criterion": "breastfeeding",
                        "requirement_type": "status",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "pregnant"
                        ],
                        "criterion": "pregnancy",
                        "requirement_type": "status",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "intention to become"
                        ],
                        "criterion": "intention to become pregnant",
                        "requirement_type": "status",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "participation in other clinical trials"
                        ],
                        "criterion": "participation in other clinical trials",
                        "requirement_type": "status",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "or_criteria": [
                            {
                                "exact_snippets": [
                                    "Breastfeeding"
                                ],
                                "criterion": "breastfeeding",
                                "requirement_type": "status",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "pregnant"
                                ],
                                "criterion": "pregnancy",
                                "requirement_type": "status",
                                "expected_value": true
                            },
                            {
                                "exact_snippets": [
                                    "intention to become"
                                ],
                                "criterion": "intention to become pregnant",
                                "requirement_type": "status",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "participation in other clinical trials"
                        ],
                        "criterion": "participation in other clinical trials",
                        "requirement_type": "status",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* For CTCL: (total skin electron beam therapy [TSEBT]) within 12 weeks, or initiation of topical steroid, nitrogen mustard, or topical retinoid within 2 weeks. Stable topical regimen for ≥4 weeks prior to Day 1 allowed.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "CTCL"
                        ],
                        "criterion": "CTCL",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "total skin electron beam therapy",
                            "within 12 weeks"
                        ],
                        "criterion": "total skin electron beam therapy",
                        "requirement_type": "time since last treatment",
                        "expected_value": {
                            "operator": "<=",
                            "value": 12
                        }
                    },
                    {
                        "exact_snippets": [
                            "initiation of topical steroid",
                            "within 2 weeks"
                        ],
                        "criterion": "topical steroid",
                        "requirement_type": "time since initiation",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2
                        }
                    },
                    {
                        "exact_snippets": [
                            "initiation of nitrogen mustard",
                            "within 2 weeks"
                        ],
                        "criterion": "nitrogen mustard",
                        "requirement_type": "time since initiation",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2
                        }
                    },
                    {
                        "exact_snippets": [
                            "initiation of topical retinoid",
                            "within 2 weeks"
                        ],
                        "criterion": "topical retinoid",
                        "requirement_type": "time since initiation",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2
                        }
                    },
                    {
                        "exact_snippets": [
                            "Stable topical regimen",
                            "≥4 weeks prior to Day 1"
                        ],
                        "criterion": "topical regimen",
                        "requirement_type": "stability duration",
                        "expected_value": {
                            "operator": ">=",
                            "value": 4
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
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                        {
                            "exact_snippets": [
                                "CTCL"
                            ],
                            "criterion": "CTCL",
                            "requirement_type": "presence",
                            "expected_value": true
                        },
                        {
                            "or_criteria": [
                                {
                                    "exact_snippets": [
                                        "total skin electron beam therapy",
                                        "within 12 weeks"
                                    ],
                                    "criterion": "total skin electron beam therapy",
                                    "requirement_type": "time since last treatment",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 12
                                    }
                                },
                                {
                                    "exact_snippets": [
                                        "initiation of topical steroid",
                                        "within 2 weeks"
                                    ],
                                    "criterion": "topical steroid",
                                    "requirement_type": "time since initiation",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2
                                    }
                                },
                                {
                                    "exact_snippets": [
                                        "initiation of nitrogen mustard",
                                        "within 2 weeks"
                                    ],
                                    "criterion": "nitrogen mustard",
                                    "requirement_type": "time since initiation",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2
                                    }
                                },
                                {
                                    "exact_snippets": [
                                        "initiation of topical retinoid",
                                        "within 2 weeks"
                                    ],
                                    "criterion": "topical retinoid",
                                    "requirement_type": "time since initiation",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2
                                    }
                                }
                            ]
                        }
                    ]
                },
                "then_criteria": {
                    "not_criteria": {
                        "exact_snippets": [
                            "Stable topical regimen",
                            "≥4 weeks prior to Day 1"
                        ],
                        "criterion": "topical regimen",
                        "requirement_type": "stability duration",
                        "expected_value": {
                            "operator": ">=",
                            "value": 4
                        }
                    }
                },
                "else_criteria": null
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Measurable disease defined as: ≥1 lesion that measures ≥1.5 centimeter (cm) single dimension via computed tomography (CT), CT/positive-emission tomography (PET) with nodal or mass lesions; quantifiable circulating tumor cells; and for CTCL: Modified Severity Weighted Assessment Tool (mSWAT) >0",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Measurable disease defined as: ≥1 lesion that measures ≥1.5 centimeter (cm) single dimension via computed tomography (CT), CT/positive-emission tomography (PET) with nodal or mass lesions"
                        ],
                        "criterion": "lesion",
                        "requirement_type": "size",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 1.5
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "quantifiable circulating tumor cells"
                        ],
                        "criterion": "circulating tumor cells",
                        "requirement_type": "quantifiability",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "for CTCL: Modified Severity Weighted Assessment Tool (mSWAT) >0"
                        ],
                        "criterion": "Modified Severity Weighted Assessment Tool (mSWAT)",
                        "requirement_type": "score",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">",
                                    "value": 0
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Measurable disease defined as: ≥1 lesion that measures ≥1.5 centimeter (cm) single dimension via computed tomography (CT), CT/positive-emission tomography (PET) with nodal or mass lesions"
                                ],
                                "criterion": "lesion",
                                "requirement_type": "size",
                                "expected_value": {
                                    "comparisons": [
                                        {
                                            "operator": ">=",
                                            "value": 1.5
                                        }
                                    ]
                                }
                            },
                            {
                                "exact_snippets": [
                                    "quantifiable circulating tumor cells"
                                ],
                                "criterion": "circulating tumor cells",
                                "requirement_type": "quantifiability",
                                "expected_value": true
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Richter's syndrome, Burkitt's lymphoma, or Burkitt-like Lymphoma (transformed DLBCL from follicular NHL are eligible)",
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                    {
                        "exact_snippets": [
                            "Richter's syndrome"
                        ],
                        "criterion": "Richter's syndrome",
                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "Burkitt's lymphoma"
                        ],
                        "criterion": "Burkitt's lymphoma",
                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "Burkitt-like Lymphoma"
                        ],
                        "criterion": "Burkitt-like Lymphoma",
                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "transformed DLBCL from follicular NHL are eligible"
                        ],
                        "criterion": "transformed DLBCL from follicular NHL",
                        "requirement_type": "eligibility",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Richter's syndrome"
                                ],
                                "criterion": "Richter's syndrome",
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Burkitt's lymphoma"
                                ],
                                "criterion": "Burkitt's lymphoma",
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Burkitt-like Lymphoma"
                                ],
                                "criterion": "Burkitt-like Lymphoma",
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}