{
    "info": {
        "nct_id": "NCT01959061",
        "official_title": "Raltitrexed and Oxaliplatin and Lipiodol Transcatheter Arterial Chemoembolization for Advanced Colorectal Cancer",
        "inclusion_criteria": "1. Histologically confirmed colorectal adenocarcinoma\n2. Disease limited to the liver Unresectable disease by surgery or other local therapies\n3. Age >18 years\n4. ECOG performance status 0-2,Child pugh A or B\n5. Expected survival ≥ 3 months\n6. Adequate hematological, hepatic, and renal function\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "1. Pregnant or lactating women\n2. Patients with severe organ dysfunction or failure\n3. With severe cardiovascular disease, or mental\n4. Extraliver metastases",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Histologically confirmed colorectal adenocarcinoma",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Histologically confirmed colorectal adenocarcinoma"
                        ],
                        "criterion": "colorectal adenocarcinoma",
                        "requirement_type": "confirmation method",
                        "expected_value": "histologically"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Histologically confirmed colorectal adenocarcinoma"
                        ],
                        "criterion": "colorectal adenocarcinoma",
                        "requirement_type": "confirmation method",
                        "expected_value": "histologically"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Disease limited to the liver Unresectable disease by surgery or other local therapies",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Disease limited to the liver"
                        ],
                        "criterion": "disease location",
                        "requirement_type": "location",
                        "expected_value": "liver"
                    },
                    {
                        "exact_snippets": [
                            "Unresectable disease by surgery or other local therapies"
                        ],
                        "criterion": "disease resectability",
                        "requirement_type": "resectability",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Disease limited to the liver"
                        ],
                        "criterion": "disease location",
                        "requirement_type": "location",
                        "expected_value": "liver"
                    },
                    {
                        "exact_snippets": [
                            "Unresectable disease by surgery or other local therapies"
                        ],
                        "criterion": "disease resectability",
                        "requirement_type": "resectability",
                        "expected_value": false
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Age >18 years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Age >18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "N/A",
                        "expected_value": {
                            "operator": ">",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Age >18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "N/A",
                        "expected_value": {
                            "operator": ">",
                            "value": 18
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. ECOG performance status 0-2,Child pugh A or B",
                "criterions": [
                    {
                        "exact_snippets": [
                            "ECOG performance status 0-2"
                        ],
                        "criterion": "ECOG performance status",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 2
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "Child pugh A or B"
                        ],
                        "criterion": "Child Pugh score",
                        "requirement_type": "category",
                        "expected_value": [
                            "A",
                            "B"
                        ]
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "ECOG performance status 0-2"
                                ],
                                "criterion": "ECOG performance status",
                                "requirement_type": "range",
                                "expected_value": {
                                    "comparisons": [
                                        {
                                            "operator": ">=",
                                            "value": 0
                                        },
                                        {
                                            "operator": "<=",
                                            "value": 2
                                        }
                                    ]
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": [
                                            "Child pugh A or B"
                                        ],
                                        "criterion": "Child Pugh score",
                                        "requirement_type": "category",
                                        "expected_value": "A"
                                    },
                                    {
                                        "exact_snippets": [
                                            "Child pugh A or B"
                                        ],
                                        "criterion": "Child Pugh score",
                                        "requirement_type": "category",
                                        "expected_value": "B"
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Expected survival ≥ 3 months",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Expected survival ≥ 3 months"
                        ],
                        "criterion": "expected survival",
                        "requirement_type": "duration",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 3
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Expected survival ≥ 3 months"
                        ],
                        "criterion": "expected survival",
                        "requirement_type": "duration",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 3
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Adequate hematological, hepatic, and renal function",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Adequate hematological"
                        ],
                        "criterion": "hematological function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "hepatic"
                        ],
                        "criterion": "hepatic function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "renal function"
                        ],
                        "criterion": "renal function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Adequate hematological"
                        ],
                        "criterion": "hematological function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "hepatic"
                        ],
                        "criterion": "hepatic function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "renal function"
                        ],
                        "criterion": "renal function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "volunteer health status",
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 75 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "maximum age of 75 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "maximum",
                        "expected_value": {
                            "operator": "<=",
                            "value": 75
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "maximum age of 75 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "maximum",
                        "expected_value": {
                            "operator": "<=",
                            "value": 75
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1. Pregnant or lactating women",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Pregnant"
                        ],
                        "criterion": "pregnancy",
                        "requirement_type": "status",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "lactating"
                        ],
                        "criterion": "lactation",
                        "requirement_type": "status",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "Pregnant"
                        ],
                        "criterion": "pregnancy",
                        "requirement_type": "status",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "lactating"
                        ],
                        "criterion": "lactation",
                        "requirement_type": "status",
                        "expected_value": false
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. With severe cardiovascular disease, or mental",
                "criterions": [
                    {
                        "exact_snippets": [
                            "severe cardiovascular disease"
                        ],
                        "criterion": "cardiovascular disease",
                        "requirement_type": "severity",
                        "expected_value": "severe"
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": [
                                "severe cardiovascular disease"
                            ],
                            "criterion": "cardiovascular disease",
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                }
            }
        },
        {
            "identified_line": {
                "line": "4. Extraliver metastases",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Extraliver metastases"
                        ],
                        "criterion": "extraliver metastases",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Extraliver metastases"
                    ],
                    "criterion": "extraliver metastases",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            }
        },
        {
            "identified_line": {
                "line": "2. Patients with severe organ dysfunction or failure",
                "criterions": [
                    {
                        "exact_snippets": [
                            "severe organ dysfunction"
                        ],
                        "criterion": "organ dysfunction",
                        "requirement_type": "severity",
                        "expected_value": "severe"
                    },
                    {
                        "exact_snippets": [
                            "organ failure"
                        ],
                        "criterion": "organ failure",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "severe organ dysfunction"
                        ],
                        "criterion": "organ dysfunction",
                        "requirement_type": "severity",
                        "expected_value": "severe"
                    },
                    {
                        "exact_snippets": [
                            "organ failure"
                        ],
                        "criterion": "organ failure",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}