{
    "info": {
        "nct_id": "NCT01895946",
        "official_title": "A Phase I, Open-Label, Multicentre Study to Compare Two Dosage Formulations of AZD5363 and to Establish the Effect of Food on the Pharmacokinetic Exposure, Safety and Tolerability of AZD5363 in Patients With Advanced Solid Malignancies",
        "inclusion_criteria": "-\n\n* Aged at least 18 years\n* The presence of a solid, malignant tumour, excluding lymphoma, that is resistance to standard therapies or for which no standard therapies exist\n* The presence of at least one lesion that can be accurately assessed at baseline by Computerised Tomography (CT), Magnetic Resonance Imaging (MRI) or plain X-ray and is suitable for repeated assessment\n* Estimated life expectancy of more than 12 weeks\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 100 Years",
        "exclusion_criteria": "-\n\n* Clinically significant abnormalities of glucose metabolism\n* Spinal cord compression or brain metastases unless asymptomatic, treated and stable (not requiring steroids)\n* Evidence of severe or uncontrolled systemic diseases, including active bleeding diatheses or active infections including hepatitis B, C and Human Immunodeficiency Virus (HIV)\n* Evidence of clinically significant cardiac abnormalities, uncontrolled hypotension, left ventricular ejection fraction below the lower limit of normal for the site or experience of significant cardiac interventional procedures\n* A bad reaction to AZD5363 or any drugs similar to it in structure or class",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
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                    {
                        "exact_snippets": [
                            "Aged at least 18 years"
                        ],
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                            "operator": ">=",
                            "value": 18
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        },
        {
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                    {
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                            "excluding lymphoma"
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                            "for which no standard therapies exist"
                        ],
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                                "for which no standard therapies exist"
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                            "expected_value": false
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                },
                "else_criteria": null
            }
        },
        {
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                "line": "* The presence of at least one lesion that can be accurately assessed at baseline by Computerised Tomography (CT), Magnetic Resonance Imaging (MRI) or plain X-ray and is suitable for repeated assessment",
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                        ],
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                    },
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                            "can be accurately assessed at baseline by Computerised Tomography (CT), Magnetic Resonance Imaging (MRI) or plain X-ray"
                        ],
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        },
        {
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                            "Estimated life expectancy",
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                        ],
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                        "requirement_type": "duration",
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                        }
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        },
        {
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        },
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        },
        {
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                        "exact_snippets": [
                            "maximum age of 100 Years"
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                        "requirement_type": "maximum",
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                            "value": 100
                        }
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                ]
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                            "maximum age of 100 Years"
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                    }
                ]
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        },
        {
            "identified_line": {
                "line": "-",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Clinically significant abnormalities of glucose metabolism",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Clinically significant abnormalities of glucose metabolism"
                        ],
                        "criterion": "glucose metabolism",
                        "requirement_type": "abnormalities",
                        "expected_value": "clinically significant"
                    }
                ]
            },
            "logical_structure": {
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                        "Clinically significant abnormalities of glucose metabolism"
                    ],
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                }
            }
        },
        {
            "identified_line": {
                "line": "* Spinal cord compression or brain metastases unless asymptomatic, treated and stable (not requiring steroids)",
                "criterions": [
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                            "brain metastases"
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                        "requirement_type": "presence",
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                        "criterion": "treatment",
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                            "not requiring steroids"
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                        "criterion": "steroid requirement",
                        "requirement_type": "necessity",
                        "expected_value": false
                    }
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                                ],
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        },
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                            "clinically significant cardiac abnormalities"
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                    },
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                            "left ventricular ejection fraction below the lower limit of normal for the site"
                        ],
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                                {
                                    "operator": "<",
                                    "value": 1
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                    }
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* A bad reaction to AZD5363 or any drugs similar to it in structure or class",
                "criterions": [
                    {
                        "exact_snippets": [
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                        ],
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                    },
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                            "bad reaction to",
                            "any drugs similar to it in structure or class"
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                    }
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                    }
                ]
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        },
        {
            "identified_line": {
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            },
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            }
        },
        {
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                    },
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                    },
                    {
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                            "hepatitis B"
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                    },
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                    },
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                        ],
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    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}