{
    "info": {
        "nct_id": "NCT01888965",
        "official_title": "A Pilot Study of Dovitinib as Maintenance and Adjuvant Therapy in Patients With Colorectal and Pancreas Cancers",
        "inclusion_criteria": "* Patients with a confirmed diagnosis of:\n\n  1. Stage 4 colon cancer either s/p metastasectomy or post-initial chemotherapy or maintenance \"standard of care\", either involving 5-fluorouracil/leucovorin (5-FU/LV) alone or continual bevacizumab alone. Patients in maintenance cohort must have had 2 consecutive CT scans showing stable disease and not be experiencing significant prior treatment-related toxicity above Grade 1.\n  2. Pancreas cancer, either s/p resection and adjuvant chemotherapy or locally advanced pancreas cancer s/p chemotherapy and radiation. Initial chemotherapy or radiation therapy may have been stopped between 2 weeks and 2 months prior to study start, and patients must have recovered from prior treatment related toxicity to grade 1 or less.\n* Prior surgery, including tumor resection or metastasectomy must have been performed at least 4 weeks prior to study enrollment.\n* No concomitant anti-cancer treatment is allowed\n* Age >/= 18 years\n* Performance status of 0-1\n* Adequate hepatic, bone marrow, and renal function\n* Partial thromboplastin time (PTT) must be </= 1.5 x upper normal limit of institution's normal range and INR (International Normalized Ratio) < 1.5.\n* Life expectancy >/= 4 months for maintenance cohorts and >/= 6 months for adjuvant cohorts\n* Women of childbearing potential must have a negative serum pregnancy test within 14 days prior to initiation of treatment and must not be lactating.\n* Subject is capable of understanding and complying with protocol demands and able to sign and date the informed consent\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Women of child-bearing potential, who are biologically able to conceive, not employing two forms of highly effective contraception or who are pregnant.\n* Women who are breast-feeding\n* Fertile males unwilling to use contraception\n* Patients with brain metastases or any history of brain metastases\n* Patients who have undergone major surgery (e.g., intra-thoracic, -abdominal, or -pelvic) </= 4 weeks prior to starting study treatment or who have not recovered from such therapy\n* Patients with a history of pulmonary embolism, or untreated deep vein thrombosis within the past 6 months\n* Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of dovitinib\n* The subject has had another active malignancy within the past 5 years except for cervical cancer in situ, in situ carcinoma of the bladder or non-melanoma carcinoma of the skin.\n* Patients who have received the last administration of an anticancer therapy including chemotherapy, immunotherapy, hormonal therapy and monoclonal antibodies </= 2 weeks prior to starting the study drug, or who have not recovered from the side effects of such therapy\n* Cirrhosis, chronic active hepatitis or chronic persistent hepatitis\n* Patients who are currently receiving prasugrel\n* No concurrent use of isoniazid, labetolol, trovafloxacin, tolcapone, and felbamate\n* No concurrent use of other investigational drugs or antineoplastic therapies.\n* Patients with impaired cardiac function or clinically significant cardiac diseases.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients with a confirmed diagnosis of:",
                "criterions": [
                    {
                        "exact_snippets": [
                            "confirmed diagnosis"
                        ],
                        "criterion": "diagnosis",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "confirmed diagnosis"
                        ],
                        "criterion": "diagnosis",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. Stage 4 colon cancer either s/p metastasectomy or post-initial chemotherapy or maintenance \"standard of care\", either involving 5-fluorouracil/leucovorin (5-FU/LV) alone or continual bevacizumab alone. Patients in maintenance cohort must have had 2 consecutive CT scans showing stable disease and not be experiencing significant prior treatment-related toxicity above Grade 1.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Stage 4 colon cancer"
                        ],
                        "criterion": "colon cancer",
                        "requirement_type": "stage",
                        "expected_value": "4"
                    },
                    {
                        "exact_snippets": [
                            "s/p metastasectomy"
                        ],
                        "criterion": "metastasectomy",
                        "requirement_type": "status",
                        "expected_value": "post"
                    },
                    {
                        "exact_snippets": [
                            "post-initial chemotherapy"
                        ],
                        "criterion": "initial chemotherapy",
                        "requirement_type": "status",
                        "expected_value": "post"
                    },
                    {
                        "exact_snippets": [
                            "maintenance \"standard of care\""
                        ],
                        "criterion": "standard of care",
                        "requirement_type": "maintenance",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "5-fluorouracil/leucovorin (5-FU/LV)"
                        ],
                        "criterion": "chemotherapy regimen",
                        "requirement_type": "involvement",
                        "expected_value": "5-fluorouracil/leucovorin (5-FU/LV)"
                    },
                    {
                        "exact_snippets": [
                            "continual bevacizumab"
                        ],
                        "criterion": "chemotherapy regimen",
                        "requirement_type": "involvement",
                        "expected_value": "bevacizumab"
                    },
                    {
                        "exact_snippets": [
                            "2 consecutive CT scans showing stable disease"
                        ],
                        "criterion": "CT scans",
                        "requirement_type": "stability",
                        "expected_value": "stable disease"
                    },
                    {
                        "exact_snippets": [
                            "not be experiencing significant prior treatment-related toxicity above Grade 1"
                        ],
                        "criterion": "treatment-related toxicity",
                        "requirement_type": "severity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 1
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "or_criteria": [
                                {
                                    "and_criteria": [
                                        {
                                            "and_criteria": [
                                                {
                                                    "exact_snippets": [
                                                        "s/p metastasectomy"
                                                    ],
                                                    "criterion": "metastasectomy",
                                                    "requirement_type": "status",
                                                    "expected_value": "post"
                                                },
                                                {
                                                    "exact_snippets": [
                                                        "Stage 4 colon cancer"
                                                    ],
                                                    "criterion": "colon cancer",
                                                    "requirement_type": "stage",
                                                    "expected_value": "4"
                                                }
                                            ]
                                        },
                                        {
                                            "and_criteria": [
                                                {
                                                    "exact_snippets": [
                                                        "post-initial chemotherapy"
                                                    ],
                                                    "criterion": "initial chemotherapy",
                                                    "requirement_type": "status",
                                                    "expected_value": "post"
                                                },
                                                {
                                                    "exact_snippets": [
                                                        "Stage 4 colon cancer"
                                                    ],
                                                    "criterion": "colon cancer",
                                                    "requirement_type": "stage",
                                                    "expected_value": "4"
                                                }
                                            ]
                                        },
                                        {
                                            "and_criteria": [
                                                {
                                                    "exact_snippets": [
                                                        "maintenance \"standard of care\""
                                                    ],
                                                    "criterion": "standard of care",
                                                    "requirement_type": "maintenance",
                                                    "expected_value": true
                                                },
                                                {
                                                    "exact_snippets": [
                                                        "Stage 4 colon cancer"
                                                    ],
                                                    "criterion": "colon cancer",
                                                    "requirement_type": "stage",
                                                    "expected_value": "4"
                                                }
                                            ]
                                        }
                                    ]
                                },
                                {
                                    "or_criteria": [
                                        {
                                            "exact_snippets": [
                                                "5-fluorouracil/leucovorin (5-FU/LV)"
                                            ],
                                            "criterion": "chemotherapy regimen",
                                            "requirement_type": "involvement",
                                            "expected_value": "5-fluorouracil/leucovorin (5-FU/LV)"
                                        },
                                        {
                                            "exact_snippets": [
                                                "continual bevacizumab"
                                            ],
                                            "criterion": "chemotherapy regimen",
                                            "requirement_type": "involvement",
                                            "expected_value": "bevacizumab"
                                        }
                                    ]
                                }
                            ]
                        }
                    ]
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": [
                                "2 consecutive CT scans showing stable disease"
                            ],
                            "criterion": "CT scans",
                            "requirement_type": "stability",
                            "expected_value": "stable disease"
                        },
                        {
                            "exact_snippets": [
                                "not be experiencing significant prior treatment-related toxicity above Grade 1"
                            ],
                            "criterion": "treatment-related toxicity",
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 1
                                    }
                                ]
                            }
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "2. Pancreas cancer, either s/p resection and adjuvant chemotherapy or locally advanced pancreas cancer s/p chemotherapy and radiation. Initial chemotherapy or radiation therapy may have been stopped between 2 weeks and 2 months prior to study start, and patients must have recovered from prior treatment related toxicity to grade 1 or less.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Pancreas cancer"
                        ],
                        "criterion": "pancreas cancer",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "s/p resection"
                        ],
                        "criterion": "resection",
                        "requirement_type": "status",
                        "expected_value": "post"
                    },
                    {
                        "exact_snippets": [
                            "adjuvant chemotherapy"
                        ],
                        "criterion": "adjuvant chemotherapy",
                        "requirement_type": "status",
                        "expected_value": "post"
                    },
                    {
                        "exact_snippets": [
                            "locally advanced pancreas cancer"
                        ],
                        "criterion": "locally advanced pancreas cancer",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "s/p chemotherapy"
                        ],
                        "criterion": "chemotherapy",
                        "requirement_type": "status",
                        "expected_value": "post"
                    },
                    {
                        "exact_snippets": [
                            "radiation"
                        ],
                        "criterion": "radiation",
                        "requirement_type": "status",
                        "expected_value": "post"
                    },
                    {
                        "exact_snippets": [
                            "Initial chemotherapy or radiation therapy may have been stopped between 2 weeks and 2 months prior to study start"
                        ],
                        "criterion": "chemotherapy or radiation therapy",
                        "requirement_type": "time since cessation",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 2
                                },
                                {
                                    "operator": "<=",
                                    "value": 8
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "patients must have recovered from prior treatment related toxicity to grade 1 or less"
                        ],
                        "criterion": "treatment related toxicity",
                        "requirement_type": "severity",
                        "expected_value": {
                            "operator": "<=",
                            "value": 1
                        }
                    }
                ]
            },
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                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "Pancreas cancer"
                                        ],
                                        "criterion": "pancreas cancer",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "s/p resection"
                                        ],
                                        "criterion": "resection",
                                        "requirement_type": "status",
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                                    },
                                    {
                                        "exact_snippets": [
                                            "adjuvant chemotherapy"
                                        ],
                                        "criterion": "adjuvant chemotherapy",
                                        "requirement_type": "status",
                                        "expected_value": "post"
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "Initial chemotherapy or radiation therapy may have been stopped between 2 weeks and 2 months prior to study start"
                                        ],
                                        "criterion": "chemotherapy or radiation therapy",
                                        "requirement_type": "time since cessation",
                                        "expected_value": {
                                            "comparisons": [
                                                {
                                                    "operator": ">=",
                                                    "value": 2
                                                },
                                                {
                                                    "operator": "<=",
                                                    "value": 8
                                                }
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": [
                                            "patients must have recovered from prior treatment related toxicity to grade 1 or less"
                                        ],
                                        "criterion": "treatment related toxicity",
                                        "requirement_type": "severity",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 1
                                        }
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                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "locally advanced pancreas cancer"
                                        ],
                                        "criterion": "locally advanced pancreas cancer",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "s/p chemotherapy"
                                        ],
                                        "criterion": "chemotherapy",
                                        "requirement_type": "status",
                                        "expected_value": "post"
                                    },
                                    {
                                        "exact_snippets": [
                                            "radiation"
                                        ],
                                        "criterion": "radiation",
                                        "requirement_type": "status",
                                        "expected_value": "post"
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "Initial chemotherapy or radiation therapy may have been stopped between 2 weeks and 2 months prior to study start"
                                        ],
                                        "criterion": "chemotherapy or radiation therapy",
                                        "requirement_type": "time since cessation",
                                        "expected_value": {
                                            "comparisons": [
                                                {
                                                    "operator": ">=",
                                                    "value": 2
                                                },
                                                {
                                                    "operator": "<=",
                                                    "value": 8
                                                }
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": [
                                            "patients must have recovered from prior treatment related toxicity to grade 1 or less"
                                        ],
                                        "criterion": "treatment related toxicity",
                                        "requirement_type": "severity",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 1
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior surgery, including tumor resection or metastasectomy must have been performed at least 4 weeks prior to study enrollment.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Prior surgery, including tumor resection or metastasectomy"
                        ],
                        "criterion": "prior surgery",
                        "requirement_type": "type",
                        "expected_value": [
                            "tumor resection",
                            "metastasectomy"
                        ]
                    },
                    {
                        "exact_snippets": [
                            "must have been performed at least 4 weeks prior to study enrollment"
                        ],
                        "criterion": "prior surgery",
                        "requirement_type": "timing",
                        "expected_value": ">= 4 weeks prior to study enrollment"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Prior surgery, including tumor resection or metastasectomy"
                                ],
                                "criterion": "prior surgery",
                                "requirement_type": "type",
                                "expected_value": [
                                    "tumor resection"
                                ]
                            },
                            {
                                "exact_snippets": [
                                    "must have been performed at least 4 weeks prior to study enrollment"
                                ],
                                "criterion": "prior surgery",
                                "requirement_type": "timing",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 4
                                }
                            }
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "Prior surgery, including tumor resection or metastasectomy"
                                ],
                                "criterion": "prior surgery",
                                "requirement_type": "type",
                                "expected_value": [
                                    "metastasectomy"
                                ]
                            },
                            {
                                "exact_snippets": [
                                    "must have been performed at least 4 weeks prior to study enrollment"
                                ],
                                "criterion": "prior surgery",
                                "requirement_type": "timing",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 4
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concomitant anti-cancer treatment is allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "No concomitant anti-cancer treatment is allowed"
                        ],
                        "criterion": "concomitant anti-cancer treatment",
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "No concomitant anti-cancer treatment is allowed"
                        ],
                        "criterion": "concomitant anti-cancer treatment",
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age >/= 18 years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Age >/= 18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "N/A",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 18
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Age >/= 18 years"
                        ],
                        "criterion": "age",
                        "requirement_type": "N/A",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 18
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Performance status of 0-1",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Performance status of 0-1"
                        ],
                        "criterion": "performance status",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 1
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Performance status of 0-1"
                        ],
                        "criterion": "performance status",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": ">=",
                                    "value": 0
                                },
                                {
                                    "operator": "<=",
                                    "value": 1
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate hepatic, bone marrow, and renal function",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Adequate hepatic"
                        ],
                        "criterion": "hepatic function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "bone marrow"
                        ],
                        "criterion": "bone marrow function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "renal function"
                        ],
                        "criterion": "renal function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Adequate hepatic"
                        ],
                        "criterion": "hepatic function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "bone marrow"
                        ],
                        "criterion": "bone marrow function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "Adequate",
                            "renal function"
                        ],
                        "criterion": "renal function",
                        "requirement_type": "adequacy",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Partial thromboplastin time (PTT) must be </= 1.5 x upper normal limit of institution's normal range and INR (International Normalized Ratio) < 1.5.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Partial thromboplastin time (PTT)",
                            "must be </= 1.5 x upper normal limit"
                        ],
                        "criterion": "partial thromboplastin time (PTT)",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 1.5
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "INR (International Normalized Ratio)",
                            "< 1.5"
                        ],
                        "criterion": "INR (International Normalized Ratio)",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 1.5
                                }
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                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Partial thromboplastin time (PTT)",
                            "must be </= 1.5 x upper normal limit"
                        ],
                        "criterion": "partial thromboplastin time (PTT)",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 1.5
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                            ]
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                    },
                    {
                        "exact_snippets": [
                            "INR (International Normalized Ratio)",
                            "< 1.5"
                        ],
                        "criterion": "INR (International Normalized Ratio)",
                        "requirement_type": "range",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 1.5
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* Women of childbearing potential must have a negative serum pregnancy test within 14 days prior to initiation of treatment and must not be lactating.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Women of childbearing potential"
                        ],
                        "criterion": "childbearing potential",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "negative serum pregnancy test"
                        ],
                        "criterion": "serum pregnancy test",
                        "requirement_type": "result",
                        "expected_value": "negative"
                    },
                    {
                        "exact_snippets": [
                            "within 14 days prior to initiation of treatment"
                        ],
                        "criterion": "serum pregnancy test",
                        "requirement_type": "timing",
                        "expected_value": "within 14 days prior to initiation of treatment"
                    },
                    {
                        "exact_snippets": [
                            "must not be lactating"
                        ],
                        "criterion": "lactation",
                        "requirement_type": "status",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": [
                                            "Women of childbearing potential"
                                        ],
                                        "criterion": "childbearing potential",
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    },
                                    {
                                        "exact_snippets": [
                                            "negative serum pregnancy test"
                                        ],
                                        "criterion": "serum pregnancy test",
                                        "requirement_type": "result",
                                        "expected_value": "negative"
                                    }
                                ]
                            },
                            {
                                "exact_snippets": [
                                    "within 14 days prior to initiation of treatment"
                                ],
                                "criterion": "serum pregnancy test",
                                "requirement_type": "timing",
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                        ]
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": [
                                "must not be lactating"
                            ],
                            "criterion": "lactation",
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                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Subject is capable of understanding and complying with protocol demands and able to sign and date the informed consent",
                "criterions": [
                    {
                        "exact_snippets": [
                            "capable of understanding and complying with protocol demands"
                        ],
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                    },
                    {
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                            "able to sign and date the informed consent"
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                    }
                ]
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                    {
                        "exact_snippets": [
                            "capable of understanding and complying with protocol demands"
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                            "able to sign and date the informed consent"
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                ]
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        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
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                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
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                ]
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                            "Healthy volunteers allowed"
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
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                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
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                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
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                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
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                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy >/= 4 months for maintenance cohorts and >/= 6 months for adjuvant cohorts",
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                    {
                        "exact_snippets": [
                            "Life expectancy >/= 4 months",
                            "maintenance cohorts"
                        ],
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                                    "operator": ">=",
                                    "value": 4
                                }
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                                {
                                    "operator": ">=",
                                    "value": 6
                                }
                            ]
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                ]
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                        "maintenance cohorts"
                    ],
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                        "Life expectancy >/= 4 months",
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                                "operator": ">=",
                                "value": 4
                            }
                        ]
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                            "Life expectancy >/= 6 months",
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                                    "value": 6
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                        }
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                }
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    ],
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        {
            "identified_line": {
                "line": "* Women of child-bearing potential, who are biologically able to conceive, not employing two forms of highly effective contraception or who are pregnant.",
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                    {
                        "exact_snippets": [
                            "Women of child-bearing potential"
                        ],
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                            "biologically able to conceive"
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                            "who are pregnant"
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                ]
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                            },
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                                    "biologically able to conceive"
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        },
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                "line": "* Women who are breast-feeding",
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                        "exact_snippets": [
                            "Women who are breast-feeding"
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                    }
                ]
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                        "Women who are breast-feeding"
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                }
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        },
        {
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                "line": "* Fertile males unwilling to use contraception",
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                    {
                        "exact_snippets": [
                            "Fertile males"
                        ],
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                    },
                    {
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                            "unwilling to use contraception"
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                            "Fertile males"
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                    {
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                        ],
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                    }
                ]
            }
        },
        {
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                            "Patients with brain metastases"
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                    },
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                            "Patients with brain metastases"
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                            "any history of brain metastases"
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                ]
            }
        },
        {
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                    {
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                        ],
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                            "intra-abdominal",
                            "intra-pelvic"
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                    },
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                        ],
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                                    "operator": "<=",
                                    "value": 4
                                }
                            ]
                        }
                    }
                ]
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                                "and_criteria": [
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                                            "undergone major surgery"
                                        ],
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                                        "requirement_type": "history",
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                                    },
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                                            "intra-thoracic, -abdominal, or -pelvic"
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                                ],
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                                        }
                                    ]
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                        ]
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                            ],
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                        }
                    }
                ]
            }
        },
        {
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                        "criterion": "pulmonary embolism",
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                    },
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                            "within the past 6 months"
                        ],
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                    }
                ]
            },
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                            "history of pulmonary embolism"
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                        ],
                        "criterion": "deep vein thrombosis",
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of dovitinib",
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                    {
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                            "Impairment of gastrointestinal (GI) function"
                        ],
                        "criterion": "gastrointestinal function",
                        "requirement_type": "impairment",
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                    },
                    {
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                            "GI disease that may significantly alter the absorption of dovitinib"
                        ],
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                        "requirement_type": "impact on absorption of dovitinib",
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                    }
                ]
            },
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                            "Impairment of gastrointestinal (GI) function"
                        ],
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                    },
                    {
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                            "GI disease that may significantly alter the absorption of dovitinib"
                        ],
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                        "requirement_type": "impact on absorption of dovitinib",
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* The subject has had another active malignancy within the past 5 years except for cervical cancer in situ, in situ carcinoma of the bladder or non-melanoma carcinoma of the skin.",
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                            "another active malignancy",
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                        ],
                        "criterion": "active malignancy",
                        "requirement_type": "presence",
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                    },
                    {
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                    },
                    {
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                            "in situ carcinoma of the bladder"
                        ],
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                        "requirement_type": "presence",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "non-melanoma carcinoma of the skin"
                        ],
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                        "expected_value": false
                    }
                ]
            },
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                            ],
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                            "requirement_type": "presence",
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                        }
                    ]
                },
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                            {
                                "exact_snippets": [
                                    "cervical cancer in situ"
                                ],
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                                "requirement_type": "presence",
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                            },
                            {
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                                ],
                                "criterion": "in situ carcinoma of the bladder",
                                "requirement_type": "presence",
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                            },
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                                ],
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                            }
                        ]
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Patients who have received the last administration of an anticancer therapy including chemotherapy, immunotherapy, hormonal therapy and monoclonal antibodies </= 2 weeks prior to starting the study drug, or who have not recovered from the side effects of such therapy",
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                    {
                        "exact_snippets": [
                            "received the last administration of an anticancer therapy including chemotherapy, immunotherapy, hormonal therapy and monoclonal antibodies </= 2 weeks prior to starting the study drug"
                        ],
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                        "requirement_type": "duration",
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                                {
                                    "operator": "<=",
                                    "value": 2
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": [
                            "have not recovered from the side effects of such therapy"
                        ],
                        "criterion": "recovery from side effects of anticancer therapy",
                        "requirement_type": "status",
                        "expected_value": false
                    }
                ]
            },
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                                    "received the last administration of an anticancer therapy including chemotherapy, immunotherapy, hormonal therapy and monoclonal antibodies </= 2 weeks prior to starting the study drug"
                                ],
                                "criterion": "time since last anticancer therapy",
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                                            "operator": "<=",
                                            "value": 2
                                        }
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                                    "have not recovered from the side effects of such therapy"
                                ],
                                "criterion": "recovery from side effects of anticancer therapy",
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                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Cirrhosis, chronic active hepatitis or chronic persistent hepatitis",
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                    {
                        "exact_snippets": [
                            "Cirrhosis"
                        ],
                        "criterion": "cirrhosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "chronic active hepatitis"
                        ],
                        "criterion": "chronic active hepatitis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "chronic persistent hepatitis"
                        ],
                        "criterion": "chronic persistent hepatitis",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": [
                            "Cirrhosis"
                        ],
                        "criterion": "cirrhosis",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "chronic active hepatitis"
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                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
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                        "criterion": "chronic persistent hepatitis",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients who are currently receiving prasugrel",
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                    {
                        "exact_snippets": [
                            "currently receiving prasugrel"
                        ],
                        "criterion": "prasugrel",
                        "requirement_type": "current use",
                        "expected_value": true
                    }
                ]
            },
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                        "currently receiving prasugrel"
                    ],
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                    "requirement_type": "current use",
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                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent use of other investigational drugs or antineoplastic therapies.",
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                    {
                        "exact_snippets": [
                            "No concurrent use of other investigational drugs"
                        ],
                        "criterion": "investigational drugs",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    },
                    {
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                            "No concurrent use of other",
                            "antineoplastic therapies"
                        ],
                        "criterion": "antineoplastic therapies",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    }
                ]
            },
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                                "No concurrent use of other investigational drugs"
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                            "requirement_type": "concurrent use",
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                        }
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                    {
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                                "No concurrent use of other",
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                            ],
                            "criterion": "antineoplastic therapies",
                            "requirement_type": "concurrent use",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with impaired cardiac function or clinically significant cardiac diseases.",
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                    {
                        "exact_snippets": [
                            "impaired cardiac function"
                        ],
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                        "requirement_type": "impairment",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "clinically significant cardiac diseases"
                        ],
                        "criterion": "cardiac diseases",
                        "requirement_type": "clinical significance",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": [
                            "impaired cardiac function"
                        ],
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                    },
                    {
                        "exact_snippets": [
                            "clinically significant cardiac diseases"
                        ],
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                        "requirement_type": "clinical significance",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent use of isoniazid, labetolol, trovafloxacin, tolcapone, and felbamate",
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                    {
                        "exact_snippets": [
                            "No concurrent use of isoniazid"
                        ],
                        "criterion": "isoniazid",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of labetolol"
                        ],
                        "criterion": "labetolol",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of trovafloxacin"
                        ],
                        "criterion": "trovafloxacin",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of tolcapone"
                        ],
                        "criterion": "tolcapone",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of felbamate"
                        ],
                        "criterion": "felbamate",
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "No concurrent use of isoniazid"
                        ],
                        "criterion": "isoniazid",
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of labetolol"
                        ],
                        "criterion": "labetolol",
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of trovafloxacin"
                        ],
                        "criterion": "trovafloxacin",
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of tolcapone"
                        ],
                        "criterion": "tolcapone",
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "No concurrent use of felbamate"
                        ],
                        "criterion": "felbamate",
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}