{
    "info": {
        "nct_id": "NCT00502567",
        "official_title": "A Phase 1, Open Label Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2171 and Selected Chemotherapy Regimens When Given in Combination to Patients With Advanced Solid Tumors",
        "inclusion_criteria": "* histologically confirmed metastatic cancer that is not amenable to surgery or radiation therapy with curative intent\n* measurable lesion by CT or other techniques according to RECIST\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Inadequate bone marrow reserve\n* history of poorly controlled hypertension",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* histologically confirmed metastatic cancer that is not amenable to surgery or radiation therapy with curative intent",
                "criterions": [
                    {
                        "exact_snippets": [
                            "histologically confirmed metastatic cancer"
                        ],
                        "criterion": "metastatic cancer",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "not amenable to surgery or radiation therapy with curative intent"
                        ],
                        "criterion": "surgery or radiation therapy",
                        "requirement_type": "amenability",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "histologically confirmed metastatic cancer"
                        ],
                        "criterion": "metastatic cancer",
                        "requirement_type": "confirmation",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "not amenable to surgery or radiation therapy with curative intent"
                        ],
                        "criterion": "surgery or radiation therapy",
                        "requirement_type": "amenability",
                        "expected_value": false
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* measurable lesion by CT or other techniques according to RECIST",
                "criterions": [
                    {
                        "exact_snippets": [
                            "measurable lesion"
                        ],
                        "criterion": "lesion",
                        "requirement_type": "measurability",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "CT or other techniques"
                        ],
                        "criterion": "imaging technique",
                        "requirement_type": "type",
                        "expected_value": [
                            "CT",
                            "other techniques"
                        ]
                    },
                    {
                        "exact_snippets": [
                            "according to RECIST"
                        ],
                        "criterion": "RECIST",
                        "requirement_type": "compliance",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": [
                                    "measurable lesion"
                                ],
                                "criterion": "lesion",
                                "requirement_type": "measurability",
                                "expected_value": true
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": [
                                            "CT or other techniques"
                                        ],
                                        "criterion": "imaging technique",
                                        "requirement_type": "type",
                                        "expected_value": [
                                            "CT"
                                        ]
                                    },
                                    {
                                        "exact_snippets": [
                                            "CT or other techniques"
                                        ],
                                        "criterion": "imaging technique",
                                        "requirement_type": "type",
                                        "expected_value": [
                                            "other techniques"
                                        ]
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": [
                            "according to RECIST"
                        ],
                        "criterion": "RECIST",
                        "requirement_type": "compliance",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Inadequate bone marrow reserve",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Inadequate bone marrow reserve"
                        ],
                        "criterion": "bone marrow reserve",
                        "requirement_type": "adequacy",
                        "expected_value": false
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Inadequate bone marrow reserve"
                    ],
                    "criterion": "bone marrow reserve",
                    "requirement_type": "adequacy",
                    "expected_value": false
                }
            }
        },
        {
            "identified_line": {
                "line": "* history of poorly controlled hypertension",
                "criterions": [
                    {
                        "exact_snippets": [
                            "history of poorly controlled hypertension"
                        ],
                        "criterion": "hypertension",
                        "requirement_type": "control",
                        "expected_value": "poorly controlled"
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "history of poorly controlled hypertension"
                    ],
                    "criterion": "hypertension",
                    "requirement_type": "control",
                    "expected_value": "poorly controlled"
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}