{
    "info": {
        "nct_id": "NCT03333655",
        "official_title": "A Multicenter Study to Explore the Mechanism of Acquired Immune Escape In Patients With Metastatic Cancer Progressing on Checkpoint Inhibitor Therapy",
        "inclusion_criteria": "* Response assessment of complete response (CR), partial response (PR), or long-term stable disease (SD) for >6 months with a cancer immunotherapy treatment for metastatic cancer or hematologic malignancies either through a marketed CPI or through participation in a Roche/Genentech CPI clinical trial.\n* Availability of tissue sample.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Pregnant, lactating, or intending to become pregnant during the study.\n* Participants receiving CPI treatment as part of a non-Roche/Genentech clinical trial.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Response assessment of complete response (CR), partial response (PR), or long-term stable disease (SD) for >6 months with a cancer immunotherapy treatment for metastatic cancer or hematologic malignancies either through a marketed CPI or through participation in a Roche/Genentech CPI clinical trial.",
            "criterions": [
                {
                    "exact_snippets": [
                        "complete response (CR)"
                    ],
                    "criterion": "response assessment",
                    "requirement_type": "type",
                    "expected_value": "complete response"
                },
                {
                    "exact_snippets": [
                        "partial response (PR)"
                    ],
                    "criterion": "response assessment",
                    "requirement_type": "type",
                    "expected_value": "partial response"
                },
                {
                    "exact_snippets": [
                        "long-term stable disease (SD) for >6 months"
                    ],
                    "criterion": "response assessment",
                    "requirement_type": "type",
                    "expected_value": "long-term stable disease"
                },
                {
                    "exact_snippets": [
                        "cancer immunotherapy treatment"
                    ],
                    "criterion": "treatment type",
                    "requirement_type": "type",
                    "expected_value": "cancer immunotherapy"
                },
                {
                    "exact_snippets": [
                        "metastatic cancer"
                    ],
                    "criterion": "cancer type",
                    "requirement_type": "type",
                    "expected_value": "metastatic cancer"
                },
                {
                    "exact_snippets": [
                        "hematologic malignancies"
                    ],
                    "criterion": "cancer type",
                    "requirement_type": "type",
                    "expected_value": "hematologic malignancies"
                },
                {
                    "exact_snippets": [
                        "marketed CPI"
                    ],
                    "criterion": "treatment source",
                    "requirement_type": "source",
                    "expected_value": "marketed CPI"
                },
                {
                    "exact_snippets": [
                        "participation in a Roche/Genentech CPI clinical trial"
                    ],
                    "criterion": "treatment source",
                    "requirement_type": "source",
                    "expected_value": "Roche/Genentech CPI clinical trial"
                }
            ]
        },
        {
            "line": "* Availability of tissue sample.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Availability of tissue sample"
                    ],
                    "criterion": "tissue sample",
                    "requirement_type": "availability",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Pregnant, lactating, or intending to become pregnant during the study.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Pregnant"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "status",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "lactating"
                    ],
                    "criterion": "lactation",
                    "requirement_type": "status",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "intending to become pregnant during the study"
                    ],
                    "criterion": "intention to become pregnant",
                    "requirement_type": "status",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Participants receiving CPI treatment as part of a non-Roche/Genentech clinical trial.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Participants receiving CPI treatment"
                    ],
                    "criterion": "CPI treatment",
                    "requirement_type": "receipt",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "non-Roche/Genentech clinical trial"
                    ],
                    "criterion": "clinical trial sponsor",
                    "requirement_type": "sponsor",
                    "expected_value": [
                        "non-Roche",
                        "non-Genentech"
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}