{
    "info": {
        "nct_id": "NCT03315975",
        "official_title": "Influenza Vaccine Responses in the Setting of Melanoma Treatment",
        "inclusion_criteria": "* adults capable of providing consent\n* have a diagnosis of locally advanced or metastatic melanoma\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* are allergic to influenza vaccination\n* have received influenza vaccination within the past 6 months\n* require prednisone, methotrexate, or other immunosuppressing medications\n* have HIV infection\n* have a history of solid organ or bone marrow transplant\n* require combination immunotherapy\n* are on other studies requiring blood draws that might exceed 450 mL total during the period of the influenza vaccine study",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* adults capable of providing consent",
            "criterions": [
                {
                    "exact_snippets": [
                        "adults"
                    ],
                    "criterion": "age",
                    "requirement_type": "category",
                    "expected_value": "adult"
                },
                {
                    "exact_snippets": [
                        "capable of providing consent"
                    ],
                    "criterion": "consent capability",
                    "requirement_type": "ability",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* have a diagnosis of locally advanced or metastatic melanoma",
            "criterions": [
                {
                    "exact_snippets": [
                        "diagnosis of locally advanced or metastatic melanoma"
                    ],
                    "criterion": "melanoma",
                    "requirement_type": "diagnosis",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "locally advanced or metastatic melanoma"
                    ],
                    "criterion": "melanoma",
                    "requirement_type": "stage",
                    "expected_value": [
                        "locally advanced",
                        "metastatic"
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* are allergic to influenza vaccination",
            "criterions": [
                {
                    "exact_snippets": [
                        "allergic to influenza vaccination"
                    ],
                    "criterion": "influenza vaccination allergy",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* have received influenza vaccination within the past 6 months",
            "criterions": [
                {
                    "exact_snippets": [
                        "received influenza vaccination"
                    ],
                    "criterion": "influenza vaccination",
                    "requirement_type": "receipt",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "within the past 6 months"
                    ],
                    "criterion": "influenza vaccination",
                    "requirement_type": "timeframe",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 6
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* have HIV infection",
            "criterions": [
                {
                    "exact_snippets": [
                        "have HIV infection"
                    ],
                    "criterion": "HIV infection",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* have a history of solid organ or bone marrow transplant",
            "criterions": [
                {
                    "exact_snippets": [
                        "history of solid organ or bone marrow transplant"
                    ],
                    "criterion": "solid organ transplant",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "history of solid organ or bone marrow transplant"
                    ],
                    "criterion": "bone marrow transplant",
                    "requirement_type": "history",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* require combination immunotherapy",
            "criterions": [
                {
                    "exact_snippets": [
                        "require combination immunotherapy"
                    ],
                    "criterion": "combination immunotherapy",
                    "requirement_type": "requirement",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* are on other studies requiring blood draws that might exceed 450 mL total during the period of the influenza vaccine study",
            "criterions": [
                {
                    "exact_snippets": [
                        "are on other studies requiring blood draws"
                    ],
                    "criterion": "participation in other studies",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "blood draws that might exceed 450 mL total"
                    ],
                    "criterion": "blood draw volume",
                    "requirement_type": "quantity",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">",
                                "value": 450
                            }
                        ]
                    }
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* require prednisone, methotrexate, or other immunosuppressing medications",
            "criterions": [
                {
                    "exact_snippets": [
                        "require prednisone"
                    ],
                    "criterion": "prednisone",
                    "requirement_type": "requirement",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "require methotrexate"
                    ],
                    "criterion": "methotrexate",
                    "requirement_type": "requirement",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "require",
                        "other immunosuppressing medications"
                    ],
                    "criterion": "immunosuppressing medications",
                    "requirement_type": "requirement",
                    "expected_value": true
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}