{
    "info": {
        "nct_id": "NCT03297125",
        "official_title": "Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using Advanced MRI",
        "inclusion_criteria": "* Newly diagnosed glioblastoma (GBM), World Health Organization (WHO) grade IV.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Optune compliance < 75%; they would be excluded from the final analyses.\n* History of craniectomy or significant skull defect (contraindication to Optune).\n* Active implantable medical device (e.g., deep brain stimulator (DBS), spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).\n* Karnofsky Performance Status (KPS) < 60.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Newly diagnosed glioblastoma (GBM), World Health Organization (WHO) grade IV.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Newly diagnosed glioblastoma (GBM)"
                    ],
                    "criterion": "glioblastoma",
                    "requirement_type": "diagnosis status",
                    "expected_value": "newly diagnosed"
                },
                {
                    "exact_snippets": [
                        "World Health Organization (WHO) grade IV"
                    ],
                    "criterion": "glioblastoma",
                    "requirement_type": "grade",
                    "expected_value": "World Health Organization (WHO) grade IV"
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Optune compliance < 75%; they would be excluded from the final analyses.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Optune compliance < 75%"
                    ],
                    "criterion": "Optune compliance",
                    "requirement_type": "quantity",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 75
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* History of craniectomy or significant skull defect (contraindication to Optune).",
            "criterions": [
                {
                    "exact_snippets": [
                        "History of craniectomy"
                    ],
                    "criterion": "craniectomy",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "significant skull defect"
                    ],
                    "criterion": "skull defect",
                    "requirement_type": "severity",
                    "expected_value": "significant"
                }
            ]
        },
        {
            "line": "* Active implantable medical device (e.g., deep brain stimulator (DBS), spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).",
            "criterions": [
                {
                    "exact_snippets": [
                        "Active implantable medical device"
                    ],
                    "criterion": "implantable medical device",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "deep brain stimulator (DBS)"
                    ],
                    "criterion": "deep brain stimulator",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "spinal cord stimulator"
                    ],
                    "criterion": "spinal cord stimulator",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "pacemaker"
                    ],
                    "criterion": "pacemaker",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "defibrillator"
                    ],
                    "criterion": "defibrillator",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "vagus nerve stimulator"
                    ],
                    "criterion": "vagus nerve stimulator",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "programmable shunt"
                    ],
                    "criterion": "programmable shunt",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Karnofsky Performance Status (KPS) < 60.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Karnofsky Performance Status (KPS) < 60"
                    ],
                    "criterion": "Karnofsky Performance Status",
                    "requirement_type": "value",
                    "expected_value": {
                        "operator": "<",
                        "value": 60
                    }
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}