{
    "info": {
        "nct_id": "NCT02946918",
        "official_title": "Levothyroxine Replacement With Liquid Gel Capsules or Tablets in Post-thyroidectomy Stage in Low Risk Differentiated Thyroid Cancer Patients",
        "inclusion_criteria": "* Age > 18 years\n* Presumed AJCC (American Joint Committee on Cancer) tumor Stage I or II\n* Planned total or near-total thyroidectomy\n* Planned goal TSH suppression 0.1-0.5 mU/L for at least 18 weeks postoperatively\n* Normal serum TSH within 12 months preceding surgery\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* AJCC Stage III or greater\n* Undifferentiated, Anaplastic or Medullary Thyroid Cancer\n* Planned postoperative TSH goal other than 0.1-0.5 mU/L\n* History of gastrointestinal malabsorption or gastric bypass surgery\n* Pregnancy\n* Use of medications that alter the absorption or metabolism of levothyroxine\n* Prior use of levothyroxine",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age > 18 years",
            "criterions": [
                {
                    "exact_snippets": [
                        "Age > 18 years"
                    ],
                    "criterion": "age",
                    "requirement_type": "N/A",
                    "expected_value": {
                        "operator": ">",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "* Presumed AJCC (American Joint Committee on Cancer) tumor Stage I or II",
            "criterions": [
                {
                    "exact_snippets": [
                        "AJCC (American Joint Committee on Cancer) tumor Stage I or II"
                    ],
                    "criterion": "AJCC tumor stage",
                    "requirement_type": "stage",
                    "expected_value": [
                        "I",
                        "II"
                    ]
                }
            ]
        },
        {
            "line": "* Planned total or near-total thyroidectomy",
            "criterions": [
                {
                    "exact_snippets": [
                        "Planned total or near-total thyroidectomy"
                    ],
                    "criterion": "thyroidectomy",
                    "requirement_type": "type",
                    "expected_value": [
                        "total",
                        "near-total"
                    ]
                }
            ]
        },
        {
            "line": "* Planned goal TSH suppression 0.1-0.5 mU/L for at least 18 weeks postoperatively",
            "criterions": [
                {
                    "exact_snippets": [
                        "Planned goal TSH suppression"
                    ],
                    "criterion": "TSH suppression",
                    "requirement_type": "planned goal",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 0.1
                            },
                            {
                                "operator": "<=",
                                "value": 0.5
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "for at least 18 weeks postoperatively"
                    ],
                    "criterion": "duration of TSH suppression",
                    "requirement_type": "minimum duration",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "* Normal serum TSH within 12 months preceding surgery",
            "criterions": [
                {
                    "exact_snippets": [
                        "Normal serum TSH"
                    ],
                    "criterion": "serum TSH",
                    "requirement_type": "normality",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "within 12 months preceding surgery"
                    ],
                    "criterion": "time since surgery",
                    "requirement_type": "duration",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 12
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* AJCC Stage III or greater",
            "criterions": [
                {
                    "exact_snippets": [
                        "AJCC Stage III or greater"
                    ],
                    "criterion": "AJCC Stage",
                    "requirement_type": "severity",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 3
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* Undifferentiated, Anaplastic or Medullary Thyroid Cancer",
            "criterions": [
                {
                    "exact_snippets": [
                        "Undifferentiated"
                    ],
                    "criterion": "thyroid cancer",
                    "requirement_type": "type",
                    "expected_value": "undifferentiated"
                },
                {
                    "exact_snippets": [
                        "Anaplastic"
                    ],
                    "criterion": "thyroid cancer",
                    "requirement_type": "type",
                    "expected_value": "anaplastic"
                },
                {
                    "exact_snippets": [
                        "Medullary"
                    ],
                    "criterion": "thyroid cancer",
                    "requirement_type": "type",
                    "expected_value": "medullary"
                }
            ]
        },
        {
            "line": "* Planned postoperative TSH goal other than 0.1-0.5 mU/L",
            "criterions": [
                {
                    "exact_snippets": [
                        "Planned postoperative TSH goal other than 0.1-0.5 mU/L"
                    ],
                    "criterion": "postoperative TSH goal",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 0.1
                            },
                            {
                                "operator": ">",
                                "value": 0.5
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* History of gastrointestinal malabsorption or gastric bypass surgery",
            "criterions": [
                {
                    "exact_snippets": [
                        "History of gastrointestinal malabsorption"
                    ],
                    "criterion": "gastrointestinal malabsorption",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "gastric bypass surgery"
                    ],
                    "criterion": "gastric bypass surgery",
                    "requirement_type": "history",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Pregnancy",
            "criterions": [
                {
                    "exact_snippets": [
                        "Pregnancy"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Use of medications that alter the absorption or metabolism of levothyroxine",
            "criterions": [
                {
                    "exact_snippets": [
                        "Use of medications that alter the absorption or metabolism of levothyroxine"
                    ],
                    "criterion": "medications",
                    "requirement_type": "effect on levothyroxine",
                    "expected_value": "alter absorption or metabolism"
                }
            ]
        },
        {
            "line": "* Prior use of levothyroxine",
            "criterions": [
                {
                    "exact_snippets": [
                        "Prior use of levothyroxine"
                    ],
                    "criterion": "levothyroxine",
                    "requirement_type": "prior use",
                    "expected_value": true
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}