{
    "info": {
        "nct_id": "NCT02894645",
        "official_title": "Ma-Spore ALL 2010 Study",
        "inclusion_criteria": "1. Confirmed diagnosis of non-Burkitt B-lineage ALL\n2. 1 to 17 years of age (before 18th birthday)\n3. Renal function within normal range for age\n4. Liver function within normal range for age\n5. Able to participate in the full 2 years of treatment\nHealthy volunteers allowed\nMust have minimum age of 1 Year\nMust have maximum age of 17 Years",
        "exclusion_criteria": "1. Age less than one year or age greater than/equals to 18 years\n2. Previous treatment with cytotoxic agents or high-dose steroids\n3. Mixed phenotype acute leukemia (MPAL)\n4. ALL as secondary malignancy\n5. Abnormal renal or liver function\n6. Doubtful compliance or unable to afford full course of therapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Confirmed diagnosis of non-Burkitt B-lineage ALL",
            "criterions": [
                {
                    "exact_snippets": [
                        "Confirmed diagnosis of non-Burkitt B-lineage ALL"
                    ],
                    "criterion": "non-Burkitt B-lineage ALL",
                    "requirement_type": "diagnosis",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "2. 1 to 17 years of age (before 18th birthday)",
            "criterions": [
                {
                    "exact_snippets": [
                        "1 to 17 years of age",
                        "before 18th birthday"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 1
                            },
                            {
                                "operator": "<",
                                "value": 18
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "3. Renal function within normal range for age",
            "criterions": [
                {
                    "exact_snippets": [
                        "Renal function within normal range for age"
                    ],
                    "criterion": "renal function",
                    "requirement_type": "range",
                    "expected_value": "normal for age"
                }
            ]
        },
        {
            "line": "4. Liver function within normal range for age",
            "criterions": [
                {
                    "exact_snippets": [
                        "Liver function within normal range"
                    ],
                    "criterion": "liver function",
                    "requirement_type": "range",
                    "expected_value": "normal for age"
                }
            ]
        },
        {
            "line": "5. Able to participate in the full 2 years of treatment",
            "criterions": [
                {
                    "exact_snippets": [
                        "Able to participate in the full 2 years of treatment"
                    ],
                    "criterion": "participation duration",
                    "requirement_type": "minimum duration",
                    "expected_value": "2 years"
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 1 Year",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 1 Year"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 1
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 17 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 17 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 17
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Age less than one year or age greater than/equals to 18 years",
            "criterions": [
                {
                    "exact_snippets": [
                        "Age less than one year"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 1
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "age greater than/equals to 18 years"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 18
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "2. Previous treatment with cytotoxic agents or high-dose steroids",
            "criterions": [
                {
                    "exact_snippets": [
                        "Previous treatment with cytotoxic agents"
                    ],
                    "criterion": "cytotoxic agents",
                    "requirement_type": "previous treatment",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "Previous treatment with",
                        "high-dose steroids"
                    ],
                    "criterion": "high-dose steroids",
                    "requirement_type": "previous treatment",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "3. Mixed phenotype acute leukemia (MPAL)",
            "criterions": [
                {
                    "exact_snippets": [
                        "Mixed phenotype acute leukemia (MPAL)"
                    ],
                    "criterion": "mixed phenotype acute leukemia",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "4. ALL as secondary malignancy",
            "criterions": [
                {
                    "exact_snippets": [
                        "ALL as secondary malignancy"
                    ],
                    "criterion": "acute lymphoblastic leukemia (ALL)",
                    "requirement_type": "secondary malignancy",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "5. Abnormal renal or liver function",
            "criterions": [
                {
                    "exact_snippets": [
                        "Abnormal renal"
                    ],
                    "criterion": "renal function",
                    "requirement_type": "normality",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "Abnormal",
                        "liver function"
                    ],
                    "criterion": "liver function",
                    "requirement_type": "normality",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "6. Doubtful compliance or unable to afford full course of therapy",
            "criterions": [
                {
                    "exact_snippets": [
                        "Doubtful compliance"
                    ],
                    "criterion": "compliance",
                    "requirement_type": "certainty",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "unable to afford full course of therapy"
                    ],
                    "criterion": "affordability",
                    "requirement_type": "ability",
                    "expected_value": true
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}