{
    "info": {
        "nct_id": "NCT02543710",
        "official_title": "Biomarker Guided Treatment in Gynaecological Cancer",
        "inclusion_criteria": "Healthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 95 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "Inclusion Criteria part 1:\n\nAll patients referred to a participating research centre with suspicion of or confirmed endometrial cancer.\n\nExclusion Criteria part 1:\n\n1. Patients who do not have endometrial cancer\n2. Patients who will or cannot give informed consent (including language barriers)\n3. Patients <18 years of age\n4. Patients who will not get surgical treatment for their endometrial cancer\n\nInclusion criteria part 2:\n\n1. Patients with endometrial or epithelial ovarian cancer who following routine clinical guidelines are offered weekly taxane (paclitaxel) treatment. This will often be a third or fourth line treatment, i.e. patients with advanced disease.\n2. Technical possibility to obtain a new tissue biopsy to determine stathmin level in the tumour recurrence.\n\nExclusion criteria part 2:\n\n1. Patients not suffering from endometrial or epithelial ovarian cancer\n2. Patients <18 years of age\n3. Patients who do not agree to the proposed treatment or will receive (part of) the treatment in a non-participating centre\n4. Patients who cannot or do not want to give informed consent (including language barriers)"
    },
    "inclusion_lines": [
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": [
                        "Must be FEMALE"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specific value",
                    "expected_value": "female"
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 95 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 95 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 95
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "line": "All patients referred to a participating research centre with suspicion of or confirmed endometrial cancer.",
            "criterions": [
                {
                    "exact_snippets": [
                        "suspicion of",
                        "endometrial cancer"
                    ],
                    "criterion": "endometrial cancer",
                    "requirement_type": "suspicion",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "confirmed",
                        "endometrial cancer"
                    ],
                    "criterion": "endometrial cancer",
                    "requirement_type": "confirmation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "1. Patients who do not have endometrial cancer",
            "criterions": [
                {
                    "exact_snippets": [
                        "do not have endometrial cancer"
                    ],
                    "criterion": "endometrial cancer",
                    "requirement_type": "presence",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "2. Patients who will or cannot give informed consent (including language barriers)",
            "criterions": [
                {
                    "exact_snippets": [
                        "Patients who will or cannot give informed consent"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "ability to give",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "language barriers"
                    ],
                    "criterion": "language barriers",
                    "requirement_type": "presence",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "3. Patients <18 years of age",
            "criterions": [
                {
                    "exact_snippets": [
                        "<18 years of age"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 18
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "4. Patients who will not get surgical treatment for their endometrial cancer",
            "criterions": [
                {
                    "exact_snippets": [
                        "Patients who will not get surgical treatment"
                    ],
                    "criterion": "surgical treatment",
                    "requirement_type": "intention",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "endometrial cancer"
                    ],
                    "criterion": "endometrial cancer",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "1. Patients with endometrial or epithelial ovarian cancer who following routine clinical guidelines are offered weekly taxane (paclitaxel) treatment. This will often be a third or fourth line treatment, i.e. patients with advanced disease.",
            "criterions": [
                {
                    "exact_snippets": [
                        "endometrial or epithelial ovarian cancer"
                    ],
                    "criterion": "cancer type",
                    "requirement_type": "presence",
                    "expected_value": [
                        "endometrial",
                        "epithelial ovarian"
                    ]
                },
                {
                    "exact_snippets": [
                        "weekly taxane (paclitaxel) treatment"
                    ],
                    "criterion": "taxane (paclitaxel) treatment",
                    "requirement_type": "frequency",
                    "expected_value": "weekly"
                },
                {
                    "exact_snippets": [
                        "third or fourth line treatment"
                    ],
                    "criterion": "treatment line",
                    "requirement_type": "order",
                    "expected_value": [
                        "third",
                        "fourth"
                    ]
                },
                {
                    "exact_snippets": [
                        "advanced disease"
                    ],
                    "criterion": "disease stage",
                    "requirement_type": "severity",
                    "expected_value": "advanced"
                }
            ]
        },
        {
            "line": "2. Technical possibility to obtain a new tissue biopsy to determine stathmin level in the tumour recurrence.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Technical possibility to obtain a new tissue biopsy"
                    ],
                    "criterion": "tissue biopsy",
                    "requirement_type": "obtainability",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "stathmin level in the tumour recurrence"
                    ],
                    "criterion": "stathmin level",
                    "requirement_type": "measurement",
                    "expected_value": "tumour recurrence"
                }
            ]
        },
        {
            "line": "1. Patients not suffering from endometrial or epithelial ovarian cancer",
            "criterions": [
                {
                    "exact_snippets": [
                        "not suffering from endometrial"
                    ],
                    "criterion": "endometrial cancer",
                    "requirement_type": "presence",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "not suffering from",
                        "epithelial ovarian cancer"
                    ],
                    "criterion": "epithelial ovarian cancer",
                    "requirement_type": "presence",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "2. Patients <18 years of age",
            "criterions": [
                {
                    "exact_snippets": [
                        "<18 years of age"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 18
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "3. Patients who do not agree to the proposed treatment or will receive (part of) the treatment in a non-participating centre",
            "criterions": [
                {
                    "exact_snippets": [
                        "Patients who do not agree to the proposed treatment"
                    ],
                    "criterion": "agreement to proposed treatment",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "will receive (part of) the treatment in a non-participating centre"
                    ],
                    "criterion": "treatment location",
                    "requirement_type": "location",
                    "expected_value": "participating centre"
                }
            ]
        },
        {
            "line": "4. Patients who cannot or do not want to give informed consent (including language barriers)",
            "criterions": [
                {
                    "exact_snippets": [
                        "cannot or do not want to give informed consent"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "ability/willingness",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "language barriers"
                    ],
                    "criterion": "language barriers",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "line": "Inclusion Criteria part 1:",
            "criterions": []
        },
        {
            "line": "Exclusion Criteria part 1:",
            "criterions": []
        },
        {
            "line": "Inclusion criteria part 2:",
            "criterions": []
        },
        {
            "line": "Exclusion criteria part 2:",
            "criterions": []
        }
    ]
}