{
    "info": {
        "nct_id": "NCT02466113",
        "official_title": "A Multi-site, Open, Perspective Study of Prognostic Value and Benefit From Chemotherapy of Stage II Colon Cancer Based on a 6 microRNA Stratified Tool",
        "inclusion_criteria": "* The informed consent has been obtained from the patient.\n* With confirmed diagnosis of stage II colon cancer.\n* With moderate/good ECOG health rating (PS): 0-1 score.\n* The patient receive no anti-cancer treatment before primary surgery.\n* The patient receive radical operation for colon cancer with negative margin.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 65 Years",
        "exclusion_criteria": "* With severe comorbidities, such as cardiovascular disease, chronic obstructive pulmonary disease, diabetes mellitus, and chronic renal dysfunction.\n* With bad compliance or contraindication to enrollment.\n* Pregnant woman or lactating woman.\n* With contraindication to receive adjuvant chemotherapy.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* The informed consent has been obtained from the patient.",
            "criterions": [
                {
                    "exact_snippets": [
                        "The informed consent has been obtained from the patient"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "obtained",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* With confirmed diagnosis of stage II colon cancer.",
            "criterions": [
                {
                    "exact_snippets": [
                        "confirmed diagnosis of stage II colon cancer"
                    ],
                    "criterion": "colon cancer",
                    "requirement_type": "stage",
                    "expected_value": "II"
                }
            ]
        },
        {
            "line": "* With moderate/good ECOG health rating (PS): 0-1 score.",
            "criterions": [
                {
                    "exact_snippets": [
                        "ECOG health rating",
                        "0-1 score"
                    ],
                    "criterion": "ECOG health rating",
                    "requirement_type": "score",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 0
                            },
                            {
                                "operator": "<=",
                                "value": 1
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* The patient receive no anti-cancer treatment before primary surgery.",
            "criterions": [
                {
                    "exact_snippets": [
                        "no anti-cancer treatment before primary surgery"
                    ],
                    "criterion": "anti-cancer treatment",
                    "requirement_type": "prior to primary surgery",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* The patient receive radical operation for colon cancer with negative margin.",
            "criterions": [
                {
                    "exact_snippets": [
                        "radical operation for colon cancer"
                    ],
                    "criterion": "colon cancer operation",
                    "requirement_type": "type",
                    "expected_value": "radical"
                },
                {
                    "exact_snippets": [
                        "negative margin"
                    ],
                    "criterion": "surgical margin",
                    "requirement_type": "status",
                    "expected_value": "negative"
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "volunteer health status",
                    "requirement_type": "allowed",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 65 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 65 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 65
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* With severe comorbidities, such as cardiovascular disease, chronic obstructive pulmonary disease, diabetes mellitus, and chronic renal dysfunction.",
            "criterions": [
                {
                    "exact_snippets": [
                        "severe comorbidities",
                        "cardiovascular disease"
                    ],
                    "criterion": "cardiovascular disease",
                    "requirement_type": "severity",
                    "expected_value": "severe"
                },
                {
                    "exact_snippets": [
                        "severe comorbidities",
                        "chronic obstructive pulmonary disease"
                    ],
                    "criterion": "chronic obstructive pulmonary disease",
                    "requirement_type": "severity",
                    "expected_value": "severe"
                },
                {
                    "exact_snippets": [
                        "severe comorbidities",
                        "diabetes mellitus"
                    ],
                    "criterion": "diabetes mellitus",
                    "requirement_type": "severity",
                    "expected_value": "severe"
                },
                {
                    "exact_snippets": [
                        "severe comorbidities",
                        "chronic renal dysfunction"
                    ],
                    "criterion": "chronic renal dysfunction",
                    "requirement_type": "severity",
                    "expected_value": "severe"
                }
            ]
        },
        {
            "line": "* With bad compliance or contraindication to enrollment.",
            "criterions": [
                {
                    "exact_snippets": [
                        "bad compliance"
                    ],
                    "criterion": "compliance",
                    "requirement_type": "quality",
                    "expected_value": "bad"
                },
                {
                    "exact_snippets": [
                        "contraindication to enrollment"
                    ],
                    "criterion": "contraindication",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Pregnant woman or lactating woman.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Pregnant woman"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "status",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "lactating woman"
                    ],
                    "criterion": "lactation",
                    "requirement_type": "status",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* With contraindication to receive adjuvant chemotherapy.",
            "criterions": [
                {
                    "exact_snippets": [
                        "contraindication to receive adjuvant chemotherapy"
                    ],
                    "criterion": "adjuvant chemotherapy",
                    "requirement_type": "contraindication",
                    "expected_value": true
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}