{
    "info": {
        "nct_id": "NCT01669369",
        "official_title": "A Prospected Randomized Multicenter Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma",
        "inclusion_criteria": "* histologically diagnosed primary classical osteosarcoma in extremities\n* staging IIB\n* MRI showing no skip lesion\n* receive standard neo-adjuvant chemotherapy, adjuvant chemotherapy,and standard surgical treatment\nHealthy volunteers allowed\nMust have minimum age of 8 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "* a history of non-standard treatment(chemotherapy or surgery)\n* secondary osteosarcoma or well-differentiated parosteal osteosarcoma\n* evident dysfunction of cardia,liver and kidney, or pregnant women or women during lactation",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* histologically diagnosed primary classical osteosarcoma in extremities",
            "criterions": [
                {
                    "exact_snippets": [
                        "histologically diagnosed"
                    ],
                    "criterion": "osteosarcoma",
                    "requirement_type": "diagnosis method",
                    "expected_value": "histological"
                },
                {
                    "exact_snippets": [
                        "primary classical osteosarcoma"
                    ],
                    "criterion": "osteosarcoma",
                    "requirement_type": "type",
                    "expected_value": "primary classical"
                },
                {
                    "exact_snippets": [
                        "osteosarcoma in extremities"
                    ],
                    "criterion": "osteosarcoma",
                    "requirement_type": "location",
                    "expected_value": "extremities"
                }
            ]
        },
        {
            "line": "* staging IIB",
            "criterions": [
                {
                    "exact_snippets": [
                        "staging IIB"
                    ],
                    "criterion": "cancer stage",
                    "requirement_type": "specific stage",
                    "expected_value": "IIB"
                }
            ]
        },
        {
            "line": "* MRI showing no skip lesion",
            "criterions": [
                {
                    "exact_snippets": [
                        "MRI showing no skip lesion"
                    ],
                    "criterion": "skip lesion",
                    "requirement_type": "presence",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* receive standard neo-adjuvant chemotherapy, adjuvant chemotherapy,and standard surgical treatment",
            "criterions": [
                {
                    "exact_snippets": [
                        "receive standard neo-adjuvant chemotherapy"
                    ],
                    "criterion": "neo-adjuvant chemotherapy",
                    "requirement_type": "receipt",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "receive",
                        "adjuvant chemotherapy"
                    ],
                    "criterion": "adjuvant chemotherapy",
                    "requirement_type": "receipt",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "receive",
                        "standard surgical treatment"
                    ],
                    "criterion": "surgical treatment",
                    "requirement_type": "receipt",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 8 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 8 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 8
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 70 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 70
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* a history of non-standard treatment(chemotherapy or surgery)",
            "criterions": [
                {
                    "exact_snippets": [
                        "a history of non-standard treatment"
                    ],
                    "criterion": "non-standard treatment",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "chemotherapy"
                    ],
                    "criterion": "chemotherapy",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "surgery"
                    ],
                    "criterion": "surgery",
                    "requirement_type": "history",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* secondary osteosarcoma or well-differentiated parosteal osteosarcoma",
            "criterions": [
                {
                    "exact_snippets": [
                        "secondary osteosarcoma"
                    ],
                    "criterion": "osteosarcoma",
                    "requirement_type": "type",
                    "expected_value": "secondary"
                },
                {
                    "exact_snippets": [
                        "well-differentiated parosteal osteosarcoma"
                    ],
                    "criterion": "osteosarcoma",
                    "requirement_type": "type",
                    "expected_value": "well-differentiated parosteal"
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* evident dysfunction of cardia,liver and kidney, or pregnant women or women during lactation",
            "criterions": [
                {
                    "exact_snippets": [
                        "evident dysfunction of cardia"
                    ],
                    "criterion": "cardia",
                    "requirement_type": "dysfunction",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "evident dysfunction of liver"
                    ],
                    "criterion": "liver",
                    "requirement_type": "dysfunction",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "evident dysfunction of kidney"
                    ],
                    "criterion": "kidney",
                    "requirement_type": "dysfunction",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "pregnant women"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "status",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "women during lactation"
                    ],
                    "criterion": "lactation",
                    "requirement_type": "status",
                    "expected_value": true
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}