{
    "info": {
        "nct_id": "NCT00599924",
        "official_title": "Phase I Study Of SU011248 In Combination With Oxaliplatin, Leucovorin, And 5-Fluorouracil In Patients With Advanced Solid Malignancies",
        "inclusion_criteria": "* Advanced solid tumor malignancy (during expansion at the maximum tolerated dose, entry will be limited to patients wtih adenocarcinoma of the colon or rectum)\n* Eastern Cooperative Oncology Group (ECOG) 0 or 1\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Prior treatment with more than 6 cycles of traditional alkylating agent-based chemotherapy regimens\n* Prior treatment with more than 2 cycles of carboplating-based chemotherapy regimens\n* For colorectal cancer patients in the expanded cohorts, prior treatment with more than 2 systemic chemotherapy regimens in the metastatic setting",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Advanced solid tumor malignancy (during expansion at the maximum tolerated dose, entry will be limited to patients wtih adenocarcinoma of the colon or rectum)",
            "criterions": [
                {
                    "exact_snippets": [
                        "Advanced solid tumor malignancy"
                    ],
                    "criterion": "solid tumor malignancy",
                    "requirement_type": "stage",
                    "expected_value": "advanced"
                },
                {
                    "exact_snippets": [
                        "adenocarcinoma of the colon or rectum"
                    ],
                    "criterion": "adenocarcinoma",
                    "requirement_type": "location",
                    "expected_value": [
                        "colon",
                        "rectum"
                    ]
                }
            ]
        },
        {
            "line": "* Eastern Cooperative Oncology Group (ECOG) 0 or 1",
            "criterions": [
                {
                    "exact_snippets": [
                        "Eastern Cooperative Oncology Group (ECOG) 0 or 1"
                    ],
                    "criterion": "Eastern Cooperative Oncology Group (ECOG) performance status",
                    "requirement_type": "value",
                    "expected_value": [
                        "0",
                        "1"
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Prior treatment with more than 6 cycles of traditional alkylating agent-based chemotherapy regimens",
            "criterions": [
                {
                    "exact_snippets": [
                        "Prior treatment with more than 6 cycles of traditional alkylating agent-based chemotherapy regimens"
                    ],
                    "criterion": "traditional alkylating agent-based chemotherapy regimens",
                    "requirement_type": "prior treatment",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "more than 6 cycles"
                    ],
                    "criterion": "cycles of traditional alkylating agent-based chemotherapy regimens",
                    "requirement_type": "quantity",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">",
                                "value": 6
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* Prior treatment with more than 2 cycles of carboplating-based chemotherapy regimens",
            "criterions": [
                {
                    "exact_snippets": [
                        "Prior treatment with more than 2 cycles of carboplating-based chemotherapy regimens"
                    ],
                    "criterion": "carboplating-based chemotherapy regimens",
                    "requirement_type": "prior treatment cycles",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">",
                                "value": 2
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* For colorectal cancer patients in the expanded cohorts, prior treatment with more than 2 systemic chemotherapy regimens in the metastatic setting",
            "criterions": [
                {
                    "exact_snippets": [
                        "colorectal cancer patients"
                    ],
                    "criterion": "colorectal cancer",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "prior treatment with more than 2 systemic chemotherapy regimens"
                    ],
                    "criterion": "systemic chemotherapy regimens",
                    "requirement_type": "prior treatment count",
                    "expected_value": {
                        "operator": ">",
                        "value": 2
                    }
                },
                {
                    "exact_snippets": [
                        "in the metastatic setting"
                    ],
                    "criterion": "metastatic setting",
                    "requirement_type": "treatment context",
                    "expected_value": true
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}