{
    "info": {
        "nct_id": "NCT00502567",
        "official_title": "A Phase 1, Open Label Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2171 and Selected Chemotherapy Regimens When Given in Combination to Patients With Advanced Solid Tumors",
        "inclusion_criteria": "* histologically confirmed metastatic cancer that is not amenable to surgery or radiation therapy with curative intent\n* measurable lesion by CT or other techniques according to RECIST\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Inadequate bone marrow reserve\n* history of poorly controlled hypertension",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* histologically confirmed metastatic cancer that is not amenable to surgery or radiation therapy with curative intent",
            "criterions": [
                {
                    "exact_snippets": [
                        "histologically confirmed metastatic cancer"
                    ],
                    "criterion": "metastatic cancer",
                    "requirement_type": "confirmation",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "not amenable to surgery or radiation therapy with curative intent"
                    ],
                    "criterion": "surgery or radiation therapy",
                    "requirement_type": "amenability",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* measurable lesion by CT or other techniques according to RECIST",
            "criterions": [
                {
                    "exact_snippets": [
                        "measurable lesion"
                    ],
                    "criterion": "lesion",
                    "requirement_type": "measurability",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "CT or other techniques"
                    ],
                    "criterion": "imaging technique",
                    "requirement_type": "type",
                    "expected_value": [
                        "CT",
                        "other techniques"
                    ]
                },
                {
                    "exact_snippets": [
                        "according to RECIST"
                    ],
                    "criterion": "RECIST",
                    "requirement_type": "compliance",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Inadequate bone marrow reserve",
            "criterions": [
                {
                    "exact_snippets": [
                        "Inadequate bone marrow reserve"
                    ],
                    "criterion": "bone marrow reserve",
                    "requirement_type": "adequacy",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* history of poorly controlled hypertension",
            "criterions": [
                {
                    "exact_snippets": [
                        "history of poorly controlled hypertension"
                    ],
                    "criterion": "hypertension",
                    "requirement_type": "control",
                    "expected_value": "poorly controlled"
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}