{
    "info": {
        "nct_id": "NCT06755866",
        "official_title": "DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer",
        "inclusion_criteria": "1. Be 18 years of age and older;\n2. First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy;\n3. The clinical stage is cT1b~cT2N+; or the clinical stage is cT3~cT4 any N, (thoracic esophageal cancer, esophagogastric junction cancer);\n4. There are no contraindications to MRI examination\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "1. Have other primary tumors;\n2. The image quality does not meet the diagnostic criteria;\n3. Those who do not cooperate with the inspection;\n4. Patients who have received prior chemoradiotherapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Be 18 years of age and older;",
                "criterions": [
                    {
                        "exact_snippets": "18 years of age and older",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "18 years of age and older",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy;",
                "criterions": [
                    {
                        "exact_snippets": "First diagnosis of esophageal squamous cell carcinoma",
                        "criterion": "esophageal squamous cell carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "first"
                        }
                    },
                    {
                        "exact_snippets": "confirmed by histopathological biopsy",
                        "criterion": "histopathological biopsy",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "First diagnosis of esophageal squamous cell carcinoma",
                        "criterion": "esophageal squamous cell carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "first"
                        }
                    },
                    {
                        "exact_snippets": "confirmed by histopathological biopsy",
                        "criterion": "histopathological biopsy",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. The clinical stage is cT1b~cT2N+; or the clinical stage is cT3~cT4 any N, (thoracic esophageal cancer, esophagogastric junction cancer);",
                "criterions": [
                    {
                        "exact_snippets": "clinical stage is cT1b~cT2N+",
                        "criterion": "clinical stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "cT1b",
                                "cT2N+"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "clinical stage is cT3~cT4 any N",
                        "criterion": "clinical stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "cT3",
                                "cT4 any N"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "thoracic esophageal cancer",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "esophagogastric junction cancer",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "clinical stage is cT1b~cT2N+",
                                "criterion": "clinical stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": [
                                        "cT1b",
                                        "cT2N+"
                                    ]
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "thoracic esophageal cancer",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "esophagogastric junction cancer",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "clinical stage is cT3~cT4 any N",
                                "criterion": "clinical stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": [
                                        "cT3",
                                        "cT4 any N"
                                    ]
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "thoracic esophageal cancer",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "esophagogastric junction cancer",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. There are no contraindications to MRI examination",
                "criterions": [
                    {
                        "exact_snippets": "no contraindications to MRI examination",
                        "criterion": "contraindications to MRI examination",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "no contraindications to MRI examination",
                        "criterion": "contraindications to MRI examination",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 80 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1. Have other primary tumors;",
                "criterions": [
                    {
                        "exact_snippets": "Have other primary tumors",
                        "criterion": "primary tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Have other primary tumors",
                    "criterion": "primary tumors",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "2. The image quality does not meet the diagnostic criteria;",
                "criterions": [
                    {
                        "exact_snippets": "image quality does not meet the diagnostic criteria",
                        "criterion": "image quality",
                        "requirement": {
                            "requirement_type": "diagnostic criteria",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "image quality does not meet the diagnostic criteria",
                    "criterion": "image quality",
                    "requirement": {
                        "requirement_type": "diagnostic criteria",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "3. Those who do not cooperate with the inspection;",
                "criterions": [
                    {
                        "exact_snippets": "do not cooperate with the inspection",
                        "criterion": "cooperation with inspection",
                        "requirement": {
                            "requirement_type": "cooperation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "do not cooperate with the inspection",
                    "criterion": "cooperation with inspection",
                    "requirement": {
                        "requirement_type": "cooperation",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "4. Patients who have received prior chemoradiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Patients who have received prior chemoradiotherapy",
                        "criterion": "prior chemoradiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients who have received prior chemoradiotherapy",
                    "criterion": "prior chemoradiotherapy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}