{
    "info": {
        "nct_id": "NCT06658782",
        "official_title": "Abbreviated Magnetic Resonance Imaging vs Ultrasound Surveillance for Liver Cancer dETection in People at High Risk of Developing Liver Cancer",
        "inclusion_criteria": "* • Participant is willing and able to give informed consent for participation in the study AND\n\n  * All genders, aged 18 years or above AND\n  * Eligible for HCC US surveillance in the opinion of the local investigators AND\n  * Child Pugh score A or B AND\n  * Diagnosed with liver cirrhosis due to ArLD, MASLD, chronic hepatitis C, chronic hepatitis B, genetic haemochromatosis AND\n  * Have an annual risk of HCC of at least 3% as determined by the aMAP score OR\n  * Participants with chronic liver disease (with or without cirrhosis) who had successful treatment for HCC, have not had a recurrence and have returned to 6 monthly surveillance with USS\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* • Contraindication to MRI\n\n  * Known allergy / reaction to intravenous gadolinium contrast\n  * Prisoners\n  * Pregnancy or breast feeding\n  * Previous liver transplant\n  * Participants who are known to have indeterminate liver nodules on prior imaging requiring ongoing follow-up with MRI or CT\n  * Previous HCC treated with curative intent and still being followed up with CT or MRI with contrast for possible recurrence\n  * Estimated glomerular filtration rate of <30 ml/min/1.73m2\n  * Participant is on haemodialysis\n  * Participants who are unlikely to comply with the study procedures in the opinion of the local investigator\n  * In the view of the clinician, if the participant has a co-morbidity likely to lead to death within the following 12 months",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* • Participant is willing and able to give informed consent for participation in the study AND",
                "criterions": [
                    {
                        "exact_snippets": "Participant is willing and able to give informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Participant is willing and able to give informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Participant is willing and able to give informed consent",
                        "criterion": "informed consent",
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                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Participant is willing and able to give informed consent",
                        "criterion": "informed consent",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* All genders, aged 18 years or above AND",
                "criterions": [
                    {
                        "exact_snippets": "All genders",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "inclusion",
                            "expected_value": [
                                "male",
                                "female",
                                "other"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "aged 18 years or above",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "All genders",
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                            "requirement_type": "inclusion",
                            "expected_value": [
                                "male",
                                "female",
                                "other"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "aged 18 years or above",
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                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Eligible for HCC US surveillance in the opinion of the local investigators AND",
                "criterions": [
                    {
                        "exact_snippets": "Eligible for HCC US surveillance",
                        "criterion": "HCC US surveillance eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eligible for HCC US surveillance",
                        "criterion": "HCC US surveillance eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Child Pugh score A or B AND",
                "criterions": [
                    {
                        "exact_snippets": "Child Pugh score A or B",
                        "criterion": "Child Pugh score",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "A",
                                "B"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Child Pugh score A or B",
                        "criterion": "Child Pugh score",
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                            "requirement_type": "severity",
                            "expected_value": [
                                "A",
                                "B"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Diagnosed with liver cirrhosis due to ArLD, MASLD, chronic hepatitis C, chronic hepatitis B, genetic haemochromatosis AND",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosed with liver cirrhosis",
                        "criterion": "liver cirrhosis",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "due to ArLD",
                        "criterion": "ArLD",
                        "requirement": {
                            "requirement_type": "cause of liver cirrhosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "due to ... MASLD",
                        "criterion": "MASLD",
                        "requirement": {
                            "requirement_type": "cause of liver cirrhosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "due to ... chronic hepatitis C",
                        "criterion": "chronic hepatitis C",
                        "requirement": {
                            "requirement_type": "cause of liver cirrhosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "due to ... chronic hepatitis B",
                        "criterion": "chronic hepatitis B",
                        "requirement": {
                            "requirement_type": "cause of liver cirrhosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "due to ... genetic haemochromatosis",
                        "criterion": "genetic haemochromatosis",
                        "requirement": {
                            "requirement_type": "cause of liver cirrhosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosed with liver cirrhosis",
                        "criterion": "liver cirrhosis",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "due to ArLD",
                                "criterion": "ArLD",
                                "requirement": {
                                    "requirement_type": "cause of liver cirrhosis",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "due to ... MASLD",
                                "criterion": "MASLD",
                                "requirement": {
                                    "requirement_type": "cause of liver cirrhosis",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "due to ... chronic hepatitis C",
                                "criterion": "chronic hepatitis C",
                                "requirement": {
                                    "requirement_type": "cause of liver cirrhosis",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "due to ... chronic hepatitis B",
                                "criterion": "chronic hepatitis B",
                                "requirement": {
                                    "requirement_type": "cause of liver cirrhosis",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "due to ... genetic haemochromatosis",
                                "criterion": "genetic haemochromatosis",
                                "requirement": {
                                    "requirement_type": "cause of liver cirrhosis",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have an annual risk of HCC of at least 3% as determined by the aMAP score OR",
                "criterions": [
                    {
                        "exact_snippets": "annual risk of HCC of at least 3%",
                        "criterion": "annual risk of HCC",
                        "requirement": {
                            "requirement_type": "risk percentage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "as determined by the aMAP score",
                        "criterion": "aMAP score",
                        "requirement": {
                            "requirement_type": "determination method",
                            "expected_value": "aMAP score"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "annual risk of HCC of at least 3%",
                                "criterion": "annual risk of HCC",
                                "requirement": {
                                    "requirement_type": "risk percentage",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "%"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "as determined by the aMAP score",
                                "criterion": "aMAP score",
                                "requirement": {
                                    "requirement_type": "determination method",
                                    "expected_value": "aMAP score"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
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                        "exact_snippets": "Healthy volunteers allowed",
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                        }
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                ]
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        },
        {
            "identified_line": {
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                        "exact_snippets": "minimum age of 18 Years",
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                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "minimum age of 18 Years",
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                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
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                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* • Contraindication to MRI",
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                    {
                        "exact_snippets": "Contraindication to MRI",
                        "criterion": "MRI",
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                        "exact_snippets": "Known allergy / reaction to intravenous gadolinium contrast",
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                ]
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        },
        {
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                        "exact_snippets": "Prisoners",
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                    }
                ]
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                    }
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                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
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                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
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                        }
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                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previous liver transplant",
                "criterions": [
                    {
                        "exact_snippets": "Previous liver transplant",
                        "criterion": "liver transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "exact_snippets": "Previous liver transplant",
                    "criterion": "liver transplant",
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                        "requirement_type": "history",
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Participants who are known to have indeterminate liver nodules on prior imaging requiring ongoing follow-up with MRI or CT",
                "criterions": [
                    {
                        "exact_snippets": "Participants who are known to have indeterminate liver nodules",
                        "criterion": "indeterminate liver nodules",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "requiring ongoing follow-up with MRI or CT",
                        "criterion": "ongoing follow-up with MRI or CT",
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                            "expected_value": true
                        }
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                    {
                        "exact_snippets": "Participants who are known to have indeterminate liver nodules",
                        "criterion": "indeterminate liver nodules",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "requiring ongoing follow-up with MRI or CT",
                        "criterion": "ongoing follow-up with MRI or CT",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previous HCC treated with curative intent and still being followed up with CT or MRI with contrast for possible recurrence",
                "criterions": [
                    {
                        "exact_snippets": "Previous HCC treated with curative intent",
                        "criterion": "previous HCC treatment",
                        "requirement": {
                            "requirement_type": "treatment intent",
                            "expected_value": "curative"
                        }
                    },
                    {
                        "exact_snippets": "still being followed up with CT or MRI with contrast",
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                            "requirement_type": "imaging modality",
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                                "CT",
                                "MRI"
                            ]
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                    {
                        "exact_snippets": "still being followed up with CT or MRI with contrast",
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                        "requirement": {
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                        }
                    }
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            "logical_structure": {
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                        "and_criteria": [
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                                "exact_snippets": "Previous HCC treated with curative intent",
                                "criterion": "previous HCC treatment",
                                "requirement": {
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                                }
                            },
                            {
                                "exact_snippets": "still being followed up with CT or MRI with contrast",
                                "criterion": "follow-up imaging",
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                                        "CT",
                                        "MRI"
                                    ]
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                    {
                        "exact_snippets": "still being followed up with CT or MRI with contrast",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
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                "criterions": [
                    {
                        "exact_snippets": "Estimated glomerular filtration rate of <30 ml/min/1.73m2",
                        "criterion": "glomerular filtration rate",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "ml/min/1.73m2"
                            }
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                    }
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                        "exact_snippets": "Estimated glomerular filtration rate of <30 ml/min/1.73m2",
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                            "requirement_type": "value",
                            "expected_value": {
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                                "unit": "ml/min/1.73m2"
                            }
                        }
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participant is on haemodialysis",
                "criterions": [
                    {
                        "exact_snippets": "Participant is on haemodialysis",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
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                    "exact_snippets": "Participant is on haemodialysis",
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                    }
                }
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        },
        {
            "identified_line": {
                "line": "* Participants who are unlikely to comply with the study procedures in the opinion of the local investigator",
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                        "exact_snippets": "unlikely to comply with the study procedures",
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                            "requirement_type": "likelihood",
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                    }
                ]
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        },
        {
            "identified_line": {
                "line": "* In the view of the clinician, if the participant has a co-morbidity likely to lead to death within the following 12 months",
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                    {
                        "exact_snippets": "co-morbidity likely to lead to death within the following 12 months",
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                    "exact_snippets": "co-morbidity likely to lead to death within the following 12 months",
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                    }
                },
                "then_criteria": {
                    "exact_snippets": "In the view of the clinician",
                    "criterion": "clinician's view",
                    "requirement": {
                        "requirement_type": "opinion",
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                    }
                },
                "else_criteria": null
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Participants with chronic liver disease (with or without cirrhosis) who had successful treatment for HCC, have not had a recurrence and have returned to 6 monthly surveillance with USS",
                "criterions": [
                    {
                        "exact_snippets": "chronic liver disease (with or without cirrhosis)",
                        "criterion": "chronic liver disease",
                        "requirement": {
                            "requirement_type": "presence",
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                        }
                    },
                    {
                        "exact_snippets": "successful treatment for HCC",
                        "criterion": "successful treatment for HCC",
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                            "requirement_type": "status",
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                        }
                    },
                    {
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                        "requirement": {
                            "requirement_type": "presence",
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                        }
                    },
                    {
                        "exact_snippets": "returned to 6 monthly surveillance with USS",
                        "criterion": "surveillance with USS",
                        "requirement": {
                            "requirement_type": "frequency",
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                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "chronic liver disease (with or without cirrhosis)",
                                "criterion": "chronic liver disease",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "successful treatment for HCC",
                                "criterion": "successful treatment for HCC",
                                "requirement": {
                                    "requirement_type": "status",
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                                }
                            }
                        ]
                    },
                    {
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                            "criterion": "HCC recurrence",
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                                "requirement_type": "presence",
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                            }
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                    },
                    {
                        "exact_snippets": "returned to 6 monthly surveillance with USS",
                        "criterion": "surveillance with USS",
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                            "expected_value": "6 monthly"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}