{
    "info": {
        "nct_id": "NCT06649565",
        "official_title": "Prospective Validation and Application of an Artificial Intelligence-based Model for Evaluating the Efficacy of Breast Cancer Patients After Neoadjuvant Therapy",
        "inclusion_criteria": "* Patients who were treated in the above research centers between January 1, 2024 and October 31, 2025;\n* ≥18 years old, female, ECOG score ≤2;\n* Pathological biopsy confirmed invasive breast cancer;\n* AJCC (8th edition) stage I-III;\n* MRI imaging data before and after neoadjuvant therapy;\n* Planned mastectomy or breast-conserving surgery after neoadjuvant therapy, and postoperative pathological information obtained.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Bilateral breast cancer, multiple lesions, or occult breast cancer;\n* Poor MRI data quality;\n* Patients who had received other anti-tumor treatments before enrollment;\n* Patients with other malignant tumors",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients who were treated in the above research centers between January 1, 2024 and October 31, 2025;",
                "criterions": [
                    {
                        "exact_snippets": "treated in the above research centers",
                        "criterion": "treatment location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "above research centers"
                        }
                    },
                    {
                        "exact_snippets": "between January 1, 2024 and October 31, 2025",
                        "criterion": "treatment date",
                        "requirement": {
                            "requirement_type": "date range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2024,
                                        "unit": "year"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2025,
                                        "unit": "year"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "treated in the above research centers",
                        "criterion": "treatment location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "above research centers"
                        }
                    },
                    {
                        "exact_snippets": "between January 1, 2024 and October 31, 2025",
                        "criterion": "treatment date",
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                            "requirement_type": "date range",
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                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2024,
                                        "unit": "year"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2025,
                                        "unit": "year"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ≥18 years old, female, ECOG score ≤2;",
                "criterions": [
                    {
                        "exact_snippets": "≥18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "female",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "ECOG score ≤2",
                        "criterion": "ECOG score",
                        "requirement": {
                            "requirement_type": "maximum score",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "≥18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "female",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "ECOG score ≤2",
                        "criterion": "ECOG score",
                        "requirement": {
                            "requirement_type": "maximum score",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pathological biopsy confirmed invasive breast cancer;",
                "criterions": [
                    {
                        "exact_snippets": "Pathological biopsy confirmed invasive breast cancer",
                        "criterion": "invasive breast cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "pathological biopsy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pathological biopsy confirmed invasive breast cancer",
                        "criterion": "invasive breast cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "pathological biopsy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AJCC (8th edition) stage I-III;",
                "criterions": [
                    {
                        "exact_snippets": "AJCC (8th edition) stage I-III",
                        "criterion": "AJCC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "AJCC (8th edition) stage I-III",
                        "criterion": "AJCC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* MRI imaging data before and after neoadjuvant therapy;",
                "criterions": [
                    {
                        "exact_snippets": "MRI imaging data before and after neoadjuvant therapy",
                        "criterion": "MRI imaging data",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": [
                                "before neoadjuvant therapy",
                                "after neoadjuvant therapy"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "MRI imaging data before and after neoadjuvant therapy",
                        "criterion": "MRI imaging data",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": [
                                "before neoadjuvant therapy",
                                "after neoadjuvant therapy"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Planned mastectomy or breast-conserving surgery after neoadjuvant therapy, and postoperative pathological information obtained.",
                "criterions": [
                    {
                        "exact_snippets": "Planned mastectomy or breast-conserving surgery",
                        "criterion": "surgery type",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": [
                                "mastectomy",
                                "breast-conserving surgery"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "after neoadjuvant therapy",
                        "criterion": "neoadjuvant therapy",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "before surgery"
                        }
                    },
                    {
                        "exact_snippets": "postoperative pathological information obtained",
                        "criterion": "postoperative pathological information",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Planned mastectomy or breast-conserving surgery",
                                        "criterion": "surgery type",
                                        "requirement": {
                                            "requirement_type": "planned",
                                            "expected_value": [
                                                "mastectomy",
                                                "breast-conserving surgery"
                                            ]
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "after neoadjuvant therapy",
                                "criterion": "neoadjuvant therapy",
                                "requirement": {
                                    "requirement_type": "timing",
                                    "expected_value": "before surgery"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "postoperative pathological information obtained",
                        "criterion": "postoperative pathological information",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Bilateral breast cancer, multiple lesions, or occult breast cancer;",
                "criterions": [
                    {
                        "exact_snippets": "Bilateral breast cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "laterality",
                            "expected_value": "bilateral"
                        }
                    },
                    {
                        "exact_snippets": "multiple lesions",
                        "criterion": "lesions",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": "multiple"
                        }
                    },
                    {
                        "exact_snippets": "occult breast cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "visibility",
                            "expected_value": "occult"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Bilateral breast cancer",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "laterality",
                                    "expected_value": "bilateral"
                                }
                            }
                        ]
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                    {
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                            {
                                "exact_snippets": "multiple lesions",
                                "criterion": "lesions",
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                                    "requirement_type": "quantity",
                                    "expected_value": "multiple"
                                }
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                        "and_criteria": [
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                                "exact_snippets": "occult breast cancer",
                                "criterion": "breast cancer",
                                "requirement": {
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                                    "expected_value": "occult"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Poor MRI data quality;",
                "criterions": [
                    {
                        "exact_snippets": "Poor MRI data quality",
                        "criterion": "MRI data quality",
                        "requirement": {
                            "requirement_type": "quality",
                            "expected_value": "poor"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Poor MRI data quality",
                    "criterion": "MRI data quality",
                    "requirement": {
                        "requirement_type": "quality",
                        "expected_value": "poor"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients who had received other anti-tumor treatments before enrollment;",
                "criterions": [
                    {
                        "exact_snippets": "Patients who had received other anti-tumor treatments before enrollment",
                        "criterion": "prior anti-tumor treatments",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "exact_snippets": "Patients who had received other anti-tumor treatments before enrollment",
                    "criterion": "prior anti-tumor treatments",
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                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients with other malignant tumors",
                "criterions": [
                    {
                        "exact_snippets": "Patients with other malignant tumors",
                        "criterion": "malignant tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "criterion": "malignant tumors",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}