{
    "info": {
        "nct_id": "NCT06345001",
        "official_title": "An Open-label Phase 1 Imaging Study to Evaluate the Biodistribution, Dosimetry, Safety and Pharmacokinetics of BAY 3630942, a 89Zr-labeled Monoclonal Antibody, With a Pre-infusion of BAY 3547922, a Monoclonal Antibody-chelator Conjugate, in Patients With Hepatocellular Carcinoma or Other Select Solid Tumors.",
        "inclusion_criteria": "* Participant (male or female) must be 18 years of age inclusive, at the time of signing the informed consent.\n* Histologically confirmed HCC or non-invasive diagnosis of HCC according to American Association for the Study of Liver Diseases (AASLD) criteria\n* Histologically or cytologically confirmed solid tumors\n* Child-Pugh class A and B7\n* Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1\n* Able to tolerate the study procedures, including 3 PET/CT scans\n* Adequate bone marrow, hepatic, and renal function\n* Agreed to take proper contraception measures\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Impaired cardiac function or clinically significant cardiac disease (i.e., congestive heart failure New York Heart Association [NYHA] Class II, III or IV).\n* Patients with arterial thrombotic or embolic events or venous pulmonary embolism within 3 months before the start of study intervention.\n* On-going systemic anticancer therapy except continued luteinizing hormone-releasing hormone (LHRH) agonist or antagonists in participants with prostate adenocarcinoma\n* Administered a radioisotope within 9 physical half-lives of that radioisotope (24 days for yttrium-90 or 90Y) before administration of the study interventions\n* Any local or locoregional therapy of intrahepatic tumor lesions, open biopsy or significant traumatic injury < 4 weeks before administration of the study interventions.\n* Known hypersensitivity to human monoclonal antibodies.\n* Any condition which, in the opinion of the Investigator, would preclude participation in this study.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Participant (male or female) must be 18 years of age inclusive, at the time of signing the informed consent.",
                "criterions": [
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                        "exact_snippets": "Participant (male or female) must be 18 years of age inclusive",
                        "criterion": "age",
                        "requirement": {
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                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
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                        "exact_snippets": "Participant (male or female) must be 18 years of age inclusive",
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                            "expected_value": {
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                                "unit": "years"
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        },
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                        "criterion": "HCC diagnosis",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "histologically confirmed"
                        }
                    },
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                        }
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                        }
                    },
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        },
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                            "requirement_type": "confirmation method",
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                                "histologically",
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                ]
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                        "exact_snippets": "Histologically or cytologically confirmed solid tumors",
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                            "requirement_type": "confirmation method",
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                                "histologically",
                                "cytologically"
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                    }
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        },
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                        "exact_snippets": "Child-Pugh class ... B7",
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                        "exact_snippets": "Child-Pugh class ... B7",
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        },
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                        "exact_snippets": "Able to tolerate the study procedures, including 3 PET/CT scans",
                        "criterion": "tolerance to study procedures",
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                            "requirement_type": "tolerance",
                            "expected_value": true
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                    }
                ]
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            }
        },
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                "line": "* Adequate bone marrow, hepatic, and renal function",
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                    {
                        "exact_snippets": "Adequate bone marrow",
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                            "requirement_type": "adequacy",
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                    },
                    {
                        "exact_snippets": "Adequate ... hepatic",
                        "criterion": "hepatic function",
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                            "requirement_type": "adequacy",
                            "expected_value": true
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                    {
                        "exact_snippets": "Adequate ... renal function",
                        "criterion": "renal function",
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                            "expected_value": true
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                    {
                        "exact_snippets": "Adequate ... hepatic",
                        "criterion": "hepatic function",
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                            "expected_value": true
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                    },
                    {
                        "exact_snippets": "Adequate ... renal function",
                        "criterion": "renal function",
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                            "expected_value": true
                        }
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                ]
            }
        },
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                "criterions": [
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                        "exact_snippets": "Agreed to take proper contraception measures",
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                        "requirement": {
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                            "expected_value": true
                        }
                    }
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                        "exact_snippets": "Agreed to take proper contraception measures",
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                        }
                    }
                ]
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        },
        {
            "identified_line": {
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                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "requirement_type": "status",
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                        }
                    }
                ]
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                        "exact_snippets": "Healthy volunteers allowed",
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                        }
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                ]
            }
        },
        {
            "identified_line": {
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                        "exact_snippets": "minimum age of 18 Years",
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                                "value": 18,
                                "unit": "Years"
                            }
                        }
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                        "exact_snippets": "minimum age of 18 Years",
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                    }
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        },
        {
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                        }
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                ]
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                        },
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                        }
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            }
        },
        {
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            "identified_line": {
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        {
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                "line": "* Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1",
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    "failed_miscellaneous": []
}