{
    "info": {
        "nct_id": "NCT06325891",
        "official_title": "Microbiota Diversity and Composition in Gastric Cancer by Gastric Mucosal Brushing: a Cross-sectional Case-control Study",
        "inclusion_criteria": "* Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy (EGD)\n* Gastric cancer group: patients with pathological diagnosis of high-grade dysplasia or gastric cancer\n* Control group: patients with no or minimal upper GI symptoms and current EGD appear normal or minimal gastritis\n* Informed consent obtained\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Had a history of GI or hepatobiliary surgery\n* Had a history of recent (within 4 weeks) antibiotic or probiotic use\n* Had a history of PPI use within 2 weeks",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy (EGD)",
                "criterions": [
                    {
                        "exact_snippets": "Adult patients (≥18 years of age)",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "undergoing esophagogastroduodenoscopy (EGD)",
                        "criterion": "procedure",
                        "requirement": {
                            "requirement_type": "undergoing",
                            "expected_value": "esophagogastroduodenoscopy (EGD)"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adult patients (≥18 years of age)",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "undergoing esophagogastroduodenoscopy (EGD)",
                        "criterion": "procedure",
                        "requirement": {
                            "requirement_type": "undergoing",
                            "expected_value": "esophagogastroduodenoscopy (EGD)"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Gastric cancer group: patients with pathological diagnosis of high-grade dysplasia or gastric cancer",
                "criterions": [
                    {
                        "exact_snippets": "pathological diagnosis of high-grade dysplasia",
                        "criterion": "high-grade dysplasia",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pathological diagnosis of ... gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "pathological diagnosis of high-grade dysplasia",
                        "criterion": "high-grade dysplasia",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pathological diagnosis of ... gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Informed consent obtained",
                "criterions": [
                    {
                        "exact_snippets": "Informed consent obtained",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "obtained",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Informed consent obtained",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "obtained",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Had a history of GI or hepatobiliary surgery",
                "criterions": [
                    {
                        "exact_snippets": "history of GI or hepatobiliary surgery",
                        "criterion": "GI or hepatobiliary surgery",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "history of GI or hepatobiliary surgery",
                    "criterion": "GI or hepatobiliary surgery",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Had a history of recent (within 4 weeks) antibiotic or probiotic use",
                "criterions": [
                    {
                        "exact_snippets": "Had a history of recent (within 4 weeks) antibiotic ... use",
                        "criterion": "antibiotic use",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Had a history of recent (within 4 weeks) ... probiotic use",
                        "criterion": "probiotic use",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Had a history of recent (within 4 weeks) antibiotic ... use",
                                "criterion": "antibiotic use",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Had a history of recent (within 4 weeks) ... probiotic use",
                                "criterion": "probiotic use",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Had a history of PPI use within 2 weeks",
                "criterions": [
                    {
                        "exact_snippets": "Had a history of PPI use within 2 weeks",
                        "criterion": "PPI use",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Had a history of PPI use within 2 weeks",
                    "criterion": "PPI use",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2,
                            "unit": "weeks"
                        }
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Control group: patients with no or minimal upper GI symptoms and current EGD appear normal or minimal gastritis",
                "criterions": [
                    {
                        "exact_snippets": "no or minimal upper GI symptoms",
                        "criterion": "upper GI symptoms",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "no or minimal"
                        }
                    },
                    {
                        "exact_snippets": "current EGD appear normal or minimal gastritis",
                        "criterion": "EGD results",
                        "requirement": {
                            "requirement_type": "appearance",
                            "expected_value": "normal or minimal gastritis"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "no or minimal upper GI symptoms",
                                "criterion": "upper GI symptoms",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "no or minimal"
                                }
                            },
                            {
                                "exact_snippets": "current EGD appear normal or minimal gastritis",
                                "criterion": "EGD results",
                                "requirement": {
                                    "requirement_type": "appearance",
                                    "expected_value": "normal"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "current EGD appear normal or minimal gastritis",
                        "criterion": "EGD results",
                        "requirement": {
                            "requirement_type": "appearance",
                            "expected_value": "minimal gastritis"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}