{
    "info": {
        "nct_id": "NCT06252662",
        "official_title": "Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in an Erector Spinae Plane Block for Mastectomies in Cancer Patients: a Randomized Control Trial",
        "inclusion_criteria": "* Patients requiring any variation of mastectomy with or without axillary lymph node dissection.\n* Patient agrees to a peripheral nerve block.\n* Patient agrees to be a study participant.\n* APS team believes a peripheral nerve block would be appropriate for the patient after reviewing medical/surgical history.\n* Surgeon agrees with the block plan by APS.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patient declines a peripheral nerve block.\n* Patient declines to be a study participant.\n* APS team believes a peripheral nerve block is not clinically indicated.\n* Surgeon does not want a peripheral nerve block.\n* Patient has allergy to local anesthestic.\n* Patient has an active infection at the site of the peripheral nerve block.\n* Patient with pre-existing neural deficits along the distribution of the block.\n* Patient with coagulopathy.\n* Patient taking antithrombotic drugs outside the ASRA guidelines.\n* Patients weight is less that 50 kg due to concerns for local anesthetic toxicity syndrome.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patient agrees to a peripheral nerve block.",
                "criterions": [
                    {
                        "exact_snippets": "Patient agrees to a peripheral nerve block.",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient agrees to a peripheral nerve block.",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient agrees to be a study participant.",
                "criterions": [
                    {
                        "exact_snippets": "Patient agrees to be a study participant.",
                        "criterion": "study participation agreement",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient agrees to be a study participant.",
                        "criterion": "study participation agreement",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* APS team believes a peripheral nerve block would be appropriate for the patient after reviewing medical/surgical history.",
                "criterions": [
                    {
                        "exact_snippets": "peripheral nerve block would be appropriate for the patient",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "appropriateness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "reviewing medical/surgical history",
                        "criterion": "medical/surgical history",
                        "requirement": {
                            "requirement_type": "review",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "peripheral nerve block would be appropriate for the patient",
                                "criterion": "peripheral nerve block",
                                "requirement": {
                                    "requirement_type": "appropriateness",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "reviewing medical/surgical history",
                                "criterion": "medical/surgical history",
                                "requirement": {
                                    "requirement_type": "review",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Surgeon agrees with the block plan by APS.",
                "criterions": [
                    {
                        "exact_snippets": "Surgeon agrees with the block plan by APS.",
                        "criterion": "surgeon agreement",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgeon agrees with the block plan by APS.",
                        "criterion": "surgeon agreement",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patient declines a peripheral nerve block.",
                "criterions": [
                    {
                        "exact_snippets": "Patient declines a peripheral nerve block.",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient declines a peripheral nerve block.",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient declines to be a study participant.",
                "criterions": [
                    {
                        "exact_snippets": "Patient declines to be a study participant.",
                        "criterion": "study participation consent",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient declines to be a study participant.",
                        "criterion": "study participation consent",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* APS team believes a peripheral nerve block is not clinically indicated.",
                "criterions": [
                    {
                        "exact_snippets": "peripheral nerve block is not clinically indicated",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "clinical indication",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "peripheral nerve block is not clinically indicated",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "clinical indication",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "APS team believes",
                        "criterion": "APS team belief",
                        "requirement": {
                            "requirement_type": "belief",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Surgeon does not want a peripheral nerve block.",
                "criterions": [
                    {
                        "exact_snippets": "Surgeon does not want a peripheral nerve block.",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "preference",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgeon does not want a peripheral nerve block.",
                        "criterion": "peripheral nerve block",
                        "requirement": {
                            "requirement_type": "preference",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient has allergy to local anesthestic.",
                "criterions": [
                    {
                        "exact_snippets": "allergy to local anesthestic",
                        "criterion": "allergy to local anesthestic",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "allergy to local anesthestic",
                    "criterion": "allergy to local anesthestic",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient has an active infection at the site of the peripheral nerve block.",
                "criterions": [
                    {
                        "exact_snippets": "active infection at the site of the peripheral nerve block",
                        "criterion": "infection at the site of the peripheral nerve block",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "active infection at the site of the peripheral nerve block",
                    "criterion": "infection at the site of the peripheral nerve block",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient with pre-existing neural deficits along the distribution of the block.",
                "criterions": [
                    {
                        "exact_snippets": "pre-existing neural deficits",
                        "criterion": "neural deficits",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "along the distribution of the block",
                        "criterion": "distribution of the block",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "along the distribution of the block"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "pre-existing neural deficits",
                        "criterion": "neural deficits",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "along the distribution of the block",
                        "criterion": "distribution of the block",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "along the distribution of the block"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient with coagulopathy.",
                "criterions": [
                    {
                        "exact_snippets": "Patient with coagulopathy",
                        "criterion": "coagulopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patient with coagulopathy",
                    "criterion": "coagulopathy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient taking antithrombotic drugs outside the ASRA guidelines.",
                "criterions": [
                    {
                        "exact_snippets": "Patient taking antithrombotic drugs outside the ASRA guidelines.",
                        "criterion": "antithrombotic drug use",
                        "requirement": {
                            "requirement_type": "compliance",
                            "expected_value": "outside ASRA guidelines"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patient taking antithrombotic drugs outside the ASRA guidelines.",
                    "criterion": "antithrombotic drug use",
                    "requirement": {
                        "requirement_type": "compliance",
                        "expected_value": "outside ASRA guidelines"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients weight is less that 50 kg due to concerns for local anesthetic toxicity syndrome.",
                "criterions": [
                    {
                        "exact_snippets": "Patients weight is less that 50 kg",
                        "criterion": "weight",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "kg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients weight is less that 50 kg",
                        "criterion": "weight",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "kg"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Patients requiring any variation of mastectomy with or without axillary lymph node dissection.",
                "criterions": [
                    {
                        "exact_snippets": "Patients requiring any variation of mastectomy",
                        "criterion": "mastectomy",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "with or without axillary lymph node dissection",
                        "criterion": "axillary lymph node dissection",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients requiring any variation of mastectomy",
                                "criterion": "mastectomy",
                                "requirement": {
                                    "requirement_type": "necessity",
                                    "expected_value": true
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "with or without axillary lymph node dissection",
                                        "criterion": "axillary lymph node dissection",
                                        "requirement": {
                                            "requirement_type": "necessity",
                                            "expected_value": "with"
                                        }
                                    },
                                    {
                                        "exact_snippets": "with or without axillary lymph node dissection",
                                        "criterion": "axillary lymph node dissection",
                                        "requirement": {
                                            "requirement_type": "necessity",
                                            "expected_value": "without"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}