{
    "info": {
        "nct_id": "NCT06152731",
        "official_title": "HRD Tests for Ovarian cancER",
        "inclusion_criteria": "* Patient aged 18-year or more\n* Histologically documented high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer\n* Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma, candidate to a first line platinum-based chemotherapy\n* Tumor tissue must be available for HRD analyses (FFPE tissue block) and\n\n  * Collected if possible during the initial surgery or the initial biopsy (before chemotherapy)\n  * With sufficient tumour surface area (> 25 mm²), with a final cellularity of at least 20%\n* Patient affiliated to an appropriate social security system\n* Patient signed consent form before any trial related activities\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Recurrent high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer\n* Non epithelial or borderline ovarian cancer\n* Other tumor, for which the treatment may interfere with the ovarian cancer treatment and/or that may have a major impact on prognosis\n* Exclusive palliative setting\n* Patient deprived of liberty or placed under the authority of a tutor",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patient aged 18-year or more",
                "criterions": [
                    {
                        "exact_snippets": "Patient aged 18-year or more",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "year"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient aged 18-year or more",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "year"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically documented high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer",
                "criterions": [
                    {
                        "exact_snippets": "Histologically documented high grade serous epithelial ovarian cancer",
                        "criterion": "high grade serous epithelial ovarian cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Histologically documented ... fallopian tube ... cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Histologically documented ... peritoneum cancer",
                        "criterion": "peritoneum cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Histologically documented high grade serous epithelial ovarian cancer",
                        "criterion": "high grade serous epithelial ovarian cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Histologically documented ... fallopian tube ... cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Histologically documented ... peritoneum cancer",
                        "criterion": "peritoneum cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma, candidate to a first line platinum-based chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma",
                        "criterion": "ovarian carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "newly diagnosed"
                        }
                    },
                    {
                        "exact_snippets": "Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma",
                        "criterion": "ovarian carcinoma",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "FIGO stage III",
                                "FIGO stage IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "candidate to a first line platinum-based chemotherapy",
                        "criterion": "platinum-based chemotherapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": "candidate to a first line"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma",
                                "criterion": "ovarian carcinoma",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": "newly diagnosed"
                                }
                            },
                            {
                                "exact_snippets": "Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma",
                                "criterion": "ovarian carcinoma",
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                                    "requirement_type": "stage",
                                    "expected_value": [
                                        "FIGO stage III",
                                        "FIGO stage IV"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "candidate to a first line platinum-based chemotherapy",
                        "criterion": "platinum-based chemotherapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": "candidate to a first line"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumor tissue must be available for HRD analyses (FFPE tissue block) and",
                "criterions": [
                    {
                        "exact_snippets": "Tumor tissue must be available",
                        "criterion": "tumor tissue",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "HRD analyses (FFPE tissue block)",
                        "criterion": "HRD analyses",
                        "requirement": {
                            "requirement_type": "sample type",
                            "expected_value": "FFPE tissue block"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Tumor tissue must be available",
                        "criterion": "tumor tissue",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "HRD analyses (FFPE tissue block)",
                        "criterion": "HRD analyses",
                        "requirement": {
                            "requirement_type": "sample type",
                            "expected_value": "FFPE tissue block"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* With sufficient tumour surface area (> 25 mm²), with a final cellularity of at least 20%",
                "criterions": [
                    {
                        "exact_snippets": "sufficient tumour surface area (> 25 mm²)",
                        "criterion": "tumour surface area",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "mm²"
                            }
                        }
                    },
                    {
                        "exact_snippets": "final cellularity of at least 20%",
                        "criterion": "cellularity",
                        "requirement": {
                            "requirement_type": "percentage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "sufficient tumour surface area (> 25 mm²)",
                        "criterion": "tumour surface area",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "mm²"
                            }
                        }
                    },
                    {
                        "exact_snippets": "final cellularity of at least 20%",
                        "criterion": "cellularity",
                        "requirement": {
                            "requirement_type": "percentage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient affiliated to an appropriate social security system",
                "criterions": [
                    {
                        "exact_snippets": "affiliated to an appropriate social security system",
                        "criterion": "social security system affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "affiliated to an appropriate social security system",
                        "criterion": "social security system affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient signed consent form before any trial related activities",
                "criterions": [
                    {
                        "exact_snippets": "Patient signed consent form",
                        "criterion": "consent form",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient signed consent form",
                        "criterion": "consent form",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "minimum age of 18 Years",
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                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Recurrent high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer",
                "criterions": [
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "recurrent"
                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "grade",
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                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "subtype",
                            "expected_value": "serous epithelial"
                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "recurrent"
                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
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                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
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                        "requirement": {
                            "requirement_type": "subtype",
                            "expected_value": "serous epithelial"
                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
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                        "requirement": {
                            "requirement_type": "type",
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                        }
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                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
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                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "high"
                        }
                    },
                    {
                        "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                        "criterion": "peritoneum cancer",
                        "requirement": {
                            "requirement_type": "subtype",
                            "expected_value": "serous epithelial"
                        }
                    }
                ]
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            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ovarian cancer",
                                        "criterion": "ovarian cancer",
                                        "requirement": {
                                            "requirement_type": "type",
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                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ovarian cancer",
                                        "criterion": "ovarian cancer",
                                        "requirement": {
                                            "requirement_type": "grade",
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                                        }
                                    },
                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ovarian cancer",
                                        "criterion": "ovarian cancer",
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                                            "expected_value": "serous epithelial"
                                        }
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                                        "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
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                                        "requirement": {
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                                        }
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                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                                        "criterion": "fallopian tube cancer",
                                        "requirement": {
                                            "requirement_type": "grade",
                                            "expected_value": "high"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                                        "criterion": "fallopian tube cancer",
                                        "requirement": {
                                            "requirement_type": "subtype",
                                            "expected_value": "serous epithelial"
                                        }
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                                        "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                                        "criterion": "peritoneum cancer",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "recurrent"
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                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                                        "criterion": "peritoneum cancer",
                                        "requirement": {
                                            "requirement_type": "grade",
                                            "expected_value": "high"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                                        "criterion": "peritoneum cancer",
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                                            "requirement_type": "subtype",
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                    {
                        "and_criteria": [
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                                "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                                "criterion": "fallopian tube cancer",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "recurrent"
                                }
                            },
                            {
                                "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                                "criterion": "fallopian tube cancer",
                                "requirement": {
                                    "requirement_type": "grade",
                                    "expected_value": "high"
                                }
                            },
                            {
                                "exact_snippets": "Recurrent high grade serous epithelial ... fallopian tube ... cancer",
                                "criterion": "fallopian tube cancer",
                                "requirement": {
                                    "requirement_type": "subtype",
                                    "expected_value": "serous epithelial"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                                "criterion": "peritoneum cancer",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "recurrent"
                                }
                            },
                            {
                                "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                                "criterion": "peritoneum cancer",
                                "requirement": {
                                    "requirement_type": "grade",
                                    "expected_value": "high"
                                }
                            },
                            {
                                "exact_snippets": "Recurrent high grade serous epithelial ... peritoneum cancer",
                                "criterion": "peritoneum cancer",
                                "requirement": {
                                    "requirement_type": "subtype",
                                    "expected_value": "serous epithelial"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Non epithelial or borderline ovarian cancer",
                "criterions": [
                    {
                        "exact_snippets": "Non epithelial or borderline ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "non epithelial",
                                "borderline"
                            ]
                        }
                    }
                ]
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            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Non epithelial or borderline ovarian cancer",
                    "criterion": "ovarian cancer",
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                        "requirement_type": "type",
                        "expected_value": [
                            "non epithelial",
                            "borderline"
                        ]
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Other tumor, for which the treatment may interfere with the ovarian cancer treatment and/or that may have a major impact on prognosis",
                "criterions": [
                    {
                        "exact_snippets": "Other tumor, for which the treatment may interfere with the ovarian cancer treatment",
                        "criterion": "other tumor",
                        "requirement": {
                            "requirement_type": "treatment interference",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Other tumor, ... that may have a major impact on prognosis",
                        "criterion": "other tumor",
                        "requirement": {
                            "requirement_type": "impact on prognosis",
                            "expected_value": "major"
                        }
                    }
                ]
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                            {
                                "exact_snippets": "Other tumor, for which the treatment may interfere with the ovarian cancer treatment",
                                "criterion": "other tumor",
                                "requirement": {
                                    "requirement_type": "treatment interference",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Other tumor, ... that may have a major impact on prognosis",
                                "criterion": "other tumor",
                                "requirement": {
                                    "requirement_type": "impact on prognosis",
                                    "expected_value": "major"
                                }
                            }
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                    {
                        "exact_snippets": "Other tumor, for which the treatment may interfere with the ovarian cancer treatment",
                        "criterion": "other tumor",
                        "requirement": {
                            "requirement_type": "treatment interference",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Other tumor, ... that may have a major impact on prognosis",
                        "criterion": "other tumor",
                        "requirement": {
                            "requirement_type": "impact on prognosis",
                            "expected_value": "major"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Exclusive palliative setting",
                "criterions": [
                    {
                        "exact_snippets": "Exclusive palliative setting",
                        "criterion": "palliative setting",
                        "requirement": {
                            "requirement_type": "exclusivity",
                            "expected_value": true
                        }
                    }
                ]
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                    "exact_snippets": "Exclusive palliative setting",
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                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient deprived of liberty or placed under the authority of a tutor",
                "criterions": [
                    {
                        "exact_snippets": "Patient deprived of liberty",
                        "criterion": "deprivation of liberty",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "placed under the authority of a tutor",
                        "criterion": "authority of a tutor",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
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                    {
                        "exact_snippets": "Patient deprived of liberty",
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                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "placed under the authority of a tutor",
                        "criterion": "authority of a tutor",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Collected if possible during the initial surgery or the initial biopsy (before chemotherapy)",
                "criterions": [
                    {
                        "exact_snippets": "Collected if possible during the initial surgery or the initial biopsy",
                        "criterion": "sample collection",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "during initial surgery or initial biopsy"
                        }
                    },
                    {
                        "exact_snippets": "(before chemotherapy)",
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                                        "exact_snippets": "Collected if possible during the initial surgery or the initial biopsy",
                                        "criterion": "sample collection",
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                                    },
                                    {
                                        "exact_snippets": "(before chemotherapy)",
                                        "criterion": "chemotherapy status",
                                        "requirement": {
                                            "requirement_type": "timing",
                                            "expected_value": "before chemotherapy"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Collected if possible during the initial surgery or the initial biopsy",
                                        "criterion": "sample collection",
                                        "requirement": {
                                            "requirement_type": "timing",
                                            "expected_value": "during initial biopsy"
                                        }
                                    },
                                    {
                                        "exact_snippets": "(before chemotherapy)",
                                        "criterion": "chemotherapy status",
                                        "requirement": {
                                            "requirement_type": "timing",
                                            "expected_value": "before chemotherapy"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}