{
    "info": {
        "nct_id": "NCT06128460",
        "official_title": "Adjuvant Chemoradiotherapy Followed by Zimberelimab for Locally Advanced Cervical Cancer (IB3, IIA2) Patients",
        "inclusion_criteria": "* Histologically confirmed cervical squamous cell carcinoma, cervical adenocarcinoma, or cervical adenosquamous carcinoma;\n* According to FIGO2018 staging, patients with locally advanced cervical cancer (IB3, IIA2) who require concurrent radiotherapy and chemotherapy;\n* Patients with radical surgery for cervical cancer;\n* Female patients: 18-70 years old;\n* ECOG physical condition score: 0~1 point;\n* Subjects have not received previous immunotherapy;\n* Expected survival ≥6 months;\n* Women of reproductive age should agree to use contraceptives (such as Iuds, contraceptives, or condoms) during the study period and for 6 months after the study ends; Have a negative serum or urine pregnancy test within 7 days prior to study enrollment and must be a non-lactating patient;\n* For adequate organ function as defined in the protocol, test samples must be collected within 7 days prior to initiation of the study therapy\n* Subjects voluntarily joined the study, signed informed consent, had good compliance, and cooperated with follow-up.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "* Subjects have histological subtypes other than those permitted by inclusion criteria;\n* Severe hypersensitivity to cepalizumab and/or any of its excipients (≥ grade 3);\n* Participate in or have participated in other clinical trials within 4 weeks before enrollment;\n* Have received or will receive inactivated vaccine within 30 days prior to the first study treatment;\n* Received a combination of systemic immune stimulants, colony-stimulating factors, interferon, interleukin, and vaccine within 6 weeks or 5 half-lives (if shorter) prior to initial administration;\n* Have been diagnosed with an immune deficiency or are receiving chronic systemic steroid therapy (doses greater than 10mg daily equivalent of prednisone) or any other form of immunosuppressive therapy within 7 days prior to the first dose;\n* Have an active autoimmune disease in the past 2 years that requires systemic treatment (such as the use of disease-modulating drugs, corticosteroids, or immunosuppressive drugs);\n* Have a history of (non-infectious) pneumonia requiring steroid treatment or have a current (non-infectious) pneumonia;\n* An active infection requiring systematic treatment;\n* Known history of HIV infection;\n* A known history of hepatitis B (defined as HBsAg reactive) or known active hepatitis C virus (defined as detection of HCV RNA[qualitative]) infection;\n* Known active tuberculosis (TB; Tuberculosis) medical history;\n* Has received allogeneic tissue/solid organ transplantation;\n* Suffering from central nervous system metastases such as brain metastases;\n* Patients with uncontrolled chest and abdominal fluid;\n* Patients with mobility disorders such as pathological fractures caused by tumor bone metastasis;\n* Insufficient hematopoietic function of bone marrow;\n* Abnormal liver;\n* Abnormal kidney;\n* Bleeding risk;\n* Cardiovascular and cerebrovascular abnormalities.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Histologically confirmed cervical squamous cell carcinoma, cervical adenocarcinoma, or cervical adenosquamous carcinoma;",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed cervical squamous cell carcinoma",
                        "criterion": "cervical squamous cell carcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed ... cervical adenocarcinoma",
                        "criterion": "cervical adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed ... cervical adenosquamous carcinoma",
                        "criterion": "cervical adenosquamous carcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Histologically confirmed cervical squamous cell carcinoma",
                        "criterion": "cervical squamous cell carcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed ... cervical adenocarcinoma",
                        "criterion": "cervical adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Histologically confirmed ... cervical adenosquamous carcinoma",
                        "criterion": "cervical adenosquamous carcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* According to FIGO2018 staging, patients with locally advanced cervical cancer (IB3, IIA2) who require concurrent radiotherapy and chemotherapy;",
                "criterions": [
                    {
                        "exact_snippets": "FIGO2018 staging, patients with locally advanced cervical cancer (IB3, IIA2)",
                        "criterion": "cervical cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IB3",
                                "IIA2"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "require concurrent radiotherapy and chemotherapy",
                        "criterion": "treatment requirement",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "concurrent radiotherapy",
                                "chemotherapy"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "FIGO2018 staging, patients with locally advanced cervical cancer (IB3, IIA2)",
                        "criterion": "cervical cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IB3",
                                "IIA2"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "require concurrent radiotherapy and chemotherapy",
                        "criterion": "treatment requirement",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "concurrent radiotherapy",
                                "chemotherapy"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with radical surgery for cervical cancer;",
                "criterions": [
                    {
                        "exact_snippets": "radical surgery for cervical cancer",
                        "criterion": "radical surgery",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "cervical cancer"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "radical surgery for cervical cancer",
                        "criterion": "radical surgery",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "cervical cancer"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Female patients: 18-70 years old;",
                "criterions": [
                    {
                        "exact_snippets": "Female patients",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "18-70 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Female patients",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "18-70 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG physical condition score: 0~1 point;",
                "criterions": [
                    {
                        "exact_snippets": "ECOG physical condition score: 0~1 point;",
                        "criterion": "ECOG physical condition score",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "point"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "point"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG physical condition score: 0~1 point;",
                        "criterion": "ECOG physical condition score",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "point"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "point"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 70 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 70 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 70 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Subjects have histological subtypes other than those permitted by inclusion criteria;",
                "criterions": [
                    {
                        "exact_snippets": "Subjects have histological subtypes other than those permitted by inclusion criteria",
                        "criterion": "histological subtypes",
                        "requirement": {
                            "requirement_type": "permitted",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Subjects have histological subtypes other than those permitted by inclusion criteria",
                        "criterion": "histological subtypes",
                        "requirement": {
                            "requirement_type": "permitted",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Severe hypersensitivity to cepalizumab and/or any of its excipients (≥ grade 3);",
                "criterions": [
                    {
                        "exact_snippets": "Severe hypersensitivity to cepalizumab and/or any of its excipients (≥ grade 3)",
                        "criterion": "hypersensitivity to cepalizumab",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "grade"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Severe hypersensitivity to cepalizumab and/or any of its excipients (≥ grade 3)",
                        "criterion": "hypersensitivity to any excipients of cepalizumab",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Severe hypersensitivity to cepalizumab and/or any of its excipients (≥ grade 3)",
                                "criterion": "hypersensitivity to cepalizumab",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "grade"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Severe hypersensitivity to cepalizumab and/or any of its excipients (≥ grade 3)",
                                "criterion": "hypersensitivity to any excipients of cepalizumab",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "grade"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participate in or have participated in other clinical trials within 4 weeks before enrollment;",
                "criterions": [
                    {
                        "exact_snippets": "Participate in or have participated in other clinical trials within 4 weeks before enrollment",
                        "criterion": "participation in other clinical trials",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Participate in or have participated in other clinical trials within 4 weeks before enrollment",
                    "criterion": "participation in other clinical trials",
                    "requirement": {
                        "requirement_type": "time frame",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 4,
                                    "unit": "weeks"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Have received or will receive inactivated vaccine within 30 days prior to the first study treatment;",
                "criterions": [
                    {
                        "exact_snippets": "Have received or will receive inactivated vaccine within 30 days prior to the first study treatment",
                        "criterion": "inactivated vaccine",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "within 30 days prior to the first study treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Have received or will receive inactivated vaccine within 30 days prior to the first study treatment",
                    "criterion": "inactivated vaccine",
                    "requirement": {
                        "requirement_type": "timing",
                        "expected_value": "within 30 days prior to the first study treatment"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Received a combination of systemic immune stimulants, colony-stimulating factors, interferon, interleukin, and vaccine within 6 weeks or 5 half-lives (if shorter) prior to initial administration;",
                "criterions": [
                    {
                        "exact_snippets": "Received a combination of systemic immune stimulants",
                        "criterion": "systemic immune stimulants",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received a combination of ... colony-stimulating factors",
                        "criterion": "colony-stimulating factors",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received a combination of ... interferon",
                        "criterion": "interferon",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received a combination of ... interleukin",
                        "criterion": "interleukin",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received a combination of ... vaccine",
                        "criterion": "vaccine",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Received a combination of systemic immune stimulants",
                                "criterion": "systemic immune stimulants",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... colony-stimulating factors",
                                "criterion": "colony-stimulating factors",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... interferon",
                                "criterion": "interferon",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... interleukin",
                                "criterion": "interleukin",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... vaccine",
                                "criterion": "vaccine",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Received a combination of systemic immune stimulants",
                                "criterion": "systemic immune stimulants",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": "5 half-lives"
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... colony-stimulating factors",
                                "criterion": "colony-stimulating factors",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": "5 half-lives"
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... interferon",
                                "criterion": "interferon",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": "5 half-lives"
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... interleukin",
                                "criterion": "interleukin",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": "5 half-lives"
                                }
                            },
                            {
                                "exact_snippets": "Received a combination of ... vaccine",
                                "criterion": "vaccine",
                                "requirement": {
                                    "requirement_type": "time since last administration",
                                    "expected_value": "5 half-lives"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have been diagnosed with an immune deficiency or are receiving chronic systemic steroid therapy (doses greater than 10mg daily equivalent of prednisone) or any other form of immunosuppressive therapy within 7 days prior to the first dose;",
                "criterions": [
                    {
                        "exact_snippets": "Have been diagnosed with an immune deficiency",
                        "criterion": "immune deficiency",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "receiving chronic systemic steroid therapy (doses greater than 10mg daily equivalent of prednisone)",
                        "criterion": "chronic systemic steroid therapy",
                        "requirement": {
                            "requirement_type": "dose",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "mg daily equivalent of prednisone"
                            }
                        }
                    },
                    {
                        "exact_snippets": "receiving ... any other form of immunosuppressive therapy within 7 days prior to the first dose",
                        "criterion": "immunosuppressive therapy",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 7 days prior to the first dose"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Have been diagnosed with an immune deficiency",
                                "criterion": "immune deficiency",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "receiving chronic systemic steroid therapy (doses greater than 10mg daily equivalent of prednisone)",
                                "criterion": "chronic systemic steroid therapy",
                                "requirement": {
                                    "requirement_type": "dose",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 10,
                                        "unit": "mg daily equivalent of prednisone"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "receiving ... any other form of immunosuppressive therapy within 7 days prior to the first dose",
                                "criterion": "immunosuppressive therapy",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "within 7 days prior to the first dose"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have an active autoimmune disease in the past 2 years that requires systemic treatment (such as the use of disease-modulating drugs, corticosteroids, or immunosuppressive drugs);",
                "criterions": [
                    {
                        "exact_snippets": "active autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "in the past 2 years",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "past 2 years"
                        }
                    },
                    {
                        "exact_snippets": "requires systemic treatment",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "treatment requirement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "disease-modulating drugs, corticosteroids, or immunosuppressive drugs",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "disease-modulating drugs",
                                "corticosteroids",
                                "immunosuppressive drugs"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "active autoimmune disease",
                                        "criterion": "autoimmune disease",
                                        "requirement": {
                                            "requirement_type": "activity",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "in the past 2 years",
                                        "criterion": "autoimmune disease",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": "past 2 years"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "requires systemic treatment",
                                "criterion": "autoimmune disease",
                                "requirement": {
                                    "requirement_type": "treatment requirement",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "disease-modulating drugs, corticosteroids, or immunosuppressive drugs",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "disease-modulating drugs",
                                "corticosteroids",
                                "immunosuppressive drugs"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have a history of (non-infectious) pneumonia requiring steroid treatment or have a current (non-infectious) pneumonia;",
                "criterions": [
                    {
                        "exact_snippets": "Have a history of (non-infectious) pneumonia requiring steroid treatment",
                        "criterion": "history of non-infectious pneumonia",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "steroid treatment"
                        }
                    },
                    {
                        "exact_snippets": "have a current (non-infectious) pneumonia",
                        "criterion": "current non-infectious pneumonia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Have a history of (non-infectious) pneumonia requiring steroid treatment",
                        "criterion": "history of non-infectious pneumonia",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "steroid treatment"
                        }
                    },
                    {
                        "exact_snippets": "have a current (non-infectious) pneumonia",
                        "criterion": "current non-infectious pneumonia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* An active infection requiring systematic treatment;",
                "criterions": [
                    {
                        "exact_snippets": "An active infection requiring systematic treatment",
                        "criterion": "active infection",
                        "requirement": {
                            "requirement_type": "treatment necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "An active infection requiring systematic treatment",
                    "criterion": "active infection",
                    "requirement": {
                        "requirement_type": "treatment necessity",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Known history of HIV infection;",
                "criterions": [
                    {
                        "exact_snippets": "Known history of HIV infection",
                        "criterion": "HIV infection",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Known history of HIV infection",
                    "criterion": "HIV infection",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* A known history of hepatitis B (defined as HBsAg reactive) or known active hepatitis C virus (defined as detection of HCV RNA[qualitative]) infection;",
                "criterions": [
                    {
                        "exact_snippets": "A known history of hepatitis B (defined as HBsAg reactive)",
                        "criterion": "hepatitis B",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "A known history of hepatitis B (defined as HBsAg reactive)",
                        "criterion": "hepatitis B",
                        "requirement": {
                            "requirement_type": "HBsAg reactivity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "known active hepatitis C virus (defined as detection of HCV RNA[qualitative]) infection",
                        "criterion": "hepatitis C virus",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "known active hepatitis C virus (defined as detection of HCV RNA[qualitative]) infection",
                        "criterion": "hepatitis C virus",
                        "requirement": {
                            "requirement_type": "HCV RNA detection",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "A known history of hepatitis B (defined as HBsAg reactive)",
                                "criterion": "hepatitis B",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "A known history of hepatitis B (defined as HBsAg reactive)",
                                "criterion": "hepatitis B",
                                "requirement": {
                                    "requirement_type": "HBsAg reactivity",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "known active hepatitis C virus (defined as detection of HCV RNA[qualitative]) infection",
                                "criterion": "hepatitis C virus",
                                "requirement": {
                                    "requirement_type": "activity",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "known active hepatitis C virus (defined as detection of HCV RNA[qualitative]) infection",
                                "criterion": "hepatitis C virus",
                                "requirement": {
                                    "requirement_type": "HCV RNA detection",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Known active tuberculosis (TB; Tuberculosis) medical history;",
                "criterions": [
                    {
                        "exact_snippets": "Known active tuberculosis (TB; Tuberculosis) medical history",
                        "criterion": "tuberculosis",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "Known active tuberculosis (TB; Tuberculosis) medical history",
                        "criterion": "tuberculosis",
                        "requirement": {
                            "requirement_type": "medical history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Known active tuberculosis (TB; Tuberculosis) medical history",
                        "criterion": "tuberculosis",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "Known active tuberculosis (TB; Tuberculosis) medical history",
                        "criterion": "tuberculosis",
                        "requirement": {
                            "requirement_type": "medical history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Has received allogeneic tissue/solid organ transplantation;",
                "criterions": [
                    {
                        "exact_snippets": "Has received allogeneic tissue/solid organ transplantation",
                        "criterion": "allogeneic tissue/solid organ transplantation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Has received allogeneic tissue/solid organ transplantation",
                    "criterion": "allogeneic tissue/solid organ transplantation",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Suffering from central nervous system metastases such as brain metastases;",
                "criterions": [
                    {
                        "exact_snippets": "central nervous system metastases",
                        "criterion": "central nervous system metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "central nervous system metastases",
                        "criterion": "central nervous system metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with uncontrolled chest and abdominal fluid;",
                "criterions": [
                    {
                        "exact_snippets": "uncontrolled chest and abdominal fluid",
                        "criterion": "chest fluid",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "uncontrolled chest and abdominal fluid",
                        "criterion": "abdominal fluid",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "uncontrolled chest and abdominal fluid",
                        "criterion": "chest fluid",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "uncontrolled chest and abdominal fluid",
                        "criterion": "abdominal fluid",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with mobility disorders such as pathological fractures caused by tumor bone metastasis;",
                "criterions": [
                    {
                        "exact_snippets": "mobility disorders",
                        "criterion": "mobility disorders",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pathological fractures",
                        "criterion": "pathological fractures",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "tumor bone metastasis",
                        "criterion": "tumor bone metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "mobility disorders",
                                        "criterion": "mobility disorders",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "pathological fractures",
                                        "criterion": "pathological fractures",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "tumor bone metastasis",
                                "criterion": "tumor bone metastasis",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Insufficient hematopoietic function of bone marrow;",
                "criterions": [
                    {
                        "exact_snippets": "Insufficient hematopoietic function of bone marrow",
                        "criterion": "hematopoietic function of bone marrow",
                        "requirement": {
                            "requirement_type": "sufficiency",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Insufficient hematopoietic function of bone marrow",
                    "criterion": "hematopoietic function of bone marrow",
                    "requirement": {
                        "requirement_type": "sufficiency",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Abnormal liver;",
                "criterions": [
                    {
                        "exact_snippets": "Abnormal liver",
                        "criterion": "liver",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "abnormal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Abnormal liver",
                    "criterion": "liver",
                    "requirement": {
                        "requirement_type": "condition",
                        "expected_value": "abnormal"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Abnormal kidney;",
                "criterions": [
                    {
                        "exact_snippets": "Abnormal kidney",
                        "criterion": "kidney",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "abnormal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Abnormal kidney",
                    "criterion": "kidney",
                    "requirement": {
                        "requirement_type": "condition",
                        "expected_value": "abnormal"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Bleeding risk;",
                "criterions": [
                    {
                        "exact_snippets": "Bleeding risk",
                        "criterion": "bleeding risk",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bleeding risk",
                        "criterion": "bleeding risk",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Cardiovascular and cerebrovascular abnormalities.",
                "criterions": [
                    {
                        "exact_snippets": "Cardiovascular ... abnormalities",
                        "criterion": "cardiovascular abnormalities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "cerebrovascular abnormalities",
                        "criterion": "cerebrovascular abnormalities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Cardiovascular ... abnormalities",
                        "criterion": "cardiovascular abnormalities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "cerebrovascular abnormalities",
                        "criterion": "cerebrovascular abnormalities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Subjects have not received previous immunotherapy;",
                "criterions": [
                    {
                        "exact_snippets": "Subjects have not received previous immunotherapy",
                        "criterion": "previous immunotherapy",
                        "requirement": {
                            "requirement_type": "receipt",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Expected survival ≥6 months;",
                "criterions": [
                    {
                        "exact_snippets": "Expected survival ≥6 months",
                        "criterion": "expected survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Women of reproductive age should agree to use contraceptives (such as Iuds, contraceptives, or condoms) during the study period and for 6 months after the study ends; Have a negative serum or urine pregnancy test within 7 days prior to study enrollment and must be a non-lactating patient;",
                "criterions": [
                    {
                        "exact_snippets": "Women of reproductive age",
                        "criterion": "gender and reproductive age",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "agree to use contraceptives (such as Iuds, contraceptives, or condoms) during the study period and for 6 months after the study ends",
                        "criterion": "contraceptive use",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "during the study period and for 6 months after the study ends"
                        }
                    },
                    {
                        "exact_snippets": "Have a negative serum or urine pregnancy test within 7 days prior to study enrollment",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "Have a negative serum or urine pregnancy test within 7 days prior to study enrollment",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "within 7 days prior to study enrollment"
                        }
                    },
                    {
                        "exact_snippets": "must be a non-lactating patient",
                        "criterion": "lactation status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "non-lactating"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* For adequate organ function as defined in the protocol, test samples must be collected within 7 days prior to initiation of the study therapy",
                "criterions": [
                    {
                        "exact_snippets": "adequate organ function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "test samples must be collected within 7 days prior to initiation of the study therapy",
                        "criterion": "test sample collection timing",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": "<=",
                                "value": 7,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Subjects voluntarily joined the study, signed informed consent, had good compliance, and cooperated with follow-up.",
                "criterions": [
                    {
                        "exact_snippets": "Subjects voluntarily joined the study",
                        "criterion": "voluntary participation",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "signed informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "had good compliance",
                        "criterion": "compliance",
                        "requirement": {
                            "requirement_type": "quality",
                            "expected_value": "good"
                        }
                    },
                    {
                        "exact_snippets": "cooperated with follow-up",
                        "criterion": "follow-up cooperation",
                        "requirement": {
                            "requirement_type": "cooperation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}