{
    "info": {
        "nct_id": "NCT05773820",
        "official_title": "A Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of WJB001 Capsules in Dose Escalation, Dose Expansion, and Efficacy Expansion in Patients With Advanced Solid Tumors",
        "inclusion_criteria": "1. ≥ 18 years or older at the time of informed consent；\n2. Patient with advanced malignant solid tumors clearly diagnosed pathologically and/or cytologically, who have failed to receive standard treatment, or who currently no have standard treatment, or who are intolerant to standard treatment;\n3. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score ≤1;\n4. Life expectancy ≥ 12 weeks;\n5. Adequate hematologic and organ function；\n6. All acute toxic effects from previous antineoplastic therapy or surgery ；\n7. Fertile women must confirm a negative blood pregnancy test within 7 days prior to the first administration of study drug;and they required to use adequate and effective contraceptive measures throughout the treatment period and within 3 months after the end of treatment;Fertile women in this protocol were defined as sexually mature women: 1) not undergoing hysterectomy or bilateral oophorectomy; 2) 24 months without a continuous period of spontaneous menopause (i.e., having had a period at any time in the previous 24 consecutive months; Amenorrhea after cancer treatment does not exclude fertility). Male participants with a sexual partner who was a woman of reproductive age had to agree to use an effective contraceptive method while using the study drug and for 3 months after the last dose；\n\n   Specific inclusion criteria：\n8. At least one measurable tumor lesion that meets the definition of RECIST v1.1, with no history of biopsy two weeks before screening(applicable to all stages);\n9. Subjects with CCNE1 overexpression (H score > 50) or amplification (DNA copy number > 7)confirmed by central laboratory (applicable to the dose expansion stage and efficacy expansion stage);\n10. For subjects with advanced uterine serous carcinoma, ≤2 lines of therapy for recurrence are allowed after first-line treatment; For subjects with advanced high-grade serous ovarian, fallopian tube, or peritoneal cancer,≤2 lines of therapy after platinum resistance are allowed(applicable to the dose expansion stage and efficacy expansion stage)；\n\nKey Exclusion criteria：\n\n1.General condition\n\n1. Pregnant or lactating women;\n2. Any known allergies to or contraindications to components of the study drug;\n3. History of substance abuse;\n4. History of alcohol abuse or consumption of more than 28 units of alcohol per week (1 unit =285 ml beer or 25 ml spirits (40%v/v) or 100 ml wine).\n\n2.Previous or current treatment:\n\n1. Previous or current treatment with Wee1 inhibitors;\n2. Received cytotoxic chemotherapy drugs,anti-tumor traditional Chinese medicine orother anti-tumor therapies (such as small molecule targeted therapy, etc.)within 4 weeks prior to the first administration of study drug;Or received the investigational drug, macromolecular drug with anti-tumor effect (e.g., monoclonal antibody, antibody-drug conjugate, or bispecific antibody, etc.) within 28 days prior to the first administration of study drug; Or need to continue receiving these medications during the study;\n3. The use of a medium or strong inhibitor or inducer of CYP3A or other product (e.g., grapefruit juice) or P-gp inhibitor or inducer was discontinued less than the time before the first dose of WJB001 was administered 5 half-lives of the drug or 14 days, whichever is shorter;\n4. Patients with a known organ transplant or stem cell transplant; Major surgery or major trauma (excluding needle biopsy for sample collection) within 4 weeks prior to the first administration of study drug;\n5. Radiation therapy was administered within 21 days prior to the first administration of study drug; (except the radiation was delivered to ≤5% of bone marrow volume).3. Past medical history, present medical history and abnormal laboratory indicators:\n\n3. Abnormal laboratory indicators:\n\n1. Having active GI abnormalities including, but not limited to, inability to take oral medication, need for intravenous nutritional support, peptic ulcer, chronic diarrhea (e.g., Crohn's disease, irritable bowel syndrome), or vomiting or other factors that the investigator believes may significantly affect drug absorption, metabolism, or excretion;\n2. History of severe ocular disease (except permanent blindness due to disease) that has not recovered to grade 1 or less;\n3. Patients with active brain metastases (except if they had CNS metastases confined to the supratentorial or cerebellar region, had been adequately treated (surgery or radiotherapy), had maintained radiological stability for at least 4 weeks, and did not require corticosteroids for symptom control);\n4. Patients with current cancer meningitis or spinal cord compression;\n5. Severe or poorly controlled hypertension, including previous history of hypertensive crisis or hypertensive encephalopathy; Adjustment of antihypertensive medication due to poor blood pressure control within 2 weeks before the first dose;Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg during the screening period;\n6. Patients with clinically significant bleeding symptoms or obvious bleeding tendency within 4 weeks before the first dose, such as gastrointestinal bleeding, gastric ulcer bleeding, obvious gross hematuria, or angiitis;\n7. Patients with active HBV and HCV infection: if HBsAg is positive or/and anti-HBc is positive, blood HBV DNA should be tested to confirm that it is above the limit of quantitative detection; If anti-HCV is positive, it is necessary to detect HCV RNA to confirm that the HCV virus copy number exceeds the quantitative detection limit；\n8. Known history of human immunodeficiency virus infection or seropositivity for HIV;\n9. History of syphilis (both treponema pallidum specific and non-specific antibodies were positive)；\n10. History of other primary solid tumor (except a cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence）; Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence; Adequately treated carcinoma in situ with no evidence of disease recurrence, such as carcinoma in situ of the cervix);\n11. history of severe or what the investigators considered clinically significant cardiac disease affected the safety assessment；\n12. Severe active infectious diseases or other diseases that seriously affect the safety of the first medication occurred during the screening period;\n13. There are other factors that the investigator considers may affect the results of the study and interfere with the patient's participation in the study;\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "Key"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. ≥ 18 years or older at the time of informed consent；",
                "criterions": [
                    {
                        "exact_snippets": "≥ 18 years or older",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "≥ 18 years or older",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Patient with advanced malignant solid tumors clearly diagnosed pathologically and/or cytologically, who have failed to receive standard treatment, or who currently no have standard treatment, or who are intolerant to standard treatment;",
                "criterions": [
                    {
                        "exact_snippets": "advanced malignant solid tumors",
                        "criterion": "tumor type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "advanced malignant solid tumors"
                        }
                    },
                    {
                        "exact_snippets": "clearly diagnosed pathologically and/or cytologically",
                        "criterion": "diagnosis method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": [
                                "pathologically",
                                "cytologically"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "failed to receive standard treatment",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "failed to receive standard treatment"
                        }
                    },
                    {
                        "exact_snippets": "currently no have standard treatment",
                        "criterion": "treatment availability",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "intolerant to standard treatment",
                        "criterion": "treatment tolerance",
                        "requirement": {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "advanced malignant solid tumors",
                                "criterion": "tumor type",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "advanced malignant solid tumors"
                                }
                            },
                            {
                                "exact_snippets": "clearly diagnosed pathologically and/or cytologically",
                                "criterion": "diagnosis method",
                                "requirement": {
                                    "requirement_type": "method",
                                    "expected_value": [
                                        "pathologically",
                                        "cytologically"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "failed to receive standard treatment",
                                "criterion": "treatment history",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "failed to receive standard treatment"
                                }
                            },
                            {
                                "exact_snippets": "currently no have standard treatment",
                                "criterion": "treatment availability",
                                "requirement": {
                                    "requirement_type": "availability",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "intolerant to standard treatment",
                                "criterion": "treatment tolerance",
                                "requirement": {
                                    "requirement_type": "tolerance",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score ≤1;",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score ≤1",
                        "criterion": "ECOG Performance Status score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score ≤1",
                        "criterion": "ECOG Performance Status score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Life expectancy ≥ 12 weeks;",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy ≥ 12 weeks;",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy ≥ 12 weeks;",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Adequate hematologic and organ function；",
                "criterions": [
                    {
                        "exact_snippets": "Adequate hematologic ... function",
                        "criterion": "hematologic function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... organ function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate hematologic ... function",
                        "criterion": "hematologic function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... organ function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. All acute toxic effects from previous antineoplastic therapy or surgery ；",
                "criterions": [
                    {
                        "exact_snippets": "All acute toxic effects from previous antineoplastic therapy or surgery",
                        "criterion": "acute toxic effects",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "All acute toxic effects from previous antineoplastic therapy or surgery",
                        "criterion": "acute toxic effects",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1.General condition",
                "criterions": [
                    {
                        "exact_snippets": "General condition",
                        "criterion": "general condition",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "General condition",
                        "criterion": "general condition",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. Pregnant or lactating women;",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Any known allergies to or contraindications to components of the study drug;",
                "criterions": [
                    {
                        "exact_snippets": "Any known allergies to ... components of the study drug",
                        "criterion": "allergies to components of the study drug",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "contraindications to components of the study drug",
                        "criterion": "contraindications to components of the study drug",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Any known allergies to ... components of the study drug",
                        "criterion": "allergies to components of the study drug",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "contraindications to components of the study drug",
                        "criterion": "contraindications to components of the study drug",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. History of substance abuse;",
                "criterions": [
                    {
                        "exact_snippets": "History of substance abuse",
                        "criterion": "substance abuse",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "History of substance abuse",
                        "criterion": "substance abuse",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. History of alcohol abuse or consumption of more than 28 units of alcohol per week (1 unit =285 ml beer or 25 ml spirits (40%v/v) or 100 ml wine).",
                "criterions": [
                    {
                        "exact_snippets": "History of alcohol abuse",
                        "criterion": "alcohol abuse",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "consumption of more than 28 units of alcohol per week",
                        "criterion": "alcohol consumption",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 28,
                                "unit": "units per week"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "History of alcohol abuse",
                        "criterion": "alcohol abuse",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "consumption of more than 28 units of alcohol per week",
                        "criterion": "alcohol consumption",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 28,
                                "unit": "units per week"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2.Previous or current treatment:",
                "criterions": [
                    {
                        "exact_snippets": "Previous or current treatment",
                        "criterion": "treatment",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "previous",
                                "current"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Previous or current treatment",
                        "criterion": "treatment",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "previous",
                                "current"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. Previous or current treatment with Wee1 inhibitors;",
                "criterions": [
                    {
                        "exact_snippets": "Previous or current treatment with Wee1 inhibitors",
                        "criterion": "treatment with Wee1 inhibitors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Previous or current treatment with Wee1 inhibitors",
                        "criterion": "treatment with Wee1 inhibitors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. The use of a medium or strong inhibitor or inducer of CYP3A or other product (e.g., grapefruit juice) or P-gp inhibitor or inducer was discontinued less than the time before the first dose of WJB001 was administered 5 half-lives of the drug or 14 days, whichever is shorter;",
                "criterions": [
                    {
                        "exact_snippets": "The use of a medium or strong inhibitor or inducer of CYP3A",
                        "criterion": "use of CYP3A inhibitor or inducer",
                        "requirement": {
                            "requirement_type": "discontinuation time",
                            "expected_value": "less than 5 half-lives of the drug or 14 days, whichever is shorter"
                        }
                    },
                    {
                        "exact_snippets": "The use of ... other product (e.g., grapefruit juice)",
                        "criterion": "use of other product (e.g., grapefruit juice)",
                        "requirement": {
                            "requirement_type": "discontinuation time",
                            "expected_value": "less than 5 half-lives of the drug or 14 days, whichever is shorter"
                        }
                    },
                    {
                        "exact_snippets": "The use of ... P-gp inhibitor or inducer",
                        "criterion": "use of P-gp inhibitor or inducer",
                        "requirement": {
                            "requirement_type": "discontinuation time",
                            "expected_value": "less than 5 half-lives of the drug or 14 days, whichever is shorter"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "The use of a medium or strong inhibitor or inducer of CYP3A",
                                "criterion": "use of CYP3A inhibitor or inducer",
                                "requirement": {
                                    "requirement_type": "discontinuation time",
                                    "expected_value": "less than 5 half-lives of the drug or 14 days, whichever is shorter"
                                }
                            },
                            {
                                "exact_snippets": "The use of ... other product (e.g., grapefruit juice)",
                                "criterion": "use of other product (e.g., grapefruit juice)",
                                "requirement": {
                                    "requirement_type": "discontinuation time",
                                    "expected_value": "less than 5 half-lives of the drug or 14 days, whichever is shorter"
                                }
                            },
                            {
                                "exact_snippets": "The use of ... P-gp inhibitor or inducer",
                                "criterion": "use of P-gp inhibitor or inducer",
                                "requirement": {
                                    "requirement_type": "discontinuation time",
                                    "expected_value": "less than 5 half-lives of the drug or 14 days, whichever is shorter"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Patients with a known organ transplant or stem cell transplant; Major surgery or major trauma (excluding needle biopsy for sample collection) within 4 weeks prior to the first administration of study drug;",
                "criterions": [
                    {
                        "exact_snippets": "Patients with a known organ transplant",
                        "criterion": "organ transplant",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "stem cell transplant",
                        "criterion": "stem cell transplant",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Major surgery",
                        "criterion": "major surgery",
                        "requirement": {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "major trauma",
                        "criterion": "major trauma",
                        "requirement": {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Patients with a known organ transplant",
                                "criterion": "organ transplant",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "stem cell transplant",
                                "criterion": "stem cell transplant",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Major surgery",
                                "criterion": "major surgery",
                                "requirement": {
                                    "requirement_type": "recency",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "major trauma",
                                "criterion": "major trauma",
                                "requirement": {
                                    "requirement_type": "recency",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Abnormal laboratory indicators:",
                "criterions": [
                    {
                        "exact_snippets": "Abnormal laboratory indicators",
                        "criterion": "laboratory indicators",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "abnormal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Abnormal laboratory indicators",
                        "criterion": "laboratory indicators",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "abnormal"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. Having active GI abnormalities including, but not limited to, inability to take oral medication, need for intravenous nutritional support, peptic ulcer, chronic diarrhea (e.g., Crohn's disease, irritable bowel syndrome), or vomiting or other factors that the investigator believes may significantly affect drug absorption, metabolism, or excretion;",
                "criterions": [
                    {
                        "exact_snippets": "active GI abnormalities including, but not limited to, inability to take oral medication",
                        "criterion": "active GI abnormalities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "need for intravenous nutritional support",
                        "criterion": "intravenous nutritional support",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "peptic ulcer",
                        "criterion": "peptic ulcer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "chronic diarrhea (e.g., Crohn's disease, irritable bowel syndrome)",
                        "criterion": "chronic diarrhea",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "vomiting",
                        "criterion": "vomiting",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "factors that the investigator believes may significantly affect drug absorption, metabolism, or excretion",
                        "criterion": "factors affecting drug absorption, metabolism, or excretion",
                        "requirement": {
                            "requirement_type": "investigator's belief",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "active GI abnormalities including, but not limited to, inability to take oral medication",
                                "criterion": "active GI abnormalities",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "need for intravenous nutritional support",
                                "criterion": "intravenous nutritional support",
                                "requirement": {
                                    "requirement_type": "necessity",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "peptic ulcer",
                        "criterion": "peptic ulcer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "chronic diarrhea (e.g., Crohn's disease, irritable bowel syndrome)",
                        "criterion": "chronic diarrhea",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "vomiting",
                        "criterion": "vomiting",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "factors that the investigator believes may significantly affect drug absorption, metabolism, or excretion",
                        "criterion": "factors affecting drug absorption, metabolism, or excretion",
                        "requirement": {
                            "requirement_type": "investigator's belief",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. History of severe ocular disease (except permanent blindness due to disease) that has not recovered to grade 1 or less;",
                "criterions": [
                    {
                        "exact_snippets": "History of severe ocular disease",
                        "criterion": "severe ocular disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "(except permanent blindness due to disease)",
                        "criterion": "permanent blindness due to disease",
                        "requirement": {
                            "requirement_type": "exception",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "that has not recovered to grade 1 or less",
                        "criterion": "recovery of ocular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "not_criteria": {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "History of severe ocular disease",
                                            "criterion": "severe ocular disease",
                                            "requirement": {
                                                "requirement_type": "history",
                                                "expected_value": true
                                            }
                                        },
                                        {
                                            "exact_snippets": "that has not recovered to grade 1 or less",
                                            "criterion": "recovery of ocular disease",
                                            "requirement": {
                                                "requirement_type": "severity",
                                                "expected_value": {
                                                    "operator": "<=",
                                                    "value": 1,
                                                    "unit": "grade"
                                                }
                                            }
                                        }
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "(except permanent blindness due to disease)",
                            "criterion": "permanent blindness due to disease",
                            "requirement": {
                                "requirement_type": "exception",
                                "expected_value": true
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Patients with active brain metastases (except if they had CNS metastases confined to the supratentorial or cerebellar region, had been adequately treated (surgery or radiotherapy), had maintained radiological stability for at least 4 weeks, and did not require corticosteroids for symptom control);",
                "criterions": [
                    {
                        "exact_snippets": "active brain metastases",
                        "criterion": "active brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "CNS metastases confined to the supratentorial or cerebellar region",
                        "criterion": "CNS metastases location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "supratentorial",
                                "cerebellar"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "adequately treated (surgery or radiotherapy)",
                        "criterion": "CNS metastases treatment",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "surgery",
                                "radiotherapy"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "maintained radiological stability for at least 4 weeks",
                        "criterion": "radiological stability",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "did not require corticosteroids for symptom control",
                        "criterion": "corticosteroid requirement",
                        "requirement": {
                            "requirement_type": "requirement",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "active brain metastases",
                            "criterion": "active brain metastases",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "CNS metastases confined to the supratentorial or cerebellar region",
                                "criterion": "CNS metastases location",
                                "requirement": {
                                    "requirement_type": "location",
                                    "expected_value": [
                                        "supratentorial",
                                        "cerebellar"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "adequately treated (surgery or radiotherapy)",
                                "criterion": "CNS metastases treatment",
                                "requirement": {
                                    "requirement_type": "treatment",
                                    "expected_value": [
                                        "surgery",
                                        "radiotherapy"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "maintained radiological stability for at least 4 weeks",
                                "criterion": "radiological stability",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "did not require corticosteroids for symptom control",
                                "criterion": "corticosteroid requirement",
                                "requirement": {
                                    "requirement_type": "requirement",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Patients with current cancer meningitis or spinal cord compression;",
                "criterions": [
                    {
                        "exact_snippets": "Patients with current cancer meningitis",
                        "criterion": "cancer meningitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Patients with ... spinal cord compression",
                        "criterion": "spinal cord compression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Patients with current cancer meningitis",
                        "criterion": "cancer meningitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Patients with ... spinal cord compression",
                        "criterion": "spinal cord compression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Severe or poorly controlled hypertension, including previous history of hypertensive crisis or hypertensive encephalopathy; Adjustment of antihypertensive medication due to poor blood pressure control within 2 weeks before the first dose;Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg during the screening period;",
                "criterions": [
                    {
                        "exact_snippets": "Severe or poorly controlled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "severe",
                                "poorly controlled"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "previous history of hypertensive crisis",
                        "criterion": "hypertensive crisis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypertensive encephalopathy",
                        "criterion": "hypertensive encephalopathy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adjustment of antihypertensive medication due to poor blood pressure control within 2 weeks before the first dose",
                        "criterion": "antihypertensive medication adjustment",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 2 weeks before the first dose"
                        }
                    },
                    {
                        "exact_snippets": "Systolic blood pressure ≥160 mmHg",
                        "criterion": "systolic blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 160,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "diastolic blood pressure ≥100 mmHg",
                        "criterion": "diastolic blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Severe or poorly controlled hypertension",
                                        "criterion": "hypertension",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": [
                                                "severe",
                                                "poorly controlled"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "previous history of hypertensive crisis",
                                        "criterion": "hypertensive crisis",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "hypertensive encephalopathy",
                                        "criterion": "hypertensive encephalopathy",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Adjustment of antihypertensive medication due to poor blood pressure control within 2 weeks before the first dose",
                                "criterion": "antihypertensive medication adjustment",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "within 2 weeks before the first dose"
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Systolic blood pressure ≥160 mmHg",
                                "criterion": "systolic blood pressure",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 160,
                                        "unit": "mmHg"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "diastolic blood pressure ≥100 mmHg",
                                "criterion": "diastolic blood pressure",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 100,
                                        "unit": "mmHg"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "7. Patients with active HBV and HCV infection: if HBsAg is positive or/and anti-HBc is positive, blood HBV DNA should be tested to confirm that it is above the limit of quantitative detection; If anti-HCV is positive, it is necessary to detect HCV RNA to confirm that the HCV virus copy number exceeds the quantitative detection limit；",
                "criterions": [
                    {
                        "exact_snippets": "Patients with active HBV and HCV infection",
                        "criterion": "active HBV and HCV infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "HBsAg is positive",
                        "criterion": "HBsAg",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "anti-HBc is positive",
                        "criterion": "anti-HBc",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "blood HBV DNA should be tested ... above the limit of quantitative detection",
                        "criterion": "blood HBV DNA",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": "above the limit of quantitative detection"
                        }
                    },
                    {
                        "exact_snippets": "anti-HCV is positive",
                        "criterion": "anti-HCV",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "HCV RNA ... HCV virus copy number exceeds the quantitative detection limit",
                        "criterion": "HCV RNA",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": "exceeds the quantitative detection limit"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "condition": {
                            "or_criteria": [
                                {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "HBsAg is positive",
                                            "criterion": "HBsAg",
                                            "requirement": {
                                                "requirement_type": "presence",
                                                "expected_value": "positive"
                                            }
                                        },
                                        {
                                            "exact_snippets": "blood HBV DNA should be tested ... above the limit of quantitative detection",
                                            "criterion": "blood HBV DNA",
                                            "requirement": {
                                                "requirement_type": "quantity",
                                                "expected_value": "above the limit of quantitative detection"
                                            }
                                        }
                                    ]
                                },
                                {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "anti-HBc is positive",
                                            "criterion": "anti-HBc",
                                            "requirement": {
                                                "requirement_type": "presence",
                                                "expected_value": "positive"
                                            }
                                        },
                                        {
                                            "exact_snippets": "blood HBV DNA should be tested ... above the limit of quantitative detection",
                                            "criterion": "blood HBV DNA",
                                            "requirement": {
                                                "requirement_type": "quantity",
                                                "expected_value": "above the limit of quantitative detection"
                                            }
                                        }
                                    ]
                                }
                            ]
                        },
                        "then_criteria": {
                            "exact_snippets": "Patients with active HBV and HCV infection",
                            "criterion": "active HBV and HCV infection",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        },
                        "else_criteria": null
                    },
                    {
                        "condition": {
                            "exact_snippets": "anti-HCV is positive",
                            "criterion": "anti-HCV",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": "positive"
                            }
                        },
                        "then_criteria": {
                            "exact_snippets": "HCV RNA ... HCV virus copy number exceeds the quantitative detection limit",
                            "criterion": "HCV RNA",
                            "requirement": {
                                "requirement_type": "quantity",
                                "expected_value": "exceeds the quantitative detection limit"
                            }
                        },
                        "else_criteria": null
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. Known history of human immunodeficiency virus infection or seropositivity for HIV;",
                "criterions": [
                    {
                        "exact_snippets": "Known history of human immunodeficiency virus infection",
                        "criterion": "human immunodeficiency virus infection",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "seropositivity for HIV",
                        "criterion": "HIV seropositivity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Known history of human immunodeficiency virus infection",
                        "criterion": "human immunodeficiency virus infection",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "seropositivity for HIV",
                        "criterion": "HIV seropositivity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "9. History of syphilis (both treponema pallidum specific and non-specific antibodies were positive)；",
                "criterions": [
                    {
                        "exact_snippets": "History of syphilis",
                        "criterion": "syphilis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "treponema pallidum specific ... antibodies were positive",
                        "criterion": "treponema pallidum specific antibodies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "non-specific antibodies were positive",
                        "criterion": "non-specific antibodies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of syphilis",
                                "criterion": "syphilis",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "treponema pallidum specific ... antibodies were positive",
                                "criterion": "treponema pallidum specific antibodies",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "non-specific antibodies were positive",
                        "criterion": "non-specific antibodies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "10. History of other primary solid tumor (except a cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence）; Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence; Adequately treated carcinoma in situ with no evidence of disease recurrence, such as carcinoma in situ of the cervix);",
                "criterions": [
                    {
                        "exact_snippets": "History of other primary solid tumor",
                        "criterion": "history of other primary solid tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence",
                        "criterion": "cured solid tumor",
                        "requirement": {
                            "requirement_type": "inactivity duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence",
                        "criterion": "cured solid tumor",
                        "requirement": {
                            "requirement_type": "recurrence risk",
                            "expected_value": "very low"
                        }
                    },
                    {
                        "exact_snippets": "Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence",
                        "criterion": "non-melanoma skin cancer or lentigo maligna",
                        "requirement": {
                            "requirement_type": "treatment adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence",
                        "criterion": "non-melanoma skin cancer or lentigo maligna",
                        "requirement": {
                            "requirement_type": "evidence of disease recurrence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Adequately treated carcinoma in situ with no evidence of disease recurrence",
                        "criterion": "carcinoma in situ",
                        "requirement": {
                            "requirement_type": "treatment adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequately treated carcinoma in situ with no evidence of disease recurrence",
                        "criterion": "carcinoma in situ",
                        "requirement": {
                            "requirement_type": "evidence of disease recurrence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "not_criteria": {
                                    "exact_snippets": "History of other primary solid tumor",
                                    "criterion": "history of other primary solid tumor",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    }
                                }
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence",
                                        "criterion": "cured solid tumor",
                                        "requirement": {
                                            "requirement_type": "inactivity duration",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 5,
                                                "unit": "years"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "cured solid tumor that has been inactive for ≥5 years before screening and has a very low risk of recurrence",
                                        "criterion": "cured solid tumor",
                                        "requirement": {
                                            "requirement_type": "recurrence risk",
                                            "expected_value": "very low"
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence",
                                "criterion": "non-melanoma skin cancer or lentigo maligna",
                                "requirement": {
                                    "requirement_type": "treatment adequacy",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Adequately treated non-melanoma skin cancer or lentigo maligna with no evidence of disease recurrence",
                                "criterion": "non-melanoma skin cancer or lentigo maligna",
                                "requirement": {
                                    "requirement_type": "evidence of disease recurrence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Adequately treated carcinoma in situ with no evidence of disease recurrence",
                                "criterion": "carcinoma in situ",
                                "requirement": {
                                    "requirement_type": "treatment adequacy",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Adequately treated carcinoma in situ with no evidence of disease recurrence",
                                "criterion": "carcinoma in situ",
                                "requirement": {
                                    "requirement_type": "evidence of disease recurrence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "11. history of severe or what the investigators considered clinically significant cardiac disease affected the safety assessment；",
                "criterions": [
                    {
                        "exact_snippets": "history of severe or what the investigators considered clinically significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "severe",
                                "clinically significant"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "history of severe or what the investigators considered clinically significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "severe",
                                "clinically significant"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "12. Severe active infectious diseases or other diseases that seriously affect the safety of the first medication occurred during the screening period;",
                "criterions": [
                    {
                        "exact_snippets": "Severe active infectious diseases",
                        "criterion": "infectious diseases",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    },
                    {
                        "exact_snippets": "Severe active infectious diseases",
                        "criterion": "infectious diseases",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "other diseases that seriously affect the safety of the first medication",
                        "criterion": "other diseases",
                        "requirement": {
                            "requirement_type": "impact on medication safety",
                            "expected_value": "seriously affect"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Severe active infectious diseases",
                                "criterion": "infectious diseases",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "severe"
                                }
                            },
                            {
                                "exact_snippets": "Severe active infectious diseases",
                                "criterion": "infectious diseases",
                                "requirement": {
                                    "requirement_type": "activity",
                                    "expected_value": "active"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "other diseases that seriously affect the safety of the first medication",
                        "criterion": "other diseases",
                        "requirement": {
                            "requirement_type": "impact on medication safety",
                            "expected_value": "seriously affect"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "13. There are other factors that the investigator considers may affect the results of the study and interfere with the patient's participation in the study;",
                "criterions": [
                    {
                        "exact_snippets": "other factors that the investigator considers may affect the results of the study and interfere with the patient's participation",
                        "criterion": "factors affecting study results and participation",
                        "requirement": {
                            "requirement_type": "consideration by investigator",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "other factors that the investigator considers may affect the results of the study and interfere with the patient's participation",
                        "criterion": "factors affecting study results and participation",
                        "requirement": {
                            "requirement_type": "consideration by investigator",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Specific inclusion criteria：",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Key Exclusion criteria：",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "2. Received cytotoxic chemotherapy drugs,anti-tumor traditional Chinese medicine orother anti-tumor therapies (such as small molecule targeted therapy, etc.)within 4 weeks prior to the first administration of study drug;Or received the investigational drug, macromolecular drug with anti-tumor effect (e.g., monoclonal antibody, antibody-drug conjugate, or bispecific antibody, etc.) within 28 days prior to the first administration of study drug; Or need to continue receiving these medications during the study;",
                "criterions": [
                    {
                        "exact_snippets": "Received cytotoxic chemotherapy drugs ... within 4 weeks prior to the first administration of study drug",
                        "criterion": "cytotoxic chemotherapy drugs",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received ... anti-tumor traditional Chinese medicine ... within 4 weeks prior to the first administration of study drug",
                        "criterion": "anti-tumor traditional Chinese medicine",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received ... other anti-tumor therapies (such as small molecule targeted therapy, etc.) within 4 weeks prior to the first administration of study drug",
                        "criterion": "other anti-tumor therapies",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received the investigational drug ... within 28 days prior to the first administration of study drug",
                        "criterion": "investigational drug",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Received ... macromolecular drug with anti-tumor effect (e.g., monoclonal antibody, antibody-drug conjugate, or bispecific antibody, etc.) within 28 days prior to the first administration of study drug",
                        "criterion": "macromolecular drug with anti-tumor effect",
                        "requirement": {
                            "requirement_type": "time since last administration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "need to continue receiving these medications during the study",
                        "criterion": "need to continue receiving medications",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "or_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Received cytotoxic chemotherapy drugs ... within 4 weeks prior to the first administration of study drug",
                                                "criterion": "cytotoxic chemotherapy drugs",
                                                "requirement": {
                                                    "requirement_type": "time since last administration",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 4,
                                                        "unit": "weeks"
                                                    }
                                                }
                                            },
                                            {
                                                "exact_snippets": "Received ... anti-tumor traditional Chinese medicine ... within 4 weeks prior to the first administration of study drug",
                                                "criterion": "anti-tumor traditional Chinese medicine",
                                                "requirement": {
                                                    "requirement_type": "time since last administration",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 4,
                                                        "unit": "weeks"
                                                    }
                                                }
                                            },
                                            {
                                                "exact_snippets": "Received ... other anti-tumor therapies (such as small molecule targeted therapy, etc.) within 4 weeks prior to the first administration of study drug",
                                                "criterion": "other anti-tumor therapies",
                                                "requirement": {
                                                    "requirement_type": "time since last administration",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 4,
                                                        "unit": "weeks"
                                                    }
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Received the investigational drug ... within 28 days prior to the first administration of study drug",
                                                "criterion": "investigational drug",
                                                "requirement": {
                                                    "requirement_type": "time since last administration",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 28,
                                                        "unit": "days"
                                                    }
                                                }
                                            },
                                            {
                                                "exact_snippets": "Received ... macromolecular drug with anti-tumor effect (e.g., monoclonal antibody, antibody-drug conjugate, or bispecific antibody, etc.) within 28 days prior to the first administration of study drug",
                                                "criterion": "macromolecular drug with anti-tumor effect",
                                                "requirement": {
                                                    "requirement_type": "time since last administration",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 28,
                                                        "unit": "days"
                                                    }
                                                }
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "need to continue receiving these medications during the study",
                                "criterion": "need to continue receiving medications",
                                "requirement": {
                                    "requirement_type": "necessity",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "Key",
                "criterions": [
                    {
                        "exact_snippets": "Key",
                        "criterion": "key",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Key",
                        "criterion": "key",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "7. Fertile women must confirm a negative blood pregnancy test within 7 days prior to the first administration of study drug;and they required to use adequate and effective contraceptive measures throughout the treatment period and within 3 months after the end of treatment;Fertile women in this protocol were defined as sexually mature women: 1) not undergoing hysterectomy or bilateral oophorectomy; 2) 24 months without a continuous period of spontaneous menopause (i.e., having had a period at any time in the previous 24 consecutive months; Amenorrhea after cancer treatment does not exclude fertility). Male participants with a sexual partner who was a woman of reproductive age had to agree to use an effective contraceptive method while using the study drug and for 3 months after the last dose；",
                "criterions": [
                    {
                        "exact_snippets": "Fertile women must confirm a negative blood pregnancy test within 7 days prior to the first administration of study drug",
                        "criterion": "blood pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "Fertile women must confirm a negative blood pregnancy test within 7 days prior to the first administration of study drug",
                        "criterion": "blood pregnancy test",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "within 7 days prior to the first administration of study drug"
                        }
                    },
                    {
                        "exact_snippets": "Fertile women ... required to use adequate and effective contraceptive measures throughout the treatment period and within 3 months after the end of treatment",
                        "criterion": "contraceptive measures",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": "adequate and effective"
                        }
                    },
                    {
                        "exact_snippets": "Fertile women ... required to use adequate and effective contraceptive measures throughout the treatment period and within 3 months after the end of treatment",
                        "criterion": "contraceptive measures",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "throughout the treatment period and within 3 months after the end of treatment"
                        }
                    },
                    {
                        "exact_snippets": "Fertile women in this protocol were defined as sexually mature women: 1) not undergoing hysterectomy or bilateral oophorectomy",
                        "criterion": "hysterectomy or bilateral oophorectomy",
                        "requirement": {
                            "requirement_type": "procedure status",
                            "expected_value": "not undergoing"
                        }
                    },
                    {
                        "exact_snippets": "Fertile women in this protocol were defined as sexually mature women: ... 2) 24 months without a continuous period of spontaneous menopause (i.e., having had a period at any time in the previous 24 consecutive months",
                        "criterion": "spontaneous menopause",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "24 months without a continuous period"
                        }
                    },
                    {
                        "exact_snippets": "Male participants with a sexual partner who was a woman of reproductive age had to agree to use an effective contraceptive method while using the study drug and for 3 months after the last dose",
                        "criterion": "contraceptive method for male participants",
                        "requirement": {
                            "requirement_type": "effectiveness",
                            "expected_value": "effective"
                        }
                    },
                    {
                        "exact_snippets": "Male participants with a sexual partner who was a woman of reproductive age had to agree to use an effective contraceptive method while using the study drug and for 3 months after the last dose",
                        "criterion": "contraceptive method for male participants",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "while using the study drug and for 3 months after the last dose"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "8. At least one measurable tumor lesion that meets the definition of RECIST v1.1, with no history of biopsy two weeks before screening(applicable to all stages);",
                "criterions": [
                    {
                        "exact_snippets": "At least one measurable tumor lesion",
                        "criterion": "measurable tumor lesion",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "lesion"
                            }
                        }
                    },
                    {
                        "exact_snippets": "meets the definition of RECIST v1.1",
                        "criterion": "RECIST v1.1 definition",
                        "requirement": {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "no history of biopsy two weeks before screening",
                        "criterion": "biopsy history",
                        "requirement": {
                            "requirement_type": "time since last biopsy",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "9. Subjects with CCNE1 overexpression (H score > 50) or amplification (DNA copy number > 7)confirmed by central laboratory (applicable to the dose expansion stage and efficacy expansion stage);",
                "criterions": [
                    {
                        "exact_snippets": "CCNE1 overexpression (H score > 50)",
                        "criterion": "CCNE1 overexpression",
                        "requirement": {
                            "requirement_type": "H score",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "CCNE1 ... amplification (DNA copy number > 7)",
                        "criterion": "CCNE1 amplification",
                        "requirement": {
                            "requirement_type": "DNA copy number",
                            "expected_value": {
                                "operator": ">",
                                "value": 7,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "10. For subjects with advanced uterine serous carcinoma, ≤2 lines of therapy for recurrence are allowed after first-line treatment; For subjects with advanced high-grade serous ovarian, fallopian tube, or peritoneal cancer,≤2 lines of therapy after platinum resistance are allowed(applicable to the dose expansion stage and efficacy expansion stage)；",
                "criterions": [
                    {
                        "exact_snippets": "advanced uterine serous carcinoma",
                        "criterion": "uterine serous carcinoma",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "≤2 lines of therapy for recurrence are allowed after first-line treatment",
                        "criterion": "lines of therapy for recurrence",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "lines"
                            }
                        }
                    },
                    {
                        "exact_snippets": "advanced high-grade serous ovarian, fallopian tube, or peritoneal cancer",
                        "criterion": "high-grade serous ovarian, fallopian tube, or peritoneal cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "≤2 lines of therapy after platinum resistance are allowed",
                        "criterion": "lines of therapy after platinum resistance",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "lines"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "advanced uterine serous carcinoma",
                                "criterion": "uterine serous carcinoma",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "advanced"
                                }
                            },
                            {
                                "exact_snippets": "\u0010 lines of therapy for recurrence are allowed after first-line treatment",
                                "criterion": "lines of therapy for recurrence",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "lines"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "advanced high-grade serous ovarian, fallopian tube, or peritoneal cancer",
                                "criterion": "high-grade serous ovarian, fallopian tube, or peritoneal cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "advanced"
                                }
                            },
                            {
                                "exact_snippets": "\u0010 lines of therapy after platinum resistance are allowed",
                                "criterion": "lines of therapy after platinum resistance",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "lines"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Radiation therapy was administered within 21 days prior to the first administration of study drug; (except the radiation was delivered to ≤5% of bone marrow volume).3. Past medical history, present medical history and abnormal laboratory indicators:",
                "criterions": [
                    {
                        "exact_snippets": "Radiation therapy was administered within 21 days prior to the first administration of study drug",
                        "criterion": "radiation therapy",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": "<=",
                                "value": 21,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "radiation was delivered to ≤5% of bone marrow volume",
                        "criterion": "radiation delivery to bone marrow",
                        "requirement": {
                            "requirement_type": "volume",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Past medical history",
                        "criterion": "past medical history",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "present medical history",
                        "criterion": "present medical history",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "abnormal laboratory indicators",
                        "criterion": "abnormal laboratory indicators",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "condition": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Radiation therapy was administered within 21 days prior to the first administration of study drug",
                                    "criterion": "radiation therapy",
                                    "requirement": {
                                        "requirement_type": "timing",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 21,
                                            "unit": "days"
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "radiation was delivered to ≤5% of bone marrow volume",
                                        "criterion": "radiation delivery to bone marrow",
                                        "requirement": {
                                            "requirement_type": "volume",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 5,
                                                "unit": "%"
                                            }
                                        }
                                    }
                                }
                            ]
                        },
                        "then_criteria": null,
                        "else_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "past medical history",
                                    "criterion": "past medical history",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                },
                                {
                                    "exact_snippets": "present medical history",
                                    "criterion": "present medical history",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                },
                                {
                                    "exact_snippets": "abnormal laboratory indicators",
                                    "criterion": "abnormal laboratory indicators",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Patients with clinically significant bleeding symptoms or obvious bleeding tendency within 4 weeks before the first dose, such as gastrointestinal bleeding, gastric ulcer bleeding, obvious gross hematuria, or angiitis;",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant bleeding symptoms",
                        "criterion": "clinically significant bleeding symptoms",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "obvious bleeding tendency within 4 weeks before the first dose",
                        "criterion": "obvious bleeding tendency",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 4 weeks before the first dose"
                        }
                    },
                    {
                        "exact_snippets": "obvious bleeding tendency within 4 weeks before the first dose",
                        "criterion": "obvious bleeding tendency",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "gastrointestinal bleeding",
                        "criterion": "gastrointestinal bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "gastric ulcer bleeding",
                        "criterion": "gastric ulcer bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "obvious gross hematuria",
                        "criterion": "obvious gross hematuria",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "angiitis",
                        "criterion": "angiitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "not_criteria": {
                                    "exact_snippets": "clinically significant bleeding symptoms",
                                    "criterion": "clinically significant bleeding symptoms",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    }
                                }
                            },
                            {
                                "and_criteria": [
                                    {
                                        "not_criteria": {
                                            "exact_snippets": "obvious bleeding tendency within 4 weeks before the first dose",
                                            "criterion": "obvious bleeding tendency",
                                            "requirement": {
                                                "requirement_type": "presence",
                                                "expected_value": false
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "obvious bleeding tendency within 4 weeks before the first dose",
                                        "criterion": "obvious bleeding tendency",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": "within 4 weeks before the first dose"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}