{
    "info": {
        "nct_id": "NCT05272462",
        "official_title": "A Phase II Trial of Oral Minoxidil for the Treatment of Recurrent Platinum Resistant Epithelial Ovarian Cancer",
        "inclusion_criteria": "Healthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 90 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "Inclusion Criteria\n\n* Participants must have recurrent platinum resistant ovarian cancer. Histologic documentation of the recurrence is not required.\n* Participants must have platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment.\n* Participants must be greater than or equal to 18 years of age.\n* Participants must have an Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2.\n* Participants must be able to take oral medications.\n\nExclusion Criteria\n\n* Participants must not have had chemotherapy or radiotherapy within 4 weeks\n* Participants must not be receiving any other investigational agents.\n* Participants must not have brain metastases\n* Participants must not have allergic reactions to minoxidil\n* Participants must not have congestive heart failure\n* Participants must not have history of cardiac disease\n* Participants must not have uncontrolled hypertension\n* Participants must not be on dialysis"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 90 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 90 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 90 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "* Participants must have recurrent platinum resistant ovarian cancer. Histologic documentation of the recurrence is not required.",
                "criterions": [
                    {
                        "exact_snippets": "recurrent platinum resistant ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "recurrent platinum resistant ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "platinum resistance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "recurrent platinum resistant ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "recurrent platinum resistant ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "platinum resistance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must have platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment.",
                "criterions": [
                    {
                        "exact_snippets": "platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment",
                        "criterion": "platinum resistant disease",
                        "requirement": {
                            "requirement_type": "recurrence time",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment",
                        "criterion": "platinum resistant disease",
                        "requirement": {
                            "requirement_type": "recurrence time",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must be greater than or equal to 18 years of age.",
                "criterions": [
                    {
                        "exact_snippets": "Participants must be greater than or equal to 18 years of age.",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Participants must be greater than or equal to 18 years of age.",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must have an Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2.",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2",
                        "criterion": "ECOG Performance Status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2",
                        "criterion": "ECOG Performance Status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must be able to take oral medications.",
                "criterions": [
                    {
                        "exact_snippets": "Participants must be able to take oral medications.",
                        "criterion": "ability to take oral medications",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Participants must be able to take oral medications.",
                        "criterion": "ability to take oral medications",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not have had chemotherapy or radiotherapy within 4 weeks",
                "criterions": [
                    {
                        "exact_snippets": "Participants must not have had chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Participants must not have had ... radiotherapy within 4 weeks",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Participants must not have had chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Participants must not have had ... radiotherapy within 4 weeks",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not be receiving any other investigational agents.",
                "criterions": [
                    {
                        "exact_snippets": "Participants must not be receiving any other investigational agents.",
                        "criterion": "receiving investigational agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Participants must not be receiving any other investigational agents.",
                    "criterion": "receiving investigational agents",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not have brain metastases",
                "criterions": [
                    {
                        "exact_snippets": "Participants must not have brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Participants must not have brain metastases",
                    "criterion": "brain metastases",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not have allergic reactions to minoxidil",
                "criterions": [
                    {
                        "exact_snippets": "allergic reactions to minoxidil",
                        "criterion": "allergic reactions to minoxidil",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "allergic reactions to minoxidil",
                    "criterion": "allergic reactions to minoxidil",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not have congestive heart failure",
                "criterions": [
                    {
                        "exact_snippets": "must not have congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "must not have congestive heart failure",
                    "criterion": "congestive heart failure",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not have uncontrolled hypertension",
                "criterions": [
                    {
                        "exact_snippets": "uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must not be on dialysis",
                "criterions": [
                    {
                        "exact_snippets": "Participants must not be on dialysis",
                        "criterion": "dialysis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Participants must not be on dialysis",
                    "criterion": "dialysis",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Inclusion Criteria",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Exclusion Criteria",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Participants must not have history of cardiac disease",
                "criterions": [
                    {
                        "exact_snippets": "history of cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "history of cardiac disease",
                    "criterion": "cardiac disease",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}