{
    "info": {
        "nct_id": "NCT04954820",
        "official_title": "A Prospective Randomized Phase II Study Assess the Schema of Retreatment With Lutathera® ([177LU]LU-DOTA-TATE) in Patients With New Progression of Intestinal Well-differenciated Neuroendocrine Tumor",
        "inclusion_criteria": "* Age ≥ 18 years,\n* Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET),\n* Patient previously treated with 4 cycles of Lutathera® (defined as \"First PRRT\"),\n* Disease control after \"First PRRT\" ≥ 12 months,\n* Patient presenting a progression of disease (clinic, biologic and/or radiologic) after a first PRRT,\n* Decision of retreatment with Lutathera® (defined as \"Second PRRT\") validated by RENATEN and/or multidisciplinary tumor board and in the scope of the French reimbursement process,\n* ECOG performance status 0-2,\n* Life expectancy ≥ 6 months as prognosticated by the physician,\n* Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion : (may be PET imaging (68Ga-based SSTR analogues) or scintigraphy imaging: 111In-pentetreotide or 99mTc-octreotide. At least 90% of lesions must be positive for SSTRi with a significant uptake (>= liver of surrounding tissue),\n* Measurable disease per RECIST 1.1 (Appendix 1), on CT/MRI scans, defined as at least 1 lesion with ≥ 1 cm in longest diameter, and ≥ 2 radiological tumors lesions in total,\n* Adequate bone marrow reserve (Hb > 8 g/dl, neutrophils ≥ 1500/mm³ and platelets ≥ 80 000/mm³),\n* Negative pregnancy test in women of childbearing potential (the β-HCG dosage must be ≤ 4 days before inclusion). Women who have no reproductive potential are postmenopausal women or women who have had permanent sterilization, eg. tubal occlusion, hysterectomy, bilateral salpingectomy),\n* Effective contraception in men or women of childbearing or pre-menopausal age and up to a minimum of 6 months following the end of treatment,\n* Patient´s signed written informed consent,\n* Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests and other study procedures,\n* Affiliation to the French Social Security System\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patient who did not respond (no CR, PR or SD) to \"first PRRT\".\n* Radiological progression after two cycles of \"Second PRRT\" according to RECIST version 1.1,\n* Grade 4 hematotoxicity and/or nephrotoxicity during the initial PRRT, or unresolved AEs categorized as Grade 2 or higher (as per Common Terminology Criteria for Adverse Events (CTCAE v5.0) from previous PRRT cycles or any other therapy for NET, excluding alopecia and peripheral neuropathy,\n* Pancreatic NET,\n* NeuroEndocrine Carcinoma,\n* Prior external beam radiation therapy to more than 25% of the bone marrow,\n* Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) < 40 mL/min or nephrotic syndrome) or hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) > 2.5 x ULN or ALT/AST > 5 x ULN if liver function abnormalities are due to the underlying malignancy and/or total serum bilirubin > 2.5 x ULN),\n* Serum albumin < 3.0 g/dL unless prothrombin time is within the normal range,\n* Uncontrolled diabetes mellitus as defined by a fasting blood glucose above 2 ULN,\n* Uncontrolled decompensated heart failure, myocardial infarction uncontrolled, stroke, pulmonary embolism or revascularization procedure, unstable angina pectoris, uncontrolled cardiac arrhythmia, and clinically significant bradycardia during the last 12 months,\n* Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy)\n* Brain metastases (unless these metastases have been treated and stabilized for at least 24 weeks, prior to enrolment in the study. Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease prior to enrolment in the study),\n* Pregnancy or breast feeding,\n* Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results,\n* Known hypersensitivity to any of the study drugs, study drug classes, or any constituent of the products,\n* Concomitant participation or participation within the last 30 days in another clinical trial,\n* History of other solid tumor in 5 years before the inclusion excepted of cancer in situ of the cervix and skin cancer (basal or squamous cell) treated and controlled.\n* Legal incapacity or physical, psychological or mental status interfering with the patient's ability to sign the informed consent or to terminate the study.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age ≥ 18 years,",
                "criterions": [
                    {
                        "exact_snippets": "Age ≥ 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age ≥ 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET),",
                "criterions": [
                    {
                        "exact_snippets": "Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET)",
                        "criterion": "intestinal neuroendocrine tumors (NET)",
                        "requirement": {
                            "requirement_type": "histological proof",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET)",
                        "criterion": "intestinal neuroendocrine tumors (NET)",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": [
                                "G1",
                                "G2"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET)",
                        "criterion": "intestinal neuroendocrine tumors (NET)",
                        "requirement": {
                            "requirement_type": "histological proof",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET)",
                        "criterion": "intestinal neuroendocrine tumors (NET)",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": [
                                "G1",
                                "G2"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient previously treated with 4 cycles of Lutathera® (defined as \"First PRRT\"),",
                "criterions": [
                    {
                        "exact_snippets": "Patient previously treated with 4 cycles of Lutathera®",
                        "criterion": "treatment with Lutathera®",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "=",
                                "value": 4,
                                "unit": "cycles"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient previously treated with 4 cycles of Lutathera®",
                        "criterion": "treatment with Lutathera®",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "=",
                                "value": 4,
                                "unit": "cycles"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG performance status 0-2,",
                "criterions": [
                    {
                        "exact_snippets": "ECOG performance status 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG performance status 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy ≥ 6 months as prognosticated by the physician,",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy ≥ 6 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy ≥ 6 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion : (may be PET imaging (68Ga-based SSTR analogues) or scintigraphy imaging: 111In-pentetreotide or 99mTc-octreotide. At least 90% of lesions must be positive for SSTRi with a significant uptake (>= liver of surrounding tissue),",
                "criterions": [
                    {
                        "exact_snippets": "Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion",
                        "criterion": "SSTRi+ disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion",
                        "criterion": "SSTRi+ disease",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 4 months prior to inclusion"
                        }
                    },
                    {
                        "exact_snippets": "PET imaging (68Ga-based SSTR analogues) or scintigraphy imaging: 111In-pentetreotide or 99mTc-octreotide",
                        "criterion": "imaging method",
                        "requirement": {
                            "requirement_type": "allowed methods",
                            "expected_value": [
                                "PET imaging (68Ga-based SSTR analogues)",
                                "scintigraphy imaging: 111In-pentetreotide",
                                "scintigraphy imaging: 99mTc-octreotide"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "At least 90% of lesions must be positive for SSTRi",
                        "criterion": "lesion positivity for SSTRi",
                        "requirement": {
                            "requirement_type": "percentage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 90,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least 90% of lesions must be positive for SSTRi",
                        "criterion": "lesion positivity for SSTRi",
                        "requirement": {
                            "requirement_type": "positivity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "significant uptake (>= liver of surrounding tissue)",
                        "criterion": "uptake level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "liver of surrounding tissue"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "exact_snippets": "Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion",
                                                        "criterion": "SSTRi+ disease",
                                                        "requirement": {
                                                            "requirement_type": "presence",
                                                            "expected_value": true
                                                        }
                                                    },
                                                    {
                                                        "exact_snippets": "Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion",
                                                        "criterion": "SSTRi+ disease",
                                                        "requirement": {
                                                            "requirement_type": "time frame",
                                                            "expected_value": "within 4 months prior to inclusion"
                                                        }
                                                    }
                                                ]
                                            },
                                            {
                                                "exact_snippets": "PET imaging (68Ga-based SSTR analogues) or scintigraphy imaging: 111In-pentetreotide or 99mTc-octreotide",
                                                "criterion": "imaging method",
                                                "requirement": {
                                                    "requirement_type": "allowed methods",
                                                    "expected_value": [
                                                        "PET imaging (68Ga-based SSTR analogues)",
                                                        "scintigraphy imaging: 111In-pentetreotide",
                                                        "scintigraphy imaging: 99mTc-octreotide"
                                                    ]
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "At least 90% of lesions must be positive for SSTRi",
                                                "criterion": "lesion positivity for SSTRi",
                                                "requirement": {
                                                    "requirement_type": "percentage",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 90,
                                                        "unit": "%"
                                                    }
                                                }
                                            },
                                            {
                                                "exact_snippets": "At least 90% of lesions must be positive for SSTRi",
                                                "criterion": "lesion positivity for SSTRi",
                                                "requirement": {
                                                    "requirement_type": "positivity",
                                                    "expected_value": true
                                                }
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "significant uptake (>= liver of surrounding tissue)",
                                "criterion": "uptake level",
                                "requirement": {
                                    "requirement_type": "comparison",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "liver of surrounding tissue"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease per RECIST 1.1 (Appendix 1), on CT/MRI scans, defined as at least 1 lesion with ≥ 1 cm in longest diameter, and ≥ 2 radiological tumors lesions in total,",
                "criterions": [
                    {
                        "exact_snippets": "Measurable disease per RECIST 1.1",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "standard",
                            "expected_value": "RECIST 1.1"
                        }
                    },
                    {
                        "exact_snippets": "on CT/MRI scans",
                        "criterion": "imaging modality",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "CT",
                                "MRI"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "at least 1 lesion with ≥ 1 cm in longest diameter",
                        "criterion": "lesion size",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "cm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "≥ 2 radiological tumors lesions in total",
                        "criterion": "number of tumor lesions",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "lesions"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Measurable disease per RECIST 1.1",
                                "criterion": "measurable disease",
                                "requirement": {
                                    "requirement_type": "standard",
                                    "expected_value": "RECIST 1.1"
                                }
                            },
                            {
                                "exact_snippets": "on CT/MRI scans",
                                "criterion": "imaging modality",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": [
                                        "CT",
                                        "MRI"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "at least 1 lesion with ≥ 1 cm in longest diameter",
                                "criterion": "lesion size",
                                "requirement": {
                                    "requirement_type": "size",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "cm"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "≥ 2 radiological tumors lesions in total",
                                "criterion": "number of tumor lesions",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "lesions"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate bone marrow reserve (Hb > 8 g/dl, neutrophils ≥ 1500/mm³ and platelets ≥ 80 000/mm³),",
                "criterions": [
                    {
                        "exact_snippets": "Adequate bone marrow reserve (Hb > 8 g/dl",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 8,
                                "unit": "g/dl"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate bone marrow reserve ... neutrophils ≥ 1500/mm³",
                        "criterion": "neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm³"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate bone marrow reserve ... platelets ≥ 80 000/mm³",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 80000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate bone marrow reserve (Hb > 8 g/dl",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 8,
                                "unit": "g/dl"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate bone marrow reserve ... neutrophils ≥ 1500/mm³",
                        "criterion": "neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm³"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate bone marrow reserve ... platelets ≥ 80 000/mm³",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 80000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test in women of childbearing potential (the β-HCG dosage must be ≤ 4 days before inclusion). Women who have no reproductive potential are postmenopausal women or women who have had permanent sterilization, eg. tubal occlusion, hysterectomy, bilateral salpingectomy),",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test in women of childbearing potential",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "Women who have no reproductive potential are postmenopausal women",
                        "criterion": "reproductive potential",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "postmenopausal"
                        }
                    },
                    {
                        "exact_snippets": "Women who have no reproductive potential are ... women who have had permanent sterilization, eg. tubal occlusion, hysterectomy, bilateral salpingectomy",
                        "criterion": "reproductive potential",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "permanent sterilization"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Negative pregnancy test in women of childbearing potential",
                                "criterion": "pregnancy test",
                                "requirement": {
                                    "requirement_type": "result",
                                    "expected_value": "negative"
                                }
                            },
                            {
                                "exact_snippets": "Negative pregnancy test in women of childbearing potential (the β-HCG dosage must be ≤ 4 days before inclusion)",
                                "criterion": "β-HCG dosage timing",
                                "requirement": {
                                    "requirement_type": "timing",
                                    "expected_value": "≤ 4 days before inclusion"
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Women who have no reproductive potential are postmenopausal women",
                                "criterion": "reproductive potential",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "postmenopausal"
                                }
                            },
                            {
                                "exact_snippets": "Women who have no reproductive potential are ... women who have had permanent sterilization, eg. tubal occlusion, hysterectomy, bilateral salpingectomy",
                                "criterion": "reproductive potential",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "permanent sterilization"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Effective contraception in men or women of childbearing or pre-menopausal age and up to a minimum of 6 months following the end of treatment,",
                "criterions": [
                    {
                        "exact_snippets": "Effective contraception in men or women of childbearing or pre-menopausal age",
                        "criterion": "contraception",
                        "requirement": {
                            "requirement_type": "effectiveness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "men or women of childbearing or pre-menopausal age",
                        "criterion": "age group",
                        "requirement": {
                            "requirement_type": "description",
                            "expected_value": [
                                "childbearing",
                                "pre-menopausal"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "up to a minimum of 6 months following the end of treatment",
                        "criterion": "contraception duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Effective contraception in men or women of childbearing or pre-menopausal age",
                                        "criterion": "contraception",
                                        "requirement": {
                                            "requirement_type": "effectiveness",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "men or women of childbearing or pre-menopausal age",
                                        "criterion": "age group",
                                        "requirement": {
                                            "requirement_type": "description",
                                            "expected_value": [
                                                "childbearing",
                                                "pre-menopausal"
                                            ]
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Effective contraception in men or women of childbearing or pre-menopausal age",
                                "criterion": "contraception",
                                "requirement": {
                                    "requirement_type": "effectiveness",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "up to a minimum of 6 months following the end of treatment",
                        "criterion": "contraception duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient´s signed written informed consent,",
                "criterions": [
                    {
                        "exact_snippets": "Patient´s signed written informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient´s signed written informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests and other study procedures,",
                "criterions": [
                    {
                        "exact_snippets": "Willingness and ability to comply with scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... treatment plan",
                        "criterion": "compliance with treatment plan",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... treatment plan",
                        "criterion": "compliance with treatment plan",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... laboratory tests",
                        "criterion": "compliance with laboratory tests",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... laboratory tests",
                        "criterion": "compliance with laboratory tests",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... other study procedures",
                        "criterion": "compliance with other study procedures",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... other study procedures",
                        "criterion": "compliance with other study procedures",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "and_criteria": [
                                                            {
                                                                "and_criteria": [
                                                                    {
                                                                        "and_criteria": [
                                                                            {
                                                                                "exact_snippets": "Willingness and ability to comply with scheduled visits",
                                                                                "criterion": "compliance with scheduled visits",
                                                                                "requirement": {
                                                                                    "requirement_type": "willingness",
                                                                                    "expected_value": true
                                                                                }
                                                                            },
                                                                            {
                                                                                "exact_snippets": "Willingness and ability to comply with scheduled visits",
                                                                                "criterion": "compliance with scheduled visits",
                                                                                "requirement": {
                                                                                    "requirement_type": "ability",
                                                                                    "expected_value": true
                                                                                }
                                                                            }
                                                                        ]
                                                                    },
                                                                    {
                                                                        "exact_snippets": "Willingness and ability to comply with ... treatment plan",
                                                                        "criterion": "compliance with treatment plan",
                                                                        "requirement": {
                                                                            "requirement_type": "willingness",
                                                                            "expected_value": true
                                                                        }
                                                                    }
                                                                ]
                                                            },
                                                            {
                                                                "exact_snippets": "Willingness and ability to comply with ... treatment plan",
                                                                "criterion": "compliance with treatment plan",
                                                                "requirement": {
                                                                    "requirement_type": "ability",
                                                                    "expected_value": true
                                                                }
                                                            }
                                                        ]
                                                    },
                                                    {
                                                        "exact_snippets": "Willingness and ability to comply with ... laboratory tests",
                                                        "criterion": "compliance with laboratory tests",
                                                        "requirement": {
                                                            "requirement_type": "willingness",
                                                            "expected_value": true
                                                        }
                                                    }
                                                ]
                                            },
                                            {
                                                "exact_snippets": "Willingness and ability to comply with ... laboratory tests",
                                                "criterion": "compliance with laboratory tests",
                                                "requirement": {
                                                    "requirement_type": "ability",
                                                    "expected_value": true
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "Willingness and ability to comply with ... other study procedures",
                                        "criterion": "compliance with other study procedures",
                                        "requirement": {
                                            "requirement_type": "willingness",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Willingness and ability to comply with ... other study procedures",
                                "criterion": "compliance with other study procedures",
                                "requirement": {
                                    "requirement_type": "ability",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Radiological progression after two cycles of \"Second PRRT\" according to RECIST version 1.1,",
                "criterions": [
                    {
                        "exact_snippets": "Radiological progression after two cycles of \"Second PRRT\" according to RECIST version 1.1",
                        "criterion": "radiological progression",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "after two cycles of \"Second PRRT\""
                        }
                    },
                    {
                        "exact_snippets": "Radiological progression after two cycles of \"Second PRRT\" according to RECIST version 1.1",
                        "criterion": "radiological progression",
                        "requirement": {
                            "requirement_type": "assessment method",
                            "expected_value": "RECIST version 1.1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiological progression after two cycles of \"Second PRRT\" according to RECIST version 1.1",
                        "criterion": "radiological progression",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "after two cycles of \"Second PRRT\""
                        }
                    },
                    {
                        "exact_snippets": "Radiological progression after two cycles of \"Second PRRT\" according to RECIST version 1.1",
                        "criterion": "radiological progression",
                        "requirement": {
                            "requirement_type": "assessment method",
                            "expected_value": "RECIST version 1.1"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Grade 4 hematotoxicity and/or nephrotoxicity during the initial PRRT, or unresolved AEs categorized as Grade 2 or higher (as per Common Terminology Criteria for Adverse Events (CTCAE v5.0) from previous PRRT cycles or any other therapy for NET, excluding alopecia and peripheral neuropathy,",
                "criterions": [
                    {
                        "exact_snippets": "Grade 4 hematotoxicity",
                        "criterion": "hematotoxicity",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "Grade 4"
                        }
                    },
                    {
                        "exact_snippets": "Grade 4 ... nephrotoxicity",
                        "criterion": "nephrotoxicity",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "Grade 4"
                        }
                    },
                    {
                        "exact_snippets": "unresolved AEs categorized as Grade 2 or higher",
                        "criterion": "adverse events",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "Grade"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "excluding alopecia and peripheral neuropathy",
                        "criterion": "adverse events",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": [
                                "alopecia",
                                "peripheral neuropathy"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Grade 4 hematotoxicity",
                                        "criterion": "hematotoxicity",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "Grade 4"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Grade 4 ... nephrotoxicity",
                                        "criterion": "nephrotoxicity",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "Grade 4"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "unresolved AEs categorized as Grade 2 or higher",
                                        "criterion": "adverse events",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": ">=",
                                                        "value": 2,
                                                        "unit": "Grade"
                                                    }
                                                ]
                                            }
                                        }
                                    },
                                    {
                                        "not_criteria": {
                                            "exact_snippets": "excluding alopecia and peripheral neuropathy",
                                            "criterion": "adverse events",
                                            "requirement": {
                                                "requirement_type": "exclusion",
                                                "expected_value": [
                                                    "alopecia",
                                                    "peripheral neuropathy"
                                                ]
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pancreatic NET,",
                "criterions": [
                    {
                        "exact_snippets": "Pancreatic NET",
                        "criterion": "Pancreatic NET",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Pancreatic NET",
                    "criterion": "Pancreatic NET",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* NeuroEndocrine Carcinoma,",
                "criterions": [
                    {
                        "exact_snippets": "NeuroEndocrine Carcinoma",
                        "criterion": "NeuroEndocrine Carcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "NeuroEndocrine Carcinoma",
                    "criterion": "NeuroEndocrine Carcinoma",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior external beam radiation therapy to more than 25% of the bone marrow,",
                "criterions": [
                    {
                        "exact_snippets": "Prior external beam radiation therapy to more than 25% of the bone marrow",
                        "criterion": "external beam radiation therapy to bone marrow",
                        "requirement": {
                            "requirement_type": "extent",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Prior external beam radiation therapy to more than 25% of the bone marrow",
                        "criterion": "external beam radiation therapy to bone marrow",
                        "requirement": {
                            "requirement_type": "extent",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) < 40 mL/min or nephrotic syndrome) or hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) > 2.5 x ULN or ALT/AST > 5 x ULN if liver function abnormalities are due to the underlying malignancy and/or total serum bilirubin > 2.5 x ULN),",
                "criterions": [
                    {
                        "exact_snippets": "Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) < 40 mL/min",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    },
                    {
                        "exact_snippets": "Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) < 40 mL/min",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "GFR",
                            "expected_value": {
                                "operator": "<",
                                "value": 40,
                                "unit": "mL/min"
                            }
                        }
                    },
                    {
                        "exact_snippets": "nephrotic syndrome",
                        "criterion": "nephrotic syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) > 2.5 x ULN",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "insufficiency"
                        }
                    },
                    {
                        "exact_snippets": "hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) > 2.5 x ULN",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "ALT/AST",
                            "expected_value": {
                                "operator": ">",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ALT/AST > 5 x ULN if liver function abnormalities are due to the underlying malignancy",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "ALT/AST",
                            "expected_value": {
                                "operator": ">",
                                "value": 5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "total serum bilirubin > 2.5 x ULN",
                        "criterion": "total serum bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) < 40 mL/min",
                                        "criterion": "renal function",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "severe"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) < 40 mL/min",
                                        "criterion": "renal function",
                                        "requirement": {
                                            "requirement_type": "GFR",
                                            "expected_value": {
                                                "operator": "<",
                                                "value": 40,
                                                "unit": "mL/min"
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "nephrotic syndrome",
                                "criterion": "nephrotic syndrome",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) > 2.5 x ULN",
                                        "criterion": "hepatic function",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "insufficiency"
                                        }
                                    },
                                    {
                                        "exact_snippets": "hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) > 2.5 x ULN",
                                        "criterion": "hepatic function",
                                        "requirement": {
                                            "requirement_type": "ALT/AST",
                                            "expected_value": {
                                                "operator": ">",
                                                "value": 2.5,
                                                "unit": "x ULN"
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "ALT/AST > 5 x ULN if liver function abnormalities are due to the underlying malignancy",
                                        "criterion": "hepatic function",
                                        "requirement": {
                                            "requirement_type": "ALT/AST",
                                            "expected_value": {
                                                "operator": ">",
                                                "value": 5,
                                                "unit": "x ULN"
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "total serum bilirubin > 2.5 x ULN",
                                "criterion": "total serum bilirubin",
                                "requirement": {
                                    "requirement_type": "level",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 2.5,
                                        "unit": "x ULN"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serum albumin < 3.0 g/dL unless prothrombin time is within the normal range,",
                "criterions": [
                    {
                        "exact_snippets": "Serum albumin < 3.0 g/dL",
                        "criterion": "serum albumin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3.0,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "prothrombin time is within the normal range",
                        "criterion": "prothrombin time",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": "within the normal range"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Serum albumin < 3.0 g/dL",
                    "criterion": "serum albumin",
                    "requirement": {
                        "requirement_type": "level",
                        "expected_value": {
                            "operator": "<",
                            "value": 3.0,
                            "unit": "g/dL"
                        }
                    }
                },
                "then_criteria": {
                    "not_criteria": {
                        "exact_snippets": "prothrombin time is within the normal range",
                        "criterion": "prothrombin time",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": "within the normal range"
                        }
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled diabetes mellitus as defined by a fasting blood glucose above 2 ULN,",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled diabetes mellitus",
                        "criterion": "diabetes mellitus",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "fasting blood glucose above 2 ULN",
                        "criterion": "fasting blood glucose",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Uncontrolled diabetes mellitus",
                        "criterion": "diabetes mellitus",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "fasting blood glucose above 2 ULN",
                        "criterion": "fasting blood glucose",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled decompensated heart failure, myocardial infarction uncontrolled, stroke, pulmonary embolism or revascularization procedure, unstable angina pectoris, uncontrolled cardiac arrhythmia, and clinically significant bradycardia during the last 12 months,",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled decompensated heart failure",
                        "criterion": "decompensated heart failure",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "myocardial infarction uncontrolled",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "stroke ... during the last 12 months",
                        "criterion": "stroke",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 12,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "pulmonary embolism ... during the last 12 months",
                        "criterion": "pulmonary embolism",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 12,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "revascularization procedure ... during the last 12 months",
                        "criterion": "revascularization procedure",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 12,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "unstable angina pectoris",
                        "criterion": "angina pectoris",
                        "requirement": {
                            "requirement_type": "stability",
                            "expected_value": "unstable"
                        }
                    },
                    {
                        "exact_snippets": "uncontrolled cardiac arrhythmia",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "clinically significant bradycardia ... during the last 12 months",
                        "criterion": "bradycardia",
                        "requirement": {
                            "requirement_type": "clinical significance",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "clinically significant bradycardia ... during the last 12 months",
                        "criterion": "bradycardia",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 12,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Uncontrolled decompensated heart failure",
                                        "criterion": "decompensated heart failure",
                                        "requirement": {
                                            "requirement_type": "control status",
                                            "expected_value": "uncontrolled"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "myocardial infarction uncontrolled",
                                        "criterion": "myocardial infarction",
                                        "requirement": {
                                            "requirement_type": "control status",
                                            "expected_value": "uncontrolled"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "stroke ... during the last 12 months",
                                        "criterion": "stroke",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 12,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "pulmonary embolism ... during the last 12 months",
                                        "criterion": "pulmonary embolism",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 12,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "revascularization procedure ... during the last 12 months",
                                        "criterion": "revascularization procedure",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 12,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "unstable angina pectoris",
                                        "criterion": "angina pectoris",
                                        "requirement": {
                                            "requirement_type": "stability",
                                            "expected_value": "unstable"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "uncontrolled cardiac arrhythmia",
                                        "criterion": "cardiac arrhythmia",
                                        "requirement": {
                                            "requirement_type": "control status",
                                            "expected_value": "uncontrolled"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "clinically significant bradycardia ... during the last 12 months",
                                        "criterion": "bradycardia",
                                        "requirement": {
                                            "requirement_type": "clinical significance",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "clinically significant bradycardia ... during the last 12 months",
                                        "criterion": "bradycardia",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 12,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy)",
                "criterions": [
                    {
                        "exact_snippets": "Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy)",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy)",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 160,
                                        "unit": "mmHg"
                                    },
                                    {
                                        "operator": ">=",
                                        "value": 95,
                                        "unit": "mmHg"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy)",
                                "criterion": "hypertension",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy)",
                                "criterion": "hypertension",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">=",
                                                "value": 160,
                                                "unit": "mmHg"
                                            },
                                            {
                                                "operator": ">=",
                                                "value": 95,
                                                "unit": "mmHg"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Brain metastases (unless these metastases have been treated and stabilized for at least 24 weeks, prior to enrolment in the study. Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease prior to enrolment in the study),",
                "criterions": [
                    {
                        "exact_snippets": "Brain metastases (unless these metastases have been treated and stabilized for at least 24 weeks",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "treatment and stabilization duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 24,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease",
                        "criterion": "history of brain metastases",
                        "requirement": {
                            "requirement_type": "imaging requirement",
                            "expected_value": [
                                "head CT scan with contrast",
                                "MRI"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease",
                        "criterion": "history of brain metastases",
                        "requirement": {
                            "requirement_type": "disease status",
                            "expected_value": "stable"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "not_criteria": {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Brain metastases (unless these metastases have been treated and stabilized for at least 24 weeks",
                                                "criterion": "brain metastases",
                                                "requirement": {
                                                    "requirement_type": "treatment and stabilization duration",
                                                    "expected_value": {
                                                        "operator": ">=",
                                                        "value": 24,
                                                        "unit": "weeks"
                                                    }
                                                }
                                            },
                                            {
                                                "and_criteria": [
                                                    {
                                                        "exact_snippets": "Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease",
                                                        "criterion": "history of brain metastases",
                                                        "requirement": {
                                                            "requirement_type": "imaging requirement",
                                                            "expected_value": [
                                                                "head CT scan with contrast",
                                                                "MRI"
                                                            ]
                                                        }
                                                    },
                                                    {
                                                        "exact_snippets": "Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease",
                                                        "criterion": "history of brain metastases",
                                                        "requirement": {
                                                            "requirement_type": "disease status",
                                                            "expected_value": "stable"
                                                        }
                                                    }
                                                ]
                                            }
                                        ]
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "Brain metastases (unless these metastases have been treated and stabilized for at least 24 weeks",
                                        "criterion": "brain metastases",
                                        "requirement": {
                                            "requirement_type": "treatment and stabilization duration",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 24,
                                                "unit": "weeks"
                                            }
                                        }
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnancy or breast feeding,",
                "criterions": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results,",
                "criterions": [
                    {
                        "exact_snippets": "Substance abuse ... may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "substance abuse",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "medical ... conditions that may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "medical conditions",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "psychological ... conditions that may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "psychological conditions",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "social conditions that may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "social conditions",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Substance abuse ... may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "substance abuse",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "medical ... conditions that may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "medical conditions",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "psychological ... conditions that may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "psychological conditions",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "social conditions that may interfere with the patient's participation in the study or evaluation of the study results",
                        "criterion": "social conditions",
                        "requirement": {
                            "requirement_type": "interference with study participation or evaluation",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Known hypersensitivity to any of the study drugs, study drug classes, or any constituent of the products,",
                "criterions": [
                    {
                        "exact_snippets": "Known hypersensitivity to any of the study drugs",
                        "criterion": "hypersensitivity to study drugs",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... study drug classes",
                        "criterion": "hypersensitivity to study drug classes",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... any constituent of the products",
                        "criterion": "hypersensitivity to constituents of the products",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Known hypersensitivity to any of the study drugs",
                        "criterion": "hypersensitivity to study drugs",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... study drug classes",
                        "criterion": "hypersensitivity to study drug classes",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... any constituent of the products",
                        "criterion": "hypersensitivity to constituents of the products",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concomitant participation or participation within the last 30 days in another clinical trial,",
                "criterions": [
                    {
                        "exact_snippets": "Concomitant participation ... in another clinical trial",
                        "criterion": "concomitant participation in another clinical trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "participation within the last 30 days in another clinical trial",
                        "criterion": "participation in another clinical trial within the last 30 days",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Concomitant participation ... in another clinical trial",
                        "criterion": "concomitant participation in another clinical trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "participation within the last 30 days in another clinical trial",
                        "criterion": "participation in another clinical trial within the last 30 days",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History of other solid tumor in 5 years before the inclusion excepted of cancer in situ of the cervix and skin cancer (basal or squamous cell) treated and controlled.",
                "criterions": [
                    {
                        "exact_snippets": "History of other solid tumor in 5 years before the inclusion",
                        "criterion": "history of other solid tumor",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "excepted of cancer in situ of the cervix",
                        "criterion": "cancer in situ of the cervix",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "excepted of ... skin cancer (basal or squamous cell) treated and controlled",
                        "criterion": "skin cancer (basal or squamous cell)",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "excepted of ... skin cancer (basal or squamous cell) treated and controlled",
                        "criterion": "skin cancer (basal or squamous cell)",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "treated and controlled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "History of other solid tumor in 5 years before the inclusion",
                                    "criterion": "history of other solid tumor",
                                    "requirement": {
                                        "requirement_type": "time frame",
                                        "expected_value": {
                                            "comparisons": [
                                                {
                                                    "operator": "<=",
                                                    "value": 5,
                                                    "unit": "years"
                                                }
                                            ]
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "or_criteria": [
                                            {
                                                "exact_snippets": "excepted of cancer in situ of the cervix",
                                                "criterion": "cancer in situ of the cervix",
                                                "requirement": {
                                                    "requirement_type": "exclusion",
                                                    "expected_value": true
                                                }
                                            },
                                            {
                                                "and_criteria": [
                                                    {
                                                        "exact_snippets": "excepted of ... skin cancer (basal or squamous cell) treated and controlled",
                                                        "criterion": "skin cancer (basal or squamous cell)",
                                                        "requirement": {
                                                            "requirement_type": "exclusion",
                                                            "expected_value": true
                                                        }
                                                    },
                                                    {
                                                        "exact_snippets": "excepted of ... skin cancer (basal or squamous cell) treated and controlled",
                                                        "criterion": "skin cancer (basal or squamous cell)",
                                                        "requirement": {
                                                            "requirement_type": "treatment status",
                                                            "expected_value": "treated and controlled"
                                                        }
                                                    }
                                                ]
                                            }
                                        ]
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Legal incapacity or physical, psychological or mental status interfering with the patient's ability to sign the informed consent or to terminate the study.",
                "criterions": [
                    {
                        "exact_snippets": "Legal incapacity",
                        "criterion": "legal capacity",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "incapacity"
                        }
                    },
                    {
                        "exact_snippets": "physical, psychological or mental status interfering with the patient's ability to sign the informed consent or to terminate the study",
                        "criterion": "physical, psychological or mental status",
                        "requirement": {
                            "requirement_type": "interference with ability",
                            "expected_value": "sign informed consent or terminate the study"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Legal incapacity",
                        "criterion": "legal capacity",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "incapacity"
                        }
                    },
                    {
                        "exact_snippets": "physical, psychological or mental status interfering with the patient's ability to sign the informed consent or to terminate the study",
                        "criterion": "physical, psychological or mental status",
                        "requirement": {
                            "requirement_type": "interference with ability",
                            "expected_value": "sign informed consent or terminate the study"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Disease control after \"First PRRT\" ≥ 12 months,",
                "criterions": [
                    {
                        "exact_snippets": "Disease control after \"First PRRT\" ≥ 12 months",
                        "criterion": "disease control duration after First PRRT",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease control after \"First PRRT\"  12 months",
                        "criterion": "disease control duration after First PRRT",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient presenting a progression of disease (clinic, biologic and/or radiologic) after a first PRRT,",
                "criterions": [
                    {
                        "exact_snippets": "progression of disease (clinic, biologic and/or radiologic)",
                        "criterion": "progression of disease",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "clinic",
                                "biologic",
                                "radiologic"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "after a first PRRT",
                        "criterion": "prior treatment",
                        "requirement": {
                            "requirement_type": "treatment type",
                            "expected_value": "PRRT"
                        }
                    },
                    {
                        "exact_snippets": "after a first PRRT",
                        "criterion": "prior treatment",
                        "requirement": {
                            "requirement_type": "treatment count",
                            "expected_value": {
                                "operator": "=",
                                "value": 1,
                                "unit": "treatment"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "progression of disease (clinic, biologic and/or radiologic)",
                                        "criterion": "progression of disease",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "clinic"
                                        }
                                    },
                                    {
                                        "exact_snippets": "progression of disease (clinic, biologic and/or radiologic)",
                                        "criterion": "progression of disease",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "biologic"
                                        }
                                    },
                                    {
                                        "exact_snippets": "progression of disease (clinic, biologic and/or radiologic)",
                                        "criterion": "progression of disease",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "radiologic"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "after a first PRRT",
                                        "criterion": "prior treatment",
                                        "requirement": {
                                            "requirement_type": "treatment type",
                                            "expected_value": "PRRT"
                                        }
                                    },
                                    {
                                        "exact_snippets": "after a first PRRT",
                                        "criterion": "prior treatment",
                                        "requirement": {
                                            "requirement_type": "treatment count",
                                            "expected_value": {
                                                "operator": "=",
                                                "value": 1,
                                                "unit": "treatment"
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Decision of retreatment with Lutathera® (defined as \"Second PRRT\") validated by RENATEN and/or multidisciplinary tumor board and in the scope of the French reimbursement process,",
                "criterions": [
                    {
                        "exact_snippets": "Decision of retreatment with Lutathera® ... validated by RENATEN and/or multidisciplinary tumor board",
                        "criterion": "retreatment with Lutathera®",
                        "requirement": {
                            "requirement_type": "validation",
                            "expected_value": [
                                "RENATEN",
                                "multidisciplinary tumor board"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Decision of retreatment with Lutathera® ... in the scope of the French reimbursement process",
                        "criterion": "retreatment with Lutathera®",
                        "requirement": {
                            "requirement_type": "scope",
                            "expected_value": "French reimbursement process"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Decision of retreatment with Lutathera® ... validated by RENATEN and/or multidisciplinary tumor board",
                                "criterion": "retreatment with Lutathera®",
                                "requirement": {
                                    "requirement_type": "validation",
                                    "expected_value": "RENATEN"
                                }
                            },
                            {
                                "exact_snippets": "Decision of retreatment with Lutathera® ... validated by RENATEN and/or multidisciplinary tumor board",
                                "criterion": "retreatment with Lutathera®",
                                "requirement": {
                                    "requirement_type": "validation",
                                    "expected_value": "multidisciplinary tumor board"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Decision of retreatment with Lutathera® ... in the scope of the French reimbursement process",
                        "criterion": "retreatment with Lutathera®",
                        "requirement": {
                            "requirement_type": "scope",
                            "expected_value": "French reimbursement process"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Affiliation to the French Social Security System",
                "criterions": [
                    {
                        "exact_snippets": "Affiliation to the French Social Security System",
                        "criterion": "affiliation to the French Social Security System",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Patient who did not respond (no CR, PR or SD) to \"first PRRT\".",
                "criterions": [
                    {
                        "exact_snippets": "Patient who did not respond (no CR, PR or SD) to \"first PRRT\".",
                        "criterion": "response to first PRRT",
                        "requirement": {
                            "requirement_type": "response",
                            "expected_value": [
                                "CR",
                                "PR",
                                "SD"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}