{
    "info": {
        "nct_id": "NCT04547465",
        "official_title": "The Role of 2D Speckle-tracking Echocardiography in Diagnosis Chemotherapy-induced Cardiomyopathy in Breast Cancer Patients With High Cardiovascular Risk Factors",
        "inclusion_criteria": "* Breast cancer patients treated by anthracycline and/or trastuzumab\n* Have at least one of these cardiovascular risks: age > 60, hypertension, atrial fibrillation, diabetes mellitus, dyslipidemia, chronic kidney disease, obesity, family history of cardiovascular diseases.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Left ventricular ejection fraction < 50% before chemotherapy\n* Chronic heart failure with NYHA functional class >= II\n* Significant valvular stenosis/regurgitation\n* Acute heart failure due to acute coronary syndrome during follow-up",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Breast cancer patients treated by anthracycline and/or trastuzumab",
                "criterions": [
                    {
                        "exact_snippets": "Breast cancer patients",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "treated by anthracycline",
                        "criterion": "anthracycline treatment",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "treated by ... trastuzumab",
                        "criterion": "trastuzumab treatment",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Breast cancer patients",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "treated by anthracycline",
                                        "criterion": "anthracycline treatment",
                                        "requirement": {
                                            "requirement_type": "treatment",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "treated by ... trastuzumab",
                                        "criterion": "trastuzumab treatment",
                                        "requirement": {
                                            "requirement_type": "treatment",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have at least one of these cardiovascular risks: age > 60, hypertension, atrial fibrillation, diabetes mellitus, dyslipidemia, chronic kidney disease, obesity, family history of cardiovascular diseases.",
                "criterions": [
                    {
                        "exact_snippets": "age > 60",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 60,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "atrial fibrillation",
                        "criterion": "atrial fibrillation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "diabetes mellitus",
                        "criterion": "diabetes mellitus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "dyslipidemia",
                        "criterion": "dyslipidemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "chronic kidney disease",
                        "criterion": "chronic kidney disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "obesity",
                        "criterion": "obesity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "family history of cardiovascular diseases",
                        "criterion": "family history of cardiovascular diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "age > 60",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 60,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "atrial fibrillation",
                        "criterion": "atrial fibrillation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "diabetes mellitus",
                        "criterion": "diabetes mellitus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "dyslipidemia",
                        "criterion": "dyslipidemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "chronic kidney disease",
                        "criterion": "chronic kidney disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "obesity",
                        "criterion": "obesity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "family history of cardiovascular diseases",
                        "criterion": "family history of cardiovascular diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Left ventricular ejection fraction < 50% before chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Left ventricular ejection fraction < 50%",
                        "criterion": "left ventricular ejection fraction",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Left ventricular ejection fraction < 50%",
                        "criterion": "left ventricular ejection fraction",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Chronic heart failure with NYHA functional class >= II",
                "criterions": [
                    {
                        "exact_snippets": "Chronic heart failure",
                        "criterion": "chronic heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "NYHA functional class >= II",
                        "criterion": "NYHA functional class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chronic heart failure",
                        "criterion": "chronic heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "NYHA functional class >= II",
                        "criterion": "NYHA functional class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Significant valvular stenosis/regurgitation",
                "criterions": [
                    {
                        "exact_snippets": "Significant valvular stenosis",
                        "criterion": "valvular stenosis",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    },
                    {
                        "exact_snippets": "Significant ... regurgitation",
                        "criterion": "valvular regurgitation",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Significant valvular stenosis",
                        "criterion": "valvular stenosis",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    },
                    {
                        "exact_snippets": "Significant ... regurgitation",
                        "criterion": "valvular regurgitation",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Acute heart failure due to acute coronary syndrome during follow-up",
                "criterions": [
                    {
                        "exact_snippets": "Acute heart failure",
                        "criterion": "acute heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "acute coronary syndrome",
                        "criterion": "acute coronary syndrome",
                        "requirement": {
                            "requirement_type": "cause",
                            "expected_value": "acute heart failure"
                        }
                    },
                    {
                        "exact_snippets": "during follow-up",
                        "criterion": "follow-up period",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "during follow-up"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Acute heart failure",
                                "criterion": "acute heart failure",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "acute coronary syndrome",
                                "criterion": "acute coronary syndrome",
                                "requirement": {
                                    "requirement_type": "cause",
                                    "expected_value": "acute heart failure"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "during follow-up",
                        "criterion": "follow-up period",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "during follow-up"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}