{
    "info": {
        "nct_id": "NCT04397601",
        "official_title": "AflibeRcept or Bevacizumab In Combination With Folfiri as Second-line Treatment of RAS Mutated metastaTIc cOlorectal Cancer patieNts",
        "inclusion_criteria": "* Cytological or histological diagnosis of RAS mutated mCRC;\n* progression at first-line chemotherapy with fluoropyrimidines, oxaliplatin and bevacizumab;\n* stage IV;\n* age <75 years;\n* ECOG Performance Status 0 or 1;\n* life expectancy> 3 months;\n* negative pregnancy test for all potentially childbearing women.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* presence of primary non-treated stenosing colorectal neoplasm;\n* active or uncontrolled infections or bleedings;\n* other concomitant uncontrolled diseases or blood laboratory values contraindicating the study drugs at clinician evaluation;\n* presence of brain metastases;\n* refusal or inability to provide informed consent;\n* impossibility to guarantee follow-up.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Cytological or histological diagnosis of RAS mutated mCRC;",
                "criterions": [
                    {
                        "exact_snippets": "Cytological or histological diagnosis of RAS mutated mCRC",
                        "criterion": "RAS mutation in mCRC",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cytological or histological diagnosis of RAS mutated mCRC",
                        "criterion": "RAS mutation in mCRC",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* progression at first-line chemotherapy with fluoropyrimidines, oxaliplatin and bevacizumab;",
                "criterions": [
                    {
                        "exact_snippets": "progression at first-line chemotherapy with fluoropyrimidines, oxaliplatin and bevacizumab",
                        "criterion": "progression at first-line chemotherapy",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "fluoropyrimidines",
                                "oxaliplatin",
                                "bevacizumab"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "progression at first-line chemotherapy with fluoropyrimidines, oxaliplatin and bevacizumab",
                        "criterion": "progression at first-line chemotherapy",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "fluoropyrimidines",
                                "oxaliplatin",
                                "bevacizumab"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* stage IV;",
                "criterions": [
                    {
                        "exact_snippets": "stage IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "stage IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* age <75 years;",
                "criterions": [
                    {
                        "exact_snippets": "age <75 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<",
                                "value": 75,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "age <75 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<",
                                "value": 75,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG Performance Status 0 or 1;",
                "criterions": [
                    {
                        "exact_snippets": "ECOG Performance Status 0 or 1",
                        "criterion": "ECOG Performance Status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "0",
                                "1"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG Performance Status 0 or 1",
                        "criterion": "ECOG Performance Status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "0",
                                "1"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* life expectancy> 3 months;",
                "criterions": [
                    {
                        "exact_snippets": "life expectancy> 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "life expectancy> 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* negative pregnancy test for all potentially childbearing women.",
                "criterions": [
                    {
                        "exact_snippets": "negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "potentially childbearing women",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "potentially childbearing women",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 75 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* presence of primary non-treated stenosing colorectal neoplasm;",
                "criterions": [
                    {
                        "exact_snippets": "presence of primary non-treated stenosing colorectal neoplasm",
                        "criterion": "primary stenosing colorectal neoplasm",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "presence of primary non-treated stenosing colorectal neoplasm",
                        "criterion": "primary stenosing colorectal neoplasm",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "non-treated"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "presence of primary non-treated stenosing colorectal neoplasm",
                        "criterion": "primary stenosing colorectal neoplasm",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "presence of primary non-treated stenosing colorectal neoplasm",
                        "criterion": "primary stenosing colorectal neoplasm",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "non-treated"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* other concomitant uncontrolled diseases or blood laboratory values contraindicating the study drugs at clinician evaluation;",
                "criterions": [
                    {
                        "exact_snippets": "other concomitant uncontrolled diseases",
                        "criterion": "concomitant diseases",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "blood laboratory values contraindicating the study drugs",
                        "criterion": "blood laboratory values",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": "study drugs"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "other concomitant uncontrolled diseases",
                        "criterion": "concomitant diseases",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "blood laboratory values contraindicating the study drugs",
                        "criterion": "blood laboratory values",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": "study drugs"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* presence of brain metastases;",
                "criterions": [
                    {
                        "exact_snippets": "presence of brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "presence of brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* refusal or inability to provide informed consent;",
                "criterions": [
                    {
                        "exact_snippets": "refusal or inability to provide informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability to provide",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "or_criteria": [
                        {
                            "exact_snippets": "refusal or inability to provide informed consent",
                            "criterion": "informed consent",
                            "requirement": {
                                "requirement_type": "ability to provide",
                                "expected_value": true
                            }
                        }
                    ]
                }
            }
        },
        {
            "identified_line": {
                "line": "* impossibility to guarantee follow-up.",
                "criterions": [
                    {
                        "exact_snippets": "impossibility to guarantee follow-up",
                        "criterion": "follow-up",
                        "requirement": {
                            "requirement_type": "possibility",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "impossibility to guarantee follow-up",
                    "criterion": "follow-up",
                    "requirement": {
                        "requirement_type": "possibility",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* active or uncontrolled infections or bleedings;",
                "criterions": [
                    {
                        "exact_snippets": "active or uncontrolled infections",
                        "criterion": "infections",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "active",
                                "uncontrolled"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "active or uncontrolled ... bleedings",
                        "criterion": "bleedings",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "active",
                                "uncontrolled"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "active or uncontrolled infections",
                                "criterion": "infections",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "active"
                                }
                            },
                            {
                                "exact_snippets": "active or uncontrolled infections",
                                "criterion": "infections",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "uncontrolled"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "active or uncontrolled ... bleedings",
                                "criterion": "bleedings",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "active"
                                }
                            },
                            {
                                "exact_snippets": "active or uncontrolled ... bleedings",
                                "criterion": "bleedings",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "uncontrolled"
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}