{
    "info": {
        "nct_id": "NCT04149691",
        "official_title": "A Phase I, Open-label, Multicentre, Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies",
        "inclusion_criteria": "* Patient or legal guardian, if permitted by local regulatory authorities, provides informed consent to participate in the study must be performed before any procedure's protocol related\n* age of ≥25 years old\n* Performance Score ≥70 in accordance with the Karnofsky Performance Score (KPS),\n* life expectancy period of at least 3 months on the screening day,\n* Have measurable disease according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)\n* subject (or his/her partner) of childbearing potential willingness to use acceptable forms of contraception\n* adequate blood, liver, renal and urine parameters\n* phosphate levels within normal range\n* HIV, HCV (hepatitis C virus) and HBV negative (hepatitis B virus),\n* adequate cardiac function\n\nInclusion Criteria Specific for parts:\n\nPart 1\n\n* Patients with histologically confirmed advanced gastric cancer, bladder cancer, squamous lung cancer or non-small cell lung cancer with squamous immunophenotype, cholangiocarcinoma, sarcoma or endometrial cancer, be refractory to prior therapies and without effective further treatment options.\n\nPart 2 and 3\n\n* Patients with histologically confirmed advanced gastric cancer, bladder cancer, squamous lung cancer or non-small cell lung cancer with squamous immunophenotype, be refractory to prior therapies and without effective further treatment options.\n* Subject's archival formalin-fixed paraffin-embedded (FFPE) tumour sample available for molecular alteration diagnostics, and/or a possibility to collect a new biopsy.\n* Present molecular alteration within FGFR 1, 2 or 3\nHealthy volunteers allowed\nMust have minimum age of 25 Years",
        "exclusion_criteria": "* Any other current malignancy or malignancy diagnosed within the past five (5) years.\n* Active brain metastases or leptomeningeal metastases.\n* concurrent anticancer treatment within 28 days before the start of trial treatment; major surgery within 28 days before the start of trial treatment); use of blood transfusion within 7 days before the start of trial treatment,\n* prior therapy with an agent directed to another FGFR inhibitor,\n* pregnancy and/or breastfeeding,\n* phosphate levels above the upper limit of normal,\n* ectopic calcification/mineralization,\n* endocrine alteration related to calcium/phosphate homeostasis e.g. parathyroid disorders, history of parathyroidectomy,\n* concomitant therapies increasing calcium/phosphate serum levels,\n* inability to take oral medicines,\n* corneal disorder and/or keratopathy,\n* persisting toxicity related to prior therapy Grade > 1 CTCAE v5.0, except polyneuropathy and alopecia,\n* clinically significant (i.e., active) cardiovascular disease. History of abdominal fistula, bowel obstruction (Grade IV), gastrointestinal perforation, intra-abdominal abscess within 6 months of enrollment. Other significant diseases, which, in the opinion of the investigator, might impair the subject's tolerance of trial treatment.\n* Receipt of any organ transplantation including allogeneic stem-cell transplantation.\n\nExclusion Criteria Specific for parts:\n\nPart 2 and 3\n\n* No FFPE tumour sample available to conduct FGFR alteration eligibility tests and no biopsy option.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patient or legal guardian, if permitted by local regulatory authorities, provides informed consent to participate in the study must be performed before any procedure's protocol related",
                "criterions": [
                    {
                        "exact_snippets": "Patient or legal guardian ... provides informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient or legal guardian ... provides informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* age of ≥25 years old",
                "criterions": [
                    {
                        "exact_snippets": "age of ≥25 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "age of ≥25 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Performance Score ≥70 in accordance with the Karnofsky Performance Score (KPS),",
                "criterions": [
                    {
                        "exact_snippets": "Performance Score ≥70 ... Karnofsky Performance Score (KPS)",
                        "criterion": "Karnofsky Performance Score (KPS)",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 70,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance Score ≥70 ... Karnofsky Performance Score (KPS)",
                        "criterion": "Karnofsky Performance Score (KPS)",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 70,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* life expectancy period of at least 3 months on the screening day,",
                "criterions": [
                    {
                        "exact_snippets": "life expectancy period of at least 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "life expectancy period of at least 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have measurable disease according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)",
                "criterions": [
                    {
                        "exact_snippets": "measurable disease according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "evaluation criteria",
                            "expected_value": "Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "measurable disease according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "evaluation criteria",
                            "expected_value": "Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* subject (or his/her partner) of childbearing potential willingness to use acceptable forms of contraception",
                "criterions": [
                    {
                        "exact_snippets": "subject (or his/her partner) of childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willingness to use acceptable forms of contraception",
                        "criterion": "willingness to use contraception",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "subject (or his/her partner) of childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willingness to use acceptable forms of contraception",
                        "criterion": "willingness to use contraception",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* phosphate levels within normal range",
                "criterions": [
                    {
                        "exact_snippets": "phosphate levels within normal range",
                        "criterion": "phosphate levels",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": "within normal range"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "phosphate levels within normal range",
                        "criterion": "phosphate levels",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": "within normal range"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HIV, HCV (hepatitis C virus) and HBV negative (hepatitis B virus),",
                "criterions": [
                    {
                        "exact_snippets": "HIV ... negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "HCV (hepatitis C virus) ... negative",
                        "criterion": "HCV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "HBV negative (hepatitis B virus)",
                        "criterion": "HBV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "HIV ... negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "HCV (hepatitis C virus) ... negative",
                        "criterion": "HCV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "HBV negative (hepatitis B virus)",
                        "criterion": "HBV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* adequate cardiac function",
                "criterions": [
                    {
                        "exact_snippets": "adequate cardiac function",
                        "criterion": "cardiac function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "adequate cardiac function",
                        "criterion": "cardiac function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Part 1",
                "criterions": [
                    {
                        "exact_snippets": "Part 1",
                        "criterion": "trial phase",
                        "requirement": {
                            "requirement_type": "phase",
                            "expected_value": "1"
                        }
                    }
                ]
            },
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                "and_criteria": [
                    {
                        "exact_snippets": "Part 1",
                        "criterion": "trial phase",
                        "requirement": {
                            "requirement_type": "phase",
                            "expected_value": "1"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with histologically confirmed advanced gastric cancer, bladder cancer, squamous lung cancer or non-small cell lung cancer with squamous immunophenotype, cholangiocarcinoma, sarcoma or endometrial cancer, be refractory to prior therapies and without effective further treatment options.",
                "criterions": [
                    {
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                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed advanced gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... bladder cancer",
                        "criterion": "bladder cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... squamous lung cancer",
                        "criterion": "squamous lung cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                        "criterion": "non-small cell lung cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                        "criterion": "non-small cell lung cancer",
                        "requirement": {
                            "requirement_type": "immunophenotype",
                            "expected_value": "squamous"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... cholangiocarcinoma",
                        "criterion": "cholangiocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... sarcoma",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... endometrial cancer",
                        "criterion": "endometrial cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "refractory to prior therapies",
                        "criterion": "refractory to prior therapies",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "without effective further treatment options",
                        "criterion": "effective further treatment options",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    }
                ]
            },
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                    {
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                                        "criterion": "gastric cancer",
                                        "requirement": {
                                            "requirement_type": "confirmation",
                                            "expected_value": "histologically confirmed"
                                        }
                                    },
                                    {
                                        "exact_snippets": "histologically confirmed advanced gastric cancer",
                                        "criterion": "gastric cancer",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "advanced"
                                        }
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                                ]
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                            {
                                "exact_snippets": "histologically confirmed ... bladder cancer",
                                "criterion": "bladder cancer",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically confirmed"
                                }
                            },
                            {
                                "exact_snippets": "histologically confirmed ... squamous lung cancer",
                                "criterion": "squamous lung cancer",
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                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically confirmed"
                                }
                            },
                            {
                                "and_criteria": [
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                                        "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                                        "criterion": "non-small cell lung cancer",
                                        "requirement": {
                                            "requirement_type": "confirmation",
                                            "expected_value": "histologically confirmed"
                                        }
                                    },
                                    {
                                        "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                                        "criterion": "non-small cell lung cancer",
                                        "requirement": {
                                            "requirement_type": "immunophenotype",
                                            "expected_value": "squamous"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "histologically confirmed ... cholangiocarcinoma",
                                "criterion": "cholangiocarcinoma",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically confirmed"
                                }
                            },
                            {
                                "exact_snippets": "histologically confirmed ... sarcoma",
                                "criterion": "sarcoma",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically confirmed"
                                }
                            },
                            {
                                "exact_snippets": "histologically confirmed ... endometrial cancer",
                                "criterion": "endometrial cancer",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically confirmed"
                                }
                            }
                        ]
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                    {
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                        "criterion": "refractory to prior therapies",
                        "requirement": {
                            "requirement_type": "status",
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                    },
                    {
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                        "criterion": "effective further treatment options",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with histologically confirmed advanced gastric cancer, bladder cancer, squamous lung cancer or non-small cell lung cancer with squamous immunophenotype, be refractory to prior therapies and without effective further treatment options.",
                "criterions": [
                    {
                        "exact_snippets": "histologically confirmed advanced gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
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                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... squamous lung cancer",
                        "criterion": "squamous lung cancer",
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                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
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                            "expected_value": "histologically confirmed"
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                        "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                        "criterion": "non-small cell lung cancer",
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                            "requirement_type": "immunophenotype",
                            "expected_value": "squamous"
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                        "exact_snippets": "without effective further treatment options",
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                        }
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                                                "exact_snippets": "histologically confirmed advanced gastric cancer",
                                                "criterion": "gastric cancer",
                                                "requirement": {
                                                    "requirement_type": "confirmation",
                                                    "expected_value": "histologically confirmed"
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                                                "exact_snippets": "histologically confirmed advanced gastric cancer",
                                                "criterion": "gastric cancer",
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                                                    "requirement_type": "stage",
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                            {
                                "and_criteria": [
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                                        "exact_snippets": "histologically confirmed ... bladder cancer",
                                        "criterion": "bladder cancer",
                                        "requirement": {
                                            "requirement_type": "confirmation",
                                            "expected_value": "histologically confirmed"
                                        }
                                    },
                                    {
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                                        "criterion": "refractory to prior therapies",
                                        "requirement": {
                                            "requirement_type": "status",
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                                        "exact_snippets": "without effective further treatment options",
                                        "criterion": "effective further treatment options",
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                                        }
                                    }
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                            {
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                                        "exact_snippets": "histologically confirmed ... squamous lung cancer",
                                        "criterion": "squamous lung cancer",
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                                            "expected_value": "histologically confirmed"
                                        }
                                    },
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                                        "exact_snippets": "refractory to prior therapies",
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                                        "requirement": {
                                            "requirement_type": "status",
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                                        "exact_snippets": "without effective further treatment options",
                                        "criterion": "effective further treatment options",
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                                            "requirement_type": "availability",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                                                "criterion": "non-small cell lung cancer",
                                                "requirement": {
                                                    "requirement_type": "confirmation",
                                                    "expected_value": "histologically confirmed"
                                                }
                                            },
                                            {
                                                "exact_snippets": "histologically confirmed ... non-small cell lung cancer with squamous immunophenotype",
                                                "criterion": "non-small cell lung cancer",
                                                "requirement": {
                                                    "requirement_type": "immunophenotype",
                                                    "expected_value": "squamous"
                                                }
                                            }
                                        ]
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                                        "exact_snippets": "refractory to prior therapies",
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                                        "requirement": {
                                            "requirement_type": "status",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "without effective further treatment options",
                                        "criterion": "effective further treatment options",
                                        "requirement": {
                                            "requirement_type": "availability",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 25 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 25 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 25 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* adequate blood, liver, renal and urine parameters",
                "criterions": [
                    {
                        "exact_snippets": "adequate blood",
                        "criterion": "blood parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate liver",
                        "criterion": "liver parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate renal",
                        "criterion": "renal parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate ... urine parameters",
                        "criterion": "urine parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "adequate blood",
                        "criterion": "blood parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate liver",
                        "criterion": "liver parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate renal",
                        "criterion": "renal parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate ... urine parameters",
                        "criterion": "urine parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Inclusion Criteria Specific for parts:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Part 2 and 3",
                "criterions": [
                    {
                        "exact_snippets": "Part 2",
                        "criterion": "trial part",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": "Part 2"
                        }
                    },
                    {
                        "exact_snippets": "Part 3",
                        "criterion": "trial part",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": "Part 3"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Part 2",
                        "criterion": "trial part",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": "Part 2"
                        }
                    },
                    {
                        "exact_snippets": "Part 3",
                        "criterion": "trial part",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": "Part 3"
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Any other current malignancy or malignancy diagnosed within the past five (5) years.",
                "criterions": [
                    {
                        "exact_snippets": "Any other current malignancy",
                        "criterion": "current malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "malignancy diagnosed within the past five (5) years",
                        "criterion": "malignancy diagnosis",
                        "requirement": {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Any other current malignancy",
                        "criterion": "current malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "malignancy diagnosed within the past five (5) years",
                        "criterion": "malignancy diagnosis",
                        "requirement": {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active brain metastases or leptomeningeal metastases.",
                "criterions": [
                    {
                        "exact_snippets": "Active brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "leptomeningeal metastases",
                        "criterion": "leptomeningeal metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Active brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "leptomeningeal metastases",
                        "criterion": "leptomeningeal metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* concurrent anticancer treatment within 28 days before the start of trial treatment; major surgery within 28 days before the start of trial treatment); use of blood transfusion within 7 days before the start of trial treatment,",
                "criterions": [
                    {
                        "exact_snippets": "concurrent anticancer treatment within 28 days before the start of trial treatment",
                        "criterion": "concurrent anticancer treatment",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "major surgery within 28 days before the start of trial treatment",
                        "criterion": "major surgery",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "use of blood transfusion within 7 days before the start of trial treatment",
                        "criterion": "use of blood transfusion",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 7,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "concurrent anticancer treatment within 28 days before the start of trial treatment",
                        "criterion": "concurrent anticancer treatment",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "major surgery within 28 days before the start of trial treatment",
                        "criterion": "major surgery",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "use of blood transfusion within 7 days before the start of trial treatment",
                        "criterion": "use of blood transfusion",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 7,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* prior therapy with an agent directed to another FGFR inhibitor,",
                "criterions": [
                    {
                        "exact_snippets": "prior therapy with an agent directed to another FGFR inhibitor",
                        "criterion": "prior therapy with FGFR inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "prior therapy with an agent directed to another FGFR inhibitor",
                    "criterion": "prior therapy with FGFR inhibitor",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* pregnancy and/or breastfeeding,",
                "criterions": [
                    {
                        "exact_snippets": "pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breastfeeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breastfeeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* phosphate levels above the upper limit of normal,",
                "criterions": [
                    {
                        "exact_snippets": "phosphate levels above the upper limit of normal",
                        "criterion": "phosphate levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": "> upper limit of normal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "phosphate levels above the upper limit of normal",
                    "criterion": "phosphate levels",
                    "requirement": {
                        "requirement_type": "comparison",
                        "expected_value": "> upper limit of normal"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* ectopic calcification/mineralization,",
                "criterions": [
                    {
                        "exact_snippets": "ectopic calcification/mineralization",
                        "criterion": "ectopic calcification/mineralization",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ectopic calcification/mineralization",
                        "criterion": "ectopic calcification/mineralization",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* endocrine alteration related to calcium/phosphate homeostasis e.g. parathyroid disorders, history of parathyroidectomy,",
                "criterions": [
                    {
                        "exact_snippets": "endocrine alteration related to calcium/phosphate homeostasis",
                        "criterion": "endocrine alteration",
                        "requirement": {
                            "requirement_type": "related to",
                            "expected_value": "calcium/phosphate homeostasis"
                        }
                    },
                    {
                        "exact_snippets": "parathyroid disorders",
                        "criterion": "parathyroid disorders",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "history of parathyroidectomy",
                        "criterion": "parathyroidectomy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "endocrine alteration related to calcium/phosphate homeostasis",
                                "criterion": "endocrine alteration",
                                "requirement": {
                                    "requirement_type": "related to",
                                    "expected_value": "calcium/phosphate homeostasis"
                                }
                            },
                            {
                                "exact_snippets": "parathyroid disorders",
                                "criterion": "parathyroid disorders",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "history of parathyroidectomy",
                        "criterion": "parathyroidectomy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* concomitant therapies increasing calcium/phosphate serum levels,",
                "criterions": [
                    {
                        "exact_snippets": "concomitant therapies increasing calcium/phosphate serum levels",
                        "criterion": "concomitant therapies",
                        "requirement": {
                            "requirement_type": "effect on calcium/phosphate serum levels",
                            "expected_value": "increasing"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "concomitant therapies increasing calcium/phosphate serum levels",
                    "criterion": "concomitant therapies",
                    "requirement": {
                        "requirement_type": "effect on calcium/phosphate serum levels",
                        "expected_value": "increasing"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* inability to take oral medicines,",
                "criterions": [
                    {
                        "exact_snippets": "inability to take oral medicines",
                        "criterion": "ability to take oral medicines",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "inability to take oral medicines",
                    "criterion": "ability to take oral medicines",
                    "requirement": {
                        "requirement_type": "ability",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* corneal disorder and/or keratopathy,",
                "criterions": [
                    {
                        "exact_snippets": "corneal disorder",
                        "criterion": "corneal disorder",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "keratopathy",
                        "criterion": "keratopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "corneal disorder",
                                "criterion": "corneal disorder",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "keratopathy",
                                "criterion": "keratopathy",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "corneal disorder",
                        "criterion": "corneal disorder",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "keratopathy",
                        "criterion": "keratopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* persisting toxicity related to prior therapy Grade > 1 CTCAE v5.0, except polyneuropathy and alopecia,",
                "criterions": [
                    {
                        "exact_snippets": "persisting toxicity related to prior therapy Grade > 1 CTCAE v5.0",
                        "criterion": "persisting toxicity related to prior therapy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "CTCAE v5.0"
                            }
                        }
                    },
                    {
                        "exact_snippets": "except polyneuropathy",
                        "criterion": "polyneuropathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "except ... alopecia",
                        "criterion": "alopecia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "persisting toxicity related to prior therapy Grade > 1 CTCAE v5.0",
                                    "criterion": "persisting toxicity related to prior therapy",
                                    "requirement": {
                                        "requirement_type": "severity",
                                        "expected_value": {
                                            "operator": ">",
                                            "value": 1,
                                            "unit": "CTCAE v5.0"
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except polyneuropathy",
                                        "criterion": "polyneuropathy",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except ... alopecia",
                                        "criterion": "alopecia",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* clinically significant (i.e., active) cardiovascular disease. History of abdominal fistula, bowel obstruction (Grade IV), gastrointestinal perforation, intra-abdominal abscess within 6 months of enrollment. Other significant diseases, which, in the opinion of the investigator, might impair the subject's tolerance of trial treatment.",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant (i.e., active) cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "clinically significant (i.e., active) cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "significance",
                            "expected_value": "clinically significant"
                        }
                    },
                    {
                        "exact_snippets": "History of abdominal fistula",
                        "criterion": "abdominal fistula",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... bowel obstruction (Grade IV)",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... bowel obstruction (Grade IV)",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "IV"
                        }
                    },
                    {
                        "exact_snippets": "History of ... gastrointestinal perforation",
                        "criterion": "gastrointestinal perforation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... intra-abdominal abscess within 6 months of enrollment",
                        "criterion": "intra-abdominal abscess",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... intra-abdominal abscess within 6 months of enrollment",
                        "criterion": "intra-abdominal abscess",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Other significant diseases, which, in the opinion of the investigator, might impair the subject's tolerance of trial treatment",
                        "criterion": "other significant diseases",
                        "requirement": {
                            "requirement_type": "investigator's opinion",
                            "expected_value": "might impair tolerance of trial treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "clinically significant (i.e., active) cardiovascular disease",
                                        "criterion": "cardiovascular disease",
                                        "requirement": {
                                            "requirement_type": "activity",
                                            "expected_value": "active"
                                        }
                                    },
                                    {
                                        "exact_snippets": "clinically significant (i.e., active) cardiovascular disease",
                                        "criterion": "cardiovascular disease",
                                        "requirement": {
                                            "requirement_type": "significance",
                                            "expected_value": "clinically significant"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "History of abdominal fistula",
                                "criterion": "abdominal fistula",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "History of ... bowel obstruction (Grade IV)",
                                        "criterion": "bowel obstruction",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "History of ... bowel obstruction (Grade IV)",
                                        "criterion": "bowel obstruction",
                                        "requirement": {
                                            "requirement_type": "grade",
                                            "expected_value": "IV"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "History of ... gastrointestinal perforation",
                                "criterion": "gastrointestinal perforation",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "History of ... intra-abdominal abscess within 6 months of enrollment",
                                        "criterion": "intra-abdominal abscess",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "History of ... intra-abdominal abscess within 6 months of enrollment",
                                        "criterion": "intra-abdominal abscess",
                                        "requirement": {
                                            "requirement_type": "timeframe",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "months"
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Other significant diseases, which, in the opinion of the investigator, might impair the subject's tolerance of trial treatment",
                                "criterion": "other significant diseases",
                                "requirement": {
                                    "requirement_type": "investigator's opinion",
                                    "expected_value": "might impair tolerance of trial treatment"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Receipt of any organ transplantation including allogeneic stem-cell transplantation.",
                "criterions": [
                    {
                        "exact_snippets": "Receipt of any organ transplantation",
                        "criterion": "organ transplantation",
                        "requirement": {
                            "requirement_type": "receipt",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "including allogeneic stem-cell transplantation",
                        "criterion": "allogeneic stem-cell transplantation",
                        "requirement": {
                            "requirement_type": "receipt",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Receipt of any organ transplantation",
                        "criterion": "organ transplantation",
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        {
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    "miscellaneous_lines": [],
    "failed_inclusion": [
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    "failed_miscellaneous": []
}