{
    "info": {
        "nct_id": "NCT03882866",
        "official_title": "3D-printed Template for Iodine-125 Seed Implantation Therapy in Patients With Locally Advanced Pancreatic Cancer: a Multicenter Study",
        "inclusion_criteria": "* Age: 18-80 years\n* Cytologically or histologically confirmed pancreatic adenocarcinoma\n* Inoperable locally advanced pancreatic cancer based on American Joint Committee on Cancer (AJCC) staging system (8th ed) (without distant metastasis)\n* Single tumor size≤ 6 cm\n* Karnofsky performance score （KPS）≥60\n* Estimated survival ≥3 months\n* Without other several comorbidity\n* Participants must have adequate organ function:\n\n  * WBC≥3×109/L; HGB≥90g/dL; PLT≥50×109/L\n  * Aspartate Transaminase (AST)/alanine aminotransferase ( ALT) ≤3 × institutional upper limit of normal\n  * Albumin≥3g/dL\n  * Total bilirubin ≤3mg/dL\n  * PT≤3 × institutional upper limit of normal or INR≤2.3\n  * Creatinine ≤1.5 × institutional upper limit of normal\n* Ability to understand and the willingness to sign a written informed consent document\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Patients with other malignant tumors\n* History of other anti-cancer therapy, including surgery,radiation, ablation and so on\n* Pregnant or lactating women\n* Patients with Immunodeficiency disease\n* Several heart disease, for example: New York Heart Association (NYHA) class III/IV congestive heart failure，active coronary heart disease and severe arrhythmia\n* Uncontrolled hypertension\n* Ongoing or active infection (>grade 2 based on National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) 4.0 edition)\n* Active tuberculosis\n* Chronic renal insufficiency\n* Other organ failure\n* History of organ transplantation\n* History of severe mental illness",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age: 18-80 years",
                "criterions": [
                    {
                        "exact_snippets": "Age: 18-80 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age: 18-80 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Cytologically or histologically confirmed pancreatic adenocarcinoma",
                "criterions": [
                    {
                        "exact_snippets": "Cytologically or histologically confirmed pancreatic adenocarcinoma",
                        "criterion": "pancreatic adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "cytologically",
                                "histologically"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cytologically or histologically confirmed pancreatic adenocarcinoma",
                        "criterion": "pancreatic adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "cytologically",
                                "histologically"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Inoperable locally advanced pancreatic cancer based on American Joint Committee on Cancer (AJCC) staging system (8th ed) (without distant metastasis)",
                "criterions": [
                    {
                        "exact_snippets": "Inoperable locally advanced pancreatic cancer",
                        "criterion": "pancreatic cancer",
                        "requirement": {
                            "requirement_type": "operability",
                            "expected_value": "inoperable"
                        }
                    },
                    {
                        "exact_snippets": "Inoperable locally advanced pancreatic cancer",
                        "criterion": "pancreatic cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "locally advanced"
                        }
                    },
                    {
                        "exact_snippets": "based on American Joint Committee on Cancer (AJCC) staging system (8th ed)",
                        "criterion": "staging system",
                        "requirement": {
                            "requirement_type": "system",
                            "expected_value": "American Joint Committee on Cancer (AJCC) 8th edition"
                        }
                    },
                    {
                        "exact_snippets": "without distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Inoperable locally advanced pancreatic cancer",
                                        "criterion": "pancreatic cancer",
                                        "requirement": {
                                            "requirement_type": "operability",
                                            "expected_value": "inoperable"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Inoperable locally advanced pancreatic cancer",
                                        "criterion": "pancreatic cancer",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "locally advanced"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "based on American Joint Committee on Cancer (AJCC) staging system (8th ed)",
                                "criterion": "staging system",
                                "requirement": {
                                    "requirement_type": "system",
                                    "expected_value": "American Joint Committee on Cancer (AJCC) 8th edition"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "without distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Single tumor size≤ 6 cm",
                "criterions": [
                    {
                        "exact_snippets": "Single tumor size≤ 6 cm",
                        "criterion": "tumor size",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "cm"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Single tumor size≤ 6 cm",
                        "criterion": "tumor size",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "cm"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky performance score （KPS）≥60",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky performance score （KPS）≥60",
                        "criterion": "Karnofsky performance score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky performance score （KPS）≥60",
                        "criterion": "Karnofsky performance score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Estimated survival ≥3 months",
                "criterions": [
                    {
                        "exact_snippets": "Estimated survival ≥3 months",
                        "criterion": "estimated survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Estimated survival ≥3 months",
                        "criterion": "estimated survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Without other several comorbidity",
                "criterions": [
                    {
                        "exact_snippets": "Without other several comorbidity",
                        "criterion": "comorbidity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Without other several comorbidity",
                        "criterion": "comorbidity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participants must have adequate organ function:",
                "criterions": [
                    {
                        "exact_snippets": "adequate organ function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "adequate organ function",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC≥3×109/L; HGB≥90g/dL; PLT≥50×109/L",
                "criterions": [
                    {
                        "exact_snippets": "WBC≥3×109/L",
                        "criterion": "white blood cell count (WBC)",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "×10^9/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "HGB≥90g/dL",
                        "criterion": "hemoglobin (HGB)",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 90,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "PLT≥50×109/L",
                        "criterion": "platelet count (PLT)",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "×10^9/L"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC≥3×109/L",
                        "criterion": "white blood cell count (WBC)",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "×10^9/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "HGB≥90g/dL",
                        "criterion": "hemoglobin (HGB)",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 90,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "PLT≥50×109/L",
                        "criterion": "platelet count (PLT)",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "×10^9/L"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Aspartate Transaminase (AST)/alanine aminotransferase ( ALT) ≤3 × institutional upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Aspartate Transaminase (AST) ... ≤3 × institutional upper limit of normal",
                        "criterion": "Aspartate Transaminase (AST)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "institutional upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "alanine aminotransferase ( ALT) ≤3 × institutional upper limit of normal",
                        "criterion": "alanine aminotransferase (ALT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "institutional upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Aspartate Transaminase (AST) ... ≤3 × institutional upper limit of normal",
                        "criterion": "Aspartate Transaminase (AST)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "institutional upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "alanine aminotransferase ( ALT) ≤3 × institutional upper limit of normal",
                        "criterion": "alanine aminotransferase (ALT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "institutional upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Albumin≥3g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Albumin≥3g/dL",
                        "criterion": "albumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Albumin≥3g/dL",
                        "criterion": "albumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Total bilirubin ≤3mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Total bilirubin ≤3mg/dL",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Total bilirubin ≤3mg/dL",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* PT≤3 × institutional upper limit of normal or INR≤2.3",
                "criterions": [
                    {
                        "exact_snippets": "PT≤3 × institutional upper limit of normal",
                        "criterion": "prothrombin time (PT)",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "× institutional upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "INR≤2.3",
                        "criterion": "international normalized ratio (INR)",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.3,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "PT≤3 × institutional upper limit of normal",
                        "criterion": "prothrombin time (PT)",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "× institutional upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "INR≤2.3",
                        "criterion": "international normalized ratio (INR)",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.3,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine ≤1.5 × institutional upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine ≤1.5 × institutional upper limit of normal",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "× institutional upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine ≤1.5 × institutional upper limit of normal",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "× institutional upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Ability to understand and the willingness to sign a written informed consent document",
                "criterions": [
                    {
                        "exact_snippets": "Ability to understand",
                        "criterion": "cognitive ability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willingness to sign a written informed consent document",
                        "criterion": "willingness to consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Ability to understand",
                        "criterion": "cognitive ability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willingness to sign a written informed consent document",
                        "criterion": "willingness to consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 80 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients with other malignant tumors",
                "criterions": [
                    {
                        "exact_snippets": "Patients with other malignant tumors",
                        "criterion": "malignant tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients with other malignant tumors",
                    "criterion": "malignant tumors",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* History of other anti-cancer therapy, including surgery,radiation, ablation and so on",
                "criterions": [
                    {
                        "exact_snippets": "History of other anti-cancer therapy, including surgery",
                        "criterion": "history of anti-cancer therapy",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "surgery"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "History of other anti-cancer therapy, including ... radiation",
                        "criterion": "history of anti-cancer therapy",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "radiation"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "History of other anti-cancer therapy, including ... ablation",
                        "criterion": "history of anti-cancer therapy",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "ablation"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of other anti-cancer therapy, including surgery",
                                "criterion": "history of anti-cancer therapy",
                                "requirement": {
                                    "requirement_type": "types",
                                    "expected_value": [
                                        "surgery"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of other anti-cancer therapy, including ... radiation",
                                "criterion": "history of anti-cancer therapy",
                                "requirement": {
                                    "requirement_type": "types",
                                    "expected_value": [
                                        "radiation"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of other anti-cancer therapy, including ... ablation",
                                "criterion": "history of anti-cancer therapy",
                                "requirement": {
                                    "requirement_type": "types",
                                    "expected_value": [
                                        "ablation"
                                    ]
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant or lactating women",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with Immunodeficiency disease",
                "criterions": [
                    {
                        "exact_snippets": "Immunodeficiency disease",
                        "criterion": "immunodeficiency disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Immunodeficiency disease",
                    "criterion": "immunodeficiency disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled hypertension",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Ongoing or active infection (>grade 2 based on National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) 4.0 edition)",
                "criterions": [
                    {
                        "exact_snippets": "Ongoing or active infection (>grade 2 based on National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) 4.0 edition)",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "ongoing",
                                "active"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Ongoing or active infection (>grade 2 based on National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) 4.0 edition)",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Ongoing or active infection (>grade 2 based on National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) 4.0 edition)",
                                "criterion": "infection",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": [
                                        "ongoing",
                                        "active"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "Ongoing or active infection (>grade 2 based on National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) 4.0 edition)",
                                "criterion": "infection",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 2,
                                        "unit": "grade"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active tuberculosis",
                "criterions": [
                    {
                        "exact_snippets": "Active tuberculosis",
                        "criterion": "tuberculosis",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Active tuberculosis",
                        "criterion": "tuberculosis",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Chronic renal insufficiency",
                "criterions": [
                    {
                        "exact_snippets": "Chronic renal insufficiency",
                        "criterion": "chronic renal insufficiency",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Chronic renal insufficiency",
                    "criterion": "chronic renal insufficiency",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Other organ failure",
                "criterions": [
                    {
                        "exact_snippets": "Other organ failure",
                        "criterion": "organ failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Other organ failure",
                    "criterion": "organ failure",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* History of organ transplantation",
                "criterions": [
                    {
                        "exact_snippets": "History of organ transplantation",
                        "criterion": "organ transplantation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "History of organ transplantation",
                    "criterion": "organ transplantation",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* History of severe mental illness",
                "criterions": [
                    {
                        "exact_snippets": "History of severe mental illness",
                        "criterion": "severe mental illness",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "History of severe mental illness",
                    "criterion": "severe mental illness",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Several heart disease, for example: New York Heart Association (NYHA) class III/IV congestive heart failure，active coronary heart disease and severe arrhythmia",
                "criterions": [
                    {
                        "exact_snippets": "New York Heart Association (NYHA) class III/IV congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "New York Heart Association (NYHA) class III/IV"
                        }
                    },
                    {
                        "exact_snippets": "active coronary heart disease",
                        "criterion": "coronary heart disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "severe arrhythmia",
                        "criterion": "arrhythmia",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}