{
    "info": {
        "nct_id": "NCT03878472",
        "official_title": "A Phase II Clinical Study of Neoadjuvant Therapy for Resectable Locally Advanced Gastric Cancer with PD-1 Antibody or in Combination with Apatinib ± S1±Oxaliplatin",
        "inclusion_criteria": "1. Aged 18-70 years old, both genders, histologically documented gastric cancer.\n2. Newly diagnosed locally advanced, potentially resectable disease without any prior antitumor treatment\n3. clinically diagnosed stage T3-4bN+M0 according to ultrasound endoscopy or enhanced CT/MRI scan.\n4. Eligible and reasonably suitable for potentially curative resection\n5. Written (signed) informed consent.\n6. Pathological tissue available\n7. ECOG: 0-1.\n8. Adequate organ function.\n9. Willingness to provide blood and tissue samples for research purposes.\n10. Good compliance with the study procedures, including lab and auxiliary examination and treatment.\n11. Female patients should not be pregnant or breast feeding.\n12. Agree to take contraception measures during treatment and in 120 days after last dose of SHR-1210.\n13. Life expectancy of at least 6 months.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "1. Patients with distant metastasis.\n2. History of chemotherapy, radiation, immunotherapy, or radical resection of gastric cancer.\n3. patients with active autoimmune disease or history of refractory autoimmune disease.\n4. patients with active malignant tumor in recent 2 years, except the tumor studied in this research or cured locally tumor like resected basal cell or squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ.\n5. uncontrollable pleural effusion, pericardial effusion, or ascites in 2 weeks before recruitment.\n6. patients who have digestive tract bleeding in 2 weeks before recruitment or with high risk of bleeding.\n7. perforation / fistula of GI tract in 6 months before recruitment.\n8. pulmonary disease history: interstitial pulmonary disease, non-infective pneumonitis, pulmonary fibrosis, acute pulmonary disease.\n9. uncontrollable systemic diseases, including diabetes, hypertension etc.\n10. severe chronic or active infections in need of systemic antibacterial, antifungal, or antiviral treatment, including TB or HIV, etc.\n11. patients with untreated chronic hepatitis B or HBV DNA over 500 IU/ml or positive HCV RNA.\n12. patients with any cardiovascular risk factors below: （1）cardiac chest pain occurring in 28 days before recruitment, defined as moderate pain that limits daily activity.\n\n（2）pulmonary embolism with symptoms occurring in 28 days before recruitment. （3）acute myocardial infarction occurring in 6 months before recruitment. （4）any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment.\n\n（5）ventricular arrhythmias of Grade 2 or grater in 6 months before recruitment, or accompanied by supraventricular tachyarrhythmias requiring medical treatment.\n\n（6）cerebrovascular accident within 6 months before recruitment. 14. patients with peripheral neuropathy NCI CTC AE grade 1, except those with only deep tendon reflex disappearing.\n\n15. moderate or severe renal injury [creatinine clearance rate≤50 ml/min (according to Cockcroft & Gault equation)], or Scr>ULN.\n\n16. dipyrimidine dehydrogenase (DPD) deficiency. 17. allergic to any drug in this study. 18. history of allogeneic stem cell transplantation or organ transplantation. 19. use of steroids (dosage>10mg/d prednisone) or other systemic immune suppressive therapy in 14 days before recruitment, except patients treated with regimens below: a. steroids for hormone replacement (dosage>10mg/d prednisone); b. steroids for local application with little systemic absorption; c. short -term (≤ 7 days) steroids for preventing allergy or vomiting.\n\n20. vaccinated with live vaccine in 4 weeks before recruitment. 21. for patients with uncontrolled epilepsy, CNS diseases or history of mental disorder, researchers should evaluate whether their diseases will impede their signing of informed consent or compliance of treatment.\n\n22. existing of potential situation which will impede drug administration or affect toxicity analysis or alcohol/ drug abuse.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Aged 18-70 years old, both genders, histologically documented gastric cancer.",
                "criterions": [
                    {
                        "exact_snippets": "Aged 18-70 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "both genders",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "inclusion",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "histologically documented gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "documentation",
                            "expected_value": "histologically documented"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Aged 18-70 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "both genders",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "inclusion",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "histologically documented gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "documentation",
                            "expected_value": "histologically documented"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Newly diagnosed locally advanced, potentially resectable disease without any prior antitumor treatment",
                "criterions": [
                    {
                        "exact_snippets": "Newly diagnosed",
                        "criterion": "diagnosis status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "newly diagnosed"
                        }
                    },
                    {
                        "exact_snippets": "locally advanced",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "locally advanced"
                        }
                    },
                    {
                        "exact_snippets": "potentially resectable",
                        "criterion": "resectability",
                        "requirement": {
                            "requirement_type": "potential",
                            "expected_value": "resectable"
                        }
                    },
                    {
                        "exact_snippets": "without any prior antitumor treatment",
                        "criterion": "prior antitumor treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Newly diagnosed",
                        "criterion": "diagnosis status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "newly diagnosed"
                        }
                    },
                    {
                        "exact_snippets": "locally advanced",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "locally advanced"
                        }
                    },
                    {
                        "exact_snippets": "potentially resectable",
                        "criterion": "resectability",
                        "requirement": {
                            "requirement_type": "potential",
                            "expected_value": "resectable"
                        }
                    },
                    {
                        "exact_snippets": "without any prior antitumor treatment",
                        "criterion": "prior antitumor treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Eligible and reasonably suitable for potentially curative resection",
                "criterions": [
                    {
                        "exact_snippets": "Eligible and reasonably suitable for potentially curative resection",
                        "criterion": "suitability for potentially curative resection",
                        "requirement": {
                            "requirement_type": "suitability",
                            "expected_value": "reasonably suitable"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eligible and reasonably suitable for potentially curative resection",
                        "criterion": "suitability for potentially curative resection",
                        "requirement": {
                            "requirement_type": "suitability",
                            "expected_value": "reasonably suitable"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Written (signed) informed consent.",
                "criterions": [
                    {
                        "exact_snippets": "Written (signed) informed consent.",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "form",
                            "expected_value": "written"
                        }
                    },
                    {
                        "exact_snippets": "Written (signed) informed consent.",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signature",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Written (signed) informed consent.",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "form",
                            "expected_value": "written"
                        }
                    },
                    {
                        "exact_snippets": "Written (signed) informed consent.",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signature",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Pathological tissue available",
                "criterions": [
                    {
                        "exact_snippets": "Pathological tissue available",
                        "criterion": "pathological tissue",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pathological tissue available",
                        "criterion": "pathological tissue",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "7. ECOG: 0-1.",
                "criterions": [
                    {
                        "exact_snippets": "ECOG: 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG: 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. Adequate organ function.",
                "criterions": [
                    {
                        "exact_snippets": "Adequate organ function.",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate organ function.",
                        "criterion": "organ function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "9. Willingness to provide blood and tissue samples for research purposes.",
                "criterions": [
                    {
                        "exact_snippets": "Willingness to provide blood ... for research purposes.",
                        "criterion": "blood samples",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness to provide ... tissue samples for research purposes.",
                        "criterion": "tissue samples",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Willingness to provide blood ... for research purposes.",
                        "criterion": "blood samples",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness to provide ... tissue samples for research purposes.",
                        "criterion": "tissue samples",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 70 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 70 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 70 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1. Patients with distant metastasis.",
                "criterions": [
                    {
                        "exact_snippets": "distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. History of chemotherapy, radiation, immunotherapy, or radical resection of gastric cancer.",
                "criterions": [
                    {
                        "exact_snippets": "History of chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... radiation",
                        "criterion": "radiation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... immunotherapy",
                        "criterion": "immunotherapy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... radical resection of gastric cancer",
                        "criterion": "radical resection of gastric cancer",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "History of chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... radiation",
                        "criterion": "radiation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... immunotherapy",
                        "criterion": "immunotherapy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... radical resection of gastric cancer",
                        "criterion": "radical resection of gastric cancer",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. patients with active autoimmune disease or history of refractory autoimmune disease.",
                "criterions": [
                    {
                        "exact_snippets": "patients with active autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "history of refractory autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": "refractory"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "patients with active autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "history of refractory autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": "refractory"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. uncontrollable pleural effusion, pericardial effusion, or ascites in 2 weeks before recruitment.",
                "criterions": [
                    {
                        "exact_snippets": "uncontrollable pleural effusion",
                        "criterion": "pleural effusion",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "uncontrollable"
                        }
                    },
                    {
                        "exact_snippets": "uncontrollable ... pericardial effusion",
                        "criterion": "pericardial effusion",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "uncontrollable"
                        }
                    },
                    {
                        "exact_snippets": "uncontrollable ... ascites",
                        "criterion": "ascites",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "uncontrollable"
                        }
                    },
                    {
                        "exact_snippets": "in 2 weeks before recruitment",
                        "criterion": "time before recruitment",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "uncontrollable pleural effusion",
                                        "criterion": "pleural effusion",
                                        "requirement": {
                                            "requirement_type": "control",
                                            "expected_value": "uncontrollable"
                                        }
                                    },
                                    {
                                        "exact_snippets": "in 2 weeks before recruitment",
                                        "criterion": "time before recruitment",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 2,
                                                "unit": "weeks"
                                            }
                                        }
                                    }
                                ]
                            },
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                                "and_criteria": [
                                    {
                                        "exact_snippets": "uncontrollable ... pericardial effusion",
                                        "criterion": "pericardial effusion",
                                        "requirement": {
                                            "requirement_type": "control",
                                            "expected_value": "uncontrollable"
                                        }
                                    },
                                    {
                                        "exact_snippets": "in 2 weeks before recruitment",
                                        "criterion": "time before recruitment",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 2,
                                                "unit": "weeks"
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "uncontrollable ... ascites",
                                        "criterion": "ascites",
                                        "requirement": {
                                            "requirement_type": "control",
                                            "expected_value": "uncontrollable"
                                        }
                                    },
                                    {
                                        "exact_snippets": "in 2 weeks before recruitment",
                                        "criterion": "time before recruitment",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 2,
                                                "unit": "weeks"
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. patients who have digestive tract bleeding in 2 weeks before recruitment or with high risk of bleeding.",
                "criterions": [
                    {
                        "exact_snippets": "digestive tract bleeding in 2 weeks before recruitment",
                        "criterion": "digestive tract bleeding",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "2 weeks before recruitment"
                        }
                    },
                    {
                        "exact_snippets": "high risk of bleeding",
                        "criterion": "risk of bleeding",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "high"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "digestive tract bleeding in 2 weeks before recruitment",
                                "criterion": "digestive tract bleeding",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "2 weeks before recruitment"
                                }
                            },
                            {
                                "exact_snippets": "high risk of bleeding",
                                "criterion": "risk of bleeding",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "high"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "high risk of bleeding",
                        "criterion": "risk of bleeding",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "high"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. pulmonary disease history: interstitial pulmonary disease, non-infective pneumonitis, pulmonary fibrosis, acute pulmonary disease.",
                "criterions": [
                    {
                        "exact_snippets": "pulmonary disease history: interstitial pulmonary disease",
                        "criterion": "interstitial pulmonary disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary disease history: ... non-infective pneumonitis",
                        "criterion": "non-infective pneumonitis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary disease history: ... pulmonary fibrosis",
                        "criterion": "pulmonary fibrosis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary disease history: ... acute pulmonary disease",
                        "criterion": "acute pulmonary disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "pulmonary disease history: interstitial pulmonary disease",
                        "criterion": "interstitial pulmonary disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary disease history: ... non-infective pneumonitis",
                        "criterion": "non-infective pneumonitis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary disease history: ... pulmonary fibrosis",
                        "criterion": "pulmonary fibrosis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary disease history: ... acute pulmonary disease",
                        "criterion": "acute pulmonary disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "9. uncontrollable systemic diseases, including diabetes, hypertension etc.",
                "criterions": [
                    {
                        "exact_snippets": "uncontrollable systemic diseases, including diabetes",
                        "criterion": "diabetes",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "uncontrollable systemic diseases, including ... hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "uncontrollable systemic diseases, including diabetes",
                        "criterion": "diabetes",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "uncontrollable systemic diseases, including ... hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "10. severe chronic or active infections in need of systemic antibacterial, antifungal, or antiviral treatment, including TB or HIV, etc.",
                "criterions": [
                    {
                        "exact_snippets": "severe chronic or active infections",
                        "criterion": "infections",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    },
                    {
                        "exact_snippets": "severe chronic or active infections",
                        "criterion": "infections",
                        "requirement": {
                            "requirement_type": "chronicity",
                            "expected_value": [
                                "chronic",
                                "active"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "in need of systemic antibacterial, antifungal, or antiviral treatment",
                        "criterion": "treatment need",
                        "requirement": {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "systemic antibacterial",
                                "antifungal",
                                "antiviral"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "including TB or HIV",
                        "criterion": "specific infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "TB",
                                "HIV"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "severe chronic or active infections",
                                        "criterion": "infections",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "severe"
                                        }
                                    },
                                    {
                                        "exact_snippets": "severe chronic or active infections",
                                        "criterion": "infections",
                                        "requirement": {
                                            "requirement_type": "chronicity",
                                            "expected_value": [
                                                "chronic",
                                                "active"
                                            ]
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "in need of systemic antibacterial, antifungal, or antiviral treatment",
                                "criterion": "treatment need",
                                "requirement": {
                                    "requirement_type": "treatment type",
                                    "expected_value": [
                                        "systemic antibacterial",
                                        "antifungal",
                                        "antiviral"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "including TB or HIV",
                        "criterion": "specific infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "TB",
                                "HIV"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "11. patients with untreated chronic hepatitis B or HBV DNA over 500 IU/ml or positive HCV RNA.",
                "criterions": [
                    {
                        "exact_snippets": "untreated chronic hepatitis B",
                        "criterion": "chronic hepatitis B",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "untreated"
                        }
                    },
                    {
                        "exact_snippets": "HBV DNA over 500 IU/ml",
                        "criterion": "HBV DNA",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 500,
                                "unit": "IU/ml"
                            }
                        }
                    },
                    {
                        "exact_snippets": "positive HCV RNA",
                        "criterion": "HCV RNA",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "untreated chronic hepatitis B",
                        "criterion": "chronic hepatitis B",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "untreated"
                        }
                    },
                    {
                        "exact_snippets": "HBV DNA over 500 IU/ml",
                        "criterion": "HBV DNA",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 500,
                                "unit": "IU/ml"
                            }
                        }
                    },
                    {
                        "exact_snippets": "positive HCV RNA",
                        "criterion": "HCV RNA",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "12. patients with any cardiovascular risk factors below: （1）cardiac chest pain occurring in 28 days before recruitment, defined as moderate pain that limits daily activity.",
                "criterions": [
                    {
                        "exact_snippets": "cardiac chest pain occurring in 28 days before recruitment",
                        "criterion": "cardiac chest pain",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 28,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "cardiac chest pain occurring in 28 days before recruitment",
                        "criterion": "cardiac chest pain",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "moderate"
                        }
                    },
                    {
                        "exact_snippets": "cardiac chest pain occurring in 28 days before recruitment",
                        "criterion": "cardiac chest pain",
                        "requirement": {
                            "requirement_type": "impact on daily activity",
                            "expected_value": "limits daily activity"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "cardiac chest pain occurring in 28 days before recruitment",
                                "criterion": "cardiac chest pain",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 28,
                                        "unit": "days"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "cardiac chest pain occurring in 28 days before recruitment",
                                "criterion": "cardiac chest pain",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "moderate"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "cardiac chest pain occurring in 28 days before recruitment",
                        "criterion": "cardiac chest pain",
                        "requirement": {
                            "requirement_type": "impact on daily activity",
                            "expected_value": "limits daily activity"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "（2）pulmonary embolism with symptoms occurring in 28 days before recruitment. （3）acute myocardial infarction occurring in 6 months before recruitment. （4）any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment.",
                "criterions": [
                    {
                        "exact_snippets": "pulmonary embolism with symptoms occurring in 28 days before recruitment",
                        "criterion": "pulmonary embolism",
                        "requirement": {
                            "requirement_type": "symptoms",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "pulmonary embolism with symptoms occurring in 28 days before recruitment",
                        "criterion": "pulmonary embolism",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 28,
                                        "unit": "days"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "acute myocardial infarction occurring in 6 months before recruitment",
                        "criterion": "acute myocardial infarction",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "acute myocardial infarction occurring in 6 months before recruitment",
                        "criterion": "acute myocardial infarction",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment",
                        "criterion": "heart failure",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment",
                        "criterion": "heart failure",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "grade 3/4 of NYHA"
                        }
                    },
                    {
                        "exact_snippets": "any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment",
                        "criterion": "heart failure",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "pulmonary embolism with symptoms occurring in 28 days before recruitment",
                                        "criterion": "pulmonary embolism",
                                        "requirement": {
                                            "requirement_type": "symptoms",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "pulmonary embolism with symptoms occurring in 28 days before recruitment",
                                        "criterion": "pulmonary embolism",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 28,
                                                        "unit": "days"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "acute myocardial infarction occurring in 6 months before recruitment",
                                        "criterion": "acute myocardial infarction",
                                        "requirement": {
                                            "requirement_type": "occurrence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "acute myocardial infarction occurring in 6 months before recruitment",
                                        "criterion": "acute myocardial infarction",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": "<=",
                                                        "value": 6,
                                                        "unit": "months"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment",
                                        "criterion": "heart failure",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment",
                                        "criterion": "heart failure",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "grade 3/4 of NYHA"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "any history of heart failure reaching grade 3/4 of NYHA in 6 months before recruitment",
                                "criterion": "heart failure",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "months"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "（5）ventricular arrhythmias of Grade 2 or grater in 6 months before recruitment, or accompanied by supraventricular tachyarrhythmias requiring medical treatment.",
                "criterions": [
                    {
                        "exact_snippets": "ventricular arrhythmias of Grade 2 or grater in 6 months before recruitment",
                        "criterion": "ventricular arrhythmias",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "Grade"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ventricular arrhythmias of Grade 2 or grater in 6 months before recruitment",
                        "criterion": "ventricular arrhythmias",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "6 months before recruitment"
                        }
                    },
                    {
                        "exact_snippets": "ventricular arrhythmias ... accompanied by supraventricular tachyarrhythmias requiring medical treatment",
                        "criterion": "supraventricular tachyarrhythmias",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "ventricular arrhythmias ... accompanied by supraventricular tachyarrhythmias requiring medical treatment",
                        "criterion": "supraventricular tachyarrhythmias",
                        "requirement": {
                            "requirement_type": "treatment requirement",
                            "expected_value": "medical treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "ventricular arrhythmias of Grade 2 or grater in 6 months before recruitment",
                                        "criterion": "ventricular arrhythmias",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 2,
                                                "unit": "Grade"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "ventricular arrhythmias of Grade 2 or grater in 6 months before recruitment",
                                        "criterion": "ventricular arrhythmias",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": "6 months before recruitment"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "ventricular arrhythmias ... accompanied by supraventricular tachyarrhythmias requiring medical treatment",
                                        "criterion": "supraventricular tachyarrhythmias",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "ventricular arrhythmias ... accompanied by supraventricular tachyarrhythmias requiring medical treatment",
                                        "criterion": "supraventricular tachyarrhythmias",
                                        "requirement": {
                                            "requirement_type": "treatment requirement",
                                            "expected_value": "medical treatment"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "15. moderate or severe renal injury [creatinine clearance rate≤50 ml/min (according to Cockcroft & Gault equation)], or Scr>ULN.",
                "criterions": [
                    {
                        "exact_snippets": "moderate or severe renal injury",
                        "criterion": "renal injury",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "moderate",
                                "severe"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "creatinine clearance rate≤50 ml/min (according to Cockcroft & Gault equation)",
                        "criterion": "creatinine clearance rate",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 50,
                                "unit": "ml/min"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Scr>ULN",
                        "criterion": "serum creatinine (Scr)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "moderate or severe renal injury",
                                "criterion": "renal injury",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": [
                                        "moderate",
                                        "severe"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "creatinine clearance rate≤50 ml/min (according to Cockcroft & Gault equation)",
                                "criterion": "creatinine clearance rate",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 50,
                                        "unit": "ml/min"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Scr>ULN",
                        "criterion": "serum creatinine (Scr)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "16. dipyrimidine dehydrogenase (DPD) deficiency. 17. allergic to any drug in this study. 18. history of allogeneic stem cell transplantation or organ transplantation. 19. use of steroids (dosage>10mg/d prednisone) or other systemic immune suppressive therapy in 14 days before recruitment, except patients treated with regimens below: a. steroids for hormone replacement (dosage>10mg/d prednisone); b. steroids for local application with little systemic absorption; c. short -term (≤ 7 days) steroids for preventing allergy or vomiting.",
                "criterions": [
                    {
                        "exact_snippets": "dipyrimidine dehydrogenase (DPD) deficiency",
                        "criterion": "DPD deficiency",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "allergic to any drug in this study",
                        "criterion": "allergy to study drug",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "history of allogeneic stem cell transplantation or organ transplantation",
                        "criterion": "history of transplantation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "use of steroids (dosage>10mg/d prednisone) or other systemic immune suppressive therapy in 14 days before recruitment",
                        "criterion": "use of steroids or immune suppressive therapy",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "mg/d prednisone"
                            }
                        }
                    },
                    {
                        "exact_snippets": "use of steroids (dosage>10mg/d prednisone) or other systemic immune suppressive therapy in 14 days before recruitment",
                        "criterion": "use of steroids or immune suppressive therapy",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "14 days before recruitment"
                        }
                    },
                    {
                        "exact_snippets": "steroids for hormone replacement (dosage>10mg/d prednisone)",
                        "criterion": "steroids for hormone replacement",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "mg/d prednisone"
                            }
                        }
                    },
                    {
                        "exact_snippets": "steroids for local application with little systemic absorption",
                        "criterion": "steroids for local application",
                        "requirement": {
                            "requirement_type": "systemic absorption",
                            "expected_value": "little"
                        }
                    },
                    {
                        "exact_snippets": "short -term (≤ 7 days) steroids for preventing allergy or vomiting",
                        "criterion": "short-term steroids for preventing allergy or vomiting",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<=",
                                "value": 7,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "and_criteria": [
                            {
                                "exact_snippets": "use of steroids (dosage>10mg/d prednisone) or other systemic immune suppressive therapy in 14 days before recruitment",
                                "criterion": "use of steroids or immune suppressive therapy",
                                "requirement": {
                                    "requirement_type": "dosage",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 10,
                                        "unit": "mg/d prednisone"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "use of steroids (dosage>10mg/d prednisone) or other systemic immune suppressive therapy in 14 days before recruitment",
                                "criterion": "use of steroids or immune suppressive therapy",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "14 days before recruitment"
                                }
                            },
                            {
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                                        {
                                            "exact_snippets": "steroids for hormone replacement (dosage>10mg/d prednisone)",
                                            "criterion": "steroids for hormone replacement",
                                            "requirement": {
                                                "requirement_type": "dosage",
                                                "expected_value": {
                                                    "operator": ">",
                                                    "value": 10,
                                                    "unit": "mg/d prednisone"
                                                }
                                            }
                                        },
                                        {
                                            "exact_snippets": "steroids for local application with little systemic absorption",
                                            "criterion": "steroids for local application",
                                            "requirement": {
                                                "requirement_type": "systemic absorption",
                                                "expected_value": "little"
                                            }
                                        },
                                        {
                                            "exact_snippets": "short -term (≤ 7 days) steroids for preventing allergy or vomiting",
                                            "criterion": "short-term steroids for preventing allergy or vomiting",
                                            "requirement": {
                                                "requirement_type": "duration",
                                                "expected_value": {
                                                    "operator": "<=",
                                                    "value": 7,
                                                    "unit": "days"
                                                }
                                            }
                                        }
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "dipyrimidine dehydrogenase (DPD) deficiency",
                        "criterion": "DPD deficiency",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "allergic to any drug in this study",
                        "criterion": "allergy to study drug",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "history of allogeneic stem cell transplantation or organ transplantation",
                        "criterion": "history of transplantation",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "20. vaccinated with live vaccine in 4 weeks before recruitment. 21. for patients with uncontrolled epilepsy, CNS diseases or history of mental disorder, researchers should evaluate whether their diseases will impede their signing of informed consent or compliance of treatment.",
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                    {
                        "exact_snippets": "vaccinated with live vaccine in 4 weeks before recruitment",
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                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "uncontrolled epilepsy",
                        "criterion": "epilepsy",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    },
                    {
                        "exact_snippets": "CNS diseases",
                        "criterion": "CNS diseases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "history of mental disorder",
                        "criterion": "mental disorder",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
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                    {
                        "and_criteria": [
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                                    "expected_value": {
                                        "operator": "<",
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                                    }
                                }
                            }
                        ]
                    },
                    {
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                                    {
                                        "exact_snippets": "uncontrolled epilepsy",
                                        "criterion": "epilepsy",
                                        "requirement": {
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                                            "expected_value": "uncontrolled"
                                        }
                                    },
                                    {
                                        "exact_snippets": "CNS diseases",
                                        "criterion": "CNS diseases",
                                        "requirement": {
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                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "history of mental disorder",
                                        "criterion": "mental disorder",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "22. existing of potential situation which will impede drug administration or affect toxicity analysis or alcohol/ drug abuse.",
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                        "criterion": "situation impeding drug administration",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "existing of potential situation which will ... affect toxicity analysis",
                        "criterion": "situation affecting toxicity analysis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "alcohol/ drug abuse",
                        "criterion": "alcohol/drug abuse",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "existing of potential situation which will impede drug administration",
                                "criterion": "situation impeding drug administration",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "existing of potential situation which will ... affect toxicity analysis",
                                "criterion": "situation affecting toxicity analysis",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "alcohol/ drug abuse",
                        "criterion": "alcohol/drug abuse",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "3. clinically diagnosed stage T3-4bN+M0 according to ultrasound endoscopy or enhanced CT/MRI scan.",
                "criterions": [
                    {
                        "exact_snippets": "clinically diagnosed stage T3-4bN+M0",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "T3-4bN+M0"
                        }
                    },
                    {
                        "exact_snippets": "according to ultrasound endoscopy or enhanced CT/MRI scan",
                        "criterion": "diagnostic method",
                        "requirement": {
                            "requirement_type": "methods",
                            "expected_value": [
                                "ultrasound endoscopy",
                                "enhanced CT",
                                "MRI scan"
                            ]
                        }
                    }
                ]
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                        "and_criteria": [
                            {
                                "exact_snippets": "clinically diagnosed stage T3-4bN+M0",
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                                    "requirement_type": "stage",
                                    "expected_value": "T3-4bN+M0"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "according to ultrasound endoscopy or enhanced CT/MRI scan",
                                        "criterion": "diagnostic method",
                                        "requirement": {
                                            "requirement_type": "methods",
                                            "expected_value": "ultrasound endoscopy"
                                        }
                                    },
                                    {
                                        "exact_snippets": "according to ultrasound endoscopy or enhanced CT/MRI scan",
                                        "criterion": "diagnostic method",
                                        "requirement": {
                                            "requirement_type": "methods",
                                            "expected_value": "enhanced CT"
                                        }
                                    },
                                    {
                                        "exact_snippets": "according to ultrasound endoscopy or enhanced CT/MRI scan",
                                        "criterion": "diagnostic method",
                                        "requirement": {
                                            "requirement_type": "methods",
                                            "expected_value": "MRI scan"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "10. Good compliance with the study procedures, including lab and auxiliary examination and treatment.",
                "criterions": [
                    {
                        "exact_snippets": "Good compliance with the study procedures",
                        "criterion": "compliance with study procedures",
                        "requirement": {
                            "requirement_type": "quality",
                            "expected_value": "good"
                        }
                    },
                    {
                        "exact_snippets": "including lab and auxiliary examination",
                        "criterion": "compliance with lab and auxiliary examination",
                        "requirement": {
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                            "expected_value": "good"
                        }
                    },
                    {
                        "exact_snippets": "including ... treatment",
                        "criterion": "compliance with treatment",
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                            "requirement_type": "quality",
                            "expected_value": "good"
                        }
                    }
                ]
            },
            "logical_structure": {
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                "criterion": "failed",
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        },
        {
            "identified_line": {
                "line": "11. Female patients should not be pregnant or breast feeding.",
                "criterions": [
                    {
                        "exact_snippets": "Female patients should not be pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Female patients should not be ... breast feeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
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        },
        {
            "identified_line": {
                "line": "12. Agree to take contraception measures during treatment and in 120 days after last dose of SHR-1210.",
                "criterions": [
                    {
                        "exact_snippets": "Agree to take contraception measures during treatment and in 120 days after last dose of SHR-1210.",
                        "criterion": "contraception measures",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
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                }
            }
        },
        {
            "identified_line": {
                "line": "13. Life expectancy of at least 6 months.",
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                    {
                        "exact_snippets": "Life expectancy of at least 6 months.",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
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                "exact_snippets": "failed",
                "criterion": "failed",
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                    "expected_value": "failed"
                }
            }
        }
    ],
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        {
            "identified_line": {
                "line": "4. patients with active malignant tumor in recent 2 years, except the tumor studied in this research or cured locally tumor like resected basal cell or squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ.",
                "criterions": [
                    {
                        "exact_snippets": "active malignant tumor in recent 2 years",
                        "criterion": "active malignant tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "active malignant tumor in recent 2 years",
                        "criterion": "active malignant tumor",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "recent 2 years"
                        }
                    },
                    {
                        "exact_snippets": "except the tumor studied in this research",
                        "criterion": "tumor studied in this research",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "cured locally tumor like resected basal cell or squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ",
                        "criterion": "cured locally tumor",
                        "requirement": {
                            "requirement_type": "examples",
                            "expected_value": [
                                "resected basal cell or squamous cell skin cancer",
                                "superficial bladder cancer",
                                "cervical carcinoma in situ"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "cured locally tumor like resected basal cell or squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ",
                        "criterion": "cured locally tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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        },
        {
            "identified_line": {
                "line": "7. perforation / fistula of GI tract in 6 months before recruitment.",
                "criterions": [
                    {
                        "exact_snippets": "perforation / fistula of GI tract",
                        "criterion": "perforation / fistula of GI tract",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "in 6 months before recruitment",
                        "criterion": "time since perforation / fistula of GI tract",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "perforation / fistula of GI tract",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "in 6 months before recruitment",
                        "criterion": "time since perforation / fistula of GI tract",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "（6）cerebrovascular accident within 6 months before recruitment. 14. patients with peripheral neuropathy NCI CTC AE grade 1, except those with only deep tendon reflex disappearing.",
                "criterions": [
                    {
                        "exact_snippets": "cerebrovascular accident within 6 months before recruitment",
                        "criterion": "cerebrovascular accident",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "peripheral neuropathy NCI CTC AE grade 1",
                        "criterion": "peripheral neuropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "NCI CTC AE grade 1"
                        }
                    },
                    {
                        "exact_snippets": "except those with only deep tendon reflex disappearing",
                        "criterion": "deep tendon reflex",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
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                            "and_criteria": [
                                {
                                    "exact_snippets": "peripheral neuropathy NCI CTC AE grade 1",
                                    "criterion": "peripheral neuropathy",
                                    "requirement": {
                                        "requirement_type": "severity",
                                        "expected_value": "NCI CTC AE grade 1"
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except those with only deep tendon reflex disappearing",
                                        "criterion": "deep tendon reflex",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}