{
    "info": {
        "nct_id": "NCT03701373",
        "official_title": "Maintenance Treatment With S-1 Versus Observation After First-line Chemotherapy in Patients With Advanced Gastric Cancer: a Randomized Phase II Study",
        "inclusion_criteria": "* Age older than 18 years\n* Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1\n* At least one measurable lesion according to the Response Evaluation Criteria in Solid Tumor (RECIST version 1.0)\n* Histologically confirmed gastric cancer with inoperable locally advanced or recurrent and/or metastatic disease, not amenable to curative therapy\n* No previous chemotherapy for metastatic GC was allowed, the interval after the end of adjuvant/neoadjuvant chemotherapy beyond 6 months was allowable\n* Life expectancy of at least 3 months\n* Adequate hematologic, hepatic and renal function. Neutrophil count ≥ 1.5 × 109/L; platelet count ≥ 100 × 109/L; Serum bilirubin ≤ 1.5 × upper limit of normal (ULN), AST or ALT ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases), alkaline phosphatase ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases, or ≤ 10 × ULN in patients with bone but no liver metastases); serum creatinine ≤ 1.5 × ULN；and albumin ≥ 25 g/L\n* Patients who achieved objective response or stable disease after 2-6 month first-line chemotherapy\n* The first-line chemotherapy regimens were doublets including platinum (cisplatin or oxaliplatin) plus fluoropyrimidine (5-FU, capecitabine, or S-1)\n* Signed informed consent\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Known hypersensitivity to platinum (cisplatin or oxaliplatin) or fluoropyrimidine (5-FU, capecitabine, or S-1)\n* History or clinical evidence of brain metastases\n* Previous chemotherapy for metastatic disease\n* Positive serum pregnancy test in women of childbearing potential\n* Subjects with reproductive potential not willing to use an effective method of contraception\n* Received any investigational drug treatment within 4 weeks of start of study treatment\n* Other prior malignancies in the past 5 years\n* Unresolved bowel obstruction or malabsorption syndrome",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age older than 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age older than 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age older than 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1",
                        "criterion": "Eastern Cooperative Oncology Group performance status (ECOG PS)",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1",
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                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least one measurable lesion according to the Response Evaluation Criteria in Solid Tumor (RECIST version 1.0)",
                "criterions": [
                    {
                        "exact_snippets": "At least one measurable lesion according to the Response Evaluation Criteria in Solid Tumor (RECIST version 1.0)",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least one measurable lesion according to the Response Evaluation Criteria in Solid Tumor (RECIST version 1.0)",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "evaluation criteria",
                            "expected_value": "RECIST version 1.0"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least one measurable lesion according to the Response Evaluation Criteria in Solid Tumor (RECIST version 1.0)",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least one measurable lesion according to the Response Evaluation Criteria in Solid Tumor (RECIST version 1.0)",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "evaluation criteria",
                            "expected_value": "RECIST version 1.0"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No previous chemotherapy for metastatic GC was allowed, the interval after the end of adjuvant/neoadjuvant chemotherapy beyond 6 months was allowable",
                "criterions": [
                    {
                        "exact_snippets": "No previous chemotherapy for metastatic GC was allowed",
                        "criterion": "previous chemotherapy for metastatic GC",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "the interval after the end of adjuvant/neoadjuvant chemotherapy beyond 6 months was allowable",
                        "criterion": "interval after adjuvant/neoadjuvant chemotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "No previous chemotherapy for metastatic GC was allowed",
                            "criterion": "previous chemotherapy for metastatic GC",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        }
                    },
                    {
                        "exact_snippets": "the interval after the end of adjuvant/neoadjuvant chemotherapy beyond 6 months was allowable",
                        "criterion": "interval after adjuvant/neoadjuvant chemotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy of at least 3 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy of at least 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy of at least 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients who achieved objective response or stable disease after 2-6 month first-line chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Patients who achieved objective response",
                        "criterion": "objective response",
                        "requirement": {
                            "requirement_type": "achievement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "stable disease after 2-6 month first-line chemotherapy",
                        "criterion": "stable disease",
                        "requirement": {
                            "requirement_type": "achievement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "2-6 month first-line chemotherapy",
                        "criterion": "first-line chemotherapy duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "month"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "month"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients who achieved objective response",
                                "criterion": "objective response",
                                "requirement": {
                                    "requirement_type": "achievement",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "2-6 month first-line chemotherapy",
                                "criterion": "first-line chemotherapy duration",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">=",
                                                "value": 2,
                                                "unit": "month"
                                            },
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "month"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "stable disease after 2-6 month first-line chemotherapy",
                                "criterion": "stable disease",
                                "requirement": {
                                    "requirement_type": "achievement",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "2-6 month first-line chemotherapy",
                                "criterion": "first-line chemotherapy duration",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">=",
                                                "value": 2,
                                                "unit": "month"
                                            },
                                            {
                                                "operator": "<=",
                                                "value": 6,
                                                "unit": "month"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Signed informed consent",
                "criterions": [
                    {
                        "exact_snippets": "Signed informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Signed informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
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                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 80 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Known hypersensitivity to platinum (cisplatin or oxaliplatin) or fluoropyrimidine (5-FU, capecitabine, or S-1)",
                "criterions": [
                    {
                        "exact_snippets": "Known hypersensitivity to platinum (cisplatin or oxaliplatin)",
                        "criterion": "hypersensitivity to platinum",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Known hypersensitivity to ... fluoropyrimidine (5-FU, capecitabine, or S-1)",
                        "criterion": "hypersensitivity to fluoropyrimidine",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Known hypersensitivity to platinum (cisplatin or oxaliplatin)",
                        "criterion": "hypersensitivity to platinum",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Known hypersensitivity to ... fluoropyrimidine (5-FU, capecitabine, or S-1)",
                        "criterion": "hypersensitivity to fluoropyrimidine",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History or clinical evidence of brain metastases",
                "criterions": [
                    {
                        "exact_snippets": "History or clinical evidence of brain metastases",
                        "criterion": "brain metastases",
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                        }
                    }
                ]
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            "logical_structure": {
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                    "exact_snippets": "History or clinical evidence of brain metastases",
                    "criterion": "brain metastases",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous chemotherapy for metastatic disease",
                "criterions": [
                    {
                        "exact_snippets": "Previous chemotherapy for metastatic disease",
                        "criterion": "chemotherapy for metastatic disease",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "exact_snippets": "Previous chemotherapy for metastatic disease",
                    "criterion": "chemotherapy for metastatic disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Positive serum pregnancy test in women of childbearing potential",
                "criterions": [
                    {
                        "exact_snippets": "Positive serum pregnancy test",
                        "criterion": "serum pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "women of childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "women of childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "reproductive status",
                            "expected_value": "childbearing potential"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Positive serum pregnancy test",
                                "criterion": "serum pregnancy test",
                                "requirement": {
                                    "requirement_type": "result",
                                    "expected_value": "positive"
                                }
                            },
                            {
                                "exact_snippets": "women of childbearing potential",
                                "criterion": "childbearing potential",
                                "requirement": {
                                    "requirement_type": "gender",
                                    "expected_value": "female"
                                }
                            },
                            {
                                "exact_snippets": "women of childbearing potential",
                                "criterion": "childbearing potential",
                                "requirement": {
                                    "requirement_type": "reproductive status",
                                    "expected_value": "childbearing potential"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Subjects with reproductive potential not willing to use an effective method of contraception",
                "criterions": [
                    {
                        "exact_snippets": "Subjects with reproductive potential",
                        "criterion": "reproductive potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "not willing to use an effective method of contraception",
                        "criterion": "willingness to use contraception",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Subjects with reproductive potential",
                        "criterion": "reproductive potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "not willing to use an effective method of contraception",
                            "criterion": "willingness to use contraception",
                            "requirement": {
                                "requirement_type": "willingness",
                                "expected_value": true
                            }
                        }
                    }
                ]
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        },
        {
            "identified_line": {
                "line": "* Received any investigational drug treatment within 4 weeks of start of study treatment",
                "criterions": [
                    {
                        "exact_snippets": "Received any investigational drug treatment within 4 weeks of start of study treatment",
                        "criterion": "investigational drug treatment",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "exact_snippets": "Received any investigational drug treatment within 4 weeks of start of study treatment",
                    "criterion": "investigational drug treatment",
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                        "requirement_type": "time since last treatment",
                        "expected_value": {
                            "operator": "<=",
                            "value": 4,
                            "unit": "weeks"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Other prior malignancies in the past 5 years",
                "criterions": [
                    {
                        "exact_snippets": "Other prior malignancies in the past 5 years",
                        "criterion": "prior malignancies",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
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                        }
                    }
                ]
            },
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                                {
                                    "operator": "<=",
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                                    "unit": "years"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Unresolved bowel obstruction or malabsorption syndrome",
                "criterions": [
                    {
                        "exact_snippets": "Unresolved bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "resolution",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "malabsorption syndrome",
                        "criterion": "malabsorption syndrome",
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                        }
                    }
                ]
            },
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                    {
                        "exact_snippets": "Unresolved bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "resolution",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "malabsorption syndrome",
                        "criterion": "malabsorption syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Histologically confirmed gastric cancer with inoperable locally advanced or recurrent and/or metastatic disease, not amenable to curative therapy",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed gastric cancer",
                        "criterion": "gastric cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "inoperable locally advanced or recurrent and/or metastatic disease",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "operability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "inoperable locally advanced or recurrent and/or metastatic disease",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "stage",
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                                "locally advanced",
                                "recurrent",
                                "metastatic"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "not amenable to curative therapy",
                        "criterion": "curative therapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Histologically confirmed gastric cancer",
                                "criterion": "gastric cancer",
                                "requirement": {
                                    "requirement_type": "confirmation method",
                                    "expected_value": "histologically confirmed"
                                }
                            },
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                                "criterion": "disease stage",
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                                    "expected_value": false
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "inoperable locally advanced or recurrent and/or metastatic disease",
                                        "criterion": "disease stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "locally advanced"
                                        }
                                    },
                                    {
                                        "exact_snippets": "inoperable locally advanced or recurrent and/or metastatic disease",
                                        "criterion": "disease stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "recurrent"
                                        }
                                    },
                                    {
                                        "exact_snippets": "inoperable locally advanced or recurrent and/or metastatic disease",
                                        "criterion": "disease stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "metastatic"
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "not amenable to curative therapy",
                        "criterion": "curative therapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate hematologic, hepatic and renal function. Neutrophil count ≥ 1.5 × 109/L; platelet count ≥ 100 × 109/L; Serum bilirubin ≤ 1.5 × upper limit of normal (ULN), AST or ALT ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases), alkaline phosphatase ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases, or ≤ 10 × ULN in patients with bone but no liver metastases); serum creatinine ≤ 1.5 × ULN；and albumin ≥ 25 g/L",
                "criterions": [
                    {
                        "exact_snippets": "Adequate hematologic ... Neutrophil count ≥ 1.5 × 109/L",
                        "criterion": "neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1.5,
                                "unit": "× 10^9/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate hematologic ... platelet count ≥ 100 × 109/L",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100,
                                "unit": "× 10^9/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... Serum bilirubin ≤ 1.5 × upper limit of normal (ULN)",
                        "criterion": "serum bilirubin",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "× ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... AST or ALT ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases)",
                        "criterion": "AST or ALT",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 2.5,
                                        "unit": "× ULN"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "× ULN"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... alkaline phosphatase ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases, or ≤ 10 × ULN in patients with bone but no liver metastases)",
                        "criterion": "alkaline phosphatase",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 2.5,
                                        "unit": "× ULN"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "× ULN"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 10,
                                        "unit": "× ULN"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... renal ... serum creatinine ≤ 1.5 × ULN",
                        "criterion": "serum creatinine",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "× ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... albumin ≥ 25 g/L",
                        "criterion": "albumin",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "g/L"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "and_criteria": [
                                                            {
                                                                "exact_snippets": "Adequate hematologic ... Neutrophil count ≥ 1.5 × 109/L",
                                                                "criterion": "neutrophil count",
                                                                "requirement": {
                                                                    "requirement_type": "quantity",
                                                                    "expected_value": {
                                                                        "operator": ">=",
                                                                        "value": 1.5,
                                                                        "unit": "× 10^9/L"
                                                                    }
                                                                }
                                                            },
                                                            {
                                                                "exact_snippets": "Adequate hematologic ... platelet count ≥ 100 × 109/L",
                                                                "criterion": "platelet count",
                                                                "requirement": {
                                                                    "requirement_type": "quantity",
                                                                    "expected_value": {
                                                                        "operator": ">=",
                                                                        "value": 100,
                                                                        "unit": "× 10^9/L"
                                                                    }
                                                                }
                                                            }
                                                        ]
                                                    },
                                                    {
                                                        "exact_snippets": "Adequate ... hepatic ... Serum bilirubin ≤ 1.5 × upper limit of normal (ULN)",
                                                        "criterion": "serum bilirubin",
                                                        "requirement": {
                                                            "requirement_type": "quantity",
                                                            "expected_value": {
                                                                "operator": "<=",
                                                                "value": 1.5,
                                                                "unit": "× ULN"
                                                            }
                                                        }
                                                    }
                                                ]
                                            },
                                            {
                                                "or_criteria": [
                                                    {
                                                        "exact_snippets": "Adequate ... hepatic ... AST or ALT ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases)",
                                                        "criterion": "AST or ALT",
                                                        "requirement": {
                                                            "requirement_type": "quantity",
                                                            "expected_value": {
                                                                "comparisons": [
                                                                    {
                                                                        "operator": "<=",
                                                                        "value": 2.5,
                                                                        "unit": "× ULN"
                                                                    }
                                                                ]
                                                            }
                                                        }
                                                    },
                                                    {
                                                        "exact_snippets": "Adequate ... hepatic ... AST or ALT ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases)",
                                                        "criterion": "AST or ALT",
                                                        "requirement": {
                                                            "requirement_type": "quantity",
                                                            "expected_value": {
                                                                "comparisons": [
                                                                    {
                                                                        "operator": "<=",
                                                                        "value": 5,
                                                                        "unit": "× ULN"
                                                                    }
                                                                ]
                                                            }
                                                        }
                                                    }
                                                ]
                                            }
                                        ]
                                    },
                                    {
                                        "or_criteria": [
                                            {
                                                "exact_snippets": "Adequate ... hepatic ... alkaline phosphatase ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases, or ≤ 10 × ULN in patients with bone but no liver metastases)",
                                                "criterion": "alkaline phosphatase",
                                                "requirement": {
                                                    "requirement_type": "quantity",
                                                    "expected_value": {
                                                        "comparisons": [
                                                            {
                                                                "operator": "<=",
                                                                "value": 2.5,
                                                                "unit": "× ULN"
                                                            }
                                                        ]
                                                    }
                                                }
                                            },
                                            {
                                                "exact_snippets": "Adequate ... hepatic ... alkaline phosphatase ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases, or ≤ 10 × ULN in patients with bone but no liver metastases)",
                                                "criterion": "alkaline phosphatase",
                                                "requirement": {
                                                    "requirement_type": "quantity",
                                                    "expected_value": {
                                                        "comparisons": [
                                                            {
                                                                "operator": "<=",
                                                                "value": 5,
                                                                "unit": "× ULN"
                                                            }
                                                        ]
                                                    }
                                                }
                                            },
                                            {
                                                "exact_snippets": "Adequate ... hepatic ... alkaline phosphatase ≤ 2.5 × ULN (or ≤ 5 × ULN in patients with liver metastases, or ≤ 10 × ULN in patients with bone but no liver metastases)",
                                                "criterion": "alkaline phosphatase",
                                                "requirement": {
                                                    "requirement_type": "quantity",
                                                    "expected_value": {
                                                        "comparisons": [
                                                            {
                                                                "operator": "<=",
                                                                "value": 10,
                                                                "unit": "× ULN"
                                                            }
                                                        ]
                                                    }
                                                }
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Adequate ... renal ... serum creatinine ≤ 1.5 × ULN",
                                "criterion": "serum creatinine",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1.5,
                                        "unit": "× ULN"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... albumin ≥ 25 g/L",
                        "criterion": "albumin",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "g/L"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* The first-line chemotherapy regimens were doublets including platinum (cisplatin or oxaliplatin) plus fluoropyrimidine (5-FU, capecitabine, or S-1)",
                "criterions": [
                    {
                        "exact_snippets": "first-line chemotherapy regimens were doublets including platinum (cisplatin or oxaliplatin) plus fluoropyrimidine (5-FU, capecitabine, or S-1)",
                        "criterion": "first-line chemotherapy regimen",
                        "requirement": {
                            "requirement_type": "composition",
                            "expected_value": [
                                "platinum (cisplatin or oxaliplatin)",
                                "fluoropyrimidine (5-FU, capecitabine, or S-1)"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}