{
    "info": {
        "nct_id": "NCT03221920",
        "official_title": "Effect of Very Low Carbohydrate Diet to Glasgow Prognostic Score, Serum Lactate and TNF Alpha on Colorectal Cancer Patients With Best Supportive Care",
        "inclusion_criteria": "* Diagnosed as colorectal adenocarcinoma pathologically\n* Decided by a digestive surgery consultant to be managed with best supportive care\n* More than 17 years old and capable of making informed consent\n* Karnofsky score > 50% or ECOG performance status <=2\n* No clinical signs of infection, with one or more of these criteria : fever, leukocytosis, local sign of infection (eg.abscess,ulcer)\n* AST < 2 times normal limit\n* ALT < 2 times normal limit\n* Serum Creatinine < 1,5 times normal limit\n* Not pregnant (for women)\n* Able to understand and willing participate and to sign informed consent form\n* No Diabetes Mellitus\n* No fat intolerance\n* No severe malnutrition or cancer cachexia\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 65 Years",
        "exclusion_criteria": "* Patient is still on other therapy for the tumour\n* Patient with coexisting diseases which prohibits the patient to follow the study protocols",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Diagnosed as colorectal adenocarcinoma pathologically",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosed as colorectal adenocarcinoma pathologically",
                        "criterion": "colorectal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosed as colorectal adenocarcinoma pathologically",
                        "criterion": "colorectal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "pathologically"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosed as colorectal adenocarcinoma pathologically",
                        "criterion": "colorectal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosed as colorectal adenocarcinoma pathologically",
                        "criterion": "colorectal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "pathologically"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Decided by a digestive surgery consultant to be managed with best supportive care",
                "criterions": [
                    {
                        "exact_snippets": "Decided by a digestive surgery consultant",
                        "criterion": "management decision",
                        "requirement": {
                            "requirement_type": "decision_maker",
                            "expected_value": "digestive surgery consultant"
                        }
                    },
                    {
                        "exact_snippets": "managed with best supportive care",
                        "criterion": "management plan",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "best supportive care"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Decided by a digestive surgery consultant",
                        "criterion": "management decision",
                        "requirement": {
                            "requirement_type": "decision_maker",
                            "expected_value": "digestive surgery consultant"
                        }
                    },
                    {
                        "exact_snippets": "managed with best supportive care",
                        "criterion": "management plan",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "best supportive care"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 17 years old and capable of making informed consent",
                "criterions": [
                    {
                        "exact_snippets": "More than 17 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">",
                                "value": 17,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "capable of making informed consent",
                        "criterion": "informed consent capability",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 17 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">",
                                "value": 17,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "capable of making informed consent",
                        "criterion": "informed consent capability",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky score > 50% or ECOG performance status <=2",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky score > 50%",
                        "criterion": "Karnofsky score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ECOG performance status <=2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Karnofsky score > 50%",
                        "criterion": "Karnofsky score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ECOG performance status <=2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No clinical signs of infection, with one or more of these criteria : fever, leukocytosis, local sign of infection (eg.abscess,ulcer)",
                "criterions": [
                    {
                        "exact_snippets": "No clinical signs of infection",
                        "criterion": "clinical signs of infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "fever",
                        "criterion": "fever",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "leukocytosis",
                        "criterion": "leukocytosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "local sign of infection (eg.abscess,ulcer)",
                        "criterion": "local sign of infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No clinical signs of infection",
                        "criterion": "clinical signs of infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "fever",
                                "criterion": "fever",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "leukocytosis",
                                "criterion": "leukocytosis",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "local sign of infection (eg.abscess,ulcer)",
                                "criterion": "local sign of infection",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST < 2 times normal limit",
                "criterions": [
                    {
                        "exact_snippets": "AST < 2 times normal limit",
                        "criterion": "AST",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times normal limit"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "AST < 2 times normal limit",
                        "criterion": "AST",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times normal limit"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ALT < 2 times normal limit",
                "criterions": [
                    {
                        "exact_snippets": "ALT < 2 times normal limit",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times normal limit"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ALT < 2 times normal limit",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times normal limit"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serum Creatinine < 1,5 times normal limit",
                "criterions": [
                    {
                        "exact_snippets": "Serum Creatinine < 1,5 times normal limit",
                        "criterion": "serum creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal limit"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Serum Creatinine < 1,5 times normal limit",
                        "criterion": "serum creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "times normal limit"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant (for women)",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant (for women)",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant (for women)",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to understand and willing participate and to sign informed consent form",
                "criterions": [
                    {
                        "exact_snippets": "Able to understand",
                        "criterion": "understanding ability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willing participate",
                        "criterion": "willingness to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "sign informed consent form",
                        "criterion": "ability to sign informed consent form",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Able to understand",
                        "criterion": "understanding ability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willing participate",
                        "criterion": "willingness to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "sign informed consent form",
                        "criterion": "ability to sign informed consent form",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No fat intolerance",
                "criterions": [
                    {
                        "exact_snippets": "No fat intolerance",
                        "criterion": "fat intolerance",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No fat intolerance",
                        "criterion": "fat intolerance",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No severe malnutrition or cancer cachexia",
                "criterions": [
                    {
                        "exact_snippets": "No severe malnutrition",
                        "criterion": "malnutrition",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not severe"
                        }
                    },
                    {
                        "exact_snippets": "No ... cancer cachexia",
                        "criterion": "cancer cachexia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No severe malnutrition",
                        "criterion": "malnutrition",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not severe"
                        }
                    },
                    {
                        "exact_snippets": "No ... cancer cachexia",
                        "criterion": "cancer cachexia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 65 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 65 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 65 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patient is still on other therapy for the tumour",
                "criterions": [
                    {
                        "exact_snippets": "Patient is still on other therapy for the tumour",
                        "criterion": "other therapy for the tumour",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patient is still on other therapy for the tumour",
                    "criterion": "other therapy for the tumour",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient with coexisting diseases which prohibits the patient to follow the study protocols",
                "criterions": [
                    {
                        "exact_snippets": "coexisting diseases which prohibits the patient to follow the study protocols",
                        "criterion": "coexisting diseases",
                        "requirement": {
                            "requirement_type": "impact on study protocol adherence",
                            "expected_value": "prohibits"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "coexisting diseases which prohibits the patient to follow the study protocols",
                        "criterion": "coexisting diseases",
                        "requirement": {
                            "requirement_type": "impact on study protocol adherence",
                            "expected_value": "prohibits"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* No Diabetes Mellitus",
                "criterions": [
                    {
                        "exact_snippets": "No Diabetes Mellitus",
                        "criterion": "Diabetes Mellitus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No Diabetes Mellitus",
                    "criterion": "Diabetes Mellitus",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}