{
    "info": {
        "nct_id": "NCT02908048",
        "official_title": "Extracellular RNA Markers of Liver Disease and Cancer",
        "inclusion_criteria": "* Lab results from within the previous 90 days.\n* Diagnosis of HCC or biliary tract cancer\n* Diagnosis of cirrhosis based on histology, imaging, or ultrasound.\n* Diagnosis of a chronic liver disease without cirrhosis.\n\nExclusion Criteria for the HCC/biliary tract cancer group:\n\n* Prior solid organ transplant.\n* Previous cancer history with the last 5 years (excluding non-melanoma skin cancer), participation in a treatment trial for HCC\n\nExclusion criteria for the cirrhosis and chronic liver disease groups:\n\n* Prior solid organ transplant.\n* Previous or current cancer history within the past 5 years (excluding non-melanoma skin cancer).\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Lab results from within the previous 90 days.",
                "criterions": [
                    {
                        "exact_snippets": "Lab results from within the previous 90 days.",
                        "criterion": "lab results",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "within the previous 90 days"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Lab results from within the previous 90 days.",
                        "criterion": "lab results",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "within the previous 90 days"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Diagnosis of HCC or biliary tract cancer",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of HCC",
                        "criterion": "HCC",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosis of ... biliary tract cancer",
                        "criterion": "biliary tract cancer",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Diagnosis of HCC",
                        "criterion": "HCC",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosis of ... biliary tract cancer",
                        "criterion": "biliary tract cancer",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Diagnosis of a chronic liver disease without cirrhosis.",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of a chronic liver disease",
                        "criterion": "chronic liver disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "without cirrhosis",
                        "criterion": "cirrhosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of a chronic liver disease",
                        "criterion": "chronic liver disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "without cirrhosis",
                        "criterion": "cirrhosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Exclusion Criteria for the HCC/biliary tract cancer group:",
                "criterions": [
                    {
                        "exact_snippets": "HCC/biliary tract cancer",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": [
                                "HCC",
                                "biliary tract cancer"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "HCC/biliary tract cancer",
                    "criterion": "cancer type",
                    "requirement": {
                        "requirement_type": "exclusion",
                        "expected_value": [
                            "HCC",
                            "biliary tract cancer"
                        ]
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior solid organ transplant.",
                "criterions": [
                    {
                        "exact_snippets": "Prior solid organ transplant.",
                        "criterion": "solid organ transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Prior solid organ transplant.",
                        "criterion": "solid organ transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previous cancer history with the last 5 years (excluding non-melanoma skin cancer), participation in a treatment trial for HCC",
                "criterions": [
                    {
                        "exact_snippets": "Previous cancer history with the last 5 years",
                        "criterion": "previous cancer history",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "excluding non-melanoma skin cancer",
                        "criterion": "non-melanoma skin cancer",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "participation in a treatment trial for HCC",
                        "criterion": "participation in a treatment trial for HCC",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Previous cancer history with the last 5 years",
                                "criterion": "previous cancer history",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "excluding non-melanoma skin cancer",
                                    "criterion": "non-melanoma skin cancer",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": true
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "participation in a treatment trial for HCC",
                        "criterion": "participation in a treatment trial for HCC",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Exclusion criteria for the cirrhosis and chronic liver disease groups:",
                "criterions": [
                    {
                        "exact_snippets": "cirrhosis",
                        "criterion": "cirrhosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "chronic liver disease",
                        "criterion": "chronic liver disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "cirrhosis",
                        "criterion": "cirrhosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "chronic liver disease",
                        "criterion": "chronic liver disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior solid organ transplant.",
                "criterions": [
                    {
                        "exact_snippets": "Prior solid organ transplant.",
                        "criterion": "solid organ transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Prior solid organ transplant.",
                        "criterion": "solid organ transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previous or current cancer history within the past 5 years (excluding non-melanoma skin cancer).",
                "criterions": [
                    {
                        "exact_snippets": "Previous or current cancer history within the past 5 years",
                        "criterion": "cancer history",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "excluding non-melanoma skin cancer",
                        "criterion": "non-melanoma skin cancer",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Previous or current cancer history within the past 5 years",
                                    "criterion": "cancer history",
                                    "requirement": {
                                        "requirement_type": "time frame",
                                        "expected_value": {
                                            "comparisons": [
                                                {
                                                    "operator": "<=",
                                                    "value": 5,
                                                    "unit": "years"
                                                }
                                            ]
                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "excluding non-melanoma skin cancer",
                                    "criterion": "non-melanoma skin cancer",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": true
                                    }
                                }
                            ]
                        }
                    },
                    {
                        "exact_snippets": "excluding non-melanoma skin cancer",
                        "criterion": "non-melanoma skin cancer",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Diagnosis of cirrhosis based on histology, imaging, or ultrasound.",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of cirrhosis based on histology, imaging, or ultrasound.",
                        "criterion": "cirrhosis",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Diagnosis of cirrhosis based on histology, imaging, or ultrasound.",
                                "criterion": "cirrhosis",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": "histology"
                                }
                            },
                            {
                                "exact_snippets": "Diagnosis of cirrhosis based on histology, imaging, or ultrasound.",
                                "criterion": "cirrhosis",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": "imaging"
                                }
                            },
                            {
                                "exact_snippets": "Diagnosis of cirrhosis based on histology, imaging, or ultrasound.",
                                "criterion": "cirrhosis",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": "ultrasound"
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}