{
    "info": {
        "nct_id": "NCT02467231",
        "official_title": "Ovarian Reserve After Cancer: Longitudinal Effects A Multicenter Prospective Cohort Study by the Oncofertility Consortium",
        "inclusion_criteria": "Healthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 11 Years\nMust have maximum age of 35 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "Inclusion Criteria for exposed population:\n\n* Postmenarchal females to be treated with chemotherapy\n* between the ages of 11-35 years,\n* with a uterus and at least one ovary\n\nInclusion Criteria for unexposed population:\n\n* healthy postmenarchal females\n* no prior or planned exposure to chemotherapy\n* between the ages of 11-35,\n* with a uterus and at least one ovary\n* regular menstrual cycles (21-35 days)\n\nExclusion criteria for all subjects:\n\n* positive pregnancy test at enrollment\n* lactation within the previous 1 month,\n* previous treatment with chemotherapy or radiation therapy with the exception of radioactive iodine for thyroid cancer.\n* previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier)\n* endocrine disorder associated with irregular menstrual cycles (Cushing's disease, Thyroid disease, hyper-prolactinemia, congenital adrenal hyperplasia).\n\nAdditional exclusions for the unexposed population:\n\n* a history of infertility, defined as at least 12 months of unprotected intercourse without conception\n* polycystic ovary syndrome (PCOS)"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 11 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 11 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 11,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 11 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 11,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 35 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 35 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 35,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 35 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 35,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "Inclusion Criteria for exposed population:",
                "criterions": [
                    {
                        "exact_snippets": "exposed population",
                        "criterion": "population exposure",
                        "requirement": {
                            "requirement_type": "exposure",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "exposed population",
                        "criterion": "population exposure",
                        "requirement": {
                            "requirement_type": "exposure",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Postmenarchal females to be treated with chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Postmenarchal females",
                        "criterion": "postmenarchal status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "postmenarchal"
                        }
                    },
                    {
                        "exact_snippets": "females",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "to be treated with chemotherapy",
                        "criterion": "treatment plan",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "chemotherapy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Postmenarchal females",
                                "criterion": "postmenarchal status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "postmenarchal"
                                }
                            },
                            {
                                "exact_snippets": "females",
                                "criterion": "gender",
                                "requirement": {
                                    "requirement_type": "gender",
                                    "expected_value": "female"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "to be treated with chemotherapy",
                        "criterion": "treatment plan",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "chemotherapy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* between the ages of 11-35 years,",
                "criterions": [
                    {
                        "exact_snippets": "between the ages of 11-35 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 11,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 35,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "between the ages of 11-35 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 11,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 35,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* with a uterus and at least one ovary",
                "criterions": [
                    {
                        "exact_snippets": "with a uterus",
                        "criterion": "uterus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at least one ovary",
                        "criterion": "ovary",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "ovary"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "with a uterus",
                        "criterion": "uterus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at least one ovary",
                        "criterion": "ovary",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "ovary"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* healthy postmenarchal females",
                "criterions": [
                    {
                        "exact_snippets": "healthy",
                        "criterion": "health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    },
                    {
                        "exact_snippets": "postmenarchal",
                        "criterion": "menstrual status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "postmenarchal"
                        }
                    },
                    {
                        "exact_snippets": "females",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "healthy",
                        "criterion": "health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    },
                    {
                        "exact_snippets": "postmenarchal",
                        "criterion": "menstrual status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "postmenarchal"
                        }
                    },
                    {
                        "exact_snippets": "females",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* no prior or planned exposure to chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "no prior or planned exposure to chemotherapy",
                        "criterion": "chemotherapy exposure",
                        "requirement": {
                            "requirement_type": "prior exposure",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no prior or planned exposure to chemotherapy",
                        "criterion": "chemotherapy exposure",
                        "requirement": {
                            "requirement_type": "planned exposure",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "no prior or planned exposure to chemotherapy",
                        "criterion": "chemotherapy exposure",
                        "requirement": {
                            "requirement_type": "prior exposure",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no prior or planned exposure to chemotherapy",
                        "criterion": "chemotherapy exposure",
                        "requirement": {
                            "requirement_type": "planned exposure",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* between the ages of 11-35,",
                "criterions": [
                    {
                        "exact_snippets": "between the ages of 11-35",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 11,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 35,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "between the ages of 11-35",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 11,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 35,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* with a uterus and at least one ovary",
                "criterions": [
                    {
                        "exact_snippets": "with a uterus",
                        "criterion": "uterus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at least one ovary",
                        "criterion": "ovary",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "with a uterus",
                        "criterion": "uterus",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at least one ovary",
                        "criterion": "ovary",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* regular menstrual cycles (21-35 days)",
                "criterions": [
                    {
                        "exact_snippets": "regular menstrual cycles (21-35 days)",
                        "criterion": "menstrual cycle length",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 21,
                                        "unit": "days"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 35,
                                        "unit": "days"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "regular menstrual cycles (21-35 days)",
                        "criterion": "menstrual cycle length",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 21,
                                        "unit": "days"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 35,
                                        "unit": "days"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* positive pregnancy test at enrollment",
                "criterions": [
                    {
                        "exact_snippets": "positive pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "positive pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* lactation within the previous 1 month,",
                "criterions": [
                    {
                        "exact_snippets": "lactation within the previous 1 month",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "lactation within the previous 1 month",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* previous treatment with chemotherapy or radiation therapy with the exception of radioactive iodine for thyroid cancer.",
                "criterions": [
                    {
                        "exact_snippets": "previous treatment with chemotherapy",
                        "criterion": "previous chemotherapy treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "previous treatment with ... radiation therapy",
                        "criterion": "previous radiation therapy treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "exception of radioactive iodine for thyroid cancer",
                        "criterion": "radioactive iodine treatment for thyroid cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "previous treatment with chemotherapy",
                                "criterion": "previous chemotherapy treatment",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "previous treatment with ... radiation therapy",
                                "criterion": "previous radiation therapy treatment",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "exception of radioactive iodine for thyroid cancer",
                        "criterion": "radioactive iodine treatment for thyroid cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier)",
                "criterions": [
                    {
                        "exact_snippets": "previous diagnosis of an illness associated with premature ovarian failure",
                        "criterion": "illness associated with premature ovarian failure",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Turner's syndrome",
                        "criterion": "Turner's syndrome",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Fragile X permutation carrier",
                        "criterion": "Fragile X permutation carrier",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "previous diagnosis of an illness associated with premature ovarian failure",
                                "criterion": "illness associated with premature ovarian failure",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Turner's syndrome",
                                "criterion": "Turner's syndrome",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "previous diagnosis of an illness associated with premature ovarian failure",
                                "criterion": "illness associated with premature ovarian failure",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Fragile X permutation carrier",
                                "criterion": "Fragile X permutation carrier",
                                "requirement": {
                                    "requirement_type": "diagnosis",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* endocrine disorder associated with irregular menstrual cycles (Cushing's disease, Thyroid disease, hyper-prolactinemia, congenital adrenal hyperplasia).",
                "criterions": [
                    {
                        "exact_snippets": "endocrine disorder associated with irregular menstrual cycles",
                        "criterion": "endocrine disorder",
                        "requirement": {
                            "requirement_type": "association",
                            "expected_value": "irregular menstrual cycles"
                        }
                    },
                    {
                        "exact_snippets": "Cushing's disease",
                        "criterion": "Cushing's disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Thyroid disease",
                        "criterion": "Thyroid disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hyper-prolactinemia",
                        "criterion": "hyper-prolactinemia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "congenital adrenal hyperplasia",
                        "criterion": "congenital adrenal hyperplasia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "endocrine disorder associated with irregular menstrual cycles",
                                "criterion": "endocrine disorder",
                                "requirement": {
                                    "requirement_type": "association",
                                    "expected_value": "irregular menstrual cycles"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Cushing's disease",
                                        "criterion": "Cushing's disease",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "Thyroid disease",
                                        "criterion": "Thyroid disease",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "hyper-prolactinemia",
                                        "criterion": "hyper-prolactinemia",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "congenital adrenal hyperplasia",
                                        "criterion": "congenital adrenal hyperplasia",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Additional exclusions for the unexposed population:",
                "criterions": [
                    {
                        "exact_snippets": "unexposed population",
                        "criterion": "population exposure status",
                        "requirement": {
                            "requirement_type": "exposure",
                            "expected_value": "unexposed"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "unexposed population",
                        "criterion": "population exposure status",
                        "requirement": {
                            "requirement_type": "exposure",
                            "expected_value": "unexposed"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* a history of infertility, defined as at least 12 months of unprotected intercourse without conception",
                "criterions": [
                    {
                        "exact_snippets": "a history of infertility, defined as at least 12 months of unprotected intercourse without conception",
                        "criterion": "infertility",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "a history of infertility, defined as at least 12 months of unprotected intercourse without conception",
                        "criterion": "infertility",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* polycystic ovary syndrome (PCOS)",
                "criterions": [
                    {
                        "exact_snippets": "polycystic ovary syndrome (PCOS)",
                        "criterion": "polycystic ovary syndrome (PCOS)",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "polycystic ovary syndrome (PCOS)",
                        "criterion": "polycystic ovary syndrome (PCOS)",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Inclusion Criteria for unexposed population:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Exclusion criteria for all subjects:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}