{
    "info": {
        "nct_id": "NCT01963182",
        "official_title": "Phase II Study: Individualization of Dosage of Irinotecan in the FOLFIRI According to the Genetic Polymorphism of UGT1A1 in the First Line Treatment of Metastatic Colorectal Cancer",
        "inclusion_criteria": "* Colorectal cancer histologically or cytologically proven\n* Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab\n* Age> 18 years\n* Presence of at least one measurable target by RECIST\n* Life expectancy> 3 months\n* Satisfactory biological functions (renal, hepatic and hematologic)\n* Affiliation to a social security scheme (or be the beneficiary of such a plan) under the terms of the Act of August 9, 2004\n* Patient has signed, after informing the informed consent form\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patients of childbearing age and not using effective contraception during treatment and for at least three months after the end of treatment with irinotecan and at least six months after the end of treatment with bevacizumab, cetuximab or panitumumab and patient pregnant or nursing\n* Patient with another pathology deemed incompatible with the entry in the protocol\n* Prior treatment in metastatic\n* Patients taking antiepileptic\n* Allergic reaction or intolerance to irinotecan\n* Heart failure , kidney , bone marrow , liver or respiratory\n* Higher bilirubin 1.5 times the upper limit of normal\n* Significant psychiatric or neurological abnormality\n* Infectious syndrome requiring treatment with antibiotics or antiviral long-term\n* Patients with chronic inflammatory bowel disease and / or bowel obstruction\n* Contraindication Association St. John's wort and yellow fever vaccine\n* Against Heart indication 5-FU\n* Concurrent treatment with a drug test , participation in a clinical trial within <30 days\n* Patient refused to sign the consent",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Colorectal cancer histologically or cytologically proven",
                "criterions": [
                    {
                        "exact_snippets": "Colorectal cancer histologically or cytologically proven",
                        "criterion": "colorectal cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Colorectal cancer histologically or cytologically proven",
                        "criterion": "colorectal cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age> 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age> 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age> 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Presence of at least one measurable target by RECIST",
                "criterions": [
                    {
                        "exact_snippets": "Presence of at least one measurable target by RECIST",
                        "criterion": "measurable target by RECIST",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Presence of at least one measurable target by RECIST",
                        "criterion": "measurable target by RECIST",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Presence of at least one measurable target by RECIST",
                        "criterion": "measurable target by RECIST",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Presence of at least one measurable target by RECIST",
                        "criterion": "measurable target by RECIST",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy> 3 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy> 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy> 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Satisfactory biological functions (renal, hepatic and hematologic)",
                "criterions": [
                    {
                        "exact_snippets": "Satisfactory biological functions (renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "satisfactory",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Satisfactory biological functions ... hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "satisfactory",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Satisfactory biological functions ... hematologic",
                        "criterion": "hematologic function",
                        "requirement": {
                            "requirement_type": "satisfactory",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Satisfactory biological functions (renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "satisfactory",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Satisfactory biological functions ... hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "satisfactory",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Satisfactory biological functions ... hematologic",
                        "criterion": "hematologic function",
                        "requirement": {
                            "requirement_type": "satisfactory",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Affiliation to a social security scheme (or be the beneficiary of such a plan) under the terms of the Act of August 9, 2004",
                "criterions": [
                    {
                        "exact_snippets": "Affiliation to a social security scheme (or be the beneficiary of such a plan)",
                        "criterion": "social security scheme affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "Affiliation to a social security scheme (or be the beneficiary of such a plan)",
                                "criterion": "social security scheme affiliation",
                                "requirement": {
                                    "requirement_type": "affiliation",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Affiliation to a social security scheme (or be the beneficiary of such a plan)",
                                "criterion": "beneficiary of social security plan",
                                "requirement": {
                                    "requirement_type": "affiliation",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient has signed, after informing the informed consent form",
                "criterions": [
                    {
                        "exact_snippets": "Patient has signed, after informing the informed consent form",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient has signed, after informing the informed consent form",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients of childbearing age and not using effective contraception during treatment and for at least three months after the end of treatment with irinotecan and at least six months after the end of treatment with bevacizumab, cetuximab or panitumumab and patient pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Patients of childbearing age",
                        "criterion": "childbearing age",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "not using effective contraception during treatment and for at least three months after the end of treatment with irinotecan and at least six months after the end of treatment with bevacizumab, cetuximab or panitumumab",
                        "criterion": "use of effective contraception",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "patient pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Patients of childbearing age",
                                                "criterion": "childbearing age",
                                                "requirement": {
                                                    "requirement_type": "presence",
                                                    "expected_value": true
                                                }
                                            },
                                            {
                                                "exact_snippets": "not using effective contraception during treatment and for at least three months after the end of treatment with irinotecan and at least six months after the end of treatment with bevacizumab, cetuximab or panitumumab",
                                                "criterion": "use of effective contraception",
                                                "requirement": {
                                                    "requirement_type": "presence",
                                                    "expected_value": false
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "patient pregnant",
                                        "criterion": "pregnancy",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "nursing",
                                "criterion": "nursing",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior treatment in metastatic",
                "criterions": [
                    {
                        "exact_snippets": "Prior treatment in metastatic",
                        "criterion": "prior treatment",
                        "requirement": {
                            "requirement_type": "context",
                            "expected_value": "metastatic"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prior treatment in metastatic",
                    "criterion": "prior treatment",
                    "requirement": {
                        "requirement_type": "context",
                        "expected_value": "metastatic"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients taking antiepileptic",
                "criterions": [
                    {
                        "exact_snippets": "Patients taking antiepileptic",
                        "criterion": "antiepileptic medication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients taking antiepileptic",
                    "criterion": "antiepileptic medication",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Allergic reaction or intolerance to irinotecan",
                "criterions": [
                    {
                        "exact_snippets": "Allergic reaction or intolerance to irinotecan",
                        "criterion": "irinotecan",
                        "requirement": {
                            "requirement_type": "reaction",
                            "expected_value": [
                                "allergic reaction",
                                "intolerance"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Allergic reaction or intolerance to irinotecan",
                        "criterion": "irinotecan",
                        "requirement": {
                            "requirement_type": "reaction",
                            "expected_value": [
                                "allergic reaction",
                                "intolerance"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Heart failure , kidney , bone marrow , liver or respiratory",
                "criterions": [
                    {
                        "exact_snippets": "Heart failure",
                        "criterion": "heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "kidney",
                        "criterion": "kidney condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "bone marrow",
                        "criterion": "bone marrow condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "liver",
                        "criterion": "liver condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "respiratory",
                        "criterion": "respiratory condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Heart failure",
                        "criterion": "heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "kidney",
                        "criterion": "kidney condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "bone marrow",
                        "criterion": "bone marrow condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "liver",
                        "criterion": "liver condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "respiratory",
                        "criterion": "respiratory condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Higher bilirubin 1.5 times the upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Higher bilirubin 1.5 times the upper limit of normal",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Higher bilirubin 1.5 times the upper limit of normal",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Significant psychiatric or neurological abnormality",
                "criterions": [
                    {
                        "exact_snippets": "Significant psychiatric ... abnormality",
                        "criterion": "psychiatric abnormality",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    },
                    {
                        "exact_snippets": "Significant ... neurological abnormality",
                        "criterion": "neurological abnormality",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Significant psychiatric ... abnormality",
                        "criterion": "psychiatric abnormality",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    },
                    {
                        "exact_snippets": "Significant ... neurological abnormality",
                        "criterion": "neurological abnormality",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with chronic inflammatory bowel disease and / or bowel obstruction",
                "criterions": [
                    {
                        "exact_snippets": "chronic inflammatory bowel disease",
                        "criterion": "chronic inflammatory bowel disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "chronic inflammatory bowel disease",
                        "criterion": "chronic inflammatory bowel disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Contraindication Association St. John's wort and yellow fever vaccine",
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                    {
                        "exact_snippets": "Contraindication Association St. John's wort",
                        "criterion": "St. John's wort",
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                            "requirement_type": "contraindication",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Contraindication Association ... yellow fever vaccine",
                        "criterion": "yellow fever vaccine",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Contraindication Association St. John's wort",
                                "criterion": "St. John's wort",
                                "requirement": {
                                    "requirement_type": "contraindication",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Contraindication Association ... yellow fever vaccine",
                                "criterion": "yellow fever vaccine",
                                "requirement": {
                                    "requirement_type": "contraindication",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Against Heart indication 5-FU",
                "criterions": [
                    {
                        "exact_snippets": "Against Heart indication",
                        "criterion": "heart indication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "5-FU",
                        "criterion": "5-FU",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": true
                        }
                    }
                ]
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            "logical_structure": {
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                    {
                        "exact_snippets": "Against Heart indication",
                        "criterion": "heart indication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "5-FU",
                        "criterion": "5-FU",
                        "requirement": {
                            "requirement_type": "usage",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent treatment with a drug test , participation in a clinical trial within <30 days",
                "criterions": [
                    {
                        "exact_snippets": "Concurrent treatment with a drug test",
                        "criterion": "concurrent treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "participation in a clinical trial within <30 days",
                        "criterion": "participation in a clinical trial",
                        "requirement": {
                            "requirement_type": "time since participation",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Concurrent treatment with a drug test",
                        "criterion": "concurrent treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "participation in a clinical trial within <30 days",
                        "criterion": "participation in a clinical trial",
                        "requirement": {
                            "requirement_type": "time since participation",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient refused to sign the consent",
                "criterions": [
                    {
                        "exact_snippets": "Patient refused to sign the consent",
                        "criterion": "consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patient refused to sign the consent",
                    "criterion": "consent",
                    "requirement": {
                        "requirement_type": "signed",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
                "criterions": [
                    {
                        "exact_snippets": "Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
                        "criterion": "treatment indication",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "FOLFIRI",
                                "bevacizumab",
                                "cetuximab",
                                "panitumumab"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
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                                        "requirement": {
                                            "requirement_type": "treatment",
                                            "expected_value": "FOLFIRI"
                                        }
                                    },
                                    {
                                        "or_criteria": [
                                            {
                                                "exact_snippets": "Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
                                                "criterion": "treatment indication",
                                                "requirement": {
                                                    "requirement_type": "treatment",
                                                    "expected_value": "bevacizumab"
                                                }
                                            },
                                            {
                                                "exact_snippets": "Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
                                                "criterion": "treatment indication",
                                                "requirement": {
                                                    "requirement_type": "treatment",
                                                    "expected_value": "cetuximab"
                                                }
                                            },
                                            {
                                                "exact_snippets": "Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
                                                "criterion": "treatment indication",
                                                "requirement": {
                                                    "requirement_type": "treatment",
                                                    "expected_value": "panitumumab"
                                                }
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Indication of treatment according to the FOLFIRI + / - bevacizumab or cetuximab or panitumumab",
                                "criterion": "treatment indication",
                                "requirement": {
                                    "requirement_type": "treatment",
                                    "expected_value": "FOLFIRI"
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Patient with another pathology deemed incompatible with the entry in the protocol",
                "criterions": [
                    {
                        "exact_snippets": "another pathology deemed incompatible with the entry in the protocol",
                        "criterion": "pathology",
                        "requirement": {
                            "requirement_type": "compatibility",
                            "expected_value": "incompatible with the entry in the protocol"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "another pathology deemed incompatible with the entry in the protocol",
                    "criterion": "pathology",
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                        "requirement_type": "compatibility",
                        "expected_value": "compatible with the entry in the protocol"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                "criterions": [
                    {
                        "exact_snippets": "Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                        "criterion": "infectious syndrome",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "antibiotics",
                                "antiviral"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                        "criterion": "infectious syndrome",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "long-term"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                                "criterion": "infectious syndrome",
                                "requirement": {
                                    "requirement_type": "treatment",
                                    "expected_value": [
                                        "antibiotics"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                                "criterion": "infectious syndrome",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": "long-term"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                                "criterion": "infectious syndrome",
                                "requirement": {
                                    "requirement_type": "treatment",
                                    "expected_value": [
                                        "antiviral"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "Infectious syndrome requiring treatment with antibiotics or antiviral long-term",
                                "criterion": "infectious syndrome",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": "long-term"
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}