{
    "info": {
        "nct_id": "NCT01645748",
        "official_title": "Multicenter Phase II Study of Weekly Docetaxel, Cisplatin, and S-1 (TPS) Induction Chemotherapy in Locally Advanced Squamous Cell Cancer of the Head and Neck",
        "inclusion_criteria": "* locally advanced stage III or IV squamous cell carcinoma of the larynx, oropharynx, or hypopharynx\n* ≥18 years old\n* absolute neutrophil count ≥1,500/µL, platelets ≥100,000/µL\n* serum bilirubin <2.0 mg/dL\n* creatinine <1.5 mg/dL\n* serum transaminase levels less than twice the upper limit of normal\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* received previous chemotherapy\n* another malignancy\n* current or history of distant metastasis\n* history of clinically significant cardiac disease within 6 months\n* active serious infection\n* nasopharyngeal carcinoma\n* psychiatric illness that would preclude obtaining informed consent",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* locally advanced stage III or IV squamous cell carcinoma of the larynx, oropharynx, or hypopharynx",
                "criterions": [
                    {
                        "exact_snippets": "locally advanced stage III or IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "squamous cell carcinoma",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "squamous cell carcinoma"
                        }
                    },
                    {
                        "exact_snippets": "larynx",
                        "criterion": "cancer location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "larynx"
                        }
                    },
                    {
                        "exact_snippets": "oropharynx",
                        "criterion": "cancer location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "oropharynx"
                        }
                    },
                    {
                        "exact_snippets": "hypopharynx",
                        "criterion": "cancer location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "hypopharynx"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "locally advanced stage III or IV",
                                        "criterion": "cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "III",
                                                "IV"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "squamous cell carcinoma",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "squamous cell carcinoma"
                                        }
                                    },
                                    {
                                        "exact_snippets": "larynx",
                                        "criterion": "cancer location",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "larynx"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "locally advanced stage III or IV",
                                        "criterion": "cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "III",
                                                "IV"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "squamous cell carcinoma",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "squamous cell carcinoma"
                                        }
                                    },
                                    {
                                        "exact_snippets": "oropharynx",
                                        "criterion": "cancer location",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "oropharynx"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "locally advanced stage III or IV",
                                        "criterion": "cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "III",
                                                "IV"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "squamous cell carcinoma",
                                        "criterion": "cancer type",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "squamous cell carcinoma"
                                        }
                                    },
                                    {
                                        "exact_snippets": "hypopharynx",
                                        "criterion": "cancer location",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "hypopharynx"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ≥18 years old",
                "criterions": [
                    {
                        "exact_snippets": "≥18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "≥18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* absolute neutrophil count ≥1,500/µL, platelets ≥100,000/µL",
                "criterions": [
                    {
                        "exact_snippets": "absolute neutrophil count ≥1,500/µL",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "µL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "platelets ≥100,000/µL",
                        "criterion": "platelets",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "µL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "absolute neutrophil count ≥1,500/µL",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "µL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "platelets ≥100,000/µL",
                        "criterion": "platelets",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "µL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* serum bilirubin <2.0 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "serum bilirubin <2.0 mg/dL",
                        "criterion": "serum bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.0,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "serum bilirubin <2.0 mg/dL",
                        "criterion": "serum bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.0,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* creatinine <1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "creatinine <1.5 mg/dL",
                        "criterion": "creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "creatinine <1.5 mg/dL",
                        "criterion": "creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* serum transaminase levels less than twice the upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "serum transaminase levels less than twice the upper limit of normal",
                        "criterion": "serum transaminase levels",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "serum transaminase levels less than twice the upper limit of normal",
                        "criterion": "serum transaminase levels",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* received previous chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "received previous chemotherapy",
                        "criterion": "previous chemotherapy",
                        "requirement": {
                            "requirement_type": "receipt",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "received previous chemotherapy",
                    "criterion": "previous chemotherapy",
                    "requirement": {
                        "requirement_type": "receipt",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* another malignancy",
                "criterions": [
                    {
                        "exact_snippets": "another malignancy",
                        "criterion": "malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "another malignancy",
                    "criterion": "malignancy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* current or history of distant metastasis",
                "criterions": [
                    {
                        "exact_snippets": "current or history of distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "current or history of distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "current or history of distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "current or history of distant metastasis",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* history of clinically significant cardiac disease within 6 months",
                "criterions": [
                    {
                        "exact_snippets": "history of clinically significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "history of clinically significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "clinical significance",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "within 6 months",
                        "criterion": "time since cardiac disease",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "history of clinically significant cardiac disease",
                                "criterion": "cardiac disease",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "history of clinically significant cardiac disease",
                                "criterion": "cardiac disease",
                                "requirement": {
                                    "requirement_type": "clinical significance",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "within 6 months",
                        "criterion": "time since cardiac disease",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* active serious infection",
                "criterions": [
                    {
                        "exact_snippets": "active serious infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "active serious infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "active serious infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "active serious infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* nasopharyngeal carcinoma",
                "criterions": [
                    {
                        "exact_snippets": "nasopharyngeal carcinoma",
                        "criterion": "nasopharyngeal carcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "nasopharyngeal carcinoma",
                    "criterion": "nasopharyngeal carcinoma",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* psychiatric illness that would preclude obtaining informed consent",
                "criterions": [
                    {
                        "exact_snippets": "psychiatric illness that would preclude obtaining informed consent",
                        "criterion": "psychiatric illness",
                        "requirement": {
                            "requirement_type": "impact on informed consent",
                            "expected_value": "preclude obtaining"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "psychiatric illness that would preclude obtaining informed consent",
                    "criterion": "psychiatric illness",
                    "requirement": {
                        "requirement_type": "impact on informed consent",
                        "expected_value": "preclude obtaining"
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}