{
    "info": {
        "nct_id": "NCT01239082",
        "official_title": "CSP #577 - Colonoscopy vs. Fecal Immunochemical Testing in Reducing Mortality From Colorectal Cancer",
        "inclusion_criteria": "* Male and female adults aged 50-75 years of age\n* Veteran\n* Able to provide informed consent\nHealthy volunteers allowed\nMust have minimum age of 50 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Symptoms of lower gastrointestinal tract disease warranting colonoscopic evaluation, including:\n\n  * More than one episode of rectal bleeding within the past 6 months\n  * Documented iron deficiency anemia\n  * Significant documented unintentional weight loss (>10% of baseline weight) over 6 months\n* Family history of CRC in a first degree relative at any age\n* Prior history of colonic disease including:\n\n  * Inflammatory bowel disease (e.g. ulcerative colitis or Crohn's disease)\n  * One or more colorectal neoplastic polyps (i.e. adenomas)\n  * Colorectal cancer\n* Prior history of colonic resection\n* Prior colonic examination, including:\n\n  * Colonoscopy within the past 9.5 years\n  * Sigmoidoscopy within the past 5 years\n  * Barium enema within the past 5 years\n  * CT colonography within the past 5 years\n* gFOBT or FIT in the past 10 months\n* Stool DNA test within the past 3 years\n* Pregnancy\n* Prisoner\n* Significant comorbidity that would preclude benefit from screening or pose significant risk for the performance of colonoscopy (e.g. severe lung disease, end-stage renal disease, end-stage liver disease, severe heart failure, recent diagnosis of cancer (with the exception of non-melanoma skin cancer))\n* Participation in a concurrent interventional study pertaining to the colon or rectum (including studies of colonoscopy or colorectal cancer screening. Waivers to this exclusion criteria can be requested and granted with the approval of the CONFIRM study co-chairs, the Cooperative Study Program and the leadership of the other study.\n* Likely inability to track the individual over time (e.g. no permanent address at the time of screening for study entry)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Male and female adults aged 50-75 years of age",
                "criterions": [
                    {
                        "exact_snippets": "Male and female",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "adults",
                        "criterion": "age group",
                        "requirement": {
                            "requirement_type": "category",
                            "expected_value": "adults"
                        }
                    },
                    {
                        "exact_snippets": "aged 50-75 years of age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 50,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Male and female",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "adults",
                        "criterion": "age group",
                        "requirement": {
                            "requirement_type": "category",
                            "expected_value": "adults"
                        }
                    },
                    {
                        "exact_snippets": "aged 50-75 years of age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 50,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Veteran",
                "criterions": [
                    {
                        "exact_snippets": "Veteran",
                        "criterion": "veteran status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Veteran",
                        "criterion": "veteran status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to provide informed consent",
                "criterions": [
                    {
                        "exact_snippets": "Able to provide informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Able to provide informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 50 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 50 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 50 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 75 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Symptoms of lower gastrointestinal tract disease warranting colonoscopic evaluation, including:",
                "criterions": [
                    {
                        "exact_snippets": "Symptoms of lower gastrointestinal tract disease",
                        "criterion": "lower gastrointestinal tract disease symptoms",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "warranting colonoscopic evaluation",
                        "criterion": "need for colonoscopic evaluation",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Symptoms of lower gastrointestinal tract disease",
                        "criterion": "lower gastrointestinal tract disease symptoms",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "warranting colonoscopic evaluation",
                        "criterion": "need for colonoscopic evaluation",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than one episode of rectal bleeding within the past 6 months",
                "criterions": [
                    {
                        "exact_snippets": "More than one episode of rectal bleeding within the past 6 months",
                        "criterion": "rectal bleeding",
                        "requirement": {
                            "requirement_type": "frequency",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "episodes"
                            }
                        }
                    },
                    {
                        "exact_snippets": "More than one episode of rectal bleeding within the past 6 months",
                        "criterion": "rectal bleeding",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 6 months"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than one episode of rectal bleeding within the past 6 months",
                        "criterion": "rectal bleeding",
                        "requirement": {
                            "requirement_type": "frequency",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "episodes"
                            }
                        }
                    },
                    {
                        "exact_snippets": "More than one episode of rectal bleeding within the past 6 months",
                        "criterion": "rectal bleeding",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 6 months"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Documented iron deficiency anemia",
                "criterions": [
                    {
                        "exact_snippets": "Documented iron deficiency anemia",
                        "criterion": "iron deficiency anemia",
                        "requirement": {
                            "requirement_type": "documentation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Documented iron deficiency anemia",
                    "criterion": "iron deficiency anemia",
                    "requirement": {
                        "requirement_type": "documentation",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Significant documented unintentional weight loss (>10% of baseline weight) over 6 months",
                "criterions": [
                    {
                        "exact_snippets": "Significant documented unintentional weight loss (>10% of baseline weight) over 6 months",
                        "criterion": "unintentional weight loss",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "% of baseline weight"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Significant documented unintentional weight loss (>10% of baseline weight) over 6 months",
                        "criterion": "unintentional weight loss",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "6 months"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Significant documented unintentional weight loss (>10% of baseline weight) over 6 months",
                                "criterion": "unintentional weight loss",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 10,
                                        "unit": "% of baseline weight"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Significant documented unintentional weight loss (>10% of baseline weight) over 6 months",
                                "criterion": "unintentional weight loss",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "6 months"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Family history of CRC in a first degree relative at any age",
                "criterions": [
                    {
                        "exact_snippets": "Family history of CRC in a first degree relative",
                        "criterion": "family history of CRC",
                        "requirement": {
                            "requirement_type": "relation",
                            "expected_value": "first degree relative"
                        }
                    },
                    {
                        "exact_snippets": "Family history of CRC in a first degree relative",
                        "criterion": "family history of CRC",
                        "requirement": {
                            "requirement_type": "age",
                            "expected_value": "any age"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Family history of CRC in a first degree relative",
                        "criterion": "family history of CRC",
                        "requirement": {
                            "requirement_type": "relation",
                            "expected_value": "first degree relative"
                        }
                    },
                    {
                        "exact_snippets": "Family history of CRC in a first degree relative",
                        "criterion": "family history of CRC",
                        "requirement": {
                            "requirement_type": "age",
                            "expected_value": "any age"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior history of colonic disease including:",
                "criterions": [
                    {
                        "exact_snippets": "Prior history of colonic disease",
                        "criterion": "colonic disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Prior history of colonic disease",
                        "criterion": "colonic disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Inflammatory bowel disease (e.g. ulcerative colitis or Crohn's disease)",
                "criterions": [
                    {
                        "exact_snippets": "Inflammatory bowel disease (e.g. ulcerative colitis or Crohn's disease)",
                        "criterion": "inflammatory bowel disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Inflammatory bowel disease (e.g. ulcerative colitis or Crohn's disease)",
                    "criterion": "inflammatory bowel disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* One or more colorectal neoplastic polyps (i.e. adenomas)",
                "criterions": [
                    {
                        "exact_snippets": "One or more colorectal neoplastic polyps (i.e. adenomas)",
                        "criterion": "colorectal neoplastic polyps",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "One or more colorectal neoplastic polyps (i.e. adenomas)",
                        "criterion": "colorectal neoplastic polyps",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "One or more colorectal neoplastic polyps (i.e. adenomas)",
                        "criterion": "colorectal neoplastic polyps",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "One or more colorectal neoplastic polyps (i.e. adenomas)",
                        "criterion": "colorectal neoplastic polyps",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Colorectal cancer",
                "criterions": [
                    {
                        "exact_snippets": "Colorectal cancer",
                        "criterion": "colorectal cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Colorectal cancer",
                    "criterion": "colorectal cancer",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior history of colonic resection",
                "criterions": [
                    {
                        "exact_snippets": "Prior history of colonic resection",
                        "criterion": "colonic resection",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prior history of colonic resection",
                    "criterion": "colonic resection",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior colonic examination, including:",
                "criterions": [
                    {
                        "exact_snippets": "Prior colonic examination",
                        "criterion": "colonic examination",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prior colonic examination",
                    "criterion": "colonic examination",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Colonoscopy within the past 9.5 years",
                "criterions": [
                    {
                        "exact_snippets": "Colonoscopy within the past 9.5 years",
                        "criterion": "colonoscopy",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 9.5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Colonoscopy within the past 9.5 years",
                    "criterion": "colonoscopy",
                    "requirement": {
                        "requirement_type": "timeframe",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 9.5,
                                    "unit": "years"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Sigmoidoscopy within the past 5 years",
                "criterions": [
                    {
                        "exact_snippets": "Sigmoidoscopy within the past 5 years",
                        "criterion": "sigmoidoscopy",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Sigmoidoscopy within the past 5 years",
                    "criterion": "sigmoidoscopy",
                    "requirement": {
                        "requirement_type": "timeframe",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 5,
                                    "unit": "years"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Barium enema within the past 5 years",
                "criterions": [
                    {
                        "exact_snippets": "Barium enema within the past 5 years",
                        "criterion": "barium enema",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Barium enema within the past 5 years",
                    "criterion": "barium enema",
                    "requirement": {
                        "requirement_type": "time frame",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 5,
                                    "unit": "years"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* CT colonography within the past 5 years",
                "criterions": [
                    {
                        "exact_snippets": "CT colonography within the past 5 years",
                        "criterion": "CT colonography",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "CT colonography within the past 5 years",
                    "criterion": "CT colonography",
                    "requirement": {
                        "requirement_type": "timeframe",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 5,
                                    "unit": "years"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* gFOBT or FIT in the past 10 months",
                "criterions": [
                    {
                        "exact_snippets": "gFOBT or FIT",
                        "criterion": "gFOBT or FIT test",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 10,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "gFOBT or FIT",
                    "criterion": "gFOBT or FIT test",
                    "requirement": {
                        "requirement_type": "timeframe",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 10,
                                    "unit": "months"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Stool DNA test within the past 3 years",
                "criterions": [
                    {
                        "exact_snippets": "Stool DNA test within the past 3 years",
                        "criterion": "stool DNA test",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "within the past 3 years"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Stool DNA test within the past 3 years",
                    "criterion": "stool DNA test",
                    "requirement": {
                        "requirement_type": "timeframe",
                        "expected_value": "within the past 3 years"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnancy",
                "criterions": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Pregnancy",
                    "criterion": "pregnancy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prisoner",
                "criterions": [
                    {
                        "exact_snippets": "Prisoner",
                        "criterion": "prisoner status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prisoner",
                    "criterion": "prisoner status",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Significant comorbidity that would preclude benefit from screening or pose significant risk for the performance of colonoscopy (e.g. severe lung disease, end-stage renal disease, end-stage liver disease, severe heart failure, recent diagnosis of cancer (with the exception of non-melanoma skin cancer))",
                "criterions": [
                    {
                        "exact_snippets": "Significant comorbidity ... severe lung disease",
                        "criterion": "severe lung disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Significant comorbidity ... end-stage renal disease",
                        "criterion": "end-stage renal disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Significant comorbidity ... end-stage liver disease",
                        "criterion": "end-stage liver disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Significant comorbidity ... severe heart failure",
                        "criterion": "severe heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Significant comorbidity ... recent diagnosis of cancer (with the exception of non-melanoma skin cancer)",
                        "criterion": "recent diagnosis of cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Significant comorbidity ... severe lung disease",
                                "criterion": "severe lung disease",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Significant comorbidity ... end-stage renal disease",
                                "criterion": "end-stage renal disease",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Significant comorbidity ... end-stage liver disease",
                                "criterion": "end-stage liver disease",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Significant comorbidity ... severe heart failure",
                                "criterion": "severe heart failure",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Significant comorbidity ... recent diagnosis of cancer (with the exception of non-melanoma skin cancer)",
                                "criterion": "recent diagnosis of cancer",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participation in a concurrent interventional study pertaining to the colon or rectum (including studies of colonoscopy or colorectal cancer screening. Waivers to this exclusion criteria can be requested and granted with the approval of the CONFIRM study co-chairs, the Cooperative Study Program and the leadership of the other study.",
                "criterions": [
                    {
                        "exact_snippets": "Participation in a concurrent interventional study pertaining to the colon or rectum",
                        "criterion": "concurrent interventional study participation",
                        "requirement": {
                            "requirement_type": "pertaining to",
                            "expected_value": [
                                "colon",
                                "rectum"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "Participation in a concurrent interventional study pertaining to the colon or rectum",
                            "criterion": "concurrent interventional study participation",
                            "requirement": {
                                "requirement_type": "pertaining to",
                                "expected_value": [
                                    "colon",
                                    "rectum"
                                ]
                            }
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": "Waivers to this exclusion criteria can be requested and granted with the approval of the CONFIRM study co-chairs, the Cooperative Study Program and the leadership of the other study.",
                    "criterion": "waiver approval",
                    "requirement": {
                        "requirement_type": "approval",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Likely inability to track the individual over time (e.g. no permanent address at the time of screening for study entry)",
                "criterions": [
                    {
                        "exact_snippets": "Likely inability to track the individual over time",
                        "criterion": "ability to track individual over time",
                        "requirement": {
                            "requirement_type": "likelihood",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no permanent address at the time of screening for study entry",
                        "criterion": "permanent address",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Likely inability to track the individual over time",
                        "criterion": "ability to track individual over time",
                        "requirement": {
                            "requirement_type": "likelihood",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no permanent address at the time of screening for study entry",
                        "criterion": "permanent address",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}