{
    "info": {
        "nct_id": "NCT01015131",
        "official_title": "A Pilot Study to Evaluate the Correlation Between 18F-FLT-PET Uptake, Ki-67 Immunohistochemistry, and Proliferation Signature in Response to Neo-Adjuvant Chemotherapy in Breast Cancer",
        "inclusion_criteria": "* Has newly-diagnosed stage IIB/IIIA/IIIB locally advanced breast cancer\n* Is eligible for pre-operative (neo-adjuvant) chemotherapy\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 35 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Has a contraindication to magnetic resonance imaging (MRI)\n* Any condition that would limit ability to undergo MRI or PET scans\n* Is a nursing mother\n* Has moderate to end-stage renal disease and is not on dialysis or has renal failure on chronic dialysis",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
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                "line": "Must have maximum age of 75 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
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                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
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                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
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                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
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                    }
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        }
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    "exclusion_lines": [
        {
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                "criterions": [
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                        "exact_snippets": "contraindication to magnetic resonance imaging (MRI)",
                        "criterion": "contraindication to MRI",
                        "requirement": {
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                            "expected_value": true
                        }
                    }
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            },
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                    }
                }
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        },
        {
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                "line": "* Any condition that would limit ability to undergo MRI or PET scans",
                "criterions": [
                    {
                        "exact_snippets": "condition that would limit ability to undergo MRI",
                        "criterion": "ability to undergo MRI",
                        "requirement": {
                            "requirement_type": "limitation",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "condition that would limit ability to undergo ... PET scans",
                        "criterion": "ability to undergo PET scans",
                        "requirement": {
                            "requirement_type": "limitation",
                            "expected_value": false
                        }
                    }
                ]
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                        "criterion": "ability to undergo MRI",
                        "requirement": {
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                            "expected_value": false
                        }
                    },
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                            "expected_value": false
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            }
        },
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                        "criterion": "nursing mother",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    "criterion": "nursing mother",
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                        "expected_value": true
                    }
                }
            }
        },
        {
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                "criterions": [
                    {
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                        "criterion": "renal disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "moderate to end-stage"
                        }
                    },
                    {
                        "exact_snippets": "not on dialysis",
                        "criterion": "dialysis status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "renal failure on chronic dialysis",
                        "criterion": "renal failure",
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                            "expected_value": true
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                    }
                ]
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                                    "expected_value": "moderate to end-stage"
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                            },
                            {
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                                "criterion": "dialysis status",
                                "requirement": {
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                                    "expected_value": false
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                    },
                    {
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                            "requirement_type": "dialysis status",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
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        {
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                "line": "* Has newly-diagnosed stage IIB/IIIA/IIIB locally advanced breast cancer",
                "criterions": [
                    {
                        "exact_snippets": "newly-diagnosed",
                        "criterion": "diagnosis status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "newly-diagnosed"
                        }
                    },
                    {
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                        "requirement": {
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                                "IIIA",
                                "IIIB"
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                        }
                    },
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                            "requirement_type": "type",
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                        }
                    }
                ]
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        },
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                "line": "* Is eligible for pre-operative (neo-adjuvant) chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "eligible for pre-operative (neo-adjuvant) chemotherapy",
                        "criterion": "pre-operative (neo-adjuvant) chemotherapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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        },
        {
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                "line": "Healthy volunteers allowed",
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                        "exact_snippets": "Healthy volunteers allowed",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
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        },
        {
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                    {
                        "exact_snippets": "Must be FEMALE",
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                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
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            "logical_structure": {
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        {
            "identified_line": {
                "line": "Must have minimum age of 35 Years",
                "criterions": [
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                        "exact_snippets": "minimum age of 35 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 35,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                "criterion": "failed",
                "requirement": {
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                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}