{
    "info": {
        "nct_id": "NCT00956280",
        "official_title": "Epidemiologic Study of KRAS Mutation in Brazilian Patients With Advanced or Metastatic Non Small Cell Lung Cancer",
        "inclusion_criteria": "* Histological or cytological confirmation of locally advanced or metastatic Non Small Cell Lung Cancer (IIIB-IV)\n* Tumour sample (block of slides) available for KRAS analysis\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Confirmation of locally advanced or metastatic NSCLC (IIIB-IV) exclusively by cytology, with no tumour sample access.\n* Previous treatment using a MEK inhibitor or any other regimen containing docetaxel (previous treatment with paclitaxel is accepted)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Histological or cytological confirmation of locally advanced or metastatic Non Small Cell Lung Cancer (IIIB-IV)",
                "criterions": [
                    {
                        "exact_snippets": "Histological or cytological confirmation",
                        "criterion": "confirmation method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": [
                                "histological",
                                "cytological"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "locally advanced or metastatic Non Small Cell Lung Cancer",
                        "criterion": "Non Small Cell Lung Cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "locally advanced",
                                "metastatic"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Non Small Cell Lung Cancer (IIIB-IV)",
                        "criterion": "Non Small Cell Lung Cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IIIB-IV"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Histological or cytological confirmation",
                                "criterion": "confirmation method",
                                "requirement": {
                                    "requirement_type": "method",
                                    "expected_value": [
                                        "histological",
                                        "cytological"
                                    ]
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "locally advanced or metastatic Non Small Cell Lung Cancer",
                                        "criterion": "Non Small Cell Lung Cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "locally advanced",
                                                "metastatic"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "Non Small Cell Lung Cancer (IIIB-IV)",
                                        "criterion": "Non Small Cell Lung Cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "IIIB-IV"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumour sample (block of slides) available for KRAS analysis",
                "criterions": [
                    {
                        "exact_snippets": "Tumour sample (block of slides) available",
                        "criterion": "tumour sample",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "KRAS analysis",
                        "criterion": "KRAS analysis",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Tumour sample (block of slides) available",
                        "criterion": "tumour sample",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "KRAS analysis",
                        "criterion": "KRAS analysis",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Confirmation of locally advanced or metastatic NSCLC (IIIB-IV) exclusively by cytology, with no tumour sample access.",
                "criterions": [
                    {
                        "exact_snippets": "locally advanced or metastatic NSCLC (IIIB-IV)",
                        "criterion": "NSCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IIIB",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "exclusively by cytology",
                        "criterion": "diagnosis method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "cytology"
                        }
                    },
                    {
                        "exact_snippets": "no tumour sample access",
                        "criterion": "tumour sample access",
                        "requirement": {
                            "requirement_type": "access",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous treatment using a MEK inhibitor or any other regimen containing docetaxel (previous treatment with paclitaxel is accepted)",
                "criterions": [
                    {
                        "exact_snippets": "Previous treatment using a MEK inhibitor",
                        "criterion": "previous treatment with MEK inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "any other regimen containing docetaxel",
                        "criterion": "previous treatment with docetaxel",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "previous treatment with paclitaxel is accepted",
                        "criterion": "previous treatment with paclitaxel",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}