{
    "info": {
        "nct_id": "NCT00920920",
        "official_title": "A International Study on MRI-guided Brachytherapy in Locally Advanced Cervical Cancer",
        "inclusion_criteria": "* Cancer of the uterine cervix considered suitable for curative treatment with definitive radio-(chemo)therapy including MRI guided BT\n* Positive biopsy showing squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.\n* Staging according to FIGO and TNM guidelines\n* MRI of pelvis at diagnosis is performed\n* MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed\n* MRI with the applicator in place at the time of (first) BT will be performed\n* Para-aortic metastatic nodes below L1-L2 are allowed\n* Patient informed consent\nHealthy volunteers allowed\nMust be FEMALE",
        "exclusion_criteria": "* Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin\n* Metastatic disease beyond para-aortic region (L1-L2)\n* Previous pelvic or abdominal radiotherapy\n* Previous total or partial hysterectomy\n* Combination of preoperative radiotherapy with surgery\n* Patients receiving BT only\n* Patients receiving EBRT only\n* Patients receiving neoadjuvant chemotherapy\n* Contra indications to MRI\n* Contra indications to BT\n* Active infection or severe medical condition endangering treatment delivery\n* Pregnant, lactating or childbearing potential without adequate contraception",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Cancer of the uterine cervix considered suitable for curative treatment with definitive radio-(chemo)therapy including MRI guided BT",
                "criterions": [
                    {
                        "exact_snippets": "Cancer of the uterine cervix",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "specificity",
                            "expected_value": "uterine cervix"
                        }
                    },
                    {
                        "exact_snippets": "considered suitable for curative treatment",
                        "criterion": "treatment suitability",
                        "requirement": {
                            "requirement_type": "suitability",
                            "expected_value": "curative treatment"
                        }
                    },
                    {
                        "exact_snippets": "definitive radio-(chemo)therapy",
                        "criterion": "treatment type",
                        "requirement": {
                            "requirement_type": "specificity",
                            "expected_value": [
                                "radiotherapy",
                                "chemotherapy"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "including MRI guided BT",
                        "criterion": "treatment guidance",
                        "requirement": {
                            "requirement_type": "guidance",
                            "expected_value": "MRI guided BT"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cancer of the uterine cervix",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "specificity",
                            "expected_value": "uterine cervix"
                        }
                    },
                    {
                        "exact_snippets": "considered suitable for curative treatment",
                        "criterion": "treatment suitability",
                        "requirement": {
                            "requirement_type": "suitability",
                            "expected_value": "curative treatment"
                        }
                    },
                    {
                        "exact_snippets": "definitive radio-(chemo)therapy",
                        "criterion": "treatment type",
                        "requirement": {
                            "requirement_type": "specificity",
                            "expected_value": [
                                "radiotherapy",
                                "chemotherapy"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "including MRI guided BT",
                        "criterion": "treatment guidance",
                        "requirement": {
                            "requirement_type": "guidance",
                            "expected_value": "MRI guided BT"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Positive biopsy showing squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.",
                "criterions": [
                    {
                        "exact_snippets": "Positive biopsy showing squamous-cell carcinoma",
                        "criterion": "squamous-cell carcinoma of the uterine cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Positive biopsy showing ... adenocarcinoma",
                        "criterion": "adenocarcinoma of the uterine cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Positive biopsy showing ... adeno-squamous cell carcinoma",
                        "criterion": "adeno-squamous cell carcinoma of the uterine cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Positive biopsy showing squamous-cell carcinoma",
                        "criterion": "squamous-cell carcinoma of the uterine cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Positive biopsy showing ... adenocarcinoma",
                        "criterion": "adenocarcinoma of the uterine cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Positive biopsy showing ... adeno-squamous cell carcinoma",
                        "criterion": "adeno-squamous cell carcinoma of the uterine cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Staging according to FIGO and TNM guidelines",
                "criterions": [
                    {
                        "exact_snippets": "Staging according to FIGO",
                        "criterion": "staging",
                        "requirement": {
                            "requirement_type": "guideline",
                            "expected_value": "FIGO"
                        }
                    },
                    {
                        "exact_snippets": "Staging according to ... TNM guidelines",
                        "criterion": "staging",
                        "requirement": {
                            "requirement_type": "guideline",
                            "expected_value": "TNM"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Staging according to FIGO",
                        "criterion": "staging",
                        "requirement": {
                            "requirement_type": "guideline",
                            "expected_value": "FIGO"
                        }
                    },
                    {
                        "exact_snippets": "Staging according to ... TNM guidelines",
                        "criterion": "staging",
                        "requirement": {
                            "requirement_type": "guideline",
                            "expected_value": "TNM"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* MRI of pelvis at diagnosis is performed",
                "criterions": [
                    {
                        "exact_snippets": "MRI of pelvis at diagnosis is performed",
                        "criterion": "MRI of pelvis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "MRI of pelvis at diagnosis is performed",
                        "criterion": "MRI of pelvis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* MRI with the applicator in place at the time of (first) BT will be performed",
                "criterions": [
                    {
                        "exact_snippets": "MRI with the applicator in place",
                        "criterion": "MRI with applicator",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at the time of (first) BT",
                        "criterion": "timing of MRI",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "at the time of (first) BT"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "MRI with the applicator in place",
                        "criterion": "MRI with applicator",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at the time of (first) BT",
                        "criterion": "timing of MRI",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "at the time of (first) BT"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Para-aortic metastatic nodes below L1-L2 are allowed",
                "criterions": [
                    {
                        "exact_snippets": "Para-aortic metastatic nodes below L1-L2 are allowed",
                        "criterion": "para-aortic metastatic nodes",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "below L1-L2"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Para-aortic metastatic nodes below L1-L2 are allowed",
                        "criterion": "para-aortic metastatic nodes",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "below L1-L2"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patient informed consent",
                "criterions": [
                    {
                        "exact_snippets": "Patient informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin",
                "criterions": [
                    {
                        "exact_snippets": "Other primary malignancies",
                        "criterion": "primary malignancies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "except carcinoma in situ of the cervix",
                        "criterion": "carcinoma in situ of the cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... basal cell carcinoma of the skin",
                        "criterion": "basal cell carcinoma of the skin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Other primary malignancies",
                                    "criterion": "primary malignancies",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except carcinoma in situ of the cervix",
                                        "criterion": "carcinoma in situ of the cervix",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                },
                                {
                                    "not_criteria": {
                                        "exact_snippets": "except ... basal cell carcinoma of the skin",
                                        "criterion": "basal cell carcinoma of the skin",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic disease beyond para-aortic region (L1-L2)",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic disease beyond para-aortic region (L1-L2)",
                        "criterion": "metastatic disease",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "beyond para-aortic region (L1-L2)"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Metastatic disease beyond para-aortic region (L1-L2)",
                    "criterion": "metastatic disease",
                    "requirement": {
                        "requirement_type": "location",
                        "expected_value": "beyond para-aortic region (L1-L2)"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous pelvic or abdominal radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Previous pelvic or abdominal radiotherapy",
                        "criterion": "pelvic or abdominal radiotherapy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Previous pelvic or abdominal radiotherapy",
                    "criterion": "pelvic or abdominal radiotherapy",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                "criterions": [
                    {
                        "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                        "criterion": "imaging of retroperitoneal space and abdomen",
                        "requirement": {
                            "requirement_type": "imaging type",
                            "expected_value": [
                                "MRI",
                                "CT",
                                "PET-CT"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                        "criterion": "imaging of retroperitoneal space and abdomen",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "at diagnosis"
                        }
                    },
                    {
                        "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                        "criterion": "imaging of retroperitoneal space and abdomen",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "performed"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                                "criterion": "imaging of retroperitoneal space and abdomen",
                                "requirement": {
                                    "requirement_type": "imaging type",
                                    "expected_value": "MRI"
                                }
                            },
                            {
                                "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                                "criterion": "imaging of retroperitoneal space and abdomen",
                                "requirement": {
                                    "requirement_type": "imaging type",
                                    "expected_value": "CT"
                                }
                            },
                            {
                                "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                                "criterion": "imaging of retroperitoneal space and abdomen",
                                "requirement": {
                                    "requirement_type": "imaging type",
                                    "expected_value": "PET-CT"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                        "criterion": "imaging of retroperitoneal space and abdomen",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "at diagnosis"
                        }
                    },
                    {
                        "exact_snippets": "MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed",
                        "criterion": "imaging of retroperitoneal space and abdomen",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "performed"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Previous total or partial hysterectomy",
                "criterions": [
                    {
                        "exact_snippets": "Previous total or partial hysterectomy",
                        "criterion": "hysterectomy",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "total",
                                "partial"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Previous total or partial hysterectomy",
                        "criterion": "hysterectomy",
                        "requirement": {
                            "requirement_type": "temporal",
                            "expected_value": "previous"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Combination of preoperative radiotherapy with surgery",
                "criterions": [
                    {
                        "exact_snippets": "preoperative radiotherapy",
                        "criterion": "preoperative radiotherapy",
                        "requirement": {
                            "requirement_type": "combination with surgery",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "combination with preoperative radiotherapy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients receiving BT only",
                "criterions": [
                    {
                        "exact_snippets": "Patients receiving BT only",
                        "criterion": "treatment type",
                        "requirement": {
                            "requirement_type": "specific treatment",
                            "expected_value": "BT only"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
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                    "requirement_type": "failed",
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                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients receiving EBRT only",
                "criterions": [
                    {
                        "exact_snippets": "Patients receiving EBRT only",
                        "criterion": "EBRT",
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                            "requirement_type": "treatment",
                            "expected_value": "only"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients receiving neoadjuvant chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Patients receiving neoadjuvant chemotherapy",
                        "criterion": "neoadjuvant chemotherapy",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "receiving"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
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                    "requirement_type": "failed",
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                }
            }
        },
        {
            "identified_line": {
                "line": "* Contra indications to MRI",
                "criterions": [
                    {
                        "exact_snippets": "Contra indications to MRI",
                        "criterion": "MRI contraindications",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
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                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Contra indications to BT",
                "criterions": [
                    {
                        "exact_snippets": "Contra indications to BT",
                        "criterion": "contraindications to BT",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Active infection or severe medical condition endangering treatment delivery",
                "criterions": [
                    {
                        "exact_snippets": "Active infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "severe medical condition",
                        "criterion": "medical condition",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
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                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant, lactating or childbearing potential without adequate contraception",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "without adequate contraception",
                        "criterion": "adequate contraception",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}