{
    "info": {
        "nct_id": "NCT00757172",
        "official_title": "A Phase II Study of Neoadjuvant Therapy With Cisplatin, Docetaxel, Panitumumab Plus Radiation Therapy Followed by Surgery in Patients With Locally Advanced Adenocarcinoma of the Distal Esophagus",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "1. ≥ 18 years old\n2. ECOG/Zubrod Performance Status 0-1\n3. Biopsy-proven resectable primary (nonrecurrent) adenocarcinoma of the distal esophagus or GE junction (Siewert Type I or II)\n\n   * Siewert Type I: adenocarcinoma of the distal esophagus\n   * Siewert Type II: adenocarcinoma of the esophago-gastric junction/real cardia\n4. Pre-registration EUS, CT of chest and upper abdomen, and PET must support a clinical stage of T3N0M0, T2-3N1M0 or T2-3N0-1M1a (celiac adenopathy must be ≤ 2 cm by EUS). Clinically staged T1 tumors and T2N0M0 tumors are not eligible. N1 does not require biopsy/FNA. Note: Patients requiring a stent for nutrition must have staging examinations and scans completed before stent placement.\n5. No definitive radiological evidence of distant metastases.\n6. No pre-existing grade 2 or greater peripheral neuropathy (CTCAE v3) of any etiology.\n7. Adequate bone marrow, hepatic and renal function prior to registration:\n\n   * WBC ≥ 3,000/mm³\n   * ANC ≥ 1,500/mm³\n   * Platelet count ≥ 100,000/mm³\n   * Hemoglobin ≥ 9.5 g/dL\n   * Creatinine ≤ 1.5 mg/dL\n   * Total bilirubin ≤ 3 mg/dL\n   * AST (SGOT) ≤ 2.0 times upper limit of normal (ULN)\n   * ALT (SGPT) ≤ 2.0 times ULN\n   * Alkaline phosphatase ≤ 2.0 times ULN\n   * Albumin ≥ 2.0 g/dL OR prealbumin ≥ 15 mg/dL\n   * Magnesium ≥ lower limit of normal (LLN)\n8. Patient must be evaluated before registration by medical oncologist, radiation oncologist and surgeon and deemed fit for protocol therapy and surgery.\n9. No prior invasive malignancy, unless disease-free for ≥ 5 years prior to registration (Exceptions: non-melanoma skin cancer, in-situ cancers).\n10. Non-pregnant and non-breast feeding. Female participants of child-bearing potential must have a negative urine or serum pregnancy test prior to registration. Perimenopausal participants must be amenorrheic ≥ 12 months to be considered not of childbearing potential. All patients of reproductive potential must agree to use an an effective method of birth-control while receiving study therapy and for six months after completion of therapy.\n11. No prior chest or upper abdomen radiotherapy; prior therapy with cisplatin, docetaxel, panitumumab or other anti-EGFR therapy or prior esophageal or gastric surgery (Exception: prior surgery to treat reflux disease)\n12. No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psyschiatric illness/social situations that would limit compliance with study requirements.\n13. No history of interstitial lung disease (eg, pneumonitis or pulmonary fibrosis or any evidence of interstitial lung disease on baseline chest CT scan\n14. No history of any medical or psychiatric condition or laboratory abnormality that in the opinion of the investigator may increase the risks associated with the study participation or investigational product(s) administration or may interfere with the interpretation of the results."
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "1. ≥ 18 years old",
                "criterions": [
                    {
                        "exact_snippets": "≥ 18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "≥ 18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. ECOG/Zubrod Performance Status 0-1",
                "criterions": [
                    {
                        "exact_snippets": "ECOG/Zubrod Performance Status 0-1",
                        "criterion": "ECOG/Zubrod Performance Status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG/Zubrod Performance Status 0-1",
                        "criterion": "ECOG/Zubrod Performance Status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Biopsy-proven resectable primary (nonrecurrent) adenocarcinoma of the distal esophagus or GE junction (Siewert Type I or II)",
                "criterions": [
                    {
                        "exact_snippets": "Biopsy-proven",
                        "criterion": "biopsy",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "resectable",
                        "criterion": "resectability",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "resectable"
                        }
                    },
                    {
                        "exact_snippets": "primary (nonrecurrent) adenocarcinoma",
                        "criterion": "adenocarcinoma",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "distal esophagus or GE junction",
                        "criterion": "location",
                        "requirement": {
                            "requirement_type": "anatomical location",
                            "expected_value": [
                                "distal esophagus",
                                "GE junction"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Siewert Type I or II",
                        "criterion": "Siewert type",
                        "requirement": {
                            "requirement_type": "classification",
                            "expected_value": [
                                "Type I",
                                "Type II"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biopsy-proven",
                        "criterion": "biopsy",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "resectable",
                        "criterion": "resectability",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "resectable"
                        }
                    },
                    {
                        "exact_snippets": "primary (nonrecurrent) adenocarcinoma",
                        "criterion": "adenocarcinoma",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "distal esophagus or GE junction",
                        "criterion": "location",
                        "requirement": {
                            "requirement_type": "anatomical location",
                            "expected_value": [
                                "distal esophagus",
                                "GE junction"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Siewert Type I or II",
                        "criterion": "Siewert type",
                        "requirement": {
                            "requirement_type": "classification",
                            "expected_value": [
                                "Type I",
                                "Type II"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Siewert Type I: adenocarcinoma of the distal esophagus",
                "criterions": [
                    {
                        "exact_snippets": "Siewert Type I: adenocarcinoma of the distal esophagus",
                        "criterion": "Siewert Type I",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adenocarcinoma of the distal esophagus",
                        "criterion": "adenocarcinoma",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "distal esophagus"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Siewert Type I: adenocarcinoma of the distal esophagus",
                        "criterion": "Siewert Type I",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adenocarcinoma of the distal esophagus",
                        "criterion": "adenocarcinoma",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "distal esophagus"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Siewert Type II: adenocarcinoma of the esophago-gastric junction/real cardia",
                "criterions": [
                    {
                        "exact_snippets": "Siewert Type II: adenocarcinoma of the esophago-gastric junction/real cardia",
                        "criterion": "Siewert Type II adenocarcinoma",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "esophago-gastric junction",
                                "real cardia"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Siewert Type II: adenocarcinoma of the esophago-gastric junction/real cardia",
                        "criterion": "Siewert Type II adenocarcinoma",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "esophago-gastric junction",
                                "real cardia"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. No pre-existing grade 2 or greater peripheral neuropathy (CTCAE v3) of any etiology.",
                "criterions": [
                    {
                        "exact_snippets": "No pre-existing grade 2 or greater peripheral neuropathy (CTCAE v3)",
                        "criterion": "peripheral neuropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No pre-existing grade 2 or greater peripheral neuropathy (CTCAE v3)",
                    "criterion": "peripheral neuropathy",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": {
                            "operator": "<",
                            "value": 2,
                            "unit": "grade"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "7. Adequate bone marrow, hepatic and renal function prior to registration:",
                "criterions": [
                    {
                        "exact_snippets": "Adequate bone marrow ... function",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... function",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... renal function",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate bone marrow ... function",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic ... function",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... renal function",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC ≥ 3,000/mm³",
                "criterions": [
                    {
                        "exact_snippets": "WBC ≥ 3,000/mm³",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC ≥ 3,000/mm³",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ANC ≥ 1,500/mm³",
                "criterions": [
                    {
                        "exact_snippets": "ANC ≥ 1,500/mm³",
                        "criterion": "ANC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ANC ≥ 1,500/mm³",
                        "criterion": "ANC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 100,000/mm³",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm³",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm³",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin ≥ 9.5 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 9.5 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 9.5,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 9.5 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 9.5,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ALT (SGPT) ≤ 2.0 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "ALT (SGPT) ≤ 2.0 times ULN",
                        "criterion": "ALT (SGPT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ALT (SGPT) ≤ 2.0 times ULN",
                        "criterion": "ALT (SGPT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Alkaline phosphatase ≤ 2.0 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "Alkaline phosphatase ≤ 2.0 times ULN",
                        "criterion": "alkaline phosphatase",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Alkaline phosphatase ≤ 2.0 times ULN",
                        "criterion": "alkaline phosphatase",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Albumin ≥ 2.0 g/dL OR prealbumin ≥ 15 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Albumin ≥ 2.0 g/dL",
                        "criterion": "albumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2.0,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "prealbumin ≥ 15 mg/dL",
                        "criterion": "prealbumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 15,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Albumin ≥ 2.0 g/dL",
                        "criterion": "albumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2.0,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "prealbumin ≥ 15 mg/dL",
                        "criterion": "prealbumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 15,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Magnesium ≥ lower limit of normal (LLN)",
                "criterions": [
                    {
                        "exact_snippets": "Magnesium ≥ lower limit of normal (LLN)",
                        "criterion": "magnesium level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 0,
                                "unit": "LLN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Magnesium ≥ lower limit of normal (LLN)",
                        "criterion": "magnesium level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 0,
                                "unit": "LLN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. Patient must be evaluated before registration by medical oncologist, radiation oncologist and surgeon and deemed fit for protocol therapy and surgery.",
                "criterions": [
                    {
                        "exact_snippets": "evaluated before registration by medical oncologist",
                        "criterion": "evaluation by medical oncologist",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "evaluated before registration by ... radiation oncologist",
                        "criterion": "evaluation by radiation oncologist",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "evaluated before registration by ... surgeon",
                        "criterion": "evaluation by surgeon",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "deemed fit for protocol therapy",
                        "criterion": "fitness for protocol therapy",
                        "requirement": {
                            "requirement_type": "fitness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "deemed fit for ... surgery",
                        "criterion": "fitness for surgery",
                        "requirement": {
                            "requirement_type": "fitness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "evaluated before registration by medical oncologist",
                                "criterion": "evaluation by medical oncologist",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "evaluated before registration by ... radiation oncologist",
                                "criterion": "evaluation by radiation oncologist",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "evaluated before registration by ... surgeon",
                                "criterion": "evaluation by surgeon",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "deemed fit for protocol therapy",
                                "criterion": "fitness for protocol therapy",
                                "requirement": {
                                    "requirement_type": "fitness",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "deemed fit for ... surgery",
                                "criterion": "fitness for surgery",
                                "requirement": {
                                    "requirement_type": "fitness",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "9. No prior invasive malignancy, unless disease-free for ≥ 5 years prior to registration (Exceptions: non-melanoma skin cancer, in-situ cancers).",
                "criterions": [
                    {
                        "exact_snippets": "No prior invasive malignancy",
                        "criterion": "prior invasive malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "unless disease-free for ≥ 5 years prior to registration",
                        "criterion": "disease-free period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Exceptions: non-melanoma skin cancer, in-situ cancers",
                        "criterion": "exceptions to prior invasive malignancy",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "non-melanoma skin cancer",
                                "in-situ cancers"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "not_criteria": {
                                "exact_snippets": "No prior invasive malignancy",
                                "criterion": "prior invasive malignancy",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        },
                        {
                            "not_criteria": {
                                "exact_snippets": "Exceptions: non-melanoma skin cancer, in-situ cancers",
                                "criterion": "exceptions to prior invasive malignancy",
                                "requirement": {
                                    "requirement_type": "types",
                                    "expected_value": [
                                        "non-melanoma skin cancer",
                                        "in-situ cancers"
                                    ]
                                }
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "unless disease-free for ≥ 5 years prior to registration",
                            "criterion": "disease-free period",
                            "requirement": {
                                "requirement_type": "duration",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 5,
                                    "unit": "years"
                                }
                            }
                        },
                        {
                            "not_criteria": {
                                "exact_snippets": "Exceptions: non-melanoma skin cancer, in-situ cancers",
                                "criterion": "exceptions to prior invasive malignancy",
                                "requirement": {
                                    "requirement_type": "types",
                                    "expected_value": [
                                        "non-melanoma skin cancer",
                                        "in-situ cancers"
                                    ]
                                }
                            }
                        }
                    ]
                }
            }
        },
        {
            "identified_line": {
                "line": "11. No prior chest or upper abdomen radiotherapy; prior therapy with cisplatin, docetaxel, panitumumab or other anti-EGFR therapy or prior esophageal or gastric surgery (Exception: prior surgery to treat reflux disease)",
                "criterions": [
                    {
                        "exact_snippets": "No prior chest or upper abdomen radiotherapy",
                        "criterion": "prior chest or upper abdomen radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "prior therapy with cisplatin",
                        "criterion": "prior therapy with cisplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "prior therapy with ... docetaxel",
                        "criterion": "prior therapy with docetaxel",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "prior therapy with ... panitumumab",
                        "criterion": "prior therapy with panitumumab",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "prior therapy with ... other anti-EGFR therapy",
                        "criterion": "prior therapy with other anti-EGFR therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "prior esophageal or gastric surgery",
                        "criterion": "prior esophageal or gastric surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "prior surgery to treat reflux disease",
                        "criterion": "prior surgery to treat reflux disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "No prior chest or upper abdomen radiotherapy",
                            "criterion": "prior chest or upper abdomen radiotherapy",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "prior therapy with cisplatin",
                                "criterion": "prior therapy with cisplatin",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "prior therapy with ... docetaxel",
                                "criterion": "prior therapy with docetaxel",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "prior therapy with ... panitumumab",
                                "criterion": "prior therapy with panitumumab",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "prior therapy with ... other anti-EGFR therapy",
                                "criterion": "prior therapy with other anti-EGFR therapy",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "not_criteria": {
                                    "exact_snippets": "prior esophageal or gastric surgery",
                                    "criterion": "prior esophageal or gastric surgery",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                }
                            },
                            {
                                "exact_snippets": "prior surgery to treat reflux disease",
                                "criterion": "prior surgery to treat reflux disease",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "12. No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psyschiatric illness/social situations that would limit compliance with study requirements.",
                "criterions": [
                    {
                        "exact_snippets": "uncontrolled intercurrent illness",
                        "criterion": "uncontrolled intercurrent illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "ongoing or active infection",
                        "criterion": "ongoing or active infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "symptomatic congestive heart failure",
                        "criterion": "symptomatic congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "unstable angina pectoris",
                        "criterion": "unstable angina pectoris",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "cardiac arrhythmia",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "psychiatric illness/social situations that would limit compliance with study requirements",
                        "criterion": "psychiatric illness/social situations",
                        "requirement": {
                            "requirement_type": "impact on compliance",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "exact_snippets": "uncontrolled intercurrent illness",
                                                        "criterion": "uncontrolled intercurrent illness",
                                                        "requirement": {
                                                            "requirement_type": "presence",
                                                            "expected_value": false
                                                        }
                                                    },
                                                    {
                                                        "exact_snippets": "ongoing or active infection",
                                                        "criterion": "ongoing or active infection",
                                                        "requirement": {
                                                            "requirement_type": "presence",
                                                            "expected_value": false
                                                        }
                                                    }
                                                ]
                                            },
                                            {
                                                "exact_snippets": "symptomatic congestive heart failure",
                                                "criterion": "symptomatic congestive heart failure",
                                                "requirement": {
                                                    "requirement_type": "presence",
                                                    "expected_value": false
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "unstable angina pectoris",
                                        "criterion": "unstable angina pectoris",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "cardiac arrhythmia",
                                "criterion": "cardiac arrhythmia",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "psychiatric illness/social situations that would limit compliance with study requirements",
                        "criterion": "psychiatric illness/social situations",
                        "requirement": {
                            "requirement_type": "impact on compliance",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "4. Pre-registration EUS, CT of chest and upper abdomen, and PET must support a clinical stage of T3N0M0, T2-3N1M0 or T2-3N0-1M1a (celiac adenopathy must be ≤ 2 cm by EUS). Clinically staged T1 tumors and T2N0M0 tumors are not eligible. N1 does not require biopsy/FNA. Note: Patients requiring a stent for nutrition must have staging examinations and scans completed before stent placement.",
                "criterions": [
                    {
                        "exact_snippets": "Pre-registration EUS, CT of chest and upper abdomen, and PET must support a clinical stage of T3N0M0, T2-3N1M0 or T2-3N0-1M1a",
                        "criterion": "clinical stage",
                        "requirement": {
                            "requirement_type": "staging",
                            "expected_value": [
                                "T3N0M0",
                                "T2-3N1M0",
                                "T2-3N0-1M1a"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "celiac adenopathy must be ≤ 2 cm by EUS",
                        "criterion": "celiac adenopathy",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "cm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Clinically staged T1 tumors and T2N0M0 tumors are not eligible",
                        "criterion": "clinical stage",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": [
                                "T1",
                                "T2N0M0"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "N1 does not require biopsy/FNA",
                        "criterion": "N1 biopsy/FNA requirement",
                        "requirement": {
                            "requirement_type": "requirement",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Patients requiring a stent for nutrition must have staging examinations and scans completed before stent placement",
                        "criterion": "stent for nutrition",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "staging examinations and scans completed before stent placement"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "5. No definitive radiological evidence of distant metastases.",
                "criterions": [
                    {
                        "exact_snippets": "No definitive radiological evidence of distant metastases.",
                        "criterion": "distant metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No definitive radiological evidence of distant metastases.",
                    "criterion": "distant metastases",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine ≤ 1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine ≤ 1.5 mg/dL",
                        "criterion": "creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine \u0010.5 mg/dL",
                        "criterion": "creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Total bilirubin ≤ 3 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Total bilirubin ≤ 3 mg/dL",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Total bilirubin \u0010 3 mg/dL",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST (SGOT) ≤ 2.0 times upper limit of normal (ULN)",
                "criterions": [
                    {
                        "exact_snippets": "AST (SGOT) ≤ 2.0 times upper limit of normal (ULN)",
                        "criterion": "AST (SGOT) level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "AST (SGOT) \u0010 2.0 times upper limit of normal (ULN)",
                        "criterion": "AST (SGOT) level",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "13. No history of interstitial lung disease (eg, pneumonitis or pulmonary fibrosis or any evidence of interstitial lung disease on baseline chest CT scan",
                "criterions": [
                    {
                        "exact_snippets": "No history of interstitial lung disease",
                        "criterion": "interstitial lung disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "any evidence of interstitial lung disease on baseline chest CT scan",
                        "criterion": "interstitial lung disease",
                        "requirement": {
                            "requirement_type": "evidence on baseline chest CT scan",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "14. No history of any medical or psychiatric condition or laboratory abnormality that in the opinion of the investigator may increase the risks associated with the study participation or investigational product(s) administration or may interfere with the interpretation of the results.",
                "criterions": [
                    {
                        "exact_snippets": "No history of any medical or psychiatric condition",
                        "criterion": "medical or psychiatric condition",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No history of any ... laboratory abnormality",
                        "criterion": "laboratory abnormality",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "10. Non-pregnant and non-breast feeding. Female participants of child-bearing potential must have a negative urine or serum pregnancy test prior to registration. Perimenopausal participants must be amenorrheic ≥ 12 months to be considered not of childbearing potential. All patients of reproductive potential must agree to use an an effective method of birth-control while receiving study therapy and for six months after completion of therapy.",
                "criterions": [
                    {
                        "exact_snippets": "Non-pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "non-pregnant"
                        }
                    },
                    {
                        "exact_snippets": "non-breast feeding",
                        "criterion": "breastfeeding status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "non-breastfeeding"
                        }
                    },
                    {
                        "exact_snippets": "Female participants of child-bearing potential must have a negative urine or serum pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "Perimenopausal participants must be amenorrheic ≥ 12 months",
                        "criterion": "amenorrhea duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "All patients of reproductive potential must agree to use an effective method of birth-control",
                        "criterion": "birth control usage",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "while receiving study therapy and for six months after completion of therapy",
                        "criterion": "birth control duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "while receiving study therapy and for six months after completion of therapy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ]
}