{
    "info": {
        "nct_id": "NCT00645060",
        "official_title": "A Phase I Study of Yttrium-90 Labeled Humanized Anti-CEA M5A Antibody in Patients With CEA Producing Advanced Malignancies",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 120 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed advanced solid tumor for which no standard or effective treatment is available\n\n  * Patients who refuse an available standard but non-curative treatment may also be eligible\n* Tumors must produce CEA as documented by either an elevated serum CEA above the upper limit of normal (ULN) or by immunohistochemical (IHC) methods\n\n  * Positive CEA IHC stain is determined if more than 30% of the tumor cells have an intensity of 2+ or greater\n* Measurable disease\n* Estimated < 1/3 of liver involvement if tumor involves the liver\n* No brain or leptomeningeal involvement with cancer\n\nPATIENT CHARACTERISTICS:\n\n* Karnofsky performance status 60-100%\n* Life expectancy ≥ 3 months\n* WBC ≥ 4,000/μL\n* ANC ≥ 1,500/μL\n* Platelet count ≥ 125,000/μL\n* Creatinine ≤ 1.5 mg/dL and/or creatinine clearance > 60 mL/min\n* Bilirubin ≤ 1.5 mg/dL\n* ALT and AST ≤ 2 times ULN\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* Patients currently being treated for severe infections or recovering from other intercurrent illnesses (such as poorly controlled diabetes or hypertension) are ineligible until recovery is deemed complete by the investigator\n* Serum anti-antibody testing must be negative for human anti-humanized antibodies (if patient received prior monoclonal antibody)\n* Serum HIV-negative\n* Serum hepatitis B antigen- and hepatitis C antibody-negative\n\nPRIOR CONCURRENT THERAPY:\n\n* At least 4 weeks since prior radiotherapy, immunotherapy, or chemotherapy (6 weeks for mitomycin C or nitrosoureas) and recovered\n* Recovered from prior major surgery\n* No prior radiotherapy to > 50% of bone marrow\n* No other concurrent chemotherapy, radiotherapy, or immunotherapy"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 120 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed advanced solid tumor for which no standard or effective treatment is available",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed advanced solid tumor",
                        "criterion": "advanced solid tumor",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically"
                        }
                    },
                    {
                        "exact_snippets": "no standard or effective treatment is available",
                        "criterion": "treatment availability",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Histologically confirmed advanced solid tumor",
                        "criterion": "advanced solid tumor",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically"
                        }
                    },
                    {
                        "exact_snippets": "no standard or effective treatment is available",
                        "criterion": "treatment availability",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients who refuse an available standard but non-curative treatment may also be eligible",
                "criterions": [
                    {
                        "exact_snippets": "Patients who refuse an available standard but non-curative treatment",
                        "criterion": "refusal of standard treatment",
                        "requirement": {
                            "requirement_type": "action",
                            "expected_value": "refusal"
                        }
                    },
                    {
                        "exact_snippets": "Patients who refuse an available standard but non-curative treatment",
                        "criterion": "refusal of standard treatment",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Patients who refuse an available standard but non-curative treatment",
                        "criterion": "refusal of standard treatment",
                        "requirement": {
                            "requirement_type": "curative",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients who refuse an available standard but non-curative treatment",
                                "criterion": "refusal of standard treatment",
                                "requirement": {
                                    "requirement_type": "action",
                                    "expected_value": "refusal"
                                }
                            },
                            {
                                "exact_snippets": "Patients who refuse an available standard but non-curative treatment",
                                "criterion": "refusal of standard treatment",
                                "requirement": {
                                    "requirement_type": "availability",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Patients who refuse an available standard but non-curative treatment",
                        "criterion": "refusal of standard treatment",
                        "requirement": {
                            "requirement_type": "curative",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumors must produce CEA as documented by either an elevated serum CEA above the upper limit of normal (ULN) or by immunohistochemical (IHC) methods",
                "criterions": [
                    {
                        "exact_snippets": "Tumors must produce CEA",
                        "criterion": "tumor CEA production",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "elevated serum CEA above the upper limit of normal (ULN)",
                        "criterion": "serum CEA level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "immunohistochemical (IHC) methods",
                        "criterion": "CEA detection method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "immunohistochemical (IHC)"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Tumors must produce CEA",
                                "criterion": "tumor CEA production",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "elevated serum CEA above the upper limit of normal (ULN)",
                                "criterion": "serum CEA level",
                                "requirement": {
                                    "requirement_type": "level",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 1,
                                        "unit": "ULN"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Tumors must produce CEA",
                                "criterion": "tumor CEA production",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "immunohistochemical (IHC) methods",
                                "criterion": "CEA detection method",
                                "requirement": {
                                    "requirement_type": "method",
                                    "expected_value": "immunohistochemical (IHC)"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Positive CEA IHC stain is determined if more than 30% of the tumor cells have an intensity of 2+ or greater",
                "criterions": [
                    {
                        "exact_snippets": "Positive CEA IHC stain ... more than 30% of the tumor cells ... intensity of 2+ or greater",
                        "criterion": "CEA IHC stain",
                        "requirement": {
                            "requirement_type": "positivity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Positive CEA IHC stain ... more than 30% of the tumor cells ... intensity of 2+ or greater",
                        "criterion": "CEA IHC stain",
                        "requirement": {
                            "requirement_type": "percentage of tumor cells",
                            "expected_value": {
                                "operator": ">",
                                "value": 30,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Positive CEA IHC stain ... more than 30% of the tumor cells ... intensity of 2+ or greater",
                        "criterion": "CEA IHC stain",
                        "requirement": {
                            "requirement_type": "intensity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "+"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "condition": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Positive CEA IHC stain ... more than 30% of the tumor cells ... intensity of 2+ or greater",
                                    "criterion": "CEA IHC stain",
                                    "requirement": {
                                        "requirement_type": "percentage of tumor cells",
                                        "expected_value": {
                                            "operator": ">",
                                            "value": 30,
                                            "unit": "%"
                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "Positive CEA IHC stain ... more than 30% of the tumor cells ... intensity of 2+ or greater",
                                    "criterion": "CEA IHC stain",
                                    "requirement": {
                                        "requirement_type": "intensity",
                                        "expected_value": {
                                            "operator": ">=",
                                            "value": 2,
                                            "unit": "+"
                                        }
                                    }
                                }
                            ]
                        },
                        "then_criteria": {
                            "exact_snippets": "Positive CEA IHC stain ... more than 30% of the tumor cells ... intensity of 2+ or greater",
                            "criterion": "CEA IHC stain",
                            "requirement": {
                                "requirement_type": "positivity",
                                "expected_value": true
                            }
                        },
                        "else_criteria": null
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease",
                "criterions": [
                    {
                        "exact_snippets": "Measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Estimated < 1/3 of liver involvement if tumor involves the liver",
                "criterions": [
                    {
                        "exact_snippets": "tumor involves the liver",
                        "criterion": "liver involvement by tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "< 1/3 of liver involvement",
                        "criterion": "liver involvement",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<",
                                "value": 0.333,
                                "unit": "fraction"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "tumor involves the liver",
                    "criterion": "liver involvement by tumor",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "< 1/3 of liver involvement",
                    "criterion": "liver involvement",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": {
                            "operator": "<",
                            "value": 0.333,
                            "unit": "fraction"
                        }
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No brain or leptomeningeal involvement with cancer",
                "criterions": [
                    {
                        "exact_snippets": "No brain ... involvement with cancer",
                        "criterion": "brain involvement with cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... leptomeningeal involvement with cancer",
                        "criterion": "leptomeningeal involvement with cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No brain ... involvement with cancer",
                        "criterion": "brain involvement with cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No ... leptomeningeal involvement with cancer",
                        "criterion": "leptomeningeal involvement with cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky performance status 60-100%",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky performance status 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky performance status 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy ≥ 3 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy ≥ 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy ≥ 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC ≥ 4,000/μL",
                "criterions": [
                    {
                        "exact_snippets": "WBC ≥ 4,000/μL",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4000,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC ≥ 4,000/μL",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4000,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ANC ≥ 1,500/μL",
                "criterions": [
                    {
                        "exact_snippets": "ANC ≥ 1,500/μL",
                        "criterion": "ANC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ANC ≥ 1,500/μL",
                        "criterion": "ANC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 125,000/μL",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 125,000/μL",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 125000,
                                "unit": "/μL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count ≥ 125,000/μL",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 125000,
                                "unit": "/μL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin ≤ 1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin ≤ 1.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin ≤ 1.5 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ALT and AST ≤ 2 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "ALT ... ≤ 2 times ULN",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AST ≤ 2 times ULN",
                        "criterion": "AST",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ALT ... ≤ 2 times ULN",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AST ≤ 2 times ULN",
                        "criterion": "AST",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": "fertile"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "must use effective contraception",
                    "criterion": "contraception use",
                    "requirement": {
                        "requirement_type": "necessity",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Patients currently being treated for severe infections or recovering from other intercurrent illnesses (such as poorly controlled diabetes or hypertension) are ineligible until recovery is deemed complete by the investigator",
                "criterions": [
                    {
                        "exact_snippets": "Patients currently being treated for severe infections",
                        "criterion": "severe infections",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "recovering from other intercurrent illnesses",
                        "criterion": "intercurrent illnesses",
                        "requirement": {
                            "requirement_type": "recovery status",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "poorly controlled diabetes",
                        "criterion": "diabetes",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "well controlled"
                        }
                    },
                    {
                        "exact_snippets": "poorly controlled ... hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control status",
                            "expected_value": "well controlled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Patients currently being treated for severe infections",
                                    "criterion": "severe infections",
                                    "requirement": {
                                        "requirement_type": "treatment status",
                                        "expected_value": false
                                    }
                                },
                                {
                                    "exact_snippets": "recovering from other intercurrent illnesses",
                                    "criterion": "intercurrent illnesses",
                                    "requirement": {
                                        "requirement_type": "recovery status",
                                        "expected_value": true
                                    }
                                }
                            ]
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "poorly controlled diabetes",
                                "criterion": "diabetes",
                                "requirement": {
                                    "requirement_type": "control status",
                                    "expected_value": "well controlled"
                                }
                            },
                            {
                                "exact_snippets": "poorly controlled ... hypertension",
                                "criterion": "hypertension",
                                "requirement": {
                                    "requirement_type": "control status",
                                    "expected_value": "well controlled"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serum anti-antibody testing must be negative for human anti-humanized antibodies (if patient received prior monoclonal antibody)",
                "criterions": [
                    {
                        "exact_snippets": "Serum anti-antibody testing must be negative for human anti-humanized antibodies",
                        "criterion": "serum anti-antibody testing",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "if patient received prior monoclonal antibody",
                        "criterion": "prior monoclonal antibody",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "if patient received prior monoclonal antibody",
                    "criterion": "prior monoclonal antibody",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "Serum anti-antibody testing must be negative for human anti-humanized antibodies",
                    "criterion": "serum anti-antibody testing",
                    "requirement": {
                        "requirement_type": "result",
                        "expected_value": "negative"
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Serum HIV-negative",
                "criterions": [
                    {
                        "exact_snippets": "Serum HIV-negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Serum HIV-negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serum hepatitis B antigen- and hepatitis C antibody-negative",
                "criterions": [
                    {
                        "exact_snippets": "Serum hepatitis B antigen- ... -negative",
                        "criterion": "hepatitis B antigen",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hepatitis C antibody-negative",
                        "criterion": "hepatitis C antibody",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Serum hepatitis B antigen- ... -negative",
                        "criterion": "hepatitis B antigen",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hepatitis C antibody-negative",
                        "criterion": "hepatitis C antibody",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
                "criterions": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 4 weeks since prior radiotherapy, immunotherapy, or chemotherapy (6 weeks for mitomycin C or nitrosoureas) and recovered",
                "criterions": [
                    {
                        "exact_snippets": "At least 4 weeks since prior radiotherapy",
                        "criterion": "time since prior radiotherapy",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least 4 weeks since prior ... immunotherapy",
                        "criterion": "time since prior immunotherapy",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least 4 weeks since prior ... chemotherapy",
                        "criterion": "time since prior chemotherapy",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "6 weeks for mitomycin C or nitrosoureas",
                        "criterion": "time since prior mitomycin C or nitrosoureas",
                        "requirement": {
                            "requirement_type": "time since treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "recovered",
                        "criterion": "recovery from prior treatment",
                        "requirement": {
                            "requirement_type": "recovery status",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "At least 4 weeks since prior radiotherapy",
                                        "criterion": "time since prior radiotherapy",
                                        "requirement": {
                                            "requirement_type": "time since treatment",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 4,
                                                "unit": "weeks"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "recovered",
                                        "criterion": "recovery from prior treatment",
                                        "requirement": {
                                            "requirement_type": "recovery status",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "At least 4 weeks since prior ... immunotherapy",
                                        "criterion": "time since prior immunotherapy",
                                        "requirement": {
                                            "requirement_type": "time since treatment",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 4,
                                                "unit": "weeks"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "recovered",
                                        "criterion": "recovery from prior treatment",
                                        "requirement": {
                                            "requirement_type": "recovery status",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "At least 4 weeks since prior ... chemotherapy",
                                        "criterion": "time since prior chemotherapy",
                                        "requirement": {
                                            "requirement_type": "time since treatment",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 4,
                                                "unit": "weeks"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "recovered",
                                        "criterion": "recovery from prior treatment",
                                        "requirement": {
                                            "requirement_type": "recovery status",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "6 weeks for mitomycin C or nitrosoureas",
                                        "criterion": "time since prior mitomycin C or nitrosoureas",
                                        "requirement": {
                                            "requirement_type": "time since treatment",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "recovered",
                                        "criterion": "recovery from prior treatment",
                                        "requirement": {
                                            "requirement_type": "recovery status",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recovered from prior major surgery",
                "criterions": [
                    {
                        "exact_snippets": "Recovered from prior major surgery",
                        "criterion": "recovery from prior major surgery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recovered from prior major surgery",
                        "criterion": "recovery from prior major surgery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent chemotherapy, radiotherapy, or immunotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent ... radiotherapy",
                        "criterion": "concurrent radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent ... immunotherapy",
                        "criterion": "concurrent immunotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent ... radiotherapy",
                        "criterion": "concurrent radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent ... immunotherapy",
                        "criterion": "concurrent immunotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Creatinine ≤ 1.5 mg/dL and/or creatinine clearance > 60 mL/min",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine ≤ 1.5 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "creatinine clearance > 60 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 60,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Creatinine \u0010 1.5 mg/dL",
                                "criterion": "creatinine level",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1.5,
                                        "unit": "mg/dL"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "creatinine clearance > 60 mL/min",
                                "criterion": "creatinine clearance",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 60,
                                        "unit": "mL/min"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior radiotherapy to > 50% of bone marrow",
                "criterions": [
                    {
                        "exact_snippets": "No prior radiotherapy to > 50% of bone marrow",
                        "criterion": "prior radiotherapy to bone marrow",
                        "requirement": {
                            "requirement_type": "extent",
                            "expected_value": {
                                "operator": "<=",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior radiotherapy to > 50% of bone marrow",
                    "criterion": "prior radiotherapy to bone marrow",
                    "requirement": {
                        "requirement_type": "extent",
                        "expected_value": {
                            "operator": ">",
                            "value": 50,
                            "unit": "%"
                        }
                    }
                }
            }
        }
    ]
}