{
    "info": {
        "nct_id": "NCT00514020",
        "official_title": "Pharmacogenomically Selected Treatment for Gastric and Gastroesophageal Junction (GEJ) Tumors: A Phase II Study",
        "inclusion_criteria": "* Patients must have histologically or cytologically confirmed adenocarcinoma of the stomach or gastroesophageal junction\n\n  * Metastatic disease\n* Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan\n* No known active brain metastases\n\n  * Patients with treated brain metastases are eligible if stable off steroids for at least 30 days\n\nPATIENT CHARACTERISTICS:\n\n* ECOG performance status ≤ 2 (Karnofsky performance status ≥ 60%)\n* Life expectancy ≥ 3 months\n* WBC ≥ 3,000/μL\n* Absolute neutrophil count ≥ 1,500/μL\n* Platelets ≥ 100,000/μL\n* Total bilirubin ≤ 1.5 x upper limit of normal (ULN)\n* AST or ALT ≤ 2.5 x ULN (< 5 x ULN if known liver metastases)\n* Creatinine clearance ≤ 1.5 x ULN\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception during and for 21 days after completion of study treatment\n* No history of allergic reactions to fluorouracil or oxaliplatin\n* No concurrent uncontrolled illness including, but not limited to, ongoing or active infection or psychiatric illness/social situations that would limit compliance with study requirements\n\nPRIOR CONCURRENT THERAPY:\n\n* No prior therapy for metastatic disease\n\n  * Prior neoadjuvant or adjuvant therapy is allowed if the disease-free interval has been longer than 6 months\n* No other concurrent chemotherapy\n* No concurrent combination anti-retroviral therapy for HIV-positive patients\n* No concurrent routine prophylaxis with filgrastim (G-CSF)\n* No other concurrent antineoplastic agents, including chemotherapy, radiation therapy, or biologic agents\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Metastatic disease",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic disease",
                        "criterion": "metastatic disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Metastatic disease",
                        "criterion": "metastatic disease",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
                "criterions": [
                    {
                        "exact_snippets": "measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "at least one lesion that can be accurately measured in at least one dimension"
                        }
                    },
                    {
                        "exact_snippets": "measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 20,
                                        "unit": "mm"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
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                                    {
                                        "operator": ">=",
                                        "value": 10,
                                        "unit": "mm"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
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                                "requirement": {
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                                }
                            },
                            {
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                                    {
                                        "exact_snippets": "measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
                                        "criterion": "measurable disease",
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                                                        "value": 20,
                                                        "unit": "mm"
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                                        }
                                    },
                                    {
                                        "exact_snippets": "measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥ 10 mm with spiral CT scan",
                                        "criterion": "measurable disease",
                                        "requirement": {
                                            "requirement_type": "size",
                                            "expected_value": {
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                                                    {
                                                        "operator": ">=",
                                                        "value": 10,
                                                        "unit": "mm"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No known active brain metastases",
                "criterions": [
                    {
                        "exact_snippets": "No known active brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No known active brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No known active brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No known active brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with treated brain metastases are eligible if stable off steroids for at least 30 days",
                "criterions": [
                    {
                        "exact_snippets": "treated brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "treated"
                        }
                    },
                    {
                        "exact_snippets": "stable off steroids for at least 30 days",
                        "criterion": "stability off steroids",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "treated brain metastases",
                    "criterion": "brain metastases",
                    "requirement": {
                        "requirement_type": "treatment status",
                        "expected_value": "treated"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "stable off steroids for at least 30 days",
                    "criterion": "stability off steroids",
                    "requirement": {
                        "requirement_type": "duration",
                        "expected_value": {
                            "operator": ">=",
                            "value": 30,
                            "unit": "days"
                        }
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* ECOG performance status ≤ 2 (Karnofsky performance status ≥ 60%)",
                "criterions": [
                    {
                        "exact_snippets": "ECOG performance status ≤ 2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Karnofsky performance status ≥ 60%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG performance status ≤ 2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Karnofsky performance status ≥ 60%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 60,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy ≥ 3 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy ≥ 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy ≥ 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC ≥ 3,000/μL",
                "criterions": [
                    {
                        "exact_snippets": "WBC ≥ 3,000/μL",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3000,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC ≥ 3,000/μL",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3000,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count ≥ 1,500/μL",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500/μL",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500/μL",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "μL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelets ≥ 100,000/μL",
                "criterions": [
                    {
                        "exact_snippets": "Platelets ≥ 100,000/μL",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "/μL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelets ≥ 100,000/μL",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "/μL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Total bilirubin ≤ 1.5 x upper limit of normal (ULN)",
                "criterions": [
                    {
                        "exact_snippets": "Total bilirubin ≤ 1.5 x upper limit of normal (ULN)",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Total bilirubin ≤ 1.5 x upper limit of normal (ULN)",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
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                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST or ALT ≤ 2.5 x ULN (< 5 x ULN if known liver metastases)",
                "criterions": [
                    {
                        "exact_snippets": "AST or ALT ≤ 2.5 x ULN",
                        "criterion": "AST or ALT levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "< 5 x ULN if known liver metastases",
                        "criterion": "AST or ALT levels with liver metastases",
                        "requirement": {
                            "requirement_type": "comparison",
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                                "operator": "<",
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                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "< 5 x ULN if known liver metastases",
                    "criterion": "AST or ALT levels with liver metastases",
                    "requirement": {
                        "requirement_type": "comparison",
                        "expected_value": {
                            "operator": "<",
                            "value": 5,
                            "unit": "x ULN"
                        }
                    }
                },
                "then_criteria": null,
                "else_criteria": {
                    "exact_snippets": "AST or ALT ≤ 2.5 x ULN",
                    "criterion": "AST or ALT levels",
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                        "requirement_type": "comparison",
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                            "operator": "<=",
                            "value": 2.5,
                            "unit": "x ULN"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception during and for 21 days after completion of study treatment",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception during and for 21 days after completion of study treatment",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "during and for 21 days after completion of study treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "must use effective contraception during and for 21 days after completion of study treatment",
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                        "requirement_type": "duration",
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                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No history of allergic reactions to fluorouracil or oxaliplatin",
                "criterions": [
                    {
                        "exact_snippets": "No history of allergic reactions to fluorouracil",
                        "criterion": "allergic reactions to fluorouracil",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No history of allergic reactions to ... oxaliplatin",
                        "criterion": "allergic reactions to oxaliplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "No history of allergic reactions to fluorouracil",
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                    {
                        "exact_snippets": "No history of allergic reactions to ... oxaliplatin",
                        "criterion": "allergic reactions to oxaliplatin",
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                    }
                ]
            }
        },
        {
            "identified_line": {
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                "criterions": [
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                        "criterion": "uncontrolled illness",
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                        }
                    },
                    {
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                        "criterion": "active infection",
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                        }
                    },
                    {
                        "exact_snippets": "psychiatric illness/social situations that would limit compliance with study requirements",
                        "criterion": "psychiatric illness or social situations",
                        "requirement": {
                            "requirement_type": "impact on compliance",
                            "expected_value": false
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
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                        "and_criteria": [
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                                "exact_snippets": "No concurrent uncontrolled illness",
                                "criterion": "uncontrolled illness",
                                "requirement": {
                                    "requirement_type": "presence",
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                                }
                            },
                            {
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                        "criterion": "psychiatric illness or social situations",
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                            "requirement_type": "impact on compliance",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No prior therapy for metastatic disease",
                "criterions": [
                    {
                        "exact_snippets": "No prior therapy for metastatic disease",
                        "criterion": "prior therapy for metastatic disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "No prior therapy for metastatic disease",
                        "criterion": "prior therapy for metastatic disease",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior neoadjuvant or adjuvant therapy is allowed if the disease-free interval has been longer than 6 months",
                "criterions": [
                    {
                        "exact_snippets": "Prior neoadjuvant or adjuvant therapy is allowed",
                        "criterion": "prior neoadjuvant or adjuvant therapy",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "disease-free interval has been longer than 6 months",
                        "criterion": "disease-free interval",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "disease-free interval has been longer than 6 months",
                    "criterion": "disease-free interval",
                    "requirement": {
                        "requirement_type": "duration",
                        "expected_value": {
                            "operator": ">",
                            "value": 6,
                            "unit": "months"
                        }
                    }
                },
                "then_criteria": {
                    "exact_snippets": "Prior neoadjuvant or adjuvant therapy is allowed",
                    "criterion": "prior neoadjuvant or adjuvant therapy",
                    "requirement": {
                        "requirement_type": "allowance",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent combination anti-retroviral therapy for HIV-positive patients",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent combination anti-retroviral therapy",
                        "criterion": "anti-retroviral therapy",
                        "requirement": {
                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "HIV-positive patients",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "HIV-positive patients",
                    "criterion": "HIV status",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": "positive"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "No concurrent combination anti-retroviral therapy",
                    "criterion": "anti-retroviral therapy",
                    "requirement": {
                        "requirement_type": "concurrency",
                        "expected_value": false
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent routine prophylaxis with filgrastim (G-CSF)",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent routine prophylaxis with filgrastim (G-CSF)",
                        "criterion": "concurrent routine prophylaxis with filgrastim (G-CSF)",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent routine prophylaxis with filgrastim (G-CSF)",
                    "criterion": "concurrent routine prophylaxis with filgrastim (G-CSF)",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent antineoplastic agents, including chemotherapy, radiation therapy, or biologic agents",
                "criterions": [
                    {
                        "exact_snippets": "No other concurrent antineoplastic agents, including chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent antineoplastic agents, including ... radiation therapy",
                        "criterion": "concurrent radiation therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent antineoplastic agents, including ... biologic agents",
                        "criterion": "concurrent biologic agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No other concurrent antineoplastic agents, including chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent antineoplastic agents, including ... radiation therapy",
                        "criterion": "concurrent radiation therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other concurrent antineoplastic agents, including ... biologic agents",
                        "criterion": "concurrent biologic agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Patients must have histologically or cytologically confirmed adenocarcinoma of the stomach or gastroesophageal junction",
                "criterions": [
                    {
                        "exact_snippets": "histologically or cytologically confirmed adenocarcinoma",
                        "criterion": "adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "adenocarcinoma of the stomach or gastroesophageal junction",
                        "criterion": "adenocarcinoma location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "stomach",
                                "gastroesophageal junction"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "histologically or cytologically confirmed adenocarcinoma",
                                "criterion": "adenocarcinoma",
                                "requirement": {
                                    "requirement_type": "confirmation method",
                                    "expected_value": "histologically"
                                }
                            },
                            {
                                "exact_snippets": "histologically or cytologically confirmed adenocarcinoma",
                                "criterion": "adenocarcinoma",
                                "requirement": {
                                    "requirement_type": "confirmation method",
                                    "expected_value": "cytologically"
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "adenocarcinoma of the stomach or gastroesophageal junction",
                                "criterion": "adenocarcinoma location",
                                "requirement": {
                                    "requirement_type": "location",
                                    "expected_value": "stomach"
                                }
                            },
                            {
                                "exact_snippets": "adenocarcinoma of the stomach or gastroesophageal junction",
                                "criterion": "adenocarcinoma location",
                                "requirement": {
                                    "requirement_type": "location",
                                    "expected_value": "gastroesophageal junction"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine clearance ≤ 1.5 x ULN",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine clearance ≤ 1.5 x ULN",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine clearance \u0010.5 x ULN",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}