{
    "info": {
        "nct_id": "NCT00447057",
        "official_title": "A Phase 2 Study of Pemetrexed Versus Pemetrexed Plus Erlotinib in Second-Line Treatment in Patients With Nonsquamous NSCLC",
        "inclusion_criteria": "* Histological or cytological diagnosis of locally advanced or metastatic NSCLC that is of nonsquamous histology and not amenable to curative therapy.\n* Failure of previous treatment with one prior platinum-based chemotherapy regimen.\n* Good performance status.\n* Adequate bone marrow reserve, renal and hepatic functions.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Serious concomitant systemic disease.\n* Inability to take oral medication.\n* Inability or unwillingness to take vitamin supplementation and corticosteroids.\n* Pregnancy / Breast-feeding.\n* Treatment with certain medicines that prevent blood from clotting.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Failure of previous treatment with one prior platinum-based chemotherapy regimen.",
                "criterions": [
                    {
                        "exact_snippets": "Failure of previous treatment",
                        "criterion": "previous treatment",
                        "requirement": {
                            "requirement_type": "outcome",
                            "expected_value": "failure"
                        }
                    },
                    {
                        "exact_snippets": "one prior platinum-based chemotherapy regimen",
                        "criterion": "prior chemotherapy regimen",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "platinum-based"
                        }
                    },
                    {
                        "exact_snippets": "one prior platinum-based chemotherapy regimen",
                        "criterion": "prior chemotherapy regimen",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "=",
                                "value": 1,
                                "unit": "regimen"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Failure of previous treatment",
                                "criterion": "previous treatment",
                                "requirement": {
                                    "requirement_type": "outcome",
                                    "expected_value": "failure"
                                }
                            },
                            {
                                "exact_snippets": "one prior platinum-based chemotherapy regimen",
                                "criterion": "prior chemotherapy regimen",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "platinum-based"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "one prior platinum-based chemotherapy regimen",
                        "criterion": "prior chemotherapy regimen",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "=",
                                "value": 1,
                                "unit": "regimen"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Good performance status.",
                "criterions": [
                    {
                        "exact_snippets": "Good performance status.",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "quality",
                            "expected_value": "good"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Good performance status.",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "quality",
                            "expected_value": "good"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate bone marrow reserve, renal and hepatic functions.",
                "criterions": [
                    {
                        "exact_snippets": "Adequate bone marrow reserve",
                        "criterion": "bone marrow reserve",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate ... renal ... functions",
                        "criterion": "renal functions",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate ... hepatic functions",
                        "criterion": "hepatic functions",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate bone marrow reserve",
                        "criterion": "bone marrow reserve",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate ... renal ... functions",
                        "criterion": "renal functions",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate ... hepatic functions",
                        "criterion": "hepatic functions",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Serious concomitant systemic disease.",
                "criterions": [
                    {
                        "exact_snippets": "Serious concomitant systemic disease",
                        "criterion": "concomitant systemic disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Serious concomitant systemic disease",
                    "criterion": "concomitant systemic disease",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": "serious"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Inability to take oral medication.",
                "criterions": [
                    {
                        "exact_snippets": "Inability to take oral medication",
                        "criterion": "ability to take oral medication",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Inability to take oral medication",
                        "criterion": "ability to take oral medication",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Inability or unwillingness to take vitamin supplementation and corticosteroids.",
                "criterions": [
                    {
                        "exact_snippets": "Inability or unwillingness to take vitamin supplementation",
                        "criterion": "vitamin supplementation",
                        "requirement": {
                            "requirement_type": "ability or willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Inability or unwillingness to take ... corticosteroids",
                        "criterion": "corticosteroids",
                        "requirement": {
                            "requirement_type": "ability or willingness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "Inability or unwillingness to take vitamin supplementation",
                            "criterion": "vitamin supplementation",
                            "requirement": {
                                "requirement_type": "ability or willingness",
                                "expected_value": true
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "Inability or unwillingness to take ... corticosteroids",
                            "criterion": "corticosteroids",
                            "requirement": {
                                "requirement_type": "ability or willingness",
                                "expected_value": true
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnancy / Breast-feeding.",
                "criterions": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Breast-feeding",
                        "criterion": "breast-feeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Breast-feeding",
                        "criterion": "breast-feeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Treatment with certain medicines that prevent blood from clotting.",
                "criterions": [
                    {
                        "exact_snippets": "Treatment with certain medicines that prevent blood from clotting.",
                        "criterion": "treatment with anticoagulant medicines",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Treatment with certain medicines that prevent blood from clotting.",
                    "criterion": "treatment with anticoagulant medicines",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Histological or cytological diagnosis of locally advanced or metastatic NSCLC that is of nonsquamous histology and not amenable to curative therapy.",
                "criterions": [
                    {
                        "exact_snippets": "Histological or cytological diagnosis",
                        "criterion": "diagnosis method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": [
                                "histological",
                                "cytological"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "locally advanced or metastatic NSCLC",
                        "criterion": "NSCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "locally advanced",
                                "metastatic"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "nonsquamous histology",
                        "criterion": "NSCLC histology",
                        "requirement": {
                            "requirement_type": "histology",
                            "expected_value": "nonsquamous"
                        }
                    },
                    {
                        "exact_snippets": "not amenable to curative therapy",
                        "criterion": "curative therapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Histological or cytological diagnosis",
                                        "criterion": "diagnosis method",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": [
                                                "histological"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "Histological or cytological diagnosis",
                                        "criterion": "diagnosis method",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": [
                                                "cytological"
                                            ]
                                        }
                                    }
                                ]
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "locally advanced or metastatic NSCLC",
                                        "criterion": "NSCLC stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "locally advanced"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "locally advanced or metastatic NSCLC",
                                        "criterion": "NSCLC stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "metastatic"
                                            ]
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "nonsquamous histology",
                        "criterion": "NSCLC histology",
                        "requirement": {
                            "requirement_type": "histology",
                            "expected_value": "nonsquamous"
                        }
                    },
                    {
                        "exact_snippets": "not amenable to curative therapy",
                        "criterion": "curative therapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}